Cardioprotective effects of CoQ10 in pediatric patients with lysosomal storage disorders by Yasmine Abuzaid, Ghada Abdul Moemn Suliman, Osama Abd Rab El Rasool Toulba, Ahmed Abd El Basset Abo Elezz, Alshimaa Badraldeen, Heba Dawoud

“…Given the role of oxidative stress in many inborn errors of metabolism, many studies are evaluating oxidative stress and hence the role of antioxidants in patients with LSDs. The aim of this study: was to study the possible effects of Coenzyme Q10 as a cardioprotective and an antioxidant drug in patients with LSDs. …”
Get full text

Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Working on this rationale, the present study was aimed to develop novel and affordable hybrid nanocarriers combined with folate and pH-responsive functionalities for targeted delivery of Resveratrol (FOL-RSV-LPHNCs). …”
Get full text

Prevalence and determinants of multidimensional frailty in hospitalized older adults with coronary heart disease: a LASSO regression analysis by Ping Zhu, Dongmei Mei, Dongmei Mei, Yan Yang, Defang Meng, Yaoyao Hu, Xiaoyan Wang

“…Conversely, higher scores on activities of daily living (ADL) (OR = 0.952; 95% CI: 0.921–0.984) and greater social support (OR = 0.935; 95% CI: 0.901–0.971) were protective against multidimensional frailty.ConclusionMultidimensional frailty is highly prevalent in hospitalized CHD patients and independently associated with psychosocial and functional factors. Early screening and integrated interventions targeting these determinants are essential to improve clinical outcomes.…”
Get full text

CULTUROLOGICAL APPROACH AS METHODOLOGICAL BASIS OF MATHEMATICAL EDUCATION by Ye. A. Perminov

“…Development of sociological, axiological and especially culturological aspects of mathematical methodology is required for the solution of the urgent problems of methodology in mathematical education.The aim of the publication is to discuss methodological aspects of culturological approach realization in mathematical education.Methodology and research methods. …”
Get full text

Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. by Amit Lampit, Harry Hallock, Michael Valenzuela

“…No significant effects were found for executive functions and attention. Moderator analyses revealed that home-based administration was ineffective compared to group-based training, and that more than three training sessions per week was ineffective versus three or fewer. …”
Get full text

Analysis of physiological, biochemical mechanism, and pigment related genes in leaf and petal coloration of Paeonia qiui by Shanrong Dong, Shuiyan Yu, Zihan Yang, Yingan Niu, Xinyue Liu, Chenxi Wei, Jianrang Luo

Get full text

Transcription factor TCF3 promotes bladder cancer development via TMBIM6-Ca2+-dependent ferroptosis by Wei-Feng Yang, Wei-Ming Guo, Qing-Tian Luo, Jingfen Lu, Zhou-Ke Tan, Yuan-Chun Ye, Gang Fan

“…However, no study has reported its role in bladder cancer. This study aimed to explore the roles and mechanisms of TMBIM6 in bladder cancer. …”
Get full text

Intermittent hypobaric hypoxia and neuroendocrine reaction of the parvocellular neurons of the paraventricular hypothalamic nucleus by V. O. Shamenko, Ye. V. Kadzharian, A. V. Abramov

“…The paraventricular nuclei of the hypothalamus (PVH) are one of the most important links of the brain`s neuroendocrine system which determine the reactivity of the hypothalamic-pituitary-adrenal axis (HPA) in response to the various stressors and thereby ensure the development of adaptive reactions by the formation of body resistance to the stress. The aim of the research was to study the functional state of the peptidergic neurons of the medial parvocellular nuclei of the paraventricular hypothalamic nucleus (PVHmp) during the multi-day action of intermittent hypobaric hypoxia and in the posthypoxic period. …”
Get full text

Hepatic progenitor cells reprogrammed from mouse fibroblasts repopulate hepatocytes in Wilson’s disease mice by Kai Liu, Li Li, Yu He, Song Zhang, Hong You, Ping Wang

“…The replacement of disordered hepatocytes with functional hepatocytes can serve as a lifelong therapeutic strategy for the treatment of WD. …”
Get full text

SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer by Xiaojing Wang, Peipei Zhang, Jiaqi Yan, Jingyi Huang, Yan Shen, Hongchao He, Hongjing Dou

“…How the deacetylase Sirtuin-6 (SIRT6) regulates glycolysis and lactate secretion in bladder cancer remains poorly defined. We thus aimed to study the biological functions of SIRT6 in bladder cancer. …”
Get full text

A phase II study of neoadjuvant chemotherapy followed by organ preservation in patients with muscle-invasive bladder cancer by Chinna Babu Dracham, Narendra Kumar, Santosh Kumar, Arun Elangovan, Budhi Singh Yadav, Ravimohan S. Mavuduru, Anupam Lal, Pramod K. Gupta, Rakesh Kapoor

“…Objective: Conservative approaches in muscle-invasive bladder cancer (MIBC) have been evolved to avoid aggressive surgery, but are limited to elderly, frail, and patients medically unfit for surgery. Our study aimed to assess the response rate of neoadjuvant chemotherapy (NACT) before radiotherapy (RT) in MIBC patients. …”
Get full text

Expression characteristics, molecular mechanisms, and clinical significance of DICER1 in breast cancer by Xi Zhang, Long Yu, Cuizhi Geng

“…Weighted gene co-expression network analysis (WGCNA) was used to identify gene modules associated with the breast cancer phenotype, and gene set enrichment analysis (GSEA) was performed to explore their biological functions. Cellular experiments were conducted to verify the effects of DICER1 on the proliferation, migration, and invasion of breast cancer cells. …”
Get full text

LL-37 regulates odontogenic differentiation of dental pulp stem cells in an inflammatory microenvironment by Yunfeng Ma, Xinyuan Liu, Ruoxi Dai, Quanli Li, Chris Ying Cao

“…However, the presence of proinflammatory factors can affect DPSCs proliferation, differentiation, migration, and other functions. LL-37 is a natural cationic polypeptide that inhibits lipopolysaccharide (LPS) activity, enhances cytokine production, and promotes the migration of stem cells. …”
Get full text

Mechanical properties of hybrid fibers and nano-silica reinforced concrete during exposure to elevated temperatures by Liangping Zhao, Gang Chen, Yu Zhang, Haitang Zhu, Huaikun Zhao, Jiyu Tang, Jiansong Yuan

“…Using a novel multi-functional testing apparatus designed for simultaneous heating and mechanical testing, the effects of varying steel fiber volume ratio (SFs, 0–1.5 % by volume) and NS dosages (0–1.5 % by weight) were examined at temperatures of 200°C (473.15 K), 400°C (673.15 K), 600°C (873.15 K), and 800°C (1073.15 K). …”
Get full text

Berberine alleviates atherosclerosis by modulating autophagy and inflammation through the RAGE-NF-κB pathway by Peng Zhang, Meiying Jin, Lei Zhang, Yanjun Cui, Xiaokang Dong, Jie Yang, Jiayu Zhang, Haopeng Wu

“…The ApoE−/− mouse model was established with a high-fat diet (HFD) to verify the effect and mechanism of BBR in vivo.ResultsFunctional and pathway enrichment analysis demonstrated that BBR significantly modulated the inflammation-related signaling pathways of AS. …”
Get full text

CREATIVE CORE WITHIN THE SCIENTIFIC RESEARCH OF EDUCATIONAL PROBLEMS by Vladimir I. Zagvyazinsky, Alfia F. Zakirova

“…The authors describe the types of hypotheses, such as working and scientific (ready), functional and explanatory. The logical and gnoseological structure of a scientific hypothesis is shown in the study. …”
Get full text

Unraveling the Molecular Mechanisms of Synthetic Acetyl Hexapeptide in E-Cadherin Activation for Tissue Rejuvenation by Nikoleta Topouzidou, Androulla N. Miliotou, Danai Nodaraki, Eleftheria Galatou, Christos Petrou, Yiannis Sarigiannis

“…Specifically, the glycoprotein E-cadherin plays a crucial role in cellular adhesion and has shown promise in wound healing studies, although its broader cellular functions remain underexplored. Despite their widespread use, many cosmetic peptides lack genetic validation of their effects. …”
Get full text

Ghrelin Immunoreactive Cell Amounts in the Abomasum in 4-Month-Old Calves by Feeding Different Amounts of Prebiotics and New Synbiotics by Astra Arne, Aija Ilgaza, Liga Astra Kalnina

“…In the gastrointestinal system, ghrelin affects multiple functions, including secretion of gastric acid, gastric motility, and pancreatic protein output. …”
Get full text

Application of multi-layer chitosan-based wound dressings in dentistry by Alexandr S. Gumenyuk, Denis I. Ushmarov, Sergey E. Gumenyuk, Tatyana V. Gaivoronskaya, Alexandr S. Sotnichenko, Karina I. Melkonyan, Yulia A. Belich, Timofey E. Grigoriev

“…Aim. To experimentally evaluate the efficacy of multi-layer chitosan-based wound dressings developed for dental purposes.Materials and Methods. …”
Get full text

Genome-Wide Identification and Characterization of the Gene Family and Their Associated Regulatory Elements in by Hadia Hussain, Aleena Alam, Iqra Mehar, Maryam Noor, Othman Al-Dossary, Bader Alsubaie, Muneera Q. Al-Mssallem, Jameel Mohammed Al-Khayri

“…Conclusion: Therefore, overall, our results provided an excellent foundation for further functional characterization of WRKY genes with an aim of Fortunella hindsii citrus crop improvement.…”
Get full text