Structural and Functional Insight into Intracameral Cefuroxime Ocular Toxic Syndrome (ICOTS) in Eyes with Disrupted Intraocular Barrier by Andrea Cusumano, Marco A. Pileri, Benedetto Falsini, Massimo Cesareo, Michele D’Ambrosio, Fabian D’Apolito, Francesco Martelli, Marco Lombardo

“…However, the long-term effects of ICOTS have not yet been studied. This study aims to provide new insights into ICOTS using multimodal imaging, retinal electrophysiology, and perimetry to assess both acute and chronic functional and structural changes in eyes with a disrupted intraocular vitreous barrier. …”
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Polymer-Functionalized Magnetic Nanoparticles for Targeted Quercetin Delivery: A Potential Strategy for Colon Cancer Treatment by Júlia Borges de Macedo, Julia Narayana Schoroeder Bueno, Carla Cristine Kanunfre, José Ricardo de Arruda Miranda, Andris Figueiroa Bakuzis, Priscileila Colerato Ferrari

“…<b>Methods</b>: After FA-CS synthesis and 3² factorial design, polymer-functionalized MNPs were produced for quercetin loading, characterized, and evaluated by drug dissolution and cytotoxicity assay. …”
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SURVEY OF A FUNCTIONAL STATE OF MASSETER MUSCLES IN EDENTELOUS PATIENTS BASED ON THE DATA OF SURFACE ELECTROMYOGYOPHY STUDIES by V.S. Kuz, V.M. Dvornyk, G.M. Kuz, G.M. Balya, O.S. Shemetov

“…The aim of our study was to study the functional state of the masseter muscles using surface electromyography in edentulous patients, who got dentures made from a thermoplastic base material «Vertex ThermoSense» in the prosthodontics clinic. …”
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Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses by Matteo Ardini, Francesco Angelucci, Francesca Rea, Luca Paluzzi, Federica Gabriele, Marta Palerma, Luana Di Leandro, Rodolfo Ippoliti, Giuseppina Pitari

“…., schizophrenia, and cancer, this strategy could serve as an invaluable tool for understanding the structure–function relationship of enzyme mutants and their role in diseases. …”
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Changes of functional brain network topology associated with nutritional indicator of patients with recurrent major depressive disorder by Guanghui Liu, Yanli Jiang, Chunpeng Zhou, Xiangxiang Wang, Min Dai, Jinping Zhang, Jing Yu, Gangzhong Zhang

“…IntroductionMajor depressive disorder (MDD) is generally categorized into first-episode MDD (fMDD) and recurrent MDD (rMDD). This study aimed to investigate the changes of brain network, as well as the relationships between relapses, brain regions, nutritional and metabolic indicators by resting-state functional magnetic resonance imaging (rs-fMRI) and graph theoretical analysis.MethodsThirty-two fMDD patients, 32 rMDD patients, and 32 healthy controls (HCs) underwent rs-fMRI scanning. …”
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Islet autoantibodies and residual beta-cell function in children with type 1 diabetes depending on age of manifestation by E. M. Romanenkova, I. M. Zufarova, D. Y. Sorokin, I. A. Eremina, E. A. Sechko, L. V. Nikankina, V. A. Peterkova, O. B. Bezlepkina, D. N. Laptev

“…Specific islet autoantibodies (AAbs) are the main diagnostic marker of T1D. Residual β-cell function, as measured by C-peptide, has repeatedly been demonstrated to be clinically important.AIM: To study the frequency and levels of residual C-peptide secretion and persistence of pancreatic AAbs in children with T1D with different duration and age of manifestation of the disease.MATERIALS AND METHODS: The levels of C-peptide and AAbs to ZnT8 (zinc transporter 8), AAbs to IA-2 (Insulinoma Antigen 2), AAbs to GAD (Glutamate Decarboxylase), IAA (insulin autoantibodies) were measured. …”
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Association and function analysis of genetic variants and the risk of gestational diabetes mellitus in a southern Chinese population by Qiulian Liang, Yan Sun, Ming Li, Ruiqi Li, Lijie Nie, Lin Lin, Xiangyuan Yu

“…CC: crude OR = 1.42, 95% CI: 1.08–1.86, p = 0.013). Functional analysis suggested that rs4134819 can alter the specific transcription factors (CPE bind and GATE-1) binding to the promoter of the XAB2 gene, regulating the transcription of XAB2. …”
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Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma by Jin-Xing Wang, Ling Zhang, Peng-Wei Zhang, Luo-Wei Yuan, Jian Jiang, Xiao-Hui Cheng, Wei Zhu, Yong Lei, Fa-Qing Tian

“…Despite advancements in therapeutic strategies, resistance to proteasome inhibitors, particularly bortezomib (BTZ), poses a substantial challenge to disease management. This study aimed to explore the efficacy of boanmycin, a novel antitumor antibiotic, in overcoming resistance to BTZ in MM. …”
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Whole-Body and Segmental Phase Angles and Cognitive Function in the Older Korean Population: Cross-Sectional Analysis by Jiaren Chen, Jong-Hwan Park, Chien-Yu Lin, Ting-Fu Lai, Du-Ri Kim, Myung-Jun Shin, Eunsoo Moon, Jung Mo Kang, Jong Won Lee, Yoon Jae Cho, Yung Liao, Tae Sik Goh, Jung Sub Lee

“…However, few studies have explored the relationship between PhAs, especially segmental PhAs, and the psychological aspects of health, particularly cognitive function. ObjectiveWe aimed to investigate the association between whole-body and segmental PhAs and cognitive function in older adults. …”
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Fortification of wheat biscuits with chia seed fiber and flower waste: Nutritional, antinutritional, functional, and storage properties by Animesh Sarkar, Md. Sumon Miah, Md. Masum, Mohammad Shaiful Alam Amin, Mahabub Alam

“…By partially substituting wheat flour with these sustainable ingredients at 20 %, 30 %, and 40 % levels, aimed to enhance the nutritional profile and functional properties of biscuits. …”
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Effects of Trimetazidine Combined with Atorvastatin on Cardiac Function in Patients with Stable Angina Pectoris of Coronary Heart Disease by Zhang N, Ren Y, Qin D, Yang X, Chen Z, Zhao L

“…Na Zhang,1 Yuanyuan Ren,1 Donghui Qin,2 Xue Yang,1 Zhuo Chen,1 Li Zhao1 1Department of Cardiology, The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China; 2Department of Pharmacy, The Second Hospital of Qiqihar, Qiqihar, Heilongjiang Province, People’s Republic of ChinaCorrespondence: Li Zhao, Email zgc016@126.comObjective: Growing evidence suggests that metabolic modulation combined with lipid-lowering therapy may provide synergistic benefits in coronary heart disease (CHD). This study aimed to evaluate the effects of trimetazidine combined with atorvastatin on cardiac function and inflammatory responses in stable angina pectoris.Methods: This retrospective study analyzed 100 CHD patients with stable angina (2019 ESC criteria) treated at the Third Affiliated Hospital of Qiqihar Medical College from 2021– 2024. …”
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The Impact of Physical Activity on Metabolic Health and Cognitive Function in Postmenopausal Women: A Cross-Sectional Study by Kinga Mruczyk, Rafał W. Wójciak, Marta Molska, Ewa Śliwicka, Tomasz Podgórski, Aleksandra Skoczek-Rubińska, Anna Borowiecka, Angelika Cisek-Woźniak

“…<b>Background</b>: This study aimed to evaluate the impact of physical activity levels on selected biochemical markers (glucose, insulin, cholesterol, triglycerides, interleukin-6 [IL-6]), brain-derived neurotrophic factor (BDNF), cognitive functions, and additional macronutrient intake in postmenopausal women. …”
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Effect of cannabinoids CB1 receptors blockade on hemodynamic parameters and endothelial function at the immobilization stress in the experiment by S. V. Gavreliuk

“…The aim of the study was to evaluate the response of hemodynamic parameters and changes in endothelial function in modeling of CB1 cannabinoid receptors blockade in chronic stress. …”
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Symptom and functional networks of patients with cancer in different latent risk subgroups based on patient-reported outcomes by Xiaojuan Hu, Zhihui Duan, Xiaokun Li, Hongyan Cao, Hui Zhao, Yanbo Zhang

“…Abstract Background Currently, risk stratification and effective management of heterogeneous patients with cancer based on patient-reported outcomes (PROs), used to evaluate clinical efficacy and outcomes, are relatively rare and urgently needed. We aimed to explore latent risk subgroups and delineate multidimensional networks of symptoms and functions based on PROs in this study. …”
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Influence of alprostadil on the dynamics of blood flow resistance index and renal graft function in the early postoperative period by P. A. Drozdov, I. V. Nesterenko, D. A. Makeev, O. S. Zhuravel, S. A. Astapovich, D. A. Solomatin, E. A. Lidzhieva

“…Aim. To evaluate the effect of continuous intravenous infusion of alprostadil solution on the dynamics of the peripheral resistance to arterial blood flow and renal graft function in the early postoperative period.Material and methods. …”
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Features of functional state restoration among military personnel after traumatic brain injury combined with acubarotrauma by A. V. Shvets, Yu. V. Podolian, M. I. Holinko

“…Aim – to study the restoration features of postconcussion symptoms and cognitive disorders based on the dynamics of the psychophysiological characteristics of combatants who received brain concussion and acubarotrauma in the acute period. …”
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Constructing an artificial intelligence-assisted system for the assessment of gastroesophageal valve function based on the hill classification (with video) by Jian Chen, Ganhong Wang, Kaijian Xia, Zhenni Wang, Luojie Liu, Xiaodan Xu

“…Abstract Objective In the functional assessment of the esophagogastric junction (EGJ), the endoscopic Hill classification plays a pivotal role in classifying the morphology of the gastroesophageal flap valve (GEFV). …”
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The relationship between systolic function and serum NGAL levels in patients with chronic heart failure of ischemic origin by V. A. Lysenko, V. V. Syvolap, M. S. Potapenko

“…The aim. To study the influence of tubulo-interstitial injury marker NGAL on systolic function in patients with CHF of ischemic origin. …”
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Metformin Activation of Sirtuin 3 Signaling Regulates Mitochondrial Function Improves Diabetes-Associated Cognitive Impairment by An JF, Su H, Zhang CQ, Wang XT, Zhang GQ, Fu LY, Xu YN, Tao L, Shen XC

“…The expression levels of proteins related to mitochondrial function were analyzed using immunohistochemical staining, immunofluorescence double staining, qRT-PCR, and Western blot. …”
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Long-Term Functional Recovery after Severe Traumatic Brain Injury with Type II Diffuse Injury by Marcia Harumy Yoshikawa, Sérgio Brasil, Davi Jorge Fontoura Solla, Robson Luís Amorim, Daniel Augustin Godoy, Angelos Kolias, Wellingson Silva Paiva

“…This study aims to describe the late clinical outcomes of patients with severe traumatic brain injury (sTBI) and the risk factors associated with it. …”
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