Evaluating functional C1INH with multiple laboratory methods across Hereditary Angioedema types by Maine Luellah Demaret Bardou, Rosemeire Navickas Constantino-Silva, Maria Luiza Oliva Alonso, Ana Júlia Ribeiro Teixeira, Pedro Francisco Giavina-Bianchi, Eli Mansour, João Bosco Pesquero, Solange Oliveira Rodrigues Valle, Anete Sevciovic Grumach

“…This study evaluates the function of C1 inhibitor (fC1INH) in patients with suspected HAE using several laboratory methods: dried blood spot (DBS), chromogenic assay, and ELISA with FXIIa and PKa (plasma kallikrein). …”
Get full text

Factors influencing on functional independence outcomes after hospitalization and rehabilitation in children with spinal cord injury by Hong-Bo Zhao, Xiang-Jiang Rong, Qi Zhang, Ting-Ting Ma, He Yan, Tian-Tian Zhou, Yan-Qing Zhang

“…Abstract Objective This study is to investigate the factors that influence functional autonomy outcomes in children who have undergone rehabilitation for spinal cord injury. …”
Get full text

What are the functional outcomes of total laryngeal transplantation? A systematic review of preclinical and clinical studies by Douglas Henderson, Douglas Henderson, Leonard Knoedler, Leonard Knoedler, Tobias Niederegger, Jakob Fenske, Olivier Mathieu, Gabriel Hundeshagen, Gabriel Hundeshagen, Max Heiland, Curtis L. Cetrulo, D. Gregory Farwell, Jerome R. Lechien, Jerome R. Lechien, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch

“…PurposeThis systematic review aims to evaluate the functional outcomes of total laryngeal transplantation by synthesizing findings from both preclinical and clinical studies. …”
Get full text

Serum extracellular matrix biomarkers in rheumatoid arthritis, psoriatic arthritis and psoriasis and their association with hand function by Helena Port, Birte Coppers, Sonja Tragl, Eva Manger, Lisa M. Niemiec, Sara Bayat, David Simon, Filippo Fagni, Giulia Corte, Anne-Christine Bay-Jensen, Koray Tascilar, Axel J. Hueber, Katja G. Schmidt, Verena Schönau, Michael Sticherling, Simon Heinrich, Sigrid Leyendecker, Daniela Bohr, Georg Schett, Arnd Kleyer, Signe Holm Nielsen, Anna-Maria Liphardt

“…Chronic inflammation triggers an accelerated remodeling of the extracellular matrix (ECM), resulting in released ECM fragments detectable in blood. We aimed to investigate levels of blood-based ECM biomarkers in patients with RA, PsA, PsO, and healthy controls and to explore the association of ECM biomarkers with hand function impairments. …”
Get full text

Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function by Philine Marie Schirge, Robert Perneczky, Toshiaki Taoka, Adriana L. Ruiz-Rizzo, Ersin Ersoezlue, Robert Forbrig, Selim Guersel, Carolin Kurz, Matthias Brendel, Julian Hellmann-Regen, Josef Priller, Anja Schneider, Frank Jessen, Emrah Düzel, Katharina Buerger, Stefan Teipel, Christoph Laske, Oliver Peters, Eike Spruth, Klaus Fliessbach, Ayda Rostamzadeh, Wenzel Glanz, Daniel Janowitz, Ingo Kilimann, Sebastian Sodenkamp, Michael Ewers, Boris-Stephan Rauchmann

“…The diffusion tensor image analysis along the perivascular space (DTI-ALPS; ALPS-Index) has emerged as a novel, non-invasive method to evaluate the glymphatic system in vivo, showing glymphatic insufficiency in AD. This study aimed to investigate alterations in the function of the glymphatic system in individuals with AD versus healthy controls (HC), and to explore its association with Aβ, cerebrovascular disease (CVD), white matter hyperintensities (WMH), and cognitive function. …”
Get full text

Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

“…The knockout mice exhibit hyperphenylalaninemia, impaired cognitive function, and decreased monoamine neurotransmitters. …”
Get full text

The Placebo Hypoalgesic Response Is Reduced in Healthy Older Adults Showing a Decline in Executive Functioning by Rischer KM, Dierolf AM, Anton F, Montoya P, González-Roldán AM, van der Meulen M

“…Findings to date are inconclusive, ranging from a reduced, to a preserved or even an amplified response in older adults. The aim of this study was to examine age-related changes in the placebo hypoalgesic response magnitude, and the potential modulating effect of executive functions, namely working memory, cognitive flexibility and inhibitory control.Methods: Thirty-nine younger (18– 36 years) and 42 healthy older adults (60– 82 years) completed a series of executive functioning tests. …”
Get full text

Heterocyclizations based on N-(R-hydrazine-1-carbonothioyl)cycloalkancarboxamides: functionalized azoles and their antimicrobial activity by О. V. Kholodniak, Yu. V. Shubina, S. I. Kovalenko

“…Even though heterocyclizations of functionally substituted hydrazines for their synthesis are well studied, N-(R-hydrazine-1-carbonothioyl)cycloalkanecarboxamides, and nowadays, remain reagents with undiscovered potential. …”
Get full text

Temporal evolution and factors influencing visual function and RNFL thickness in ethambutol-associated optic neuropathy by Taimin Guo, Yue Fu, Xiaoyu Xu, Xiaoning Liu, Yurong Zhang, Hui Yang

“…Abstract Purpose This study aimed to investigate the temporal evolution and influencing factors of visual function and optic nerve structure in ethambutol-associated optic neuropathy (EON). …”
Get full text

Investigation of the effect of intravitreal bevacizumab treatment on left heart function using speckle tracking echocardiography by Mehmet Şahinbaş, İdris Buğra Çerik, Duygu Yalınbaş Yeter

“…Although these agents have been shown to increase the risk of cardiovascular events in systemic use, the effect of local applications is unclear. In our study, we aimed to investigate the effects of anti-VEGF agents on left heart functions after intravitreal injection using speckle tracking echocardiography. …”
Get full text

Cardiovascular risk factors are associated with lower posterior-medial network functional connectivity in older adults by Léa Chauveau, Julie Gonneaud, Géraldine Poisnel, Brigitte Landeau, Antoine Garnier-Crussard, Anne-Lise Pitel, Daniel Roquet, Edelweiss Touron, Sacha Haudry, Florence Mezenge, Anne Chocat, Denis Vivien, Vincent de La Sayette, Gaël Chételat, Robin de Flores, for the Medit-Ageing Research Group

“…While modifiable cardiovascular risk factors may offer prevention opportunities to preserve brain aging, their effects on AT/PM functional connectivity remain unknown. This study aims to investigate these associations in older adults, considering major risk categories and exploring potential interactions with protective lifestyle habits and AD risk factors. …”
Get full text

Structural and functional changes of the heart in patients with chronic ischemic heart failure, associated with renal dysfunction by D. A. Lashkul

“…The effects of CKD on other left ventricular and myocardial parameters, however, have been less characterized. The aim of the study was to examine the structural and functional changes, geometric remodeling of the heart in patients with ischemic chronic heart failure, being hospitalized, according to the presence of renal dysfunction. …”
Get full text

The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity by Burak Arslan, Wagner S. Brum, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Kübra Tan, Paolo Vitali, Maxime Montembeault, Jesse Klostranec, Arthur C. Macedo, Cecile Tissot, Serge Gauthier, Juan Lantero-Rodriguez, Eduardo R. Zimmer, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L. Benedet, Nicholas J. Ashton

“…Given the imminent use of certain blood biomarkers in the routine diagnostic work-up of patients with suspected AD, knowledge on the potential impact of comorbidities on the utility of blood biomarkers is important. We aimed to evaluate the association between kidney function, assessed through estimated glomerular filtration rate (eGFR) calculated from plasma creatinine and AD blood biomarkers, as well as their influence over predicting Aβ-positivity. …”
Get full text

Effects of a multi-modal static and dynamic balance and hand function training program on multi-dimensional balance ability, hand function, and life-space mobility in rural older a... by Xinyu Yang, Shasha Li, Xiangdong Xu, Guojing Guo, Xiaofang Song, Yashuang Sun, Mengxue Shi, Canqi Ren

“…Objective This study aims to investigate whether a combined balance and hand training program can provide programmatic references and empirical evidence for improving functional outcomes in rural older adults. …”
Get full text

Long-term impact on cardiopulmonary function and quality of life among patients recovered from SARS-CoV-2 infection in a 6-month follow-up period in Lima, Peru: FUNCTION cohort stu... by Carlos Seas, Larissa Otero, Eduardo Gotuzzo, Fernando Mejia, Rodrigo Cachay, Takashi Watanabe-Tejada, Katiuska Cuno, Marcela Gil-Zacarias, Carolina Coombes, Isabel Ballena, Felix Medina, Oscar Gayoso

“…Longitudinal assessments and reversibility of changes across the spectrum of disease severity are required to understand the long-term impact of COVID-19.Methods and analysis A prospective cohort study aims to assess the impact of SARS-CoV-2 infection on cardiopulmonary function and quality of life after the acute phase of the disease over a 6-month follow-up period. …”
Get full text

Research on Virtualization of Mobile Core Network Architecture by Wei Xiong, Bingyi Fang, Yunyong Zhang, Jun Wu, Sufen Li

Get full text

Les disfluences dans le discours radiophonique : signification (s) et fonction (s) communicative (s) by Hamza Kernou

“…This work aims to study verbal disfluences, language tics and disfluencing repetition, in "the antenna is yours", an interactive radio program from Algiers-Chaîne III. …”
Get full text

Sentence Structure Analysis in Patients with Ischemic Stroke by Janice L. Hinkle, Rudolf Cymorr Kirby P. Martinez

“…Aim. The aim of this study was to investigate if using Developmental Sentence Scoring (DSS) on sentences written by patients on a Mini-Mental State Examination (MMSE) could provide a simple metric of cognitive function. …”
Get full text

Child Self-Regulation and Behavior Questionnaire and Assessment of Executive Functions Scale: Adaptation Study for 4–6-Year-Old Children by Asiye İvrendi, Ezgi Dülger Ceylan

“…This research aimed to adapt two measurement tools assessing self-regulation and executive function skills in children aged 4–6 years into the Turkish language. …”
Get full text

The effects of structured coordinative exercise protocol on physical fitness, motor competence and inhibitory control in preschool children by Ali Mert Şendil, Umut Canlı, Bodor Bin sheeha, Nouf H. Alkhamees, Alexios Batrakoulis, Sameer Badri Al-Mhanna

Get full text