Comprehensive structural and functional analyses of RAD50 nsSNPs: from prediction to impact assessment by Samina Malik, Mirza Jawad Ul Hasnain, Mirza Jawad Ul Hasnain, Gul Zaib, Haleema Saadia, Arif Malik, Ayesha Zahid

“…This complex orchestrates cellular responses to the DNA double-strand breaks (DSBs) through several pathways for genome stability. This study aims to investigate the functional impact of non-synonymous single-nucleotide polymorphisms (nsSNPs) in RAD50 (a breast cancer-associated gene) and focuses on their consequences on protein structure and interaction within the MRN complex.MethodsA total of 1,806 nsSNPs were retrieved and subjected to variant analysis using a set of computational tools and ConSurf. …”
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Research progress on resistance exercise therapy for improving cognitive function in patients with AD and muscle atrophy by Wenyao Li, Wei Fang, Yier Zhang, Yier Zhang, Qiulu Chen, Wuyue Shentu, Qilun Lai, Lin Cheng, Sicheng Yan, Qi Kong, Song Qiao

“…Consequently, further investigation is warranted to determine whether tailored guidelines—such as variations in the frequency and duration of resistance exercise—should be established for patients with varying levels of dementia, in order to optimize the benefits for those experiencing cognitive impairment. This study aimed to review the relationship between AD and skeletal muscle atrophy, the impact of skeletal muscle atrophy on AD cognition, the mechanism by which resistance exercise improves cognition through skeletal muscle improvement, and the optimal resistance exercise mode to elucidate the additional advantages of resistance exercise in treating cognitive function in patients with AD and skeletal muscle atrophy.…”
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Effect of ischemic injury characteristics on left ventricular systolic function in patients with acute myocardial infarction by V. E. Oleinikov, L. I. Salyamova, N. A. Donetskskaya, A. V. Vdovkin

“…Aim. To study laboratory and magnetic resonance imaging (MRI) characteristics of infarction area depending on left ventricular (LV) global systolic function in patients with acute myocardial infarction (AMI) after revascularization.Material and methods. …”
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Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function by Ligang Shan, Ying Tao, Jiubo Fan, Yuyu Zhou, Danyang Zhao, Yanlong Liu, Xiaoli Han, Suriyakala Perumal Chandran, Fan Wang

“…Consequently, age may moderate the impact of the FGF19 subclass on cognitive function. This study aimed to investigate the association among the FGF19 subclass in cerebrospinal fluid (CSF), cognition, and age and further explore the moderating effects of age on cognitive changes related to the FGF19 subclass. …”
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RELATION OF HYPERURICAEMIA, RENAL FUNCTION AND ARTERIAL HYPERTENSION IN A LARGE REGION OF THE EASTERN SIBERIA INHABITANTS by Yu. I. Grinshtein, V. V. Shabalin, R. R. Ruf, M. M. Petrova, I. P. Artyukhov, S. A. Shalnova

“…Aim. To investigate on the prevalence of hyperuricaemia (HU) among citizens and rural areas inhabitants of Krasnoyarsk region, and to assess possible relation of HU with arterial hypertansion (AH), HU and renal function.Material and methods. …”
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The role of intimate partner violence perpetrators' resting state functional connectivity in treatment compliance and recidivism by Ángel Romero-Martínez, María Beser, Leonor Cerdá-Alberich, Fernando Aparici, Luis Martí-Bonmatí, Carolina Sarrate-Costa, Marisol Lila, Luis Moya-Albiol

“…Therefore, our first aim was to assess whether men convicted of IPV (n = 53) presented different rsFC patterns from a control group of non-violent (n = 47) men. …”
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The First Clinical and Functional Results of Myopia Correction Using a Solid-State Laser Unit by N. V. Maychuk, A. V. Tikhov, Kh. P. Takhchidi, N. Sh. Sarkhadov, I. S. Malyshev

“…Modern keratorefractive surgery (CRS) is a high-tech field of ophthalmology aimed at solving various problems of correcting a wide range of ametropias. …”
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Age-related differences in eye blink-related neural activity and functional connectivity during driving by Emad Alyan, Stefan Arnau, Stephan Getzmann, Julian Elias Reiser, Melanie Karthaus, Edmund Wascher

“…Previous studies suggest that age-related changes in cognitive and motor functions can influence driving performance. Herein, we investigated age-related differences and differences between reactive and proactive driving in blink behavior-related potentials, and source-level functional connectivity. …”
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No sex difference in the association of pre-stroke physical activity with functional independence after ischemic stroke by Shuangfang Fang, Baixiang Zhang, Hanhan Lei, Yidan Zhang, Huiying Lin, Qingfa Chen, Huapin Huang, Nan Liu, Houwei Du

“…We aimed to explore the association of pre-stroke physical activity and functional outcomes in patients with acute ischemic stroke according to sex. …”
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A Pilot Study Assessing Left Ventricle Diastolic Function in the Parasternal Long-axis View by Mümin Murat Yazici, Nurullah Parça, Enes Hamdioğlu, Meryem Kaçan, Özcan Yavas¸i, Özlem Bilir

“…Based on the hypothesis that E-point septal separation (EPSS) measured by M-mode in the parasternal long-axis (PSLA) view may facilitate the assessment of diastolic function in emergency patient care, we aimed to investigate whether EPSS measured by M-mode in the PSLA view correlates with spectral Doppler assessment in patients with grade 1 diastolic dysfunction. …”
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Features of subset composition and functional activity of blood lymphocytes in tick-borne infections of different etiologies by O. V. Voronkova, E. N. Ilyinskikh, R. R. Hasanova, I. E. Esimova, K. V. Nevskaya, M. R. Karpova, N. A. Chernyshov, A. V. Yampolskaya, O. V. Yampolskaya

“…Aim. To perform a comparative assessment of subset composition and functional activity of peripheral blood lymphocytes in patients with tick-borne encephalitis (TBE) and ixodid tick-borne borreliosis (ITBB) in the acute phase of the disease.Materials and methods. …”
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Effects of Physical Therapy Management on Gross Motor Function and Spasticity among Diplegic Cerebral Palsy by Hamza Ahmed, Muhammad Abid Khan, Syed Meeran Hasnain, Raman Kumar, Fouzia Hussain

“…This study aims to evaluate the effectiveness of physical therapy-based interventions in improving gross motor function and reducing spasticity. …”
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LONGITUDINAL STUDY ON LIVER FUNCTIONS IN PATIENTS WITH THALASSEMIA MAJOR BEFORE AND AFTER DEFERASIROX (DFX) THERAPY by Ashraf Tawfik Soliman, Mohamed Yassin, Fawzia AlYafei, Lolwa Al-Naimi, Noora Almarri, Aml Sabt, Vincenzo De Sanctis

“…The recent use of Deferasirox (Exjade- DFX ), an  oral single dose therapy has improved the compliance to chelation therapy. Aims: To study the long-term liver functions in BMT patients, seronegative for liver infections before versus after DFX therapy in relation to ferritin level and IGF-I level. …”
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Vascular Adaptations in Pregnancy: The Critical Role of Endothelial Function and Nitric Oxide in Maternal-Fetal Health by Hina Riaz, Urooj Bhatti, Keenjher Rani, Afsheen Abro, Rabia Uqaili, Rubina Ahmdani

“… Background: Endothelial dysfunction is a critical factor in hypertensive disorders of pregnancy, such as preeclampsia. This study aimed to evaluate the role of endothelial function, nitric oxide (NO), and endothelin-1 (ET-1) in normotensive and hypertensive pregnancies to understand the underlying vascular adaptations. …”
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Clinical description of measles complications in adults in connection with changes in the functional state of the autonomic nervous system by Yu. Yu. Riabokon, S. O. Bilokobyla, O. V. Riabokon

“…Aim of the work – to analyze measles complications in adults depending on the severity of the course and to find out their relationship with the functional state of the autonomic nervous system. …”
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STRUCTURAL AND FUNCTIONAL FEATURES OF LEFT VENTRICLE IN PATIENTS WITH HEART FAILURE, CORONARY HEART DISEASE AND THYROTOXICOSIS by E. V. PASHCHENKO, A. I. CHESNIKOVA, V. P. TERENTYEV, V. I. KUDINOV, E. A. DEVETYAROVA

“…Aim. This study was designed to determine the structural and functional features of left ventricle in patients with heart failure, coronary heart disease and thyrotoxicosis.Materials and methods. 85 patients aged 58.3±5.6 years were divided into 3 groups: the main one – 25 patients with coronary  heart disease (CHD), chronic heart failure (CHF) II-III functional  classes (FC) and thyrotoxicosis, average age –59.23±3.81; the 1st  comparison group – 30 patients with CHD and CHF FC II-III without  thyroid dysfunction, the average age – 57.6±2.73; the 2nd  comparison group – 30 patients with thyrotoxicosis without  concomitant cardiovascular diseases (CVD), the average age –  45.4±3.51. …”
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Lung function and peak oxygen uptake in chronic obstructive pulmonary disease phenotypes with and without emphysema. by Øystein Rasch-Halvorsen, Erlend Hassel, Ben M Brumpton, Haldor Jenssen, Martijn A Spruit, Arnulf Langhammer, Sigurd Steinshamn

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Low prevalence of infantile functional gastrointestinal disorders (FGIDs) in a multi-ethnic Asian population by Kee Seang Chew, Jun Min Em, Zhong Lin Koay, Muhammad Yazid Jalaludin, Ruey Terng Ng, Lucy Chai See Lum, Way Seah Lee

“…Background: Functional gastrointestinal disorders (FGIDs) are common in children. …”
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Damage to white matter networks resulting from small vessel disease and the effects on cognitive function by Natalie Busby, Janina Wilmskoetter, Roger Newman-Norlund, Sarah Newman-Norlund, Sara Sayers, Sarah C. Wilson, Nicholas Riccardi, Alex Teghipco, Rebecca W. Roth, Lumi Bakos, Chris Rorden, Julius Fridriksson, Leonardo Bonilha

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Functional characterization of seven terpene synthases from Ophiopogon japonicus via engineered Escherichia coli by Wen Xu, Qing Ma, Tong Chen, Haiyan Zhang, Guanglei Ma, Sibongile Mafu, Juan Guo, Xiaohui Fan, Guanghong Cui, Baolong Jin

“…The candidate terpene synthase genes were identified from the root and leaf transcriptome data of O. japonicus in Zhejiang and the functions of these enzymes were identified using engineered Escherichia coli. …”
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