Evaluation of the Influence of <i>Tanacetum vulgare</i> Extract on Cognitive Functions and Hippocampal BDNF Expression by Borislava Lechkova, Michaela Shishmanova-Doseva, Niko Benbassat, Reneta Gevrenova, Pepa Atanassova, Nadya Penkova, Lyudmil Peychev, Petar Hrischev, Zhivko Peychev, Stanislava Ivanova

“…However, the literature data on its effects on cognitive function are scarce. The aim of the present work was to evaluate the effects of two doses of <i>T. vulgare</i> alcohol extract on cognitive functions, hippocampal brain-derived neurotrophic factor (BDNF) expression, and organ toxicity in rats. …”
Get full text

Mitochondrial function: A new direction for the targeted treatment of cardiovascular diseases with Chinese herbal medicine by Lin Yang, Liang Wang, Baofeng Yang, Yue Zhang

“…Recent studies have found that traditional Chinese medicine (TCM) possesses the potential to effectively address cardiovascular diseases while enhancing the structural integrity and functional capacity of mitochondria. This review aims to offer a comprehensive analysis of the modulatory effects of TCM on cardiac mitochondria and its therapeutic ramifications for cardiovascular conditions.…”
Get full text

Evaluation of risk factors, functionalities, and quality of life in patients with pediatric acute arterial ischemic stroke by Fatih Mehmet Akif-Özdemir, Ülkühan Öztoprak, Ali Fettah, Utku Arman Örün, Mustafa Kılıç, Fatma Gül Sarıkaya, Betül Derinkuyu, Deniz Yüksel

“…At last follow-up, the patients` functionality (Barthel Index, Functional Independence Measure), quality of life (SF-36 questionnaire), and motor outcomes (Gross Motor Function Classification System) were recorded prospectively/crosssectionally. …”
Get full text

Effects of aerobic, strength, and combined exercise on cognitive functions in older adults: a systematic review by Enrique Cerda-Vega, Catalina Irarrázabal-Guerra, Leyla Sabja-Sepúlveda, Nasley Guajardo-Sandoval, Nicolás Roa-Chiarleoni, Verónica Morales-Sánchez, Rafael E. Reigal, Nuria Pérez-Romero

“… Introduction: Aging is associated with a decline in cognitive functions, increasing the risk of neurocognitive impairment and limitation of activities of daily living and participation. …”
Get full text

Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease by Jie Fang, Yingying Miao, Fan Zou, Yarui Liu, Jiangle Zuo, Xiangming Qi, Haibao Wang

“…This study aimed to investigate the changes in cerebellar-cerebral FC in ESRD patients and its relationship with neuropsychological and clinical indexes.Methods Resting-state functional magnetic resonance imaging and neuropsychological assessment were performed on 37 ESRD patients and 35 control subjects. …”
Get full text

Chitosan-functionalized viscose fiber from post-consumer cotton waste for durable biomedical materials by Rois Uddin Mahmud, Rubel Alam, Raijul Islam, Zahid Hasan, Md Moniruzzaman, Tarikul Islam

“…This study aims to transform post-consumer textile waste (cellulosic materials) into viscose fiber using a xanthation technique, as well as to develop value-added antibacterial chitosan functionalized viscose (CFV) fiber for biomedical applications (e.g., sanitary pad) through an economic up-cycling wet spinning integrated chitosan coating approach. …”
Get full text

Regional quantification of metabolic liver function using hyperpolarized [1-13C] pyruvate MRI by Uffe Kjaergaard, Andrea Lund, Mohsen Redda, Mattias Hedegaard Kristensen, Malene Aastrup, Nikolaj Bøgh, Kim Sivesgaard, Michael A. Ohliger, Daniel B. Vigneron, Lotte Bonde Bertelsen, Aage Kristian Olsen Alstrup, Esben Søvsø Szocska Hansen, Frank Viborg Mortensen, Christoffer Laustsen

“…However, liver volume does not always correlate with function. We suggest that metabolism might be a better surrogate for function than volume. …”
Get full text

Not All Platelets Are Created Equal: A Review on Platelet Aging and Functional Quality in Regenerative Medicine by Fábio Ramos Costa, Joseph Purita, Rubens Martins, Bruno Costa, Lucas Villasboas de Oliveira, Stephany Cares Huber, Gabriel Silva Santos, Luyddy Pires, Gabriel Azzini, André Kruel, José Fábio Lana

“…In addition, we present strategies for pre-procedural optimization, advanced processing techniques, and adjunctive therapies aimed at enhancing platelet quality. Finally, we challenge the prevailing emphasis on high-volume blood collection, highlighting the limitations of quantity-focused protocols and advocating for a shift toward biologically precise, function-driven regenerative interventions. …”
Get full text

Effects of plasma-activated water on structural and functional properties of PSE-like chicken protein isolate by Ke Li, Yanfang Zhou, Chenyan Zhu, Manting Du, Bo Chen, Dianbo Zhao, Yanhong Bai

“…The present investigation aimed to improve the functional properties of PPI by employing plasma activation water (PAW), with the ultimate goal of enhancing its utility in various applications. …”
Get full text

Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis by Zhong Li, Xingxing Jin, Meng Zhang, Hongxia Wang, Wangyi Liu, Beiran Wang, Baolin Wu, Xuekun Li

“…Neuroimaging studies have identified brain structural and functional alterations in HIV-infected patients; however, the results are inconsistent. …”
Get full text

Sialic Acid and Colchicine Functionalized Silica Nanoparticles: A Novel Approach to Leishmanicidal Selective Treatments by Adan Jesus Galue-Parra, Sandra Jimenez-Falcao, Esther Arribas-Yuste, Clotilde Marin, Jose Manuel Mendez-Arriaga

“…Current treatments, primarily based on pentavalent antimonials, are associated with severe side effects and increasing resistance. This study aims to develop a novel therapeutic strategy using a nanomaterial functionalized with sialic acid (SA) and colchicine (COL) to selectively target <i>Leishmania braziliensis</i> parasites. …”
Get full text

Hypertension, Sarcopenia, and Global Cognitive Function in Community-Dwelling Older Women: A Preliminary Study by Hélio José Coelho-Júnior, Bruno Bavaresco Gambassi, Maria-Claudia Irigoyen, Ivan de Oliveira Gonçalves, Paula de Lourdes Lauande Oliveira, Paulo Adriano Schwingel, Cândida Helena Lopes Alves, Ricardo Yukio Asano, Marco Carlos Uchida, Bruno Rodrigues

“…The present study aimed to investigate whether sarcopenia interferes in the association between HTN and cognitive function in community-dwelling older women. …”
Get full text

New Function for Safety Signal Monitoring in MID‐NET®: The Case of an Anti‐COVID‐19 Drug by Yusuke Okada, Takashi Ando, Fumitaka Takahashi, Kenichi Watanabe, Kazuhiro Kajiyama, Tomoaki Hasegawa, Satomi Inomata, Yuki Kinoshita, Shinya Watanabe, Yoshiaki Uyama

“…The customizable analytical conditions include exposure and control drugs, 46 outcomes related to liver and kidney functions, blood tests, biomarkers, and time period of interest. …”
Get full text

Probing Wnt pathway and functional signal in equine melanocytic neoplasms through quantitative proteomics and immunohistochemistry by Parichart Tesena, Ruethaiwan Vinijkumthorn, Amornthep Kingkaw, Petchpailin Yanyongsirikarn, Khajornpol Phasuk, Sekkarin Ploypetch, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Nawarus Prapaiwan

“…This study, therefore, aimed to identify signature proteins from tissue biopsies to distinguish early EMN, severe EMN, and normal groups. …”
Get full text

Mapping Coverage and Typology Based on Function and Spatial Configuration of Forests in Latium Region, Central Italy by Marco di Cristofaro, Federico Valerio Moresi, Mauro Maesano, Luigi Portoghesi, Michele Munafò, Paolo De Fioravante, Daniela Tonti, Marco Ottaviano, Marco Marchetti, Giuseppe Scarascia-Mugnozza

“…By combining open-source and ancillary high-resolution cartographic datasets, this study aims to map trees and forests in the Latium region in central Italy, highlighting their spatial configuration, function, and forest typology. …”
Get full text

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region by Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti‐Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun‐Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haass

“…We screened a panel of monoclonal antibodies against TREM2, with the aim to selectively compete for α‐secretase‐mediated shedding. …”
Get full text

The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis by Xindi Lin, Shaogen Zhong, Mengxing Wang, Yi Mao, Yuhan Wu, Jiayi Lu, Wei Zhong, Di Wu, Jun Ma

“…Consequently, this study aimed to identify specific brain regional activities associated with MDA function. …”
Get full text

Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia by Mengying Zheng, Bingnan Liu, Yuanyuan Shao, Luogang Hua, Rong Fu, Huaquan Wang, Ting Wang, Weiwei Qi, Zonghong Shao, Chunyan Liu

“…This study is aimed at investigating the effects of shikonin, a pyruvate kinase M2 (PKM2) inhibitor, on the functions of myeloid dendritic cells (mDCs) in a mouse model of severe aplastic anemia (AA) generated by total body irradiation and lymphocyte infusion. …”
Get full text

Preclinical characterisation of changes in cardiac function and circulating biomarkers following differential irradiation of thoracic volumes by Refik Kuburas, Mihaela Ghita-Pettigrew, Gerard M. Walls, Brianna N. Kerr, Kathryn H. Brown, Cecilia Facchi, Alan McWilliam, Marcel van Herk, Kaye J. Williams, Karl T. Butterworth

“…Understanding the potential interplay between the heart and lungs is important in the context of optimising cardiac dose distributions that may increase lung doses and minimising the impact of lung dose on cardiac function.…”
Get full text

Identification of key interactive genes and their potential biological functions in type 2 diabetes and Sjögren’s syndrome by Yibing Wang, Huilin Zeng, Xiangjie Hu, Guangzhao Zhang, Liangliang Zhou, Xingyuan Yu, Yuchun Zhang

Get full text