Transcriptomic analysis reveals the function of m6A regulators in aged cochlea by Yanbing Lai, Bo Su, Xiaodi Wang, Chenghui Zeng, Hanqi Chu, Liangqiang Zhou, Dan Bing

“…N6-methyladenosine (m6A) modification in regulating gene expression and cellular functions has been implicated in the development of various diseases. …”
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Quantifying the spatial impact of an invasive Acacia on ecosystem functioning using remote sensing by André Große-Stoltenberg, Christiane Werner, Christine Hellmann, Jens Oldeland, Jan Thiele

“…Furthermore, invader-induced changes beyond the canopy, as well as the environmental context, are rarely considered. This study aimed to assess the impacts of an invasive tree on ecosystem functioning at the landscape scale using remote sensing, taking into account both spatial effects and environmental heterogeneity. …”
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Thrombus iodine-based perviousness is associated with recanalisation and functional outcomes in endovascular thrombectomy by Yu Sun, Song Jin, Huiying Wang, Chao Tian, Song Liu, Ming Wei, Tao Ren, Leilei Luo, Sifei Wang, Lejun Fu, Jingjing Guo, Chen Cao, Luotong Wang, Shuang Xia, Tong Han, Nina Hao

“…Background Dual-energy CT (DECT) provides several novel methods to assess thrombus perviousness. We aimed to evaluate whether the novel thrombus perviousness measured with DECT is associated with improved recanalisation and better functional outcomes in acute ischaemic stroke (AIS) patients with endovascular thrombectomy (EVT).Methods 108 AIS patients with middle cerebral artery occlusion who underwent DECT angiography on admission and received EVT treatment between April 2020 and September 2023 were retrospectively analysed. …”
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Subjective experience, psychosocial functioning and different psychomotor clusters in catatonia: How are they connected? by Geva A. Brandt, Stefan Fritze, Dilsa Cemre Akkoc Altinok, Sebastian Volkmer, Jacqueline Kukovic, Jonas Daub, Katharina M. Kubera, Georg Northoff, Andreas Meyer-Lindenberg, Dusan Hirjak

“…Background: Catatonia involves decreased, increased, and abnormal psychomotor activity, but most previous studies mainly focused on motor signs, neglecting the patients' subjective experiences. This study aimed to characterize psychomotor activity levels as introduced in the ICD-11 and their relation to subjectivity and overall psychosocial functioning in catatonia. …”
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Association of A1AT With Poor Functional Outcome in Patients With Acute Ischemic Stroke by Paula García‐Rodríguez, Marcel Lamana‐Vallverdú, Daisy R. Guamán‐Pilco, Anna Penalba, Laura Ramiro, Alba Simats, Júlia Faura, Alejandro Bustamante, Noelia Díaz‐Troyano, Joan Montaner

“…Background This study aimed to investigate whether A1AT (α‐1 antitrypsin) bloodstream levels, measured acutely after ischemic stroke, can predict the outcome of patients with stroke. …”
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The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis by Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, Kristian Helin, Andreas Nygaard Madsen, Steen Seier Poulsen, Madhusudhan Bysani, Karl Bacos, Charlotte Ling, Marcelo Javier Perone, Birgitte Holst, Thomas Mandrup-Poulsen

“…Aims. Posttranslational modifications of histones and transcription factors regulate gene expression and are implicated in beta-cell failure and diabetes. …”
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Myocardial functional status in patients with arterial hypertension and hyperaldosteronism: orthogonal electrocardiography assessment by Kh. F. Samedova, N. M. Chikhladze, E. V. Blinova, T. A. Sakhnova, L. M. Sergakova, G. N. Litonova, E. Sh. Kozhemyakina, I. E. Chazova

“…Aim. To study orthogonal electrocardiography (ECG) parameters among arterial hypertension (AH) patients, in regard to renin-angiotensin-aldosterone system (RAAS) functional status. …”
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Functionalized Silver Nanoparticles as Multifunctional Agents Against Gut Microbiota Imbalance and Inflammation by Mihaela Stoyanova, Vera Gledacheva, Miglena Milusheva, Mina Todorova, Nikoleta Kircheva, Silvia Angelova, Iliyana Stefanova, Mina Pencheva, Yulian Tumbarski, Bela Vasileva, Kamelia Hristova-Panusheva, Zlatina Gospodinova, Natalia Krasteva, George Miloshev, Milena Georgieva, Stoyanka Nikolova

“…Density Functional Theory (DFT) calculations were conducted to identify possible mechanisms by which AgNPs could prevent microorganisms from growing. …”
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Assessment of NUDT5 in Endometrial Carcinoma: Functional Insights, Prognostic and Therapeutic Implications by Hongfei Yu, Lingling Zu, Yuqin Zang, Fei Teng, Tao Wang, Ming Wu, Yingmei Wang, Fengxia Xue

“…<b>Conclusions</b>: These findings suggest that <i>NUDT5</i> functions as an oncogene in EC, serving as a potential diagnostic and prognostic biomarker. …”
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Brain functional network abnormalities in Parkinson’s disease patients at different disease stages by Wei Wei, Xinhui Wang, Chao Han, Yu Shen, Panlong Li, Yan Bai, Shuo Liu, Jingyao Xu, Yanhong Shi, Zhou Li, Meiyun Wang

“…BackgroundParkinson’s disease (PD) is a neurodegenerative disorder with some progressive impairment and an unclear pathogenesis.PurposeThis study aimed to use resting-state functional magnetic resonance imaging (rs-fMRI) and graph analysis approaches to compare changes in brain functional network topology in PD at different disease stages.Materials and methodsA total of 58 PD patients, comprising 29 early-stage PD (PD-E) and 29 middle-to-late stage PD (PD-M), and 29 age- and sex-matched healthy control (HC) participants, were recruited. …”
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Role of the functional status of the autonomic nervous system in the clinical course of purulent meningitis by D. A. Zadiraka, O. V. Ryabokon

“…Heart rate variability clearly reflects the degree of regulatory system tension caused by the influence of both physiological and pathological factors. Research aim: to increase the autonomic dysfunction diagnostics efficiency for patients suffering from purulent meningitis in the disease dynamics based on the complex of clinical evidence and functional status of autonomic nervous system. …”
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Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity by Su Y, Shui J, Qi D, Bai J, Xu X, Huang Y, Li R, Wu Q, Wang H, Cao C, Su Z, Zhang S

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Influence of catheter ablation for atrial fibrillation on atrial and ventricular functional mitral regurgitation by Masaharu Masuda, Kimiko Sekiya, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Yasuhiro Matsuda, Yosuke Hata, Hiroyuki Uematsu, Taku Toyoshima, Naoko Higashino, Toshiaki Mano

“…Abstract Aims The purpose of this study was to compare the impact of catheter ablation on cardiac structural reverse remodelling and atrial (AFMR) and ventricular (VFMR) functional mitral regurgitation (MR), and the long‐term prognosis of patients with AFMR and VFMR. …”
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Identification and Functional Analysis of PANoptosis‐Associated Genes in the Progression From Sepsis to ARDS by Zhong‐Hua Lu, Yan Tang, Hu Chen, Feng Liu, Mei Liu, Lu Fu, Xian‐Kai Wang, Ming‐Juan Li, Wei‐Li Yu, Yun Sun

“…NDRG1 showed a positive correlation with activated dendritic cells, whereas DDX3X, PTPRC, and TNFSF8 were positively associated with neutrophils and negatively correlated with CD56bright NK cells. Functional enrichment analysis highlighted spliceosome function, MAPK signaling, endocytosis, and antigen processing pathways as significantly associated with these PRGs. …”
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Impact of Heat Stress on Ovarian Function and circRNA Expression in Hu Sheep by Jianwei Zou, Lili Wei, Zhihua Mo, Yishan Liang, Jun Lu, Juhong Zou, Fan Wang, Shaoqiang Wu, Hai’en He, Wenman Li, Yanna Huang, Qinyang Jiang

“…Climate change poses an increasing threat to livestock reproduction, with heat stress (HS) known to significantly impair ovarian function. This study aimed to elucidate the impact of HS on ovarian function and circRNA expression profiles in Hu sheep. …”
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Nanoparticle-functionalized acrylic bone cement for local therapeutic delivery to spine metastases by Ateeque Siddique, Mansoureh Mohseni Garakani, Megan E. Cooke, Michael H. Weber, Derek H. Rosenzweig

“…Aim: Polymethylmethacrylate bone cement is often used to reconstruct critical-sized defects generated by the surgical resection of spinal metastases. …”
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Ankle Somatosensation and Lower-Limb Neuromuscular Function on a Lunar Gravity Analogue by Ashleigh Marchant, Nick Ball, Jeremy Witchalls, Sarah B. Wallwork, Gordon Waddington

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Lung function of tuberculosis patients after completion of treatment in Sidama, South Ethiopia by Endrias Markos Woldesemayat, Jaime H. Vera, Clea Tanner, Alemu Tamiso, Amare Assefa, Yohannes Markos Woldesenbet

“…This study aimed to examine lung function parameters among adults who have undergone treatment for pulmonary TB.MethodsA comparative cross-sectional study was conducted in eight rural communities of Dale district of Sidama Region, Southern Ethiopia. …”
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Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis by Mengmeng Zhang, Hong Lv, Xiaoyin Bai, Gechong Ruan, Qing Li, Kai Lin, Hong Yang, Jiaming Qian

“…Mitochondrial injury is a key mechanism regulating both aging and inflammation. This study aims to reveal the role of mitochondrial damage in the pathogenesis of adult- and elderly-onset UC. …”
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Executive Functions Training and Giftedness (Capacitatión en funciones ejecutivas y superdotación) by Eirini Zoi Kontostavlou, Athanasios Drigas

“…Moreover, executive function training can be achieved by brain training programs, that aim to improve basic brain functions. …”
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