Effects of Lacticaseibacillus paracasei K56 on perceived stress among pregraduate students: a double-blind, randomized, placebo-controlled trial by Yiran Guan, Ruixin Zhu, Wen Zhao, Langrun Wang, Li You, Zhaozhong Zeng, Qiuyue Jiang, Zeyang Zhu, Jiayu Gou, Qi Zhang, Jie Guo, Keji Li, Liang Zhao, Yixuan Li, Pengjie Wang, Bing Fang, Weilian Hung, Jian He, Liwei Zhang, Ran Wang, Jingjing He

“…Pre- and post-treatment serum biomarkers, gut microbiota composition and metabolites were also detected.ResultsThere was no difference in changes of PSS-10 scores from baseline to 2 weeks between the K56 groups and the placebo [mean (standard error): −1.68 (0.48) vs. -0.39 (0.46), p = 0.055]. …”
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Array-CGH increased the diagnostic rate of developmental delay or intellectual disability in Taiwan by Chung-Lin Lee, Chen-Hao Lee, Chih-Kuang Chuang, Huei-Ching Chiu, Yen-Jiun Chen, Chao-Ling Chou, Peih-Shan Wu, Chih-Ping Chen, Hsiang-Yu Lin, Shuan-Pei Lin

“…A previous study has reported a detection rate of 10%–20% for this array.1 This study aimed to investigate and compare the diagnosis rate for DD/ID using array-CGH and conventional chromosome study in DD/ID patients in Taiwan. …”
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A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosisResearch in context by Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Rachael Bartlett, Christen G. Chisholm, Jody Gorman, Anthony Dosseto, Florian Dux, Lachlan E. McInnes, Heath Ecroyd, Luke McAlary, Peter J. Crouch, Paul S. Donnelly, Justin J. Yerbury

“…Methods: We utilised a 3D checkerboard approach to investigate whether a matrix of different concentrations CuATSM, ebselen and telbivudine could provide therapeutic improvements on cell survival, SOD1 folding and aggregation in SOD1G93A-transfected NSC-34 cells, compared to CuATSM alone. …”
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Characterization of risk factors for early ambulation in paraplegic dogs with absent pain perception undergoing decompressive surgery for thoracolumbar intervertebral disk extrusio... by Sérgio A. Gomes, Sérgio A. Gomes, Sérgio A. Gomes, Sérgio A. Gomes, Rui Damásio Alvites, Rui Damásio Alvites, Rui Damásio Alvites, Rui Damásio Alvites, Bruna Lopes, Bruna Lopes, Bruna Lopes, André Coelho, André Coelho, André Coelho, Mike Targett, Jorge Ribeiro, Jorge Ribeiro, Jorge Ribeiro, Débora Gouveia, Débora Gouveia, Débora Gouveia, Ângela Martins, Ângela Martins, Ângela Martins, Artur S. P. Varejão, Artur S. P. Varejão, Artur S. P. Varejão, Ana Colette Maurício, Ana Colette Maurício, Ana Colette Maurício, Ana Lúcia Luís, Ana Lúcia Luís, Ana Lúcia Luís

“…Furthermore, the outcome of paraplegic APP French Bulldogs (FBs) is anecdotally considered poor. The aims of this study were threefold within a large population of TL-IVDE paraplegic dogs with APP undergoing decompressive surgery: (1) to characterize early spontaneous pelvic limb movement and ambulation following surgery; (2) to identify risk factors for the recovery of ambulation; and (3) to compare the outcome of FBs and Dachshunds presenting with APP.MethodsA single-center, retrospective case series of dogs with paraplegia and APP diagnosed with TL-IVDE based on CT or MRI, all undergoing surgical decompression (hemilaminectomy ± durotomy). …”
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Plasma Epstein-Barr Virus DNA load for diagnostic and prognostic assessment in intestinal Epstein-Barr Virus infection by Chunxiang Ma, Chunxiang Ma, Chunxiang Ma, Mingshan Jiang, Mingshan Jiang, Mingshan Jiang, Jiaxin Li, Jiaxin Li, Jiaxin Li, Zhen Zeng, Zhen Zeng, Zhen Zeng, Yushan Wu, Yushan Wu, Yushan Wu, Rui Cheng, Rui Cheng, Rui Cheng, Hao Lin, Hao Lin, Hao Lin, Jiangmei Pang, Jiangmei Pang, Jiangmei Pang, Fang Yin, Fang Yin, Fang Yin, Yongbin Jia, Yongbin Jia, Yongbin Jia, Lili Li, Lili Li, Lili Li, Hu Zhang, Hu Zhang, Hu Zhang

“…BackgroundThe prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure of intestinal EBV infection remains unexplored. This study aims to identify ideal threshold levels for plasma EBV DNA loads in the diagnosis and outcome prediction of intestinal EBV infection, particularly in cases of primary intestinal lymphoproliferative diseases and inflammatory bowel disease (IBD).MethodsReceiver operating characteristic (ROC) curves were examined to determine suitable thresholds for plasma EBV DNA load in diagnosing intestinal EBV infection and predicting its prognosis.Results108 patients were retrospectively assigned to the test group, while 56 patients were included in the validation group. …”
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Machine learning discrimination of Gleason scores below GG3 and above GG4 for HSPC patients diagnosis by Bingyu Zhu, Longguo Dai, Huijian Wang, Kun Zhang, Chongjian Zhang, Yang Wang, Feiyu Yin, Ji Li, Enfa Ning, Qilin Wang, Libo Yang, Hong Yang, Ruiqian Li, Jun Li, Chen Hu, Hongyi Wu, Haiyang Jiang, Yu Bai

“…Abstract This study aims to develop machine learning (ML)-assisted models for analyzing datasets related to Gleason scores in prostate cancer, conducting statistical analyses on the datasets, and identifying meaningful features. …”
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Mechanism of fumonisin B1 on growth performance and intestinal structural integrity of juvenile grass carp (Ctenopharyngodon idella) by Daiyu Chen, Weidan Jiang, Pei Wu, Yang Liu, Hongmei Ren, Xiaowan Jin, Xiaoqiu Zhou, Lin Feng

“…A total of 720 juvenile grass carp (10.92 ± 0.02 g) were fed with four different levels of FB1 diets (0, 2.06, 3.94, and 8.05 mg/kg) for 30 d and each group had 3 replicates of 60 fish. …”
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Interventions to improve mental health and well-being in care-experienced children and young people aged less than 25: the CHIMES systematic review by Rhiannon Evans, Sarah MacDonald, Robert Trubey, Jane Noyes, Michael Robling, Simone Willis, Soo Vinnicombe, Maria Boffey, Charlotte Wooders, Asmaa El-Banna, GJ Melendez-Torres

“…There was no clear difference between interventions that reported high levels of implementation and/or acceptability and effectiveness. …”
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Unfavorable variants of folate metabolism genes in patients with acute coronary syndrome in non-obstructive coronary atherosclerosis by V. V. Ryabov, S. B. Gomboeva, Yu. D. Lugacheva, I. B. Kulagina, R. P. Karpov

“…Aim. To study the occurrence of allelic variants of folate cycle enzymes’ genes, which are unfavorable with respect to the risk of thrombophilia, to analyze the serum level of homocysteine, and to assess their impact on the development of acute coronary syndrome (ACS) in non-obstructive coronary atherosclerosis (NOCA). …”
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Clinical performance of the atrial fibrillation in the Russian population depending on the antithrombotic therapy: findings from the GLORIA-AF registry phase 2 by E. V. Shlyakhto, S. V. Villevalde, A. V. Ezhov, S. A. Zenin, N. A. Koziolova, O. Yu. Korennova, T. N. Novikova, K. V. Protasov, G. A. Chumakova, C. Teutsch, S. Lu, G. Y. H. Lip, M. V. Huisman

“…Patients in the Russian cohort receiving dabigatran differ from the global cohort of patients by greater comorbidity. …”
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Assessing rehabilitation potential of the masticatory musculature in patients with temporomandibular myofascial pain syndrome: A randomized prospective controlled study by E. N. Iarygina, V. V. Shkarin, Yu. A. Makedonova, S. V. Dyachenko

“…Treatment for patients with temporomandibular myofascial pain syndrome is primarily aimed at improving the psychological and physical state of the patient, as well as restoring lost functions, which is defined by the rehabilitation potential. …”
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Evaluation of efficacy and safety of long-term use of amtolmetin guacil in rheumatic diseases: results of a 9-month observational AURORA study (Amtolmetin guacil: allRussian Regist... by A. E. Karateev, E. L. Nasonov, S. I. Glukhova, A. A. Barakat, R. L. Gibadullina, E. A. Ageeva, O. S. Fedorova, T. S. Timofeeva, G. R. Mikhailova, A. E. Nasonova

“…A good choice for long-term therapy may be amtolmetin guacil (AMG), which rarely induce gastrointestinal AE. The aim of the study was to assess the effect and safety of long-term use of AMG in RD. …”
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Lung Health of Early COPD (LHEC): A Multi-Center Cohort Study—Rational and Design by Li W, Lei J, Li B, Tang X, Peng Y, Huang K, Yang T

“…We will analyze the changes in lung function, CT images, symptoms, biomarkers, and other relevant parameters across the different groups.Discussion: There is an urgent need for a more precise definition of early COPD for intervention at an earlier stage. …”
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SINGING ETHOS, PATHOS, AND ETHNOS: THREE GENERATIONS, FOUR ISRAELI EUROVISION VICTORIES, 1978–2018 / ПЕСНИ ЭТОСА, ПАФОСА И ЭТНОСА: ТРИ ПОКОЛЕНИЯ — ЧЕТЫРЕ ПОБЕДЫ ИЗРАИЛЯ НА «ЕВРОВИ... by RITZAREV MARINA / РЫЦАРЕВА МАРИНА ГРИГОРЬЕВНА

“…Phylo-vernacular elements, ingrained in each country’s cultural roots, are here mixed with a general, global pop style creating onto-vernacular, aimed at intercultural communication aesthetic preferences. …”
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Leave as Fast as You Can: Using Generative AI to Automate and Accelerate Hospital Discharge Reports by Alex Trejo Omeñaca, Esteve Llargués Rocabruna, Jonny Sloan, Michelle Catta-Preta, Jan Ferrer i Picó, Julio Cesar Alfaro Alvarez, Toni Alonso Solis, Eloy Lloveras Gil, Xavier Serrano Vinaixa, Daniela Velasquez Villegas, Ramon Romeu Garcia, Carles Rubies Feijoo, Josep Maria Monguet i Fierro, Beatriu Bayes Genis

“…The system was developed through iterative cycles, integrating various instruction flows and evaluating five different LLMs combined with prompt engineering strategies and agent-based architectures. …”
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Detection of water surface targets based on improved Deformable DETR by Pengjiu WANG, Junbin Gong, Wei LUO, Xiao HUANG, Junjie GUO

“…The experimental results on different datasets verify the effectiveness of the algorithm. …”
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Condición Física, Actividad Física y Calidad de Vida en Estudiantes Universitarios Chilenos (Physical Fitness, Physical Activity and Quality of Life in Chilean College Students) by Catalina Munoz Strale, Frano Giakoni-Ramírez, Franco Pinochet, Andrés Godoy-Cumillaf, Paola Fuentes-Merino, Daniel Duclos-Bastías

“…Conclusions: Significant relationships between BMI and different aspects of FC, as well as correlations between FC and QoL, and PA and QoL, were found in Chilean university students. …”
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Health economic impact of patients with phenylketonuria (PKU) in France – A nationwide study of health insurance claims data by Jean-Baptiste Arnoux, Claire Douillard, Francois Maillot, Stéphane Bouée, Christian Jacob, Kim Maren Schneider, Julia Theil, Sybil Charrière

“…If left untreated, it can lead to severe irreversible intellectual disability and can cause seizures, behavior disturbance, and white matter disease. This study aimed at evaluating the health economic impact of patients with PKU in France. …”
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A Tertiary Study on Open-Source Software Research by Saima Imtiaz, Salma Imtiaz, Ahmad Almadhor, Rastislav Kulhanek

“…By synthesizing the findings from secondary studies, this research aims to offer a meta-level understanding of the OSS field, uncovering overlooked areas and defining a research agenda. …”
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Peculiarities of heart rate variability in children with gastroesophageal reflux disease by L. N. Boyarskaya, К. A. Ivanova, L. V. Kravets, Т. О. Levchuk

“…The study of heart rate variability (HRV) in recent times is used as the most informative noninvasive method for quantitative assessment of autonomic regulation of heart rate. The aim of research. Determining the characteristics of autonomic regulation in children with gastroesophageal reflux disease. …”
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