Hydrocortisone, vitamin C, and thiamine may not improve the outcome of patients with sepsis or septic shock: a systematic review and meta-analysis by Zhuangli Li, Xiaoli Zhang, Yongliang Wu, Chao Xie, Chengjiang Liu, Xiuyu He, Zehua Wu, Guofang Hua, Yuedong Li

“…Background. This study aimed to conduct a systematic review and meta-analysis of the efficacy of hydrocortisone, vitamin C, and thiamine (HVT) in patients with sepsis or septic shock. …”
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Efficacy of PARPi re-maintenance therapy for recurrent ovarian cancer by Yulin Wang, Yunjie Yang, Binghong Guo, Binghong Guo, Xiaoyan Li, Renakezi Tuersun, Ye Cao, Jundong Li, Jihong Liu, Su Li, Tao Liu, Yongwen Huang

“…The structural domains of BRCA mutations with different sensitivity to PARPi might serve as a promising biomarker for optimizing treatment. …”
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Optimizing fodder yield and quality through integrated organic nutrient amendments in multi-crop system by Santosh Onte, Santosh Onte, Vrushabh Vijay Fiskey, Manjunath S. Melavanki, Airadevi P. Angadi, Prasanna S. Pyati, Magan Singh, Dileep Kumar, Sanjivkumar Angadarao Kochewad, Sudhir Kumar, Hari Om, Vijendra Kumar Meena, Kamal Garg, Vetrivel Karunakaran, Manish Kanwat, Babu Lal Meena, Yogananda Shivalli Boregowda, Rahul Bellagi, K. Naveena, Sunil Chandersheker, Elisa Azura Azman, Sanjeev Kumar

“…These treatments comprised of different combination of farmyard manure (FYM), Plant growth promoting rhizobacteria (PGPR) and foliar spray of panchagavya for maize (M), berseem (B), and cowpea (C) and a treatment with recommended dose of fertilizers. …”
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Impaired response inhibition to negative emotional stimuli in depressed adolescents with non-suicidal self-injury: a neurophysiological perspective by Lin Zhao, Su Hong, Xinyu Peng, Xiaoqing He, Jinhui Hu, Lingli Ma, Xinyi Liu, Wanqing Tao, Ran Chen, Zhenghao Jiang, Chenyu Zhang, Jing Liao, Jiaojiao Xiang, Qi Zeng, Linqi Dai, Qi Zhang, Wo Wang, Li Kuang

“…The ERP time-domain features related to response inhibition were extracted from the difference waves, converted to the time-frequency features using the short-time Fourier transform (STFT), and the time-frequency values of the region of interest (ROI) were extracted and statistically analyzed.ResultsUnder exposure to negative emotional stimuli, depressed adolescents with NSSI exhibited significantly larger P300 amplitudes compared to both depressed adolescents and healthy controls. …”
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Ibrutinib in the Treatment of Refractory Chronic Lymphocytic Leukemia by EA Nikitin, EA Dmitrieva, MA Panteleev, EI Emelina, VL Ivanova, YuB Kochkareva, EG Arshanskaya, IE Lazarev, EE Markova, LA Mukha, NG Novitskaya, MM Pankrashkina, VV Glazunova, AV Shubina, SA Chernysh, NK Khuazheva, EV Naumova, SA Lugovskaya, ME Pochtar’, TN Obukhova, OYu Vinogradova, GE Gendlin, VV Ptushkin

“…Background & Aims. This paper presents the results of the observational study of ibrutinib in patients with chronic lymphocytic leukemia (CLL), conducted in SP Botkin Municipal Clinical Hospital. …”
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Life’s Essential 8 cardiovascular health, cardiovascular-kidney-metabolic syndrome stages, and incident cardiovascular events: a nationwide 10-year prospective cohort study in Chin... by Mian Li, Min Xu, Yi Ding, Hong Lin, Guijun Qin, Tiange Wang, Yu Xu, Yuhong Chen, Shuangyuan Wang, Zhiyun Zhao, Jie Zheng, Li Yan, Lixin Shi, Zhengnan Gao, Lulu Chen, Tianshu Zeng, Ruying Hu, Zhen Ye, Xuefeng Yu, Gang Chen, Qing Su, Yiming Mu, Xulei Tang, Qin Wan, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, Yingfen Qin, Li Chen, Xinguo Hou, Yanan Huo, Qiang Li, Hong Qiao, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Guang Ning, Jieli Lu, Weiqing Wang, Yufang Bi

“…Variation was observed in the association between cardiovascular-kidney-metabolic stage and CVD events with different CVH status or numbers of optimal CVH metrics. …”
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In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis by Nicole Vasilenko, Maria P. Tieck, Maria P. Tieck, Tanja Michel, Sonja Schembecker, Patricia Schwarz, Anna Guenther, Christoph Ruschil, Christoph Ruschil, Sven Poli, Sven Poli, Ulf Ziemann, Ulf Ziemann, Antje Giede-Jeppe, Antje Giede-Jeppe, Gisela Gabernet, Alex Dulovic, Markus C. Kowarik, Markus C. Kowarik

“…Recently, molecular mimicry between EBNA1 and specific GlialCAM, CRYAB and ANO2 peptides has been suggested as a possible pathophysiological mechanism. The aim of this study was to analyse anti-EBV antibodies in MS patients against (I) EBV lifecycle proteins, (II) putative cross-reactive peptides, and (III) during treatment.MethodsIn this retrospective cross-sectional study, 258 serum samples were included consisting of EBV-negative (n = 25) and EBV-positive (n = 36) controls, 192 MS samples including untreated relapsing-remitting MS (RRMS) with and without relapses, secondary progressive MS (SPMS) and primary progressive MS (PPMS) patients, and 106 patients on 8 different treatment regimens. …”
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Efficacy and safety of reduning injection for severe pneumonia: a systematic review and meta-analysis by Yan Wang, Yan Wang, Baichuan Xu, Baichuan Xu, Peng Zhang, Peng Zhang, Suyun Li, Suyun Li, Suyun Li, Yang Xie, Yang Xie, Yang Xie

“…ObjectivesReduning (RDN) injection is a traditional Chinese medicine (TCM) extract injection commonly used as an adjunct therapy for severe pneumonia (SP) in clinical practice in China; however, further validation is required. This study aims to systematically assess the efficacy and safety of RDN injection in treating SP.MethodsThe study was conducted using the data from CNKI, WanFang, VIP, SinoMed, PubMed, Embase, Cochrane Library, and Web of Science databases from their inception to 6 April 2024. …”
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Age-stratified associations between radiotherapy and SPMs for FPHNC: a population-based cohort study by Yuan-Yuan Li, Qiong Liu, Si-Qi Ying, Xiu-Quan Wu, Xiao-Hui Zhang, Xiao-Mei Xie, Bing-Dong Sui, Yan Jin, Yang Jiao, Franklin R. Tay

“…The increasing use of radiotherapy raises concerns about the elevated risk of radiation-associated SPMs. This study aimed to investigate the age-stratified association between radiotherapy and SPM risk in survivors of non-metastatic primary HNC. …”
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Cost‐effectiveness of a multicomponent intervention against cognitive decline by Christian Brettschneider, Elżbieta Buczak‐Stec, Melanie Luppa, Andrea Zülke, Bernhard Michalowsky, Anika Rädke, Alexander Bauer, Christine Brütting, Robert P. Kosilek, Isabel Zöllinger, Juliane Döhring, Martin Williamson, Birgitt Wiese, Wolfgang Hoffmann, Thomas Frese, Jochen Gensichen, Hanna Kaduszkiewicz, Jochen René Thyrian, Steffi G. Riedel‐Heller, Hans‐Helmut König, the AGEWELL.DE study group

“…Abstract INTRODUCTION The societal costs of dementia and cognitive decline are substantial and likely to increase during the next decades due to the increasing number of people in older age groups. The aim of this multicenter cluster‐randomized controlled trial was to assess the cost‐effectiveness of a multi‐domain intervention to prevent cognitive decline in older people who are at risk for dementia. …”
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Predictive multigenic scale. Analysis of own results in metastatic breast cancer by R. M. Paltuev, S. N. Aleksakhina, A. S. Artemyeva, E. A. Baychorov, S. Yu. Bakharev, A. A. Bozhok, V. A. Vasin, V. I. Vladimirov, O. A. Volynshchikova, A. Yu. Vorontsov, E. A. Gaysina, A. A. Hoffman, E. N. Imyanitov, V. V. Klimenko, A. V. Komyakhov, M. M. Konstantinovа, M. V. Kopp, A. G. Kudaybergenova, I. A. Lalak, D. L. Matevosyan, N. M. Mudzhiri, O. V. Poltareva, O. I. Sevryukova, V. F. Semiglazov, T. Yu. Semiglazova, M. M. Urezkova, L. A. Churilova

“…In 18 cases, there were some principal discrepancies in the tumor subtype that implied totally different treatment regimens. The proposed polygenic signature allows accurate identification of the tumor subtype in patients with metastatic breast cancer and choice of an optimal treatment strategy.   …”
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Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study by David Goncalves, Marie Benaiteau, Marie Benaiteau, Véronique Rogemond, Véronique Rogemond, Sterenn Closs, Sterenn Closs, Anne-Laurie Pinto, Anne-Laurie Pinto, Maroua Dhairi, Maroua Dhairi, Marine Villard, Marine Villard, Géraldine Picard, Géraldine Picard, Nicole Fabien, Jérôme Honnorat, Jérôme Honnorat

“…CSF samples were all tested using 3 different assays: cIFA, hIFA, and cCBA. Serum samples were all tested using at least 1 cCBA and 1 hCBA for the detection of the following autoantibodies: CASPR2, GABABR, and LGI1.Results & DiscussionAmong the 2135 CSF tested, 93 (4.4%) were positive using both cIFA and hIFA, 1 (0.05%) was positive using only cIFA, and 6 (0.3%) were positive using only hIFA. …”
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Efficacy and safety of topical minocycline preparations for papulopustular rosacea: a systematic review and meta-analysis by Awadh Alamri, Awadh Alamri, Abdulrahman H. Alsamadani, Abdulrahman H. Alsamadani, Rose A. Alraddadi, Rose A. Alraddadi, Mulham Kalantan, Mulham Kalantan, Randa Khafaji, Randa Khafaji, Bader Bashrahil, Bader Bashrahil, Hassan Bogari, Hassan Bogari, Athoub Kadasa, Athoub Kadasa, Abdulhadi Jfri, Abdulhadi Jfri, Abdulhadi Jfri

“…Further studies, however, should assess the efficacy of different concentrations and combinations of minocycline to better delineate the effect of this drug in the clinical aspect.Systematic review registrationPROSPERO, identifier CRD42023447486, https://www.crd.york.ac.uk/PROSPERO/view/CRD42023447486.…”
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6-year treatment follow-up with an extended-release alkaline formulation (Sibnayal®) in primary distal renal tubular acidosis by Aurélia Bertholet-Thomas, Aurélie De Mul, Julie Bernardor, Gwenaëlle Roussey-Kesler, Ludmila Podracka, Robert Novo, François Nobili, Bertrand Knebelmann, Jérôme Harambat, Emilija Golubovic, Olivia Boyer, Massimo Di Maio, Mathilde Cailliez, Véronique Baudouin, Laure Chidler, Véronique Leblanc, Justine Bacchetta

“…Abstract Background Distal renal tubular acidosis (dRTA) is a rare disease characterized by hyperchloremic metabolic acidosis affecting growth, bone and kidney health. Methods The aim of B22CS study was to evaluate long-term safety and efficacy (anthropometric/pubertal, tubular damages/kidney function, bone biomarkers, compliance assessments) of Sibnayal®, a prolonged-release alkalinizing formulation with twice daily dosing, in children and adults with dRTA. …”
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Providing continuity of care for people living with noncommunicable diseases in humanitarian settings: A qualitative study of health actors' experiences in Lebanon by C. Akik, Z. El Dirani, R. Willis, C. Truppa, C. Zmeter, S. Aebischer Perone, J. Roswall, R. Hamadeh, K. Blanchet, B. Roberts, M.F. Fouad, P. Perel, É. Ansbro

“…Continuity of care (CoC) involves following an individual over time and across different levels of healthcare (management, longitudinal, informational and interpersonal continuity); it is an essential component of good quality, person-centred NCD care. …”
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Ridge and furrow cultivation raises water and nitrogen use efficiency and crop climate adaptability by Kun Han, Guangxu Yao, Zhongrui Li, Yueying Wang, Mengjiao Li, Tangyuan Ning, Yakov Kuzyakov

“…Here, we performed a meta-analysis and literature review to provide a comprehensive characterization of RF cultivation on the basis of the main aims, and management of water and nutrients. The most important difference between RF and flat cultivation practices is the complete change in water infiltration and fluxes in soils as well as associated nutrient losses, especially nitrogen (N). …”
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Assessing the impact of contraceptive use on reproductive cancer risk among women of reproductive age—a systematic review by Shayesteh Jahanfar, Julie Mortazavi, Amy Lapidow, Cassandra Cu, Cassandra Cu, Jude Al Abosy, Kathyrn Morris, Juan Camilo Becerra-Mateus, Meredith Steinfeldt, Olivia Maurer, Jiang Bohang, Paola Andrenacci, Marwa Badawy, Moazzam Ali

“…Further research is needed to explore contraceptive impacts across different genetic profiles and dosing regimens.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, Prospero (CRD42022332647).…”
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Elevated thiamine level is associated with activating interaction between HIF-1α and SLC19A3 in experimental myopic guinea pigs by Zhongyu Ma, Jiawen Hao, Zhaohui Yang, Miao Zhang, Ruixue Zhang, Jizhao Xin, Bo Bao, Xuewei Yin, Xuewei Yin, Hongsheng Bi, Hongsheng Bi, Hongsheng Bi, Dadong Guo, Dadong Guo, Dadong Guo, Dadong Guo

“…Myopia is the most common eye disease that damages the visual health of adolescents, and currently, choroidal hypoxia is one of the prevailing doctrines of myopia, as well as the choroid as an ocular nutrient-supporting tissue, in which thiamine may play a role. This study aimed to investigate the process of thiamine changes in choroidal tissue of guinea pigs with negative lens-induced myopia (LIM).MethodsThe right eyes of guinea pigs in the LIM group wore −6.0D lenses to model experimental myopia. …”
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Severe Hypofunction of Allogeneic Hematopoietic Stem Cell Transplant in Patients with Oncohematological Diseases: Incidence, Risk Factors, and Outcomes by TA Rudakova, AD Kulagin, OU Klimova, IK Golubovskaya, EI Darskaya, TA Bykova, AG Smirnova, EV Morozova, SN Bondarenko, IS Moiseev, AV Beinarovich, DE Pevtsov, AL Alyanskii, EV Babenko, IM Barkhatov, BV Afanas’ev

“…Aim. Based on strict criteria, to assess incidence, pretransplantation risk factors, and outcomes of severe hypofunction of graft, i.e. poor graft function (sPGF), following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adults. …”
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Liver fibrosis progression analyzed with AI predicts renal decline by Dan-Qin Sun, Jia-Qi Shen, Xiao-Fei Tong, Ya-Yun Ren, Hai-Yang Yuan, Yang-Yang Li, Xin-Lei Wang, Sui-Dan Chen, Pei-Wu Zhu, Xiao-Dong Wang, Christopher D. Byrne, Giovanni Targher, Lai Wei, Vincent W.S. Wong, Dean Tai, Arun J. Sanyal, Hong You, Ming-Hua Zheng

“…Background & Aims: The relationship between biopsy-proven liver fibrosis progression and renal function decline in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) has not been fully elucidated. …”
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