Optimal early endpoint for second-line or subsequent immune checkpoint inhibitors in previously treated advanced solid cancers: a systematic review by Jingqiu Li, Xiaoding Zhou, Lei Wu, Jiabao Ma, Yan Tan, Songke Wu, Jie Zhu, Qifeng Wang, Qiuling Shi

“…This systematic review aimed to explore the most optimal early efficacy endpoint for such trials. …”
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High-risk HPV distribution and importance of continuing cervical cancer screening of women aged 65 years and older: a study based on 2 152 766 women in China by Bo Wu, Yu Jiang, Jiahui Wang, Xiaotian Li, He Wang, Fanghui Zhao, Zichen Ye, Yingyu Zhong, Shuyan Jin, Xuelian Zhao, Yueyun Wang

“…The most common genotypes in older women were HPV52, HPV16, HPV58, HPV56 and HPV68, with HPV18, HPV16 and HPV33 being major causes of CIN2+, along with frequent double infections such as HPV52/58, HPV16/52 and HPV52/56, while CIN2+ was predominantly associated with HPV33/39, HPV35/31 and HPV18/39, which differ from those in younger women. A dose-response relationship between hr-HPV infections and CIN2+ risk was observed in women aged≥65 (p for trend<0.001). …”
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SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper by João Pedro Ferreira, Francisco Vasques‐Nóvoa, Francisca Saraiva, Ana C. Oliveira, Jorge Almeida, Ana Beatriz Batista, Arsénio Barbosa, Ana Filipa Ferreira, Cátia Costa, Diogo Santos‐Ferreira, Fernando Friões, Cândida Goncalves, João Tiago Guimarães, Marta Leite, Pedro Marques, Joana Mascarenhas, Maria Inês Matos, Catarina Pereira, Pedro Rodrigues, Abhinav Sharma, Gualter Silva, Inês Pereira‐Sousa, Carla Sousa, Faiez Zannad, Joana Pimenta, Ricardo Fontes‐Carvalho, Adelino Leite‐Moreira

“…A sample size of 108 patients was estimated to provide 80% power, at a 0.05 alfa level, to detect a 0.15 LogNT‐proBNP difference between the spironolactone/dapagliflozin combination and dapagliflozin alone sequence. …”
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Evaluating methods for identifying and quantifying Streptococcus pneumoniae co-colonization using next-generation sequencing data by Jada Hackman, Martin L. Hibberd, Todd D. Swarthout, Jason Hinds, James Ashall, Carmen Sheppard, Gerry Tonkin-Hill, Kate Gould, Comfort Brown, Jacquline Msefula, Andrew A. Mataya, Michiko Toizumi, Lay-Myint Yoshida, Neil French, Robert S. Heyderman, Stefan Flasche, Brenda Kwambana, Stéphane Hué

“…This study assessed the sensitivity of different genomic serotyping methods for identifying pneumococcal serotypes during co-carriage. …”
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How many doses and what type of antibiotic should be used as systemic antibiotic prophylaxis in primary hip and knee arthroplasty? A register-based study on 301,204 primary total a... by Olav Lutro, Marianne Bollestad Tjørhom, Tesfaye Hordofa Leta, Jan-Erik Gjertsen, Geir Hallan, Trond Bruun, Marianne Westberg, Tina Strømdal Wik, Christian Thomas Pollmann, Stein Håkon Lygre, Ove Furnes, Lars Engesæter, Håvard Dale

“… Background and purpose: Guidelines for systemic antibiotic prophylaxis (SAP) in arthroplasty surgery vary worldwide from repeated doses to only 1 preoperatively. We aimed to investigate, primarily whether 4 doses reduced the risk of PJI compared with 1 to 3 doses, and secondarily if there was a difference between types of antibiotics. …”
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The establishment of a molecular diagnostic platform for mitochondrial diseases: From conventional to next-generation sequencing by Ni-Chin Tsai, Chai-Wai Liou, Yin-Hua Cheng, Hao-Ting Lien, Tzu-Ling Lin, Tsu-Kung Lin, Min-Yu Lan, Pi-Lien Hung, Tzu-Jou Wang, Chen-Hao Lee, Yi-Chih Liang, Kuo-Chung Lan

“…Background: The aim of this study was to create a molecular diagnostic platform and establish a diagnostic pipeline for patients highly suspected of mitochondrial disorders. …”
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Changes in Cardiovascular Health, Genetic Risk, and Cardiometabolic Diseases: Evidence From a Large‐Scale Cohort Study by Shuaizhou Chen, Jialin Li, Qiuhong Man, Chengxin Hu, Jinchen Li, Jianwei Wang, Siyu Wu, Kelin Xu, Mei Cui, Tiejun Zhang, Xingdong Chen, Chen Suo, Yanfeng Jiang

“…These findings underscore the importance of interventions aimed at promoting cardiovascular well‐being across entire populations, offering valuable insights for targeted preventive strategies and healthcare interventions.…”
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Neuroprotective effects of healthful plant-based diets on retinal structure: insights from a large cohort by Qian Zhu, Xiaoxin Liu, Yuan Qu, Yan Jiang, Xinyi Liu, Yu Xiao, Kangjia Lv, Yupeng Xu, Kun Liu

“…Objective: This study aims to investigate the associations between four commonly used diet assessment scores and retinal sublayer thickness in a large-scale population. …”
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Impact of metagenomics next-generation sequencing on etiological diagnosis and early outcomes in sepsis by Feixiang Xu, Chen Chen, Su Lu, Mingming Xue, Hailin Ding, Yanli Song, Yun Zhang, Keyu Sun, Lunxian Tang, Wei Wang, Meitang Wang, Yan Tang, Dingyu Tan, Chenling Yao, Dongwei Shi, Enqiang Mao, Mian Shao, Youguo Ying, Chunmei Zhou, Lihong Huang, Hu Peng, Zhongshu Kuang, Sanqiang Wang, Qingbian Ma, Si Sun, Dongfeng Guo, Tianwen Gu, Bin Yang, Linhao Ma, Chengjin Gao, Xiaoye Lu, Hong Zhang, Ruilan Wang, Chaoyang Tong, Zhenju Song

“…Abstract Background Clinical implications of metagenomics next-generation sequencing (mNGS) in sepsis have not been fully evaluated. This study aimed to determine the diagnostic, therapeutic, and prognostic impacts of mNGS in sepsis. …”
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Risk factors of cervical insufficiency in women with PCOS undergoing IVF-ET treatment: a case-control study by Xueqing Zhao, Xueqing Zhao, Xueqing Zhao, Xueqing Zhao, Xueqing Zhao, Shenglong Ye, Xin Yan, Rong Li, Rong Li, Rong Li, Rong Li, Rong Li, Yongqing Wang, Yongqing Wang, Yongqing Wang, Yongqing Wang, Yongqing Wang

“…ObjectiveThis study aims to investigate the risk factors associated with cervical insufficiency (CI) in women with polycystic ovarian syndrome (PCOS) who have undergone in vitro fertilization and embryo transfer (IVF-ET) treatment.MethodsThis study included 746 women diagnosed with PCOS. …”
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The study on risk assessment of carotid plaques in the Northern Chinese population based on LASSO regression by Kun Yuan, Chongjian Li, Junmin Chu, Yilin Huang, Jiayi Song, Liguang Dong, Ying Yang, Hongyu Wang, Jinbo Liu, Xinhua An, Xiaoyuan Tian, Lin Mu, Ye Tian, Zengwu Wang, Linfeng Zhang

“…Further studies may be useful to validate the applicability in different regions and populations.…”
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Renal resistive index as an early predictor and discriminator of acute kidney injury in critically ill patients; A prospective observational cohort study. by Jelle L G Haitsma Mulier, Sander Rozemeijer, Jantine G Röttgering, Angelique M E Spoelstra-de Man, Paul W G Elbers, Pieter Roel Tuinman, Monique C de Waard, Heleen M Oudemans-van Straaten

“…Measuring flow resistance in the renal circulation, Renal Resistive Index (RRI), could become part of vital organ function assessment using Doppler ultrasound. Our aim was to determine whether RRI on ICU admission is an early predictor and discriminator of AKI developed within the first week.…”
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Enhanced allergic Eustachian tube response in surfactant protein D knockout mice induced by ovalbumin by Xuan Yu, Hejie Li, Wei Tang, Xi Lian, Wenting Yu, Ting Li, Shimin Zong, Hongjun Xiao

“…Objective: This study aimed to investigate the morphological and functional changes in the ET induced by ovalbumin under SPD gene deficiency and to explore the underlying mechanisms. …”
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Cultivability of Escherichia coli and Staphylococcus aureus in the presence of hydroethanolic extracts of Lantana camara stems and leaves: Importance of bioactive compounds in the... by Carlain Emar Tchapo Djappa, fils Mamert Onana, Antoine Tamsa Arfao, Claire Stéphane Metsopkeng, Maka Mouande Arnold Alex, Sophie Laurent, Céline Henoumont, Hugues Fouotsa, Pierre Mkounga, Ephrem Augustin Nkengfack

“…The Kruskal-Wallis test shows that the abundance of cultivable cells of each bacterial species differed significantly from one incubation temperature to another at each extract concentration and at each incubation temperature for each part of the plant (P<0.05). …”
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Circulating short-chain fatty acids and Mediterranean food patterns. A potential role for the prediction of type 2 diabetes risk: The Di@bet.es Study by Gemma Llauradó, Lídia Cedó, Elisenda Climent, Joan Badia, Gemma Rojo-Martínez, Juana Flores-Le Roux, Oscar Yanes, Maria Vinaixa, Minerva Granado-Casas, Didac Mauricio, Sonia Fernández-Veledo, Joan Vendrell

“…In addition, an association between baseline consumption of high-fiber foods with incident T2D emerged, suggesting a different behaviour between healthy and prediabetic subjects. …”
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Second-line pembrolizumab for advanced HCC: Meta-analysis of the phase III KEYNOTE-240 and KEYNOTE-394 studies by Richard S. Finn, Kangsheng Gu, Xi Chen, Philippe Merle, Kyung-Hun Lee, Mohamed Bouattour, Peiguo Cao, Wei Wang, Ann-Lii Cheng, Liangjun Zhu, Ho Yeong Lim, Masatoshi Kudo, Yueyin Pan, Ting-Tsung Chang, Julien Edeline, Wei Li, Ping Yang, Chen Li, Jianfeng Li, Abby B. Siegel, Shukui Qin

“…Background &amp; Aims: We performed a meta-analysis of data from the KEYNOTE-240 and KEYNOTE-394 studies to obtain a more precise estimate of the pembrolizumab treatment effect in participants with previously treated advanced hepatocellular carcinoma (HCC). …”
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Culture-sensitive lifestyle intervention tailored to non-Western migrant older adults improves physical performance: A randomized controlled trial by Esmée J.M. Biersteker, Jantine van den Helder, Nannette van der Spek, Mieke Holwerda, Hinke Kruizenga, Peter J.M. Weijs, Michael Tieland

“…However, regular community-based lifestyle interventions often lack a culture-sensitive approach. The aim of this study was to assess the effects of a newly developed culture-sensitive lifestyle intervention on physical performance in non-Western Surinamese older adults. …”
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Single nuclear‐spatial transcriptomic sequencing reveals distinct puncture‐induced cell subpopulations in the intervertebral disc of a rat model by Guoyan Liang, Jing Tan, Chong Chen, Yuying Liu, Yongyu Ye, Xiaolin Pan, Qiujian Zheng, Yunbing Chang, Feng‐Juan Lyu

“…Abstract Objective We aim to investigate the spatiotemporal dynamics of intervertebral disc (IVD) cell subpopulations in IVD degeneration (IVDD). …”
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Ameliorative Effect of N-Acetylcysteine Against 5-Fluorouracil-Induced Cardiotoxicity via Targeting TLR4/NF-κB and Nrf2/HO-1 Pathways by Omer Abdelbagi, Medhat Taha, Abdullah G. Al-Kushi, Mohammad Ahmad Alobaidy, Tourki A. S. Baokbah, Hatem A. Sembawa, Zohor Asaad Azher, Rami Obaid, Omar Babateen, Bayan T. Bokhari, Naeem F. Qusty, Hesham A. Malak

“…Identifying a protective agent that does not affect its anticancer efficacy is essential. Our study aimed to investigate the cardioprotective effect of N-acetyl cysteine (NAC) against 5-FU-induced cardiac injury and to elucidate the underlying mechanisms. …”
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How well do coverage surveys and programmatically reported mass drug administration coverage match? Results from 214 mass drug administration campaigns in 15 countries, 2008–2017 by Karsor Kollie, Nebiyu Negussu, Scott D Nash, Donal Bisanzio, Fiona M Fleming, Pamela S Mbabazi, Richard Reithinger, Kathryn L Zoerhoff, Katherine Gass, John Kraemer, Brian B Fuller, Lynsey Blair, Roland Bougma, Aboulaye Meite, Bizuayehu Gashaw, Nana-Kwadwo Biritwum, Jean Frantz Lemoine, Helena Ullyartha Pangaribuan, Eksi Wijayanti, Clara Fabienne Rasoamanamihaja, Lazarus Juziwelo, Square Mkwanda, Pradip Rimal, Issa Gnandou, Bocar Diop, Ameyo Monique Dorkenoo, Rachel Bronzan, Edridah Muheki Tukahebwa, Fatima Kabole, Violetta Yevstigneyeva, Lauren Courtney, Joseph Koroma, Egide Endayishimye, Margaret C Baker

“…Reported coverage is often the easiest and least expensive way to estimate coverage; however, it is prone to inaccuracies due to errors in data compilation and imprecise denominators, and in some cases measures treatments offered as opposed to treatments swallowed.Objective Analyses presented here aimed to understand (1) how often coverage calculated using routinely reported data and survey data would lead programme managers to make the same programmatic decisions; (2) the magnitude and direction of the difference between these two estimates, and (3) whether there is meaningful variation by region, age group or country.Methods We analysed and compared reported and surveyed treatment coverage data from 214 MDAs implemented between 2008 and 2017 in 15 countries in Africa, Asia and the Caribbean. …”
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