Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer by Zongming Dong, Xiaosa Chang, Xing Luo, Hui Li, Ming Deng, Zeyu Huang, Tingting Chen, Yu Chen, Bishao Sun, Yingbing Wu, Ronghua Wu, Qingjian Wu, Jingzhen Zhu, Ji Zheng

“…However, its effects and mechanisms of action in the context of PCa remain unclear. Our study aims to examine the therapeutic role and mechanisms of action of CH in PCa. …”
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New Minimally Invasive Method for Treating Posterior Pelvic Ring Fractures: Biomechanical Validation and Clinical Application of Sacroiliac Joint Locking Plate by Liang Jin, Xiaorui Hao, Zhenzhu Zhang, Qiaoli Zhang, Shuxin Zhang, Fei Zhou, Shuirong Yang, Weijie Zheng, Xiaohui Xiong, Wanchen Gong, Yukun Wang, Xiaojie Chen, Jiexin Huang

“…Methods Biomechanical research was conducted using standard pelvic bone models from Synbone, Switzerland, to create Denis II zone unstable posterior pelvic ring fracture models, and to assess the stability of the SJP under different loads compared with traditional fixation methods. …”
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Newly diagnosed atrial fibrillation detected by noninvasive screening methods in clinical practice by Luis Aguinaga, MD, MBA, PhD, RMFAC, FACC, FESC, Walter Bernal, MD, Alejandro Bravo, MD, Raúl Weiss, MD, Leonardo Pilon, MD, Gabriela Reyes, MD, Domingo Pozzer, MD, Alejandro Polti, MD, Daniel Ortigoza, MD, Verónica Tapia, MD, Paola Naput, MD, Sofía Guardiet, MD, Sergio Blanco, MD, Carlos Labadet, MD, Enrique Retyk, MD, Roberto Keegan, MD

“…Background: Patient characteristics and outcomes of newly diagnosed atrial fibrillation (AF) have been investigated in large registries. Objective: The study aimed to address the role of non-invasive screening tools in diagnosing AF in the Argentinian clinical practice. …”
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Comparative Analysis of AI Models for Atypical Pigmented Facial Lesion Diagnosis by Alessandra Cartocci, Alessio Luschi, Linda Tognetti, Elisa Cinotti, Francesca Farnetani, Aimilios Lallas, John Paoli, Caterina Longo, Elvira Moscarella, Danica Tiodorovic, Ignazio Stanganelli, Mariano Suppa, Emi Dika, Iris Zalaudek, Maria Antonietta Pizzichetta, Jean Luc Perrot, Gabriele Cevenini, Ernesto Iadanza, Giovanni Rubegni, Harald Kittler, Philipp Tschandl, Pietro Rubegni

“…AI, however, holds the potential to enhance diagnostic accuracy and provide reliable support to clinicians. This work aimed to evaluate and compare the effectiveness of machine learning (logistic regression of lesion features and patient metadata) and deep learning (CNN analysis of images) models in dermoscopy diagnosis and the management of aPFLs. …”
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Machine Learning Models Derived from [¹⁸F]FDG PET/CT for the Prediction of Recurrence in Patients with Thymomas by Angelo Castello, Luigi Manco, Margherita Cattaneo, Riccardo Orlandi, Lorenzo Rosso, Giorgio Alberto Croci, Luigia Florimonte, Giovanni Scribano, Alessandro Turra, Stefano Ferrero, Mario Nosotti, Gianpaolo Carrafiello, Massimo Castellani, Paolo Mendogni

“…<b>Background/Objectives:</b> This study aimed to develop machine learning (ML) models to predict recurrence in thymoma patients using conventional and radiomic signatures extracted from preoperative [¹⁸F]FDG PET/CT. …”
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Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study by Wen-Fang Zhong, Xiao-Meng Wang, Huan Chen, Wei-Qi Song, Jian Gao, Pei-Liang Chen, Qiao-Qiao Shen, Fang-Fei You, Chuan Li, Yue-Bin Lv, Zhi-Hao Li, Xiao-Ming Shi, Chen Mao

“…Abstract Background This study aims to evaluate the combination effects of physical activity (PA), cognitive activity (CA), and dietary patterns impacts cognitive impairment among older adults, and whether these associations differ by apolipoprotein E (APOE) genotype. …”
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Long-Term Hepatic and Extrahepatic Outcomes of Chronic Hepatitis C Patients After Sofosbuvir-Based Treatment (LONGHEAD Study) by Chung-Feng Huang, Jeong Heo, Rong-Nan Chien, Yang-Hyun Baek, Jia-Horng Kao, Ju-Hyun Kim, Ting-Tsung Chang, Kwan-Soo Byun, Jyh-Jou Chen, Sook-Hyang Jeong, Tsung-Hui Hu, Young-Seok Kim, Cheng-Yuan Peng, Won-Young Tak, Horng-Yuan Wang, Seung-Kew Yoon, I.-Shyan Sheen, Youn-Jae Lee, Yu-Chun Hsu, Hyung-Joon Yim, Pei-Chien Tsai, Ming-Lun Yeh, Sang-Hoon Ahn, Chia-Yen Dai, Seung-Woon Paik, Jee-Fu Huang, Yoon-Jun Kim, Wan-Long Chuang, Young-Suk Lim, Ming-Lung Yu

“…Abstract Background/Aims Direct-acting antivirals (DAAs) are highly effective in treating hepatitis C virus (HCV) infection. …”
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COMPARATIVE ANALYSIS OF QUALITY OF LIFE AFTER THORACIC ENDOVASCULAR AORTIC REPAIR AND OPTIMAL MEDICAL THERAPY IN PATIENTS WITH UNCOMPLICATED TYPE B AORTIC DISSECTION by Anna Yu. Shkandala, Oleh V. Zelenchuk, Serhii M. Furkalo, Borys M. Todurov, Andrii V. Khokhlov, Nataliia O. Yashchenko, Serhii M. Sudakevych

“…The value of the mental component according to the SF-36 questionnaire at the 3rd year of observation was not significantly different between the study groups (47.0 (39.5; 55.5) points vs. 38 (30.0; 41.0), p=0.093). …”
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Assessment of SMOS Root Zone Soil Moisture: A Comparative Study Using SMAP, ERA5, and GLDAS by Nitu Ojha, Ali Mahmoodi, Arnaud Mialon, Philippe Richaume, Sylvain Ferrant, Yann H. Kerr

“…The results between SMOS RZSM and in-situ SM show an average correlation coefficient between 0.54 and 0.8 with an average unbiased root mean square difference (ubRMSD) within the threshold of 0.04 m3/m3. …”
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Supplementation of Yupingfeng polysaccharides in low fishmeal diets enhances intestinal health through influencing the intestinal barrier, immunity, and microflora in Macrobrachium... by Mingyang Liu, Mingyang Liu, Cunxin Sun, Cunxin Sun, Qunlan Zhou, Qunlan Zhou, Pao Xu, Pao Xu, Aimin Wang, Xiaochuan Zheng, Xiaochuan Zheng, Bo Liu, Bo Liu

“…IntroductionThis study aimed to investigate the effects of a low-fishmeal diet (LF, substituting soybean meal for 40% fish meal) and the supplementation of 500 mg/kg and 1000 mg/kg Yu Ping Feng (YPF) polysaccharides on the growth performance, antioxidant enzyme activities, intestinal ultrastructure, non-specific immunity, and microbiota of Macrobrachium rosenbergii.MethodsThe study involved the administration of different diets to M. rosenbergii, including a control diet, a low-fishmeal diet (LF), and LF diets supplemented with 500 mg/kg and 1000 mg/kg YPF polysaccharides. …”
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The effect of renal function on the clinical outcomes and management of patients hospitalized with hyperglycemic crises by Sumaya N. Almohareb, Sumaya N. Almohareb, Sumaya N. Almohareb, Norah Aljammaz, Nada Yousif, Mayar Sunbul, Raghad Alsemary, Lama Alkhathran, Mohammed Aldhaeefi, Omar A. Almohammed, Abdulrahman I. Alshaya, Abdulrahman I. Alshaya, Abdulrahman I. Alshaya

“…The primary outcome was to determine the difference in time to close the AG between the two groups. …”
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Combined modulatory effects of dietary arginine and olive leaf phenolic extract on growth performance and immune functions of broiler chickens, and meat antioxidant potential durin... by Ahmed Alfifi, Marwa I. Abd El-Hamid, Sherief M. Abdel-Raheem, H. S. Al-Khalaifah, Wessam Youssef, Samah S. Khalil, Afaf Al-Nasser, Eman Elkhawaga, Eman Mahmoud Elmehrath, Arwa H. Nassar, Gamilat A. Elsaid, Amal S. A. El Oksh, Doaa Ibrahim

“…Methods Broilers (n = 250) were randomly assigned into control (without supplementations) and four groups fed control diets plus 1.5 g/kg arginine alone (G) or with three different levels of OLE; 0.25%, 0.5% and 1% (G + OLEǀ, G + OLEǀǀǀ and G + OLEǀǀǀ, respectively). …”
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The first generic tirzepatide GP30931: physicochemical and biological similarity to the reference drug by I. A. Lugovik, A. V. Babina, S. S. Arutyunyan, D. О. Ermolaeva, V. B. Saparova, T. N. Kobeleva, P. G. Zaikin, A. D. Mikushina, A. S. Bukatin, I. E. Eliseev, B. Ts. Zajchik, Y. S. Keruchenko, I. S. Ohrimenko, E. V. Bocharov, A. Kh. Taldaev, V. A. Lushpa, I. E. Makarenko, R. V. Drai

“…The content of all types of impurities in GP30931 did not exceed the Munjaro values. The difference in EC50 values for activation of GLP-1 and GIP receptors was ≤5 %, the comparative biological activity was within 0.80–1.25.Conclusion. …”
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Linking biogenic high-temperature ice nucleating particles in Arctic soils and streams to their microbial producers by L. Z. Jensen, L. Z. Jensen, L. Z. Jensen, J. K. Simonsen, J. K. Simonsen, A. Pastor, A. Pastor, C. Pearce, C. Pearce, C. Pearce, P. Nørnberg, P. Nørnberg, L. C. Lund-Hansen, L. C. Lund-Hansen, K. Finster, K. Finster, K. Finster, K. Finster, T. Šantl-Temkiv, T. Šantl-Temkiv, T. Šantl-Temkiv, T. Šantl-Temkiv

“…In addition, the transfer of bioINPs from soils into freshwater and marine systems has not been quantified. This study aimed to address these open questions by analyzing soil and freshwater samples from northeast Greenland to determine the microbial composition along with the INP concentrations and size distributions. …”
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Ferroptosis-related protein biomarkers for diagnosis, differential diagnosis, and short-term mortality in patients with sepsis in the intensive care unit by Zhangrui Zeng, Zhangrui Zeng, Zhangrui Zeng, Jie Deng, Jie Deng, Jie Deng, Gang Wang, Gang Wang, Zixiang Luo, Zixiang Luo, Zixiang Luo, Weijia Xiao, Weijia Xiao, Weijia Xiao, Wenchao Xie, Wenchao Xie, Wenchao Xie, Jinbo Liu, Jinbo Liu, Jinbo Liu, Ke Li, Ke Li

“…Diagnostic efficacy was evaluated using ROC curve analysis.ResultsBaseline serum levels of ACSL4, GPX4, PTGS2, CL-11, IL-6, IL-8, PCT, and hs-CRP significantly differed among sepsis, non-septic, and healthy individuals (all p-value &lt; 0.01). …”
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Cocreating the Visualization of Digital Mobility Outcomes: Delphi-Type Process With Patients by Jack Lumsdon, Cameron Wilson, Lisa Alcock, Clemens Becker, Francesco Benvenuti, Tecla Bonci, Koen van den Brande, Gavin Brittain, Philip Brown, Ellen Buckley, Marco Caruso, Brian Caulfield, Andrea Cereatti, Laura Delgado-Ortiz, Silvia Del Din, Jordi Evers, Judith Garcia-Aymerich, Heiko Gaßner, Tova Gur Arieh, Clint Hansen, Jeffrey M Hausdorff, Hugo Hiden, Emily Hume, Cameron Kirk, Walter Maetzler, Dimitrios Megaritis, Lynn Rochester, Kirsty Scott, Basil Sharrack, Norman Sutton, Beatrix Vereijken, Ioannis Vogiatzis, Alison Yarnall, Alison Keogh, Alma Cantu

“…Mobilise-D has validated digital mobility outcomes to provide novel outcomes and end points in clinical research of 4 different long-term health conditions (Parkinson disease, multiple sclerosis, chronic obstructive pulmonary disease, and proximal femoral fracture). …”
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Ultrasound and genetic findings in a case series of fetuses presenting vertebral defects by Wanqin Xie, Lin Zhou, Ai Hu, Jing Chen, Jialun Pang, Hui Xi, Yingchun Luo, Jiancheng Hu, Shuting Yang, Xiaoyang Gao, Hanzhe Kuang, Wanglan Tang, Rui Liu, Silong Wang, Ying Peng

“…Abstract Purpose This study aimed to summarize the ultrasound and genetic features in a case series of fetuses presenting vertebral defects, to provide useful information for prenatal counseling and prognostic evaluation. …”
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Unravelling the Neuroprotective Effects of a Novel Formulation Based on Plant Extracts, Mg, and Vitamin B6 by Simonetta Cristina Di Simone, Alessandra Acquaviva, Maria Loreta Libero, Nilofar Nilofar, Fatma Tunali, Paola Angelini, Giancarlo Angeles Flores, Gaia Cusumano, Lucia Recinella, Sheila Leone, Giustino Orlando, Gokhan Zengin, Luigi Menghini, Claudio Ferrante, Annalisa Chiavaroli

“…The aim of the present study was to investigate the phenolic composition and the efficacy of an innovative formulation based on Mg, Vitamin B6, and water extracts from <i>Vitex agnus-castus</i>, <i>Crocus sativus</i>, <i>Melissa officinalis</i>, <i>Betula pendula</i>, and <i>Betula pubescens</i> developed as an effective tool to face neuroinflammation and depression symptoms occurring in premenstrual syndrome (PMS). …”
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Associations between parental perceptions of neighbourhood environments and active travel to school: IPEN Adolescent study by Anna Timperio, Scott Duncan, Muhammad Akram, Javier Molina-García, Delfien Van Dyck, Anthony Barnett, Ferdinand Salonna, Anjana RM, James F. Sallis, Michal Vorlíček, Erica Hinckson, Kelli L. Cain, Terry L. Conway, Wan Abdul Manan Wan Muda, Mika Moran, Adewale L. Oyeyemi, Andreia Pizarro, Rodrigo S. Reis, Sheikh Muhammad Rezwan, Jasper Schipperijn, Ester Cerin

“…Abstract Background Studies of correlates of active transport to and from school (ATS) focus mainly on children, have a limited conceptualisation of ATS trips, lack heterogeneity in built environments, and rarely consider effect modifiers. This study aimed to estimate associations of parent-perceived neighbourhood environment characteristics with self-reported ATS among adolescents from 14 countries, and whether associations differ by sex, city/region, and distance to school. …”
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Changes in social contact patterns in Germany during the SARS-CoV-2 pandemic – an analysis based on the COVIMOD study by Huynh Thi Phuong, Antonia Bartz, Andrzej K. Jarynowski, Berit Lange, Christopher I. Jarvis, Nicole Rübsamen, Rafael T. Mikolajczyk, Stefan Scholz, Tom Berger, Torben Heinsohn, Vitaly Belik, André Karch, Veronika K. Jaeger

“…Associations between demographics and other factors, e.g. perceived pandemic threat level, might help explain variations in social contact behaviours. We aimed to estimate contact numbers during the pandemic in Germany and assess factors associated with changes therein. …”
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