The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm by Zhiran Wang, Dmitrii Lebedev, Simeng Li, Sudharshan Rao, Kevin Wu, Lorcan Doyle, Kieran Wynne, Alfonso Blanco, Margaritha M. Mysior, Jeremy C. Simpson, Dimitri Scholz, Petra Wülfroth, Kai Zacharowski, Walter Kolch, Vadim Zhernovkov, Günther Eissner

“…FX06, a fibrin-derived peptide naturally occurring in the human body, formerly known as Bβ15-42, is a promising therapeutic candidate for endothelial complications like capillary leakage in COVID-19 and other forms of acute respiratory disorders. The aim of this project is to investigate whether FX06 can attenuate COVID-19 cytokine-triggered inflammatory processes in vitro.MethodsTo mimic the inflammatory status of COVID-19, a human pulmonary microvascular endothelial cell line (ECs) – HULEC-5a, was treated with a cytokine cocktail comprised of ten different cytokines or chemokines at concentrations found in serum profiles of COVID-19 patients with severe illness, further referred to as the severe cytokine cocktail. …”
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Associations of HLA-G 3’UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis by Ines Zemni, Daria Bortolotti, Sabrine Dhouioui, Sana Baroudi, Malek Ferjani, Inès Nasri, Yosr Zenzri, Md Ataur Rahman, Abdel Halim Harrath, Roberta Rizzo, Nadia Boujelbene, Inès Zidi

“…Results: The Del/Del genotype and Del allele frequencies were different between GC patients and healthy donors (HD) (OR [95 % CI] = 2.483 [1.070–5.410], p = 0.025 vs. …”
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Radiation dose escalation in locally advanced oesophageal cancer: a systematic review and hierarchical Bayesian meta-analysisResearch in context by Yang-Hong Dai, Po-Huang Chen, Yi-Jhih Huang, Ding-Jie Lee, Po-Chien Shen, Cheng-Hsiang Lo, Yu-Guang Chen, Yu-Fu Su, Jen-Fu Yang, Ying-Fu Wang, Wen-Yen Huang, Chun-Shu Lin, Chih-Cheng Tsao, Katherine A. Vallis

“…High-dose radiotherapy significantly improved LRPFS, with the largest benefit observed at 1-year (median difference: 18.6%; 95% credible interval [CrI]: 10.7–26.1%). …”
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Prognostic value of primary gross tumor volume and standardized uptake value of F-FDG in PET/CT for distant metastasis in locoregionally advanced nasopharyngeal carcinoma by Ya-Nan Jin, Ji-Jin Yao, Si-Yang Wang, Wang-Jian Zhang, Guan-Qun Zhou, Fan Zhang, Zhi-Bin Cheng, Jun Ma, Hao-Yuan Mo, Ying Sun

“…Effort should therefore be made to stratify locoregionally advanced nasopharyngeal carcinoma patients into different groups based on the risk of metastasis to improve prognosis and tailor individualized treatments. …”
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The global burden of disease attributable to suboptimal fruit and vegetable intake, 1990–2021: a systematic analysis of the global burden of disease study by Xiang Xu, Pengguang Yan, Wenjin Chen, Wei Wei, Blake Thomson, Shuaizhi Ruan, Zhong Cao, Chengzhu Ou, Pascal Geldsetzer, Taotao Han, Jing Wang, Simiao Chen, Jingnan Li

“…Abstract Background Suboptimal fruit and vegetable intake remains a significant global public health concern. This study aimed to estimate the global intake and the disease burden attributable to suboptimal fruit and vegetable intake. …”
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Identification of Metabolites of Ferulic Acid in Human after Oral Administration by Qian PAN, Wei LI, Yang YANG, Yong-qiang ZHAO, Li LIAN, Qing-qing CONG, Li-hong WANG, Yue-lin SONG, Qian HONG

“…Therefore, this study aims at identifying the metabolites of FA after oral administration and speculating on possible metabolic pathways. …”
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Detection of tick-borne pathogens in blood-fed ticks from animals across nine Asian countries by Hye-Ryung Byun, Mi-Sun Rieu, Seong-Ryeong Ji, Hyun-Young Nam, Seulgi Seo, Chang-Yong Choi, Bui Khanh Linh, Hien Le Thanh, Morakot Kaewthamasorn, Ana Sahara, Remil L. Galay, Shang-Lin Wang, Tuvshinjargal Erdenechimeg, Nyambayar Batbayar, Shin Matsui, Noritomo Kawaji, Muhammad Avais, Joon-Seok Chae

“…Ticks (n = 261) were collected from different animals across nine Asian countries between 2022 and 2023. …”
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Early menopause is associated with higher disease activity independent of inflammation in postmenopausal-onset rheumatoid arthritis by Zhi-Ming Ouyang, Yao-Wei Zou, Ye Lu, Jie Pan, Tao Wu, Pei-Wen Jia, Hu-Wei Zheng, Yun Su, Le-Feng Chen, Jian-Zi Lin, Kui-Min Yang, Pei-Yu Lin, Jin-Yuan Han, Jian-Da Ma, Lie Dai

“…Abstract Objective Early menopause (EM, age ≤ 45 years) is associated with an increased risk of developing rheumatoid arthritis (RA). We aimed to investigate its impact on disease characteristics in RA patients. …”
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Strategies for sustainable behavior and emission reduction through individual carbon footprint analysis by A. Haryanto, A.D. Santoso, M. Hanif, I.M. Ihsan, R. Oktivia, J. Prayitno, A.C. Tridakusumah, V. Pebriyanti, S. Triyono, H. Daulay, N. Irawati, M.I. Mawardi, S. Sundari, L.P. Panggabean, C. Indrawanto

“…Behavioral interventions, institutional policies promoting sustainable practices, and comparative studies across different sectors are recommended for future research. …”
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Evaluating the accuracy of generative artificial intelligence models in dental age estimation based on the Demirjian's method by Allan Abuabara, Thais Vilalba Paniagua Machado do Nascimento, Seandra Maria Trentini, Angela Mairane Costa Gonçalves, Maria Angélica Hueb de Menezes-Oliveira, Isabela Ribeiro Madalena, Svenja Beisel-Memmert, Christian Kirschneck, Livia Azeredo Alves Antunes, Cristiano Miranda de Araujo, Flares Baratto-Filho, Flares Baratto-Filho, Erika Calvano Küchler

“…Due to the probabilistic nature of ChatGPT, Gemini, and DeepSeek, which can produce varying responses to the same question, three responses were collected per case per day (three different computers) from each model on three separate days. …”
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Reciprocal impact of mental health and quality of life in children and adolescents—a cross-lagged panel analysis by Markus A. Wirtz, Janine Devine, Michael Erhart, Michael Erhart, Franziska Reiß, Maren Böcker, Maren Böcker, Maren Böcker, Anja A. Schulz, Fionna Zöllner, Ann-Kathrin Napp, Ulrike Ravens-Sieberer, Anne Kaman

“…Cross-lagged-panel models, which offer higher internal validity than traditional cross-sectional and longitudinal analyses, were estimated using structural equation modeling (maximum likelihood).ResultsDifferent prediction models proved to be valid for children vs. adolescents (Δχ2df = 48 = 167.84, p < 0.001). …”
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Microbiota profiling from biopsied tissues in complex infections: a diagnostic and prognostic analysis through metagenomic next-generation sequencing by Tiange Song, Tiange Song, Tiange Song, Lin Yin, Lin Yin, Lin Yin, Xiaoli Zhou, Xiaoli Zhou, Xiaoli Zhou, Xiaoyan Tao, Xiaoyan Tao, Xiaoyan Tao, Dandan Tie, Dandan Tie, Dandan Tie, Jie Zhang, Jie Zhang, Jie Zhang, Li Jiang, Li Jiang, Li Jiang

“…In skeletal articular biopsied tissues, Staphylococcus presented the highest mean abundance among different species of bacteria (21.2% of all bacterial reads, standard deviation (SD) 38.9). …”
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An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis by Xiaolu Yang, Xiaolu Yang, Yilun Li, Yilun Li, Yaqi Peng, Yuan Chang, Binglu He, Binglu He, Tianqi Zhang, Tianqi Zhang, Shiyu Zhang, Cuizhi Geng, Yunjiang Liu, Xiaolong Li, Jun Hao, Li Ma

“…ObjectiveOur previous study found that Achaete-scute complex homolog 1 (ASCL1) is involved in classifying BC subtypes with different prognostic and pathological characteristics. …”
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Higher monomeric C-reactive protein levels are associated with premature coronary artery disease by Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Sergey Okhota, Sergey Okhota, Olga Saburova, Yuliya Avtaeva, Tatiana Kuznetsova, Konstantin Guria, Lyudmila Prokofieva, Tatiana Riazantseva, Tatiana Riazantseva, Shang-Rong Ji, Yi Wu, Zufar Gabbasov

“…Monomeric CRP (mCRP) is a locally produced form of CRP that has emerged as a potential biomarker of inflammation.AimThis study investigated whether mCRP levels are associated with premature CAD.Materials and methodsThis study comprised 103 participants of both sexes, including 50 patients 56 ± 7 years old with premature CAD and 53 patients 51 ± 10 years old without CAD. …”
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Predicting prognosis of sepsis in patients based on right ventricular strain imaging development and validation of a nomogram model by Qinxin Wang, Hongmin Chen, Bingyi Zhang, Chang Zhou, Boyuan Xing, Chang Li, Shijin Xu, Yun Liu

“…PASP and RV-GS/PASP ratio significantly differed between the two groups (p < 0.05). Multivariable logistic regression analysis identified age >67 years, SOFA score ≥7.5, procalcitonin ≥5.7 ng/ml, lactate ≥3.5 mmol/L, RV-FWS ≥−19.4%, and RV-GS/PASP ≥−0.55 as independent risk factors for poor sepsis outcomes. …”
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Device‐Measured Physical Activity, Sedentary Behaviour and Risk of Chronic Kidney Diseases Across Levels of Grip Strength by Yu He, Jing Wang, Weijie Zhang, Xinru Chen, Qiqi Wu, Yuxuan Li, Yiliang Ou, Yaping Liu, Hongliang Feng, Jihui Zhang, Sizhi Ai, Yannis Yan Liang, Yuping Ning, Jun Zhang

“…ABSTRACT Background The study aimed to investigate whether the associations of accelerometer‐measured physical activity (PA) and sedentary behaviour (SB) with incident chronic kidney disease (CKD) vary based on different levels of hand grip strength, identifying the modifying role of grip strength in these associations. …”
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The effect of acupuncture combined with hyperbaric oxygenation compared with hyperbaric oxygenation alone for patients with traumatic brain injury: a systematic review and meta-ana... by Geng Li, Binyang Wang, Shuochen Fan, Shuangli Liu, Lu Shao, Chuanxiong Li, Yongjiang Fang, Jianfeng Li, Meihua Qiu, Yuping Zhang, Lei Pan, Lei Pan

“…ObjectiveThis study aimed to evaluate the effects of acupuncture combined with hyperbaric oxygenation (HBO) compared with HBO alone in improving the disturbance of consciousness (DOC) of people with traumatic brain injury (TBI).MethodsThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in this study. …”
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Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and... by Sid Solaković, Nina Solaković, Anes Jogunčić, Hajrudin Spahović, Fedja Hajrulahović, Mensur Vrcić, Emir Solaković, Amina Godinjak, Iryna Skrypchenko, Olena Dorofieieva, Kseniia Yarymbash

“…In the total population, no difference was observed in changes of constraint-induced movement therapy between the standard exercise group and the control one after 4 years from baseline. …”
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Spatiotemporal variations in water quality parameters and assessment of the current status and challenges of eutrophication in Lake Dian by Huayu Li, Hucai Zhang, Lizeng Duan, Qi Liu, Donglin Li, Jiaping Huang, Jiawen Fu, Lihua Zi, Tianbao Xu

“…Understanding the spatiotemporal distribution and evolutionary patterns of lake water quality parameters is essential for formulating precise ecological management strategies. This study aimed to investigate the high-resolution spatial and temporal variations in water quality parameters across different regions of Lake Dian (including Caohai and Waihai) and its major inflowing rivers, as well as to objectively assess its pollution status and future trends. …”
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Hand Grip Strength Cut‐Off Points as a Discriminator of Sarcopenia and Sarcopenic Obesity: Results from the ELSA‐Brasil Cohort by Clarice Alves Santos, Helena Fraga Maia, Francisco José Gondim Pitanga, Maria da Conceição Chagas deAlmeida, Maria de Jesus Mendes daFonseca, Estela Mota Leão deAquino, Letícia de Oliveira Cardoso, Rosane Harter Griep, Sandhi Maria Barreto, Claudia Kimie Suemoto, Paulo Lotufo, Isabela Bensenor, Sheila Maria Alvim deMatos

“…However, no study evaluated the performance capacity of HGS compared to other biomarkers in discriminating these conditions in adults. Objective The study aimed to evaluate the performance of HGS as discriminator of sarcopenia and sarcopenic obesity, compared to urinary biomarkers of creatinine and potassium in 24 h for Brazilian adults. …”
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