Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages by Antonio Sica, Marta Di Martile, Valentina Farini, Francesca Maria Consonni, Daniela Trisciuoglio, Marianna Desideri, Elisabetta Valentini, Simona D'Aguanno, Maria Grazia Tupone, Simonetta Buglioni, Cristiana Ercolani, Enzo Gallo, Bruno Amadio, Irene Terrenato, Maria Laura Foddai, Donatella Del Bufalo

“…Our previous studies have demonstrated that bcl-2 affects melanoma progression and regulates the tumor microenvironment. The aim of this study was to evaluate whether bcl-2 expression in melanoma cells could influence tumor-promoting functions of tumor-associated macrophages, a major constituent of the tumor microenvironment that affects anticancer immunity favoring tumor progression.Methods THP-1 monocytic cells, monocyte-derived macrophages and melanoma cells expressing different levels of bcl-2 protein were used. …”
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Relative age effect on the physical activity and sedentary behavior in children and adolescents aged 10 to 18 years old: a cross-sectional study in Japan by Takaaki Mori, Takumi Aoki, Kan Oishi, Tetsuo Harada, Chiaki Tanaka, Shigeho Tanaka, Hideki Tanaka, Kazuhiko Fukuda, Yasuko Kamikawa, Nobuhiro Tsuji, Keisuke Komura, Shohei Kokudo, Noriteru Morita, Kazuhiro Suzuki, Masashi Watanabe, Ryoji Kasanami, Taketaka Hara, Ryo Miyazaki, Takafumi Abe, Koji Yamatsu, Daisuke Kume, Hedenori Asai, Naofumi Yamamoto, Taishi Tsuji, Tomoki Nakaya, Kojiro Ishii

“…Moreover, the relative age effect on sedentary behavior might show an opposite association with physical activity. Therefore, we aimed to clarify the relative age effects on physical activity and sedentary behavior across different school stages in Japanese children and adolescents. …”
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A highly scalable deep learning language model for common risks prediction among psychiatric inpatients by Enzhao Zhu, Jiayi Wang, Guoquan Zhou, Chunbo Li, Fazhan Chen, Kang Ju, Liangliang Chen, Yichao Yin, Yi Chen, Yanping Zhang, Xu Zhang, Xinlin Zhou, Zongyuan Wang, Jianping Qiu, Hui Wang, Weizhong Shi, Feng Wang, Dong Wang, Zhihao Chen, Jiaojiao Hou, Hui Li, Zisheng Ai

“…Analysis was carried out between August 2024 and June 2024. Models with different architectures and input settings were compared with each other. …”
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Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T by Kexin Wang, Licheng Ju, Guanda Qiao, Yajie Liang, Yihan Wu, Chengyan Chu, Joshua Rogers, Yuguo Li, Suyi Cao, Valina L. Dawson, Ted M Dawson, Piotr Walczak, Jiadi Xu

“…Both pMCAO and tMCAO models were utilized to examine the B1-dependence patterns and pH sensitivity of the different CEST contrasts in ischemic lesions compared to contralateral region. …”
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China's annual forest age dataset at a 30 m spatial resolution from 1986 to 2022 by R. Shang, R. Shang, X. Lin, J. M. Chen, J. M. Chen, Y. Liang, K. Fang, M. Xu, Y. Yan, W. Ju, G. Yu, N. He, L. Xu, L. Liu, J. Li, W. Li, J. Zhai, Z. Hu

“…For undisturbed forests, forest age was estimated using machine learning models trained separately for different regions and forest cover types, with inputs including forest height, vegetation indices, climate, terrain, and soil data. …”
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Educación Física en Casa de Calidad. Propuesta de aplicación curricular en Educación Secundaria Obligatoria (Quality Physical Education at Home. Curricular implementation proposal... by Rafael Burgueño, Alberto Bonet-Medina, Álvaro Cerván-Cantón, Rubén Espejo, Francisco Borja Fernández-Berguillo, Felipe Gordo-Ruiz, Hugo Linares-Martínez, Samuel Montenegro-Lozano, Natalia Ordoñez-Tejero, Juan José Vergara-Luque, Francisco Javier Gil-Espinosa

“…Therefore, this study aims at showing a didactic proposal that, based on Middle Secondary School Physical Education curriculum, promotes adolescents’ physical activity at home. …”
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Effects of various supplemental levels of multi-enzyme complex on amino acid profiles in egg yolk, antioxidant capacity, cecal microbial community and metabolites of laying hens by Qixin Huang, Rui Chen, Rui Chen, Wenzi Wu, Wenzi Wu, Jinghui Fan, Xin Ma, Zhou Chen, Zhou Chen, Wenxin Ye, Wenxin Ye, Lichun Qian

“…This study aimed to investigate the effects of multi-enzyme (alkaline protease, xylanase, glucanase, β-mannanase, cellulase, acid protease, glucoamylase, and α-galactosidase) on antioxidant capacity, egg quality, amino acid profiles in yolk, cecal microflora and metabolites in laying hens. …”
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Predictors and Outcomes of Excellent Recanalization Versus Successful Recanalization After Thrombectomy in Proximal and Distal Medium Vessel Occlusion Strokes: A Multinational Stud... by Vivek Yedavalli, Hamza Adel Salim, Basel Musmar, Nimer Adeeb, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Benjamin Y. Q. Tan, Jeremy J. Heit, Robert W. Regenhardt, Nicole M. Cancelliere, Joshua D. Bernstock, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Muhammed Amir Essibayi, Ajit S. Puri, Christian Dyzmann, Marco Colasurdo, Xavier Barreau, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Thomas R. Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E. Siegler, Thanh N. Nguyen, Ricardo Varela, Amanda Baker, David Altschul, Nestor R. Gonzalez, Markus A. Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Mohammad Ali Aziz‐Sultan, Constantin Hecker, Hamza Shaikh, David S. Liebeskind, Alessandro Pedicelli, Andrea M. Alexandre, Illario Tancredi, Tobias D. Faizy, Erwah Kalsoum, Boris Lubicz, Aman B. Patel, Vitor Mendes Pereira, Adrien Guenego, Adam A. Dmytriw

“…Background Acute ischemic stroke arising from medium vessel occlusions (MeVO) poses substantial challenges in treatment and management. This study aims to elucidate the outcomes and factors contributing to achieving excellent recanalization (modified Thrombolysis in Cerebral Infarction [mTICI] 2c–3) versus successful recanalization (mTICI 2b) in patients with MeVO stroke undergoing mechanical thrombectomy (MT). …”
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Model-guided development of pharmacokinetic/pharmacodynamic cut-offs and evaluation of sitafloxacin dosing regimens against target pathogens by Hailan Wu, Hailan Wu, Hailan Wu, Yi Li, Yi Li, Yi Li, Xin Li, Xin Li, Xin Li, Yaxin Fan, Yaxin Fan, Yaxin Fan, Beining Guo, Beining Guo, Beining Guo, Xiaofen Liu, Xiaofen Liu, Xiaofen Liu, Wanzhen Li, Wanzhen Li, Wanzhen Li, Mengting Chen, Mengting Chen, Mengting Chen, Yan Chen, Yan Chen, Yan Chen, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang

“…The probabilities of attainment (PTAs) and cumulative fraction of response (CFR) values for different sitafloxacin dosing regimens against Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were calculated via Monte Carlo simulation.ResultsPopPK modelling revealed that the PK profile of sitafloxacin was consistent with a two-compartment model with first-order elimination. …”
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Therapeutic effects of raw rhubarb on gastrointestinal complications in ischemic stroke: An integrated analysis of gut microbiota, metabolomics, and network pharmacology by Zhanhao Ye, Dongmin Cao, Wenxing Ao, Ting Li, Minghua Xian, Shumei Wang

“…However, its therapeutic mechanisms remain largely unknown. This study aims to investigate the therapeutic effects and potential mechanisms of RR on GITC in IS through an integrated analysis of gut microbiota, metabolomics, and network pharmacology. …”
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OP-5 ACUTE-ON-CHRONIC LIVER FAILURE (ACLF) CRITERIA IN ALCOHOL-ASSOCIATED HEPATITIS: IMPLICATIONS FOR LIVER TRANSPLANTATION by LUIS ANTONIO DÍAZ PIGA, Paula Huerta, Renata Farias, Bastian Alcayaga, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Katherine Maldonado, Juan Pablo Roblero, Daniela Simian, Blanca Norero, Raul Lazarte, José Antonio Velarde, Jacqueline Córdova, Fátima Higuera-de-la-Tijera, Alfredo Servin-Caamaño, Jesús Varela, Scherezada Mejía Loza, Rita Silva, Cristina Melo Rocha, Roberta C. Araujo, Gustavo Henrique Pereira, Claudia Alves Couto, Fernando Bessone, Mario Tanno, Gustavo Romero, Manuel Mendizabal, Sebastián Marciano, Gonzalo Gomez Perdiguero, Melisa Dirchwolf, Pedro Montes, Patricia Guerra Salazar, Geraldine Ramos, Susana Castro Sánchez, Juan Carlos Restrepo, Enrique Carrera, Mayur Brahmania, Ashwani K. Singal, Winston Dunn, Ramon Bataller, Vijay Shah, Patrick S. Kamath, Marco Arrese, Juan Pablo Arab

“…Conflict of interest: No Introduction and Objectives: Background: Severe alcohol-associated hepatitis (AH) is considered a common precipitant of acute-on-chronic liver failure (ACLF). This study aims to characterize the association between AH and ACLF, focusing on mortality across different ACLF grades. …”
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GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis by Teresa Rubio-Tomás, David Martí-Aguado, Delia Blaya, Silvia Ariño, Beatriz Aguilar-Bravo, Raquel A. Martínez García de la Torre, Marc Miravet-Marti, Raquel Ferrer-Lorente, Laura Zanatto, Zengqing Xu, Laura Garcia-Tercero, Carlos Mateos-Sánchez, Juan José Lozano, Isabella Dotti, Johanne Poisson, Marion Tanguy, Azucena Salas, Pierre-Emmanuel Rautou, Ramon Bataller, Pau Sancho-Bru

“…Background & Aims: Cellular senescence is characterized by the loss of proliferative capacity, cell cycle arrest, and the acquisition of a proinflammatory senescence-associated secretory phenotype (SASP). …”
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Associations of the triglyceride–glucose index and triglyceride–glucose/body mass index with all-cause mortality in Chinese centenarians by Shiju Yan, Wenjing Dong, Yue Niu, Lingyun Song, Ping Pang, Di Sun, Yue Zhang, Wei Wang, Hongyan Hu, Xinye Jin, Jie Zhang, Qing Luo, Ding Sun, Hao Li, Zehao Zhang, Zeyu Qu, Qiao Zhu, Yujian Chen, Chaoxue Ning, Shihui Fu, Shanshan Yang, Shengshu Wang, Yao He, Bin Wang, Yali Zhao, Guoqing Yang, Xiangmei Chen, Miao Liu, Yizhi Chen

“…Moreover, the concordance of the associations of the TyG index and TyG–BMI with all-cause mortality in different subgroups was further explored by subgroup analysis. …”
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Imaging diagnosis of cryptogenic multifocal ulcerous stenosing enteritis by Xiaoyan Zhang, Li Ma, Mengsu Xiao, Jing Qin, Mengyuan Zhou, Hong Yang, Wei Liu, Lin Cong, Weixun Zhou, Gechong Ruan, Jingjuan Liu, Guannan Zhang, Wenbo Li, Qingli Zhu

“…Abstract Objective This study aimed to summarize the intestinal ultrasound (IUS) and computed tomography enterography (CTE) features of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) and compare the performance of IUS and CTE in the evaluation of CMUSE in a single tertiary center. …”
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Effects of Dietary β-Carotene on the Gonadal Color, Pigmentation, and Regulation Mechanisms in Sea Urchin Strongylocentrotus Intermedius by Weixiao Di, Yinuo Zhang, Huinan Zuo, Haijing Liu, Lina Wang, Jun Ding, Yaqing Chang, Rantao Zuo

“…Adult sea urchins (initial weight: 9.33 ± 0.21 g) of three cages were given one of the dry feeds with different doses of β-carotene (0 mg/kg, 150 mg/kg, 300 mg/kg) or fresh kelp (<i>Saccharina japonica</i>). …”
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Use of ChatGPT in HIV Infection Counselling and Literacy by José Ganicho, Maria Carlos, Gonçalo Cristóvão, Claudina Cruz, Marta Leal, Ana Raquel Garrote, Diogo Bento, Diana Seixas, Maria José Manata, Fernando Maltez

“…(4.58), “What are the different regimens of pre-exposure prophylaxis?” (4.63), “After I start taking pre-exposure prophylaxis, do I have to take it forever?” …”
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Efficacy and safety of everolimus for patients with focal cortical dysplasia type 2 by Se Hee Kim, Hoon‐Chul Kang, Yun Ho Roh, Jongsung Hahn, Kyung Lok Min, Seok‐Jin Lee, Donghwa Yang, Han Som Choi, Soyoung Park, Jeong Ho Lee, Sang‐Guk Lee, Se Hoon Kim, Min Jung Chang, Heung Dong Kim

“…Abstract Objective This study aimed to evaluate the effectiveness and safety of everolimus in treating seizures associated with focal cortical dysplasia type 2 (FCD 2). …”
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Predicting Surgical Site Infections in Spine Surgery: Association of Postoperative Lymphocyte Reduction by Akiyoshi Miyamoto, Masato Tanaka, Angel Oscar Paz Flores, Dongwoo Yu, Mukul Jain, Christan Heng, Tadashi Komatsubara, Shinya Arataki, Yoshiaki Oda, Kensuke Shinohara, Koji Uotani

“…However, there is still controversy concerning which serological markers can predict spinal SSI. This study aims to evaluate excellent and early indicators for detecting SSI, focusing on spine instrumented surgery. …”
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SIGNIFICANCE OF ETV6-RUNX1 FUSION GENE TRANSCRIPT DETECTION IN PEDIATRIC B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA WITH TRANSLOCATION t(12;21)(p13;q22) by G. A. Tsaur, Т. О. Riger, A. M. Popov, T. Yu. Verzhbitskaya, L. V. Vakhonina, A. A. Vlasova, Yu. V. Olshanskaya, А. N. Kazakova, O. V. Streneva, O. V. Makarova, S. V. Tsvirenko, L. I. Saveliev, О. R. Arakaev, L. G. Fechina

“…While ETV6-RUNX1 status at day 15 did not allow to divide patients with different outcomes. By ROC curve analysis we determined threshold levels (TL) for ETV6-RUNX1/ABL1 ratio at days 0, 15, 36 and 85. …”
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Typology of out-of-home eaters: a description of sociodemographic, lifestyle, nutritional and environmental characteristics in the NutriNet-Santé cohort by Emma Meyer, Benjamin Allès, Justine Berlivet, Sandrine Péneau, Alice Bellicha, Mathilde Touvier, Brigitte Langevin, Philippe Pointereau, Denis Lairon, Serge Hercberg, Emmanuelle Kesse-Guyot, Julia Baudry

“…This study contributes to the understanding of different OOH consumer characteristics and could provide a basis for further research in the field. …”
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