Complement system is activated in acute inflammatory response to environmental particulates in the lungs by Kerui Zhang, Akiko Honda, Tomoya Sagawa, Natsuko Miyasaka, Binyang Qiu, Raga Ishikawa, Tomoaki Okuda, Takayuki Kameda, Kaori Sadakane, Takamichi Ichinose, Hirohisa Takano

“…However, the relationship between PM-induced complement system activation, acute inflammation, and the contributing factors remains unclear. In this study, we aimed to investigate the intensity of acute inflammatory responses, as well as the activation levels of complement C5 and its related products, C5aR1 and C5b-9, following exposure to different types of PM. …”
Get full text

Stray Dogs as Reservoirs and Sources of Infectious and Parasitic Diseases in the Environment of the City of Uralsk in Western Kazakhstan by Askar Nametov, Rashid Karmaliyev, Bekzhassar Sidikhov, Kenzhebek Murzabayev, Kanat Orynkhanov, Bakytkanym Kadraliyeva, Balaussa Yertleuova, Dosmukan Gabdullin, Zulkyya Abilova, Laura Dushayeva

“…In 2024, 1213 stray dogs were captured from different city districts and examined at the veterinary clinic and laboratory of Zhangir Khan University. …”
Get full text

Conservative treatments for women with stress urinary incontinence: a systematic review and network meta-analysis by Mengzhen Li, Mengzhen Li, Kexin Qiu, Kexin Qiu, Haoran Guo, Haoran Guo, Mengsi Fan, Mengsi Fan, Li Yan, Li Yan

“…ObjectiveThis study aimed to compare the effectiveness of various conservative treatment strategies for women with stress urinary incontinence.MethodsA comprehensive search of PubMed, Web of Science, Embase, and the Cochrane Library was conducted from their inception through March 2024, without restrictions on language or location. …”
Get full text

Investigating the knowledge attitude and practice of evidence based medicine education in Sudanese medical students: a cross sectional study by Mohammed Hammad Jaber Amin, Mohammed Haydar Awad, Elmontasirbillah Salah Mohamed Ginawi, Amjed Siddig Khalid Mohammed, Eltayep Hasab Elrasoul Noureldaiem Ibrahim, Ola Yaser Mohammed Yassen, Leina Elfatih Salah Mohamed Ali Elomeiri, Aseel Hisham Mohamed Abdelhalim Hakim Hussain, Tasneem Abdelrahman Eltahir, Fatima Saif Alyazal Ahmed Mohmmed, Rayan Abdalla Elawad Wedatalla, Khaild Hayder Awad, Rayan Kamal eldin Mahgoub, Abdalazez Mohamed Ali Karar, Ayat Yousif Mohammed Saeed, Asma Eltayeb Abdalla Mohamed, Rawan Salah Mohamed Ginawi, Fatin Mohamed Kaidan Sidar, Reham Rrdwan Abdalrab Saifalsorori, Othman Ibrahim Abdullah Osman, Mohammed Adil Ibrahim Nouri, Manasik Adam Ahmed Mohamed, Nadreen Babikir Mohammad Ibrahim, Maha Mujtaba Mahmoud Mohamed, Abd Elrahman Ahmed Bashir Mohamed, Faris Mohamed AbdAllah MohamedAhmed, Mohammad Rabie Mohammad Hassan, Shahd Abdelkhalig Abdelrahman Mohamed, Hafiz Elhadi Bashar Hadi, Hanan Mohamed Naeim Gandour Gandour, Nirmeen Ali Farah Ahmed, Noon Mohamed El-Fatih Ahmed, Maria Mohammed AlMogtaba AbdElaziz Osman, Sara Elmuntasir Ibrahim Elhadi

“…It has become an essential part of practicing in all aspects of healthcare. Objective We aimed to investigate evidence-based medicine education of medical students in Sudan. …”
Get full text

Transcutaneous electrical nerve stimulation as an adjuvant treatment for thoracolumbar acute hyperesthesia in chondrodystrophic dogs: a prospective blinded controlled clinical stud... by Débora Gouveia, Débora Gouveia, Débora Gouveia, Ana Cardoso, Ana Cardoso, Carla Carvalho, Marina Moisés, André Coelho, André Coelho, André Coelho, Maria Manuel Balça, Maria Manuel Balça, Maria Manuel Balça, Rui Alvites, Rui Alvites, Rui Alvites, Rui Alvites, Ana Colette Maurício, Ana Colette Maurício, Ana Colette Maurício, António Ferreira, António Ferreira, Ângela Martins, Ângela Martins, Ângela Martins

“…While all dogs transitioned from a hyperesthetic to a non-painful state, SG showed a significantly faster recovery from T2 (48 h) to T4. A significant difference was observed between groups in DIVAS scores (p < 0.001). …”
Get full text

Towards Phenotyping Characteristics and Mechanism of Conduction Delay in Patients With Nonischemic Heart Failure With Reduced Ejection Fraction: Insights From Cardiac Magnetic Reso... by Di Zhou, Mengdi Jiang, Leyi Zhu, Huaying Zhang, Weichun Wu, Jing Xu, Wenjing Yang, Yining Wang, Xinqiao Lian, Wenli Zhou, Tingting Zheng, Arlene Sirajuddin, Andrew E. Arai, Xiaohan Fan, Shihua Zhao, Minjie Lu

“…A crucial step in addressing this issue is conducting a comprehensive pathophysiological assessment to understand the mechanisms underlying dyssynchrony and inefficient cardiac contraction. This study aims to utilize cardiac magnetic resonance imaging to explore underlying pathophysiological impairments in patients with heart failure with reduced ejection fraction with different QRS morphologies, seeking to identify better indicators for clinical assessment. …”
Get full text

Health information management of older, multimorbid patients in German primary care: feasibility and first results of the outcome measures of a cluster-randomised controlled pilot... by Astrid-Alexandra Klein, Maria Hanf, Truc Sophia Dinh, Franziska Brosse, Jenny Petermann, Steve Piller, Sylvia Schulz-Rothe, Lena Schäfer, Karola Mergenthal, Hanna M. Seidling, Sophia Klasing, Nina Timmesfeld, Bahareh Yousefi, Marjan van den Akker, Karen Voigt

“…This trial tested the feasibility and implementability of a complex intervention which aimed at improving the availability of health information among patients and different healthcare providers. …”
Get full text

MS4A7 based metabolic gene signature as a prognostic predictor in lung adenocarcinoma by Yan Jiang, Zhengyu Shu, Lei Cheng, Lei Cheng, Haowei Wang, Taiping He, Liwen Fu, Chao Zhao, Xuefei Li, Weicheng Zeng, Weicheng Zeng

“…Single-cell RNA sequencing was employed to identify the expression profile and role of MS4A7 in different macrophage populations within the LUAD.ResultsThe constructed prognostic model displayed high predictive accuracy, outperforming single gene-based predictions. …”
Get full text

A multicentre implementation trial of an Artificial Intelligence-driven biomarker to inform Shared decisions for androgen deprivation therapy in men undergoing prostate radiotherap... by Eric Wegener, Michael Ng, Mario Guerrieri, Timothy N. Showalter, Jeremy de Leon, Sagar Ramani, Marcus Dreosti, Tee Lim, Bradley Wong, Michael Chao, Kathryn Hogan, Avi Raman, Scott McClintock, Darren Foreman, Matthew Brown, Stephen McCombie, Kevin McMillan, Kieran Beattie, Mark Frydenberg, Lih-Ming Wong, Dickon Hayne, John Yaxley, Phillip Stricker, Jarad Martin

“…A potential limitation is the variability in clinical practice across different centers inherent in real-world studies. Trial Registration Australian New Zealand Clinical Trials Registry, ACTRN12623000713695p. …”
Get full text

Diagnosis value of targeted and metagenomic sequencing in respiratory tract infection by Yukun Kuang, Yukun Kuang, Weiping Tan, Weiping Tan, Chaohui Hu, Zehan Dai, Lihong Bai, Lihong Bai, Jiyu Wang, Jiyu Wang, Huai Liao, Huai Liao, Haihong Chen, Haihong Chen, Rongling He, Rongling He, Pengyuan Zhu, Jun Liu, Canmao Xie, Canmao Xie, Zunfu Ke, Zunfu Ke, Zunfu Ke, Ke-Jing Tang, Ke-Jing Tang, Ke-Jing Tang

“…But tNGS presented a slightly higher detection rate per species than mNGS (PWilcoxon=1.212e-05; standard mean difference = 0.2887091), as detection rates for 32 out of 48 species were higher than those of mNGS. …”
Get full text

Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24 by Yu Liu, Xiaoli Zhang, Kun Chen, Hongying Wang, Junhu Yuan, Yiming Ma, Jianhui Ma, Fanyu Zhang, Bing-zhi Wang, Yinong Wang, Xinhua Zhao

“…The neutrophils isolated from human peripheral blood were stimulated with PMA to release NETs, which were collected and added to the cultures of different CRC cell lines for in vitro studies. Macrophage phagocytosis was assessed with flow cytometry in vitro and in vivo. …”
Get full text

Interaction of Body Mass Index and Glycemic Status on Cardiovascular Outcomes in Patients With Cancer Treated With Anthracyclines by Iokfai Cheang, Xu Zhu, Xinyi Lu, Ying Li, Gehui Ni, Ying Yang, Yue Zhang, Qing‐Wen Ren, Mei‐Zhen Wu, Rongrong Gao, Kai‐Hang Yiu, Xinli Li

“…Background Anthracycline‐based chemotherapy is a vital treatment for various cancers but carries notable risks of cardiotoxicity. This study aimed to assess how different body mass index values and glycemic status influence the risk of major adverse cardiovascular events (MACE) in chemotherapy‐naïve adult patients with cancer treated with anthracyclines. …”
Get full text

Retrospective analysis of the effectiveness and tolerability of nab‐paclitaxel in Chinese elderly patients with advanced non‐small‐cell lung carcinoma by Shuhang Wang, Qiuping Liang, Yujia Chi, Minglei Zhuo, Tongtong An, Jianchun Duan, Zhijie Wang, Yuyan Wang, Jia Zhong, Xue Yang, Hanxiao Chen, Jie Wang, Jun Zhao

“…Real‐world data on the elderly Chinese population are lacking. This study aimed to analyze the effectiveness and tolerability of nab‐paclitaxel in Chinese elderly patients (≥65 years) with advanced NSCLC. …”
Get full text

Identification of PET/CT radiomic signature for classification of locally recurrent rectal cancer: A network-based feature selection approach by Sara Dalmonte, Maria Adriana Cocozza, Dajana Cuicchi, Daniel Remondini, Lorenzo Faggioni, Paolo Castellucci, Andrea Farolfi, Emilia Fortunati, Alberta Cappelli, Riccardo Biondi, Arrigo Cattabriga, Gilberto Poggioli, Stefano Fanti, Gastone Castellani, Francesca Coppola, Nico Curti

“…Identifying LRRC through imaging is complex, due to the mismatch between fibrosis and inflammatory pelvic tissue. This work aimed to develop a machine learning model for predicting LRRC using radiomic features extracted from 18F-FDG Positron Emission Tomography/Computed Tomography (PET/CT). …”
Get full text

The prevalence of wide QRS complex (≥110 ms) among the population, depending on sex, age and place of residence by G. A. Muromtseva, V. G. Vilkov, S. A. Shalnova, V. V. Konstantinov, A. D. Deev, S. E. Evstifeeva, Yu. A. Balanova, A. E. Imaeva, A. V. Kapustina, N. S. Karamnova, E. V. Shlyakhto, S. A. Boytsov, S. V. Nedogoda, A. A. Shabunova, T. M. Chernykh, O. A. Belova, E. V. Indukaeva, Yu. I. Grinshteyn, I. A. Trubacheva, A. Yu. Efanov, Z. T. Astakhova, N. V. Kulakova

“…Aim. To assess the prevalence of wide QRS complex (≥110 ms) among the population, depending on sex, age, place of residence (urban or rural area), the presence of obesity and cardiovascular disease.Material and methods. …”
Get full text

Active left atrial ejection fraction as a non-invasive marker in pulmonary hypertension secondary to heart failure by Di Zhou, Xin Li, Jing Xu, Yining Wang, Weichun Wu, Arlene Sirajuddin, Shihua Zhao, Zhihong Liu, Minjie Lu

“…The integration of active LAEF and HF subtypes may stratify individuals at different levels of risk.…”
Get full text

A practical distribution pattern of α-SMA-positive carcinoma associated fibroblasts indicates poor prognosis of patients with pancreatic ductal adenocarcinoma by Bo Li, Meilong Shi, Yang Wang, Penghao Li, Xiaoyi Yin, Guoxiao Zhang, Xiaochao Kang, Huan Wang, Suizhi Gao, Kailian Zheng, Xiaohan Shi, Xiongfei Xu, Yukun Zhou, Hui Jiang, Wei Jing, Shiwei Guo, Gang Jin

“…Purpose The present study aimed to clarify the distribution pattern of carcinoma associated fibroblasts (CAFs) across pancreatic ductal adenocarcinoma (PDAC) and its prognostic prediction value.Methods Data of two cohorts were retrospectively collected from consecutive patients who underwent primary pancreatic resection from January 2015 to December 2017. …”
Get full text

Global, regional, and national burden of heart failure and its underlying causes, 1990–2021: results from the global burden of disease study 2021 by Jun Ran, Ping Zhou, Jinxi Wang, Xuemei Zhao, Yan Huang, Qiong Zhou, Mei Zhai, Yuhui Zhang

“…Abstract Background Heart failure (HF) remains a significant public health challenge globally. This study aims to systematically analyze the global HF disease burden from 1990 to 2021 across temporal, spatial, and demographic dimensions to provide evidence for targeted prevention and control strategies. …”
Get full text

Effect of Traditional Chinese Formula Dingkun Pill on Primary Dysmenorrhea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial by Xuesong Ding, Shiyang Zhu, Yan Deng, Xiao Ma, Jingwen Gan, Yanfang Wang, Aijun Sun

“…Therefore, this trial aimed to assess the efficacy and safety of DKP in patients with PD. …”
Get full text

Blunted cardiovascular responses in individuals with type 2 diabetes and hypertension during cold and heat exposure by Mojdeh Rafieian, Erlend Hoftun Farbu, Anje Christina Höper, Anje Christina Höper, Rasmus Valtonen, Rasmus Valtonen, Henna Hyrkäs-Palmu, Juha Perkiömäki, Juha Perkiömäki, Craig Crandall, Jouni J. K. Jaakkola, Jouni J. K. Jaakkola, Tiina Maria Ikäheimo, Tiina Maria Ikäheimo

“…IntroductionThe effect of type 2 diabetes (T2D) on indices of cardiovascular function during exposure to cold or hot environmental temperatures is not well known. Therefore, the aim of our study was to assess the effect of short-term whole-body cold and heat exposure on the cardiovascular responses in individuals with T2D.Material and methods10 participants with T2D and hypertension (mean age 64 ± 4 years) and 10 controls (mean age 63 ± 5 years) underwent 90 min of whole-body exposure to cold (10°C; 10% relative humidity) and heat (40°C; 50% relative humidity) in a randomized sequence on differing days. …”
Get full text