Dynamic Patch-Based Sample Generation for Pulmonary Nodule Segmentation in Low-Dose CT Scans Using 3D Residual Networks for Lung Cancer Screening by Ioannis D. Marinakis, Konstantinos Karampidis, Giorgos Papadourakis, Mostefa Kara

“…Data augmentation techniques, including random flips, affine transformations, elastic deformations, and swaps, were applied in the 3D space to enhance the robustness of the training process and mitigate overfitting. …”
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2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment by Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang

“…The nanoLC-Obitrap-MS technology was utilized to detect the content of selected small molecules with differential metabolic activity in the hippocampus and mitochondria of mice to evaluate their permeability through the blood-brain barrier (BBB) and outer mitochondrial membrane. …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…Methods A novel anti-MSLN×4-1BB bispecific antibody (bsAb) was generated via antibody engineering, and its affinity and activity were detected via enzyme-linked immunosorbent assay (ELISA), flow cytometry, and T-cell activation and luciferase reporter assays. …”
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Circulating tumor cells in breast cancer: clinical and molecular parallels by A. V. Zyuzyukina, M. O. Vatrushkina, T. N. Zamay, O. S. Kolovskaya, G. S. Zamay, A. S. Kichkailo, R. A. Zukov

“…The study included 22 patients with BC. Detection of CTCs and circulating tumor microemboli was carried out in 3.5 ml of the blood of BC patients with the help of the MDA-231 aptamer which is affine for breast cancer cells, labeled with the fluorescent Cy3 dye. …”
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Carboxyl-containing quinazolines and related heterocycles as carriers of anti-inflammatory activity by N. I. Krasovska, V V. Stavytskyi, I. S. Nosulenko, O. Yu. Voskoboinik, S. I. Kovalenko

“…The conducted in vivo screening of anti-inflammatory activity among carboxyl-containing quinazolines and related heterocyclic compounds allowed to detect series of substances that by the level of anti-inflammatory activity compete with reference-compound “Diclofenac sodium” on the carrageenan-induced paw edema model. …”
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Synthesis, Radiolabeling, and Biological Evaluation of 68Ga-Mucin1 and Its Folate Hybrid Peptide Conjugates for the Diagnosis of Ovarian Cancer by Samiah Alhabardi, Hesham Radwan, Basim Alotaibi, Yousif Almalki, Ehab Elzayat, Zakia Shinwari, Subhani M. Okarvi, Ibrahim Aljammaz

“…In vitro studies on KB cancer cells showed that substantial amounts of the radioconjugates were associated with cell fractions and held great affinities and specificities toward the KB cell line. …”
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Immunoreactivity Analysis of MHC-I Epitopes Derived from the Nucleocapsid Protein of SARS-CoV-2 via Computation and Vaccination by Dongbo Jiang, Zilu Ma, Junqi Zhang, Yubo Sun, Tianyuan Bai, Ruibo Liu, Yongkai Wang, Liang Guan, Shuaishuai Fu, Yuanjie Sun, Yuanzhe Li, Bingquan Zhou, Yulin Yang, Shuya Yang, Yuanhang Chang, Baozeng Sun, Kun Yang

“…Enzyme-Linked Immunosorbent Assay (ELISA) was used to detect whether the preferred epitope induced humoral immunity. …”
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Computationally guided fabrication of chlorpyrifos electrochemical sensor based on molecularly imprinted polymer decorated with au nanoparticles by Martin N. Saad, Amr M. Mahmoud, Mina Wadie, Sawsan M. Amer, Ibrahim M. El-Sherbiny, Hoda M. Marzouk

“…First, a computational simulation was used to test the binding affinities of CPF using numerous monomers. The most stable complex, identified through the simulation, was formed with both MD and OPD. …”
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Computational Immunogenetic Analysis of Botulinum Toxin A Immunogenicity and HLA Gene Haplotypes: New Insights by Eqram Rahman, Parinitha Rao, Munim Ahmed, William Richard Webb, Jean D. A. Carruthers

“…Although some claim that neurotoxin-associated proteins (NAPs) shield BoNT-A from immune detection or are themselves immunogenic, there is limited molecular evidence supporting either view. …”
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Far-red fluorescent genetically encoded calcium ion indicators by Rochelin Dalangin, Bill Z. Jia, Yitong Qi, Abhi Aggarwal, Kenryo Sakoi, Mikhail Drobizhev, Rosana S. Molina, Ronak Patel, Ahmed S. Abdelfattah, Jihong Zheng, Daniel Reep, Jeremy P. Hasseman, The GENIE Project Team, Yufeng Zhao, Jiahui Wu, Kaspar Podgorski, Alison G. Tebo, Eric R. Schreiter, Thomas E. Hughes, Takuya Terai, Marie-Eve Paquet, Sean G. Megason, Adam E. Cohen, Yi Shen, Robert E. Campbell

“…FR-GECOs offer sensitive and fast detection of single action potentials in neurons, and enable in vivo all-optical manipulation and measurement of cellular activities in combination with optogenetic actuators.…”
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Consistent trends from different methods for monitoring SARS-CoV-2 in urban wastewater during a 29-month longitudinal study by Janine McCalder, Janine McCalder, Jangwoo Lee, Jangwoo Lee, Judy Qiu, Qiaozhi Li, Linnet Immaraj, Nicole Acosta, María A. Bautista, Melissa Wilson, Barbara Waddell, Kristine Du, Aito Ueno, Rhonda Clark, Rhonda Clark, Alexander Krusina, Danielle A. Southern, Tyler Williamson, Tyler Williamson, Chloe Papparis, Paul Montesclaros, Lance Non, September Stefani, Gail Visser, Puja Pradhan, Norma Ruecker, John Conly, John Conly, John Conly, John Conly, John Conly, John Conly, Steve Hrudey, Kevin Frankowski, Bonita Lee, Bonita Lee, Michael D. Parkins, Michael D. Parkins, Michael D. Parkins, Xiaoli Pang, Xiaoli Pang, Casey R. J. Hubert

“…Rigorous method development and validation to detect and quantify SARS-CoV-2 RNA in wastewater has led to important advances in community disease surveillance using quantitative molecular biology tools. …”
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Predominant T-cell epitopes of SARS-CoV-2 restricted by multiple prevalent HLA-B and HLA-C allotypes in Northeast Asia by Yu Zhao, Min Peng, Chengtao He, Min Li, Min Li, Xuelian Han, Xuelian Han, Qiang Fu, Yandan Wu, Fangping Yue, Chunguang Yan, Guangyu Zhao, Guangyu Zhao, Chuanlai Shen

“…These data will facilitate the design of T-cell-directed vaccines and SARS-CoV-2-specific T-cell detection tools tailored to the Northeast Asian population. …”
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Isolation, Identification, Whole-genome Characterization, and Comparative Genomic Analysis of Pathogenic Aeromonas hydrophila A01 from Pelteobagrus fulvidraco by Wei GAO, Ling SHAO

“…【Method】Bacterial strains were isolated and purified bacterial strains from the affected fish, and their identification was based on morphological, physiological, and biochemical traits. PCR detection for virulence genes and drug sensitivity tests were conducted. …”
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18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy by Michael L. Alosco, Jhony Mejía Pérez, Julia E. Culhane, Ranjani Shankar, Christopher J. Nowinski, Samantha Bureau, Nidhi Mundada, Karen Smith, Alinda Amuiri, Breton Asken, Jenna R. Groh, Annalise Miner, Erika Pettway, Sydney Mosaheb, Yorghos Tripodis, Charles Windon, Gustavo Mercier, Robert A. Stern, Lea T. Grinberg, David N. Soleimani-Meigooni, Bradley T. Christian, Tobey J. Betthauser, Thor D. Stein, Ann C. McKee, Chester A. Mathis, Eric E. Abrahamson, Milos D. Ikonomovic, Sterling C. Johnson, Jesse Mez, Renaud La Joie, Daniel Schonhaut, Gil D. Rabinovici

“…Additional studies in larger samples and PET-to-autopsy correlations are required to further elucidate the potential of 18F-MK-6240 to detect tau pathology in CTE.…”
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A network toxicology and machine learning approach to investigate the mechanism of kidney injury from melamine and cyanuric acid co-exposure by Zhan Wang, Zhaokai Zhou, Zihao Zhao, Junjie Zhang, Shengli Zhang, Luping Li, Yingzhong Fan, Qi Li

“…Molecular docking simulations demonstrated strong binding affinities between MC and the two hub proteins. Conclusion: MC exposure induces significant kidney injury and fibrosis. …”
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LH Gene Cloning, Sequence Feature Analysis and Prokaryotic Expression in Conger myriaster by Yan CHEN, Bao SHI, Chenggang WANG, Wanjun BO, Kewen YAN, Meijun TAO, Xinyu ZHAO, Xiaodong MA

“…Western blot analysis revealed that histidine tagged LH protein reacted with anti-His antibody, LH protein yielded clear bands of 26.5 kDa were detected. The observed size is in accordance with the anticipated molecular weight expression, indicating successful expression of the fusion protein carrying 6×His tag. …”
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Whole-rock geochemistry and crystal chemistry of apatite at intrusive suites of the Qeynarjeh-Angouran district (west of Zanjan): an approach to the identification of skarn-causati... by Afsoon Dastour, Ebrahim Tale Fazel, Ashraf Torkian

“…Whole-rock geochemical data has been carried out in the Geochemistry Laboratory of Istanbul University of Technology, by X-ray fluorescence (WDXRF) wavelength-based model S8 TIGER to detect the main oxide elements (in terms of wt.%) and inductively coupled plasma mass spectrometer (ICP-MS), ELAN DRC-e model for identification of minor and rare earth elements (in terms of ppm). …”
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Providing a model of consumer behavior in creating brand attachment with an emphasis on the packaging component of food industry companies by maziar Ghasemzadeh Sangroudi, karim hamdi, SHADAN VAHABZADEH MUNSHI

“…And based on the components detected in relation to these three dimensions, the structures of the primary model of consumer behavior in creating brand attachment were identified as follows: communication factors, logistics factors, economic factors, bio-social factors, brand loyalty, brand awareness, perceived quality, brand associations, personal, cultural, psychological, marketing mix. …”
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A Tensor Space for Multi-View and Multitask Learning Based on Einstein and Hadamard Products: A Case Study on Vehicle Traffic Surveillance Systems by Fernando Hermosillo-Reynoso, Deni Torres-Roman

“…As a case study, we present a multitask model of vehicle traffic surveillance for occlusion detection and vehicle-size classification tasks, with a low-rank MV-DTF layer, achieving up to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>92.81</mn><mo>%</mo></mrow></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>95.10</mn><mo>%</mo></mrow></semantics></math></inline-formula> in the normalized weighted Matthews correlation coefficient metric in individual tasks, representing a significant <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>6</mn><mo>%</mo></mrow></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>7</mn><mo>%</mo></mrow></semantics></math></inline-formula> improvement compared to the single-task single-view models.…”
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Noirceur de l’âme, lumière de la Une by Myriam Boucharenc

“…It seems that it is the intensive exploitation of historical, anthropological and rhetorical affinities between the « fait divers» and the « réclame», which has contributed to making Détective a fundamentally advertising weekly magazine.…”
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