Experimental evolution of plant rhizobacteria reveals emerging adaptive mutations by Jiahui Li, Yingying Zhang, Wenjun Jiang, Li-Qun Zhang

“…Pseudomonas spp. are important biocontrol agents for plant diseases, with strong affinity for plant roots and large populations in the rhizosphere, making them key models for studying PGPR colonization mechanisms. …”
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Identification of CD36 as a contributor in inflammatory response of rheumatoid arthritis and screening of feasible bioactive drugs targeting it by Dan Xuan, Xiaowan Wang, Dandan Feng, Li Wang, Yonghui Xia

“…In addition, drug prediction was performed through virtual screening. mRNA and protein expression of cluster of differentiation 36 (CD36) were detected by RT-qPCR and Western blot. After RA fibroblast-like synovial cells (RA-FLS) were treated with piceatannol and epicatechin, cell proliferation was detected by CCK-8 assay, and flow cytometry was used to detect cell cycle and apoptosis, and the secretion of inflammatory cytokines was detected by enzyme-linked immunosorbent assay. …”
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Enhancing Smart City Functions through the Mitigation of Electricity Theft in Smart Grids: A Stacked Ensemble Method by Muhammad Hashim, Laiq Khan, Nadeem Javaid, Zahid Ullah, Ifra Shaheen

“…This research introduced a stacked ensemble method for electricity theft detection (ETD) in a smart grid. The framework detects anomalous consumers in two stages; in the first stage, four powerful classifiers are stacked and detect suspicious activity, and the output of these consumers is fed to a single classifier for the second-stage classification to get better results. …”
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Beyond nitrate transport: AtNRT2.4 responds to local and systemic nitrogen signaling in Arabidopsis by Huaifang Zhang, Jinxia Huang, Yanmei Li, Jinling Zhao, Weitao Mai, Luqman Khan, Meng Zhang, Wenquan Wang, Changying Zeng, Xin Chen

“…Results Through split-root experiments, this study demonstrated that nitrate transporter 2.4 (AtNRT2.4) can respond to both local and systemic nitrate signals, modulating the transcription of genes such as AtANR1 and AtCIPK23, thereby altering root architecture. Beyond merely detecting the fluctuations of environmental nitrate concentrations, AtNRT2.4 was actively engaged in the dual-affinity transition of AtNRT1.1 and suppressed the expression of AtNLP7, which is crucial for responding to intracellular nitrate signals. …”
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Jinxinkang granule alleviates chronic heart failure by enhancing GPER/AMPK/PCG-1α-mediated fatty acid oxidation by Haixiang Zhong, Liu He, Wanru Zhong, Lili Wang, Jianmin Luo, Qi Chen, Rong Li, Rong Zhang, Zhongqiu Liu, Yuanyuan Cheng

“…Additionally, molecular docking analysis showed that dihydroisotanshinone I has a high binding affinity with GPER at -8.5 kcal/mol, which has the similar binding sites with G-1, a GPER agonist. …”
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In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China by Weilun Zuo, Weilun Zuo, Chen Wei, Meiyan He, Mengyao Zhang, Jiangli Liang, Xiao Ma, Na Gao, Qin Gu, Yan Ma, Jingyan Li, Shuyuan Liu, Yan Huang, Mingbo Sun, Li Shi

“…LC-MS/MS analysis and binding affinity detection allowed the identification of expression and antigenicity of pertactin. …”
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Soybean fermentation drives the production of native neuroprotective peptides based on a peptidomics strategy by Li Zhang, Shilin Gong, Yilang Zuo, Lili Zhang, Jiaqian Chen, Yuqing Xu, Yuyao Wu, Yonghua Zhao, Jian-Lin Wu, Na Li

“…Furthermore, molecular docking revealed the high binding affinity of newly identified peptides with monoamine oxidases (MAOs). …”
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Esculetin inhibits the PI3K/Akt/mTOR pathway and enhances anti-colorectal cancer activity via binding to ENO1 by Jianing Ma, Miaomiao Zhang, Shulipan Mulati, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Weiyi Zhang, Weiyi Zhang, Weiyi Zhang, Weiyi Zhang

“…The molecular mechanisms of Esc’s antitumor properties were elucidated through network pharmacology, transcriptome sequencing technology, drug affinity responsive target stability (DARTS), and molecular docking. …”
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Tracking the Caribbean Magmatic Evolution: The British Virgin Islands as a Transition Between the Greater and Lesser Antilles Arcs by Noémie Bosc, Delphine Bosch, Mélanie Noury, Olivier Bruguier, Lény Montheil, Douwe J. J. vanHinsbergen, Jean‐Jacques Cornée, Jonathan Outin, Mélody Philippon

“…Geochemistry of the studied samples reveals typical volcanic arc signatures, including a calc‐alkaline affinity, strong negative HFSE anomalies, and LILE enrichment. …”
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Identification of novel angiotensin I-converting enzyme inhibitory peptides from walnut (Juglans sigillata Dode) protein hydrolysates and their vascular endothelial protective prop... by Wenyun Xiong, Lixia Guo, Yiting Zhang, Shurui Li, Zihuan Wu, Shengbao Cai

“…The objective of this study was to explore novel functional peptides derived from walnut protein isolate (WPI) that exhibited gastrointestinal stability, angiotensin I-converting enzyme (ACE1) inhibitory activity, and endothelial protective properties. Among the 81 detected peptides, 36 peptides with Glu, Leu, Pro, and Asp as the predominant residues were predicted to exhibit ACE1 inhibitory activity. …”
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Evaluation of Tissue Tropism and Horizontal Transmission of a Duck Enteritis Virus Vectored Vaccine in One-Day-Old Chicken by Yassin Abdulrahim, Yingying You, Linggou Wang, Zhixiang Bi, Lihua Xie, Saisai Chen, Benedikt B. Kaufer, Armando Mario Damiani, Kehe Huang, Jichun Wang

“…In this work, tissue affinity and horizontal transmission in 1-day-old chickens were systematically evaluated after DEV-H5 vector vaccine inoculation. …”
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Long‐Circulating Nanobody Confers Durable Prophylaxis against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Infection by Geetha Jyothi Vaskuri, Gang Ye, Fan Bu, Dong Yang, Colleen B. Jonsson, Hailey Turner‐Hubbard, Sydney Winecke, Alise Mendoza, Fang Li, Chalet Tan

“…Compared to Nanosota‐3A‐Fc, Nanosota‐3A‐Fc‐YTE exhibits identical binding to the SARS‐CoV‐2 spike protein yet displays eightfold higher binding affinity for human neonatal Fc receptor (hFcRn) at pH 6.0. …”
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A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions. by Jessica B Hostetler, Sumana Sharma, S Josefin Bartholdson, Gavin J Wright, Rick M Fairhurst, Julian C Rayner

“…Using a method specifically designed to detect low-affinity, extracellular protein-protein interactions, we confirmed a predicted interaction between P. vivax 6-cysteine proteins P12 and P41, further suggesting that the proteins are natively folded and functional. …”
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Juvenile Idiopathic Arthritis Subtype- and Sex-specific Associations with Genetic Variants in the PSMA6/PSMC6/PSMA3 Gene Cluster by Tatjana Sjakste, Natalia Paramonova, Ingrida Rumba-Rozenfelde, Ilva Trapina, Olga Sugoka, Nikolajs Sjakste

“…The plasma proteasome level was found to be significantly higher in females having four-locus risk genotypes compared with protective genotypes (p < 0.001). Sequence affinity to transcription factors and similarity to splicing signals, microRNAs and/or hairpin precursors potentially depend on allele substitutions in disease susceptible loci. …”
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Bombali virus (Filoviridae: <i>Orthoebolavirus: Orthoebolavirus bombaliense</i>) by Tatiana E. Sizikova, Vitaliy N. Lebedev, Sergey V. Borisevich

“…When comparing the concentration of the Bombali virus in the organs of infected bats, the highest level of accumulation was detected in the lungs which indirectly indicates the possibility of aerosol infection of Mops condylurus. …”
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Subclinical Aortic Root Pathology in Close Relatives of Patients with Bicuspid Aortic Valve by Ivaniv Y., Lozynska N., Ivaniv I.

“…According to various sources, among the relatives of the first degree (FDR) of affinity the prevalence of BAV is 9.0-21.0%. However, there is no convincing information that would confirm the hereditary nature of the onset of aortic aneurysm in these individuals. …”
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The Acute-Phase Serum Amyloid A Promotes Cytokines Production in Oyster <i>Crassostrea gigas</i> by Junlei Cheng, Weilin Wang, Xuemei Cheng, Xuesong Li, Luyi Lun, Xingye Lian, Lingling Wang, Linsheng Song

“…The mRNA expression of <i>Cg</i>SAA in normal individuals was detectable but at a low level, with the lowest expression level in the tissue of labial palp and a slightly higher expression level in hemocytes. …”
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The effect of gene polymorphism of certain cytokines on echocardiographic parameters in patients with chronic rheumatic heart disease by V. S. Petrov

“…Echocardiography was performed on a Philips Affinity 50 machine. Genotyping was carried out using polymorphic TNF-α markers (G308A, IL-10 G1082A, IL-17A G197A, IL-17F А161Н0 by polymerase chain reaction with an electrophoretic scheme for detecting the result of “SNP-EXPRESS”.Results. …”
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Preparation of MOF-5 imprinted chromium ferrite and its application in decontaminating metronidazole and penicillin G contaminated water system by Babatunde K. Adeleke, Olamide A. Olalekan, Adewale Adewuyi, Woei Jye Lau, Olalere G. Adeyemi

“…CrFe2O4@MOF-5 exhibited a higher affinity (91.67 mg g− 1) for PG than CrFe2O4 (53.82 mg g− 1). …”
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Short-Term Fertilization with the Nitrogen-Fixing Bacterium (NFB) <i>Kosakonia radicincitans</i> GXGL-4A Agent Can Modify the Transcriptome Expression Profiling of Cucumber (<i>Cuc... by Baoyun Feng, Erxing Wang, Yating Zhang, Lurong Xu, Yanwen Xue, Yunpeng Chen

“…A total of 418 differentially expressed genes (DEGs) were detected. The transcription levels of genes <i>Csa5G161290</i> and <i>Csa3G027720</i>, which encode nitrate transporters, showed significant up-regulation (3.04- and 2.27-fold, respectively) in roots inoculated with GXGL-4A. …”
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