Adoptive transfer of natural killer cells in therapeutic treatment of COVID-19 patients by Abdulaziz Alamri

“…We discuss potential sources of NK cells for adoptive transfer therapy, critical factors influencing their therapeutic efficacy, and considerations for clinical translation in COVID-19 treatment. …”
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Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

“…Immunotherapy, including adoptive T cell transfer therapy, has not impacted the outcomes in patients with PDAC, due in part to the hostile tumor microenvironment (TME) which limits T cell trafficking and persistence. …”
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Prospectives of T-cells genetic programming in adoptive immunotherapy of malignancies by O. L. Morozova, V. V. Yakovlev, N. A. Sushentsev

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Safe engineering of CAR T cells for adoptive cell therapy of cancer using long‐term episomal gene transfer by Chuan Jin, Grammatiki Fotaki, Mohanraj Ramachandran, Berith Nilsson, Magnus Essand, Di Yu

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Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling. by Rinat Sharir, Jonathan Semo, Sara Shimoni, Tamar Ben-Mordechai, Natalie Landa-Rouben, Sofia Maysel-Auslender, Aviv Shaish, Michal Entin-Meer, Gad Keren, Jacob George, Jacob George

“…<h4>Background</h4>Ischemic cardiac damage is associated with upregulation of cardiac pro-inflammatory cytokines, as well as invasion of lymphocytes into the heart. Regulatory T cells (Tregs) are known to exert a suppressive effect on several immune cell types. …”
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Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews by Yanni Zhou, Juan Shan, Yingjia Guo, Shengfu Li, Dan Long, Youping Li, Li Feng

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Adoptively transferred macrophages for cancer immunotherapy by Jennifer L Guerriero, Kyung Soo Park, Alexander P Gottlieb, Morgan E Janes, Supriya Prakash, Neha Kapate, Vineeth Chandran Suja, Lily Li-Wen Wang, Samir Mitragotri

“…Here, we demonstrate that adoptively transferred macrophages, with optimal activation prior to administration, act as a potent cellular cancer therapeutic platform against a murine melanoma model.Method The macrophage therapy was prepared from bone marrow-derived macrophages, pretreated ex vivo with an activation cocktail containing interferon-γ, tumor necrosis factor-α, polyinosinic:polycytidylic acid, and anti-CD40 antibody. …”
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Metabolic reprogramming of naïve regulatory T cells by IL-7 and IL-15 promotes their persistence and performance upon adoptive transfer by Jessica Filoni, Arianna Ferrari, Tatiana Jofra, Anna Rita Putignano, Lorenzo Da Dalt, Susanna Cesarano, Carla Di Dedda, Fabrizia Bonacina, Federica Marchesi, Giuseppe Danilo Norata, Chiara Bonini, Lorenzo Piemonti, Paolo Monti

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Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cells by Gregory B Lesinski, Chrystal M Paulos, Hannah M Knochelmann, Megan M Wyatt, Guillermo O Rangel Rivera, Anna C Cole, Megen C Wittling

“…Background How distinct methods of host preconditioning impact the efficacy of adoptively transferred antitumor T helper cells is unknown.Methods CD4+ T cells with a transgenic T-cell receptor that recognize tyrosinase-related peptide (TRP)-1 melanoma antigen were polarized to the T helper 17 (Th17) phenotype and then transferred into melanoma-bearing mice preconditioned with either total body irradiation or chemotherapy.Results We found that preconditioning mice with a non-myeloablative dose of total body irradiation (TBI of 5 Gy) was more effective than using an equivalently dosed non-myeloablative chemotherapy (cyclophosphamide (CTX) of 200 mg/kg) at augmenting therapeutic activity of antitumor TRP-1 Th17 cells. …”
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ADOPTIVE CELL THERAPY: CURRENT ADVANCES by T. V. Shamova, A. O. Sitkovskaya, L. N. Vashchenko, E. E. Kechedzhieva

“…The main part of the article provides information on the mechanisms of adoptive T cell (unmodified and genetically modified) transfer, the creation of dendritic cell vaccines and cytokine-induced killers (CIK). …”
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Regional and intratumoral adoptive T-cell therapy by I. Olivera, I. Etxeberria, C. Luri-Rey, P. Molero-Glez, I. Melero

“…Building upon the experience of regional administration in other immunotherapies, the regional administration of adoptive cell therapies is being assessed to overcome this challenge, granting a first round of access of the transferred T cells to the tumor niche and thereby ensuring their activation and expansion. …”
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Adoptive transfer of membrane-restricted IL-12-TCR T cells promotes antigen spreading and elimination of antigen-negative tumor variants by James L Gulley, Ling Zhang, Christian S Hinrichs, John S Davies, Andrew Sinkoe, Wiem Lassoued, Farrah Karimipour, Philip Homan, Daniel Burnett, Scott M Norberg, Alex Kuznetsov, Margaret Cam, Ping Xue

“…Target antigen loss resulting either from non-uniform antigen expression or defects in antigen processing and presentation machinery is one well-characterized resistance mechanism. Constitutively expressed membrane-anchored interleukin-12 (caIL-12) has demonstrated enhanced antitumor activity and low systemic exposure in multiple preclinical adoptive T-cell treatment models with homogeneous tumor antigen expression. …”
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Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells by Mimi Zhou, Yali Feng, Xiaoli Zhang, Jianguo Chen, Naijuan Yao, Shan Fu, Tianzhi Ni, Yi Chen, Fei Xie, Sahasrabda Roy, Jinfeng Liu, Yuan Yang, Yingli He, Yingren Zhao, Nan Yang

“…Furthermore, T cells and platelet-derived microparticles (PMPs) co-culture assay revealed that PMPs adoptively transferred integrin β3 to T cells and positively regulated T cell immune response. …”
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IL-2/α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment. by Benedikt Mahr, Lukas Unger, Karin Hock, Nina Pilat, Ulrike Baranyi, Christoph Schwarz, Svenja Maschke, Andreas Michael Farkas, Thomas Wekerle

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NIVO-TIL: combination anti-PD-1 therapy and adoptive T-cell transfer in untreated metastatic melanoma: an exploratory open-label phase I trial by Jean-Matthieu L'Orphelin, Ugo Lancien, Jean-Michel Nguyen, Francisco J.S. Coronilla, Soraya Saiagh, Julie Cassecuel, Lise Boussemart, Anne Dompmartin, Brigitte Dréno

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An integral membrane constitutively active heparanase enhances the tumor infiltration capability of NK cells by Sofia Liborio-Ramos, Isaac Quiros-Fernandez, Neta Ilan, Soaad Soboh, Malik Farhoud, Ruken Süleymanoglu, Michele Bennek, Sara Calleja-Vara, Martin Müller, Israel Vlodavsky, Angel Cid-Arregui

Subjects: “…Adoptive cell transfer…”
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Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers by Alexandra M. Gustafson, Aaron J. Dinerman, Kyle J. Hitscherich, Maria R. Parkhurst, Hyunmi Halas, Donald E. White, Chuong D. Hoang, Jonathan M. Hernandez, Mei Li M. Kwong, Nicholas D. Klemen, Steven A. Rosenberg, Stephanie L. Goff, James C. Yang

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The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis by Ángela Bella, Ignacio Melero, Pedro Berraondo, Fernando Aranda

Subjects: “…Adoptive cell transfer…”
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Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models by Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda

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Regenerative and hepatospecific activity of total RNA from xenogenic bone marrow cells by N. A. Onishchenko, A. O. Nikolskaya, Z. Z. Gonikova, L. A. Kirsanova, M. Yu. Shagidulin, V. I. Sevastianov

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