Prospectives of T-cells genetic programming in adoptive immunotherapy of malignancies by O. L. Morozova, V. V. Yakovlev, N. A. Sushentsev

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Regional and intratumoral adoptive T-cell therapy by I. Olivera, I. Etxeberria, C. Luri-Rey, P. Molero-Glez, I. Melero

“…Building upon the experience of regional administration in other immunotherapies, the regional administration of adoptive cell therapies is being assessed to overcome this challenge, granting a first round of access of the transferred T cells to the tumor niche and thereby ensuring their activation and expansion. …”
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ADOPTIVE CELL THERAPY: CURRENT ADVANCES by T. V. Shamova, A. O. Sitkovskaya, L. N. Vashchenko, E. E. Kechedzhieva

“…The main part of the article provides information on the mechanisms of adoptive T cell (unmodified and genetically modified) transfer, the creation of dendritic cell vaccines and cytokine-induced killers (CIK). …”
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Adoptive transfer of natural killer cells in therapeutic treatment of COVID-19 patients by Abdulaziz Alamri

“…Therapeutic strategies include adoptive transfer, cytokine modulation, and optimized delivery. …”
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Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

“…These models shall serve an indepth study of how to overcome barriers that limit antitumor activity of adoptively transferred T cells.…”
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Safe engineering of CAR T cells for adoptive cell therapy of cancer using long‐term episomal gene transfer by Chuan Jin, Grammatiki Fotaki, Mohanraj Ramachandran, Berith Nilsson, Magnus Essand, Di Yu

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Navigating the manufacturing, testing and regulatory complexities of regulatory T cells for adoptive cell therapy by Larissa A. Pikor, Sindhu Arivazhagan, Michael Mendicino, Sarmitha Sathiamoorthy

“…Adoptive transfer of Tregs for the treatment of autoimmune disorders such as arthritis and allergic airway inflammation, graft-versus-host disease (GvHD) and rejection following transplant have shown promise in early phase clinical trials. …”
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Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling. by Rinat Sharir, Jonathan Semo, Sara Shimoni, Tamar Ben-Mordechai, Natalie Landa-Rouben, Sofia Maysel-Auslender, Aviv Shaish, Michal Entin-Meer, Gad Keren, Jacob George, Jacob George

“…<h4>Conclusion</h4>Treg numbers are increased whereas their function is compromised in mice with that underwent experimental infarction. Transfer of exogeneous Tregs results in attenuation of myocardial remodeling whereas their ablation has no effect. …”
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Adoptive Cell Therapy of Induced Regulatory T Cells Expanded by Tolerogenic Dendritic Cells on Murine Autoimmune Arthritis by Jie Yang, Lidong Liu, Yiming Yang, Ning Kong, Xueyu Jiang, Juan Sun, Rufeng Xie

“…Following adoptive transfer of iTregs and iTregmtDC to mice with CIA, the clinical and histopathologic scores, serum levels of IFN-γ, TNF-α, IL-17, IL-6, IL-10, TGF-β and anti-CII antibodies, and the distribution of the CD4+ Th subset were assessed. …”
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Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews by Yanni Zhou, Juan Shan, Yingjia Guo, Shengfu Li, Dan Long, Youping Li, Li Feng

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Metabolic reprogramming of naïve regulatory T cells by IL-7 and IL-15 promotes their persistence and performance upon adoptive transfer by Jessica Filoni, Arianna Ferrari, Tatiana Jofra, Anna Rita Putignano, Lorenzo Da Dalt, Susanna Cesarano, Carla Di Dedda, Fabrizia Bonacina, Federica Marchesi, Giuseppe Danilo Norata, Chiara Bonini, Lorenzo Piemonti, Paolo Monti

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CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors by Yi Sun, Eduardo Davila, YuJie Guo, Richard D Schulick, Elliott Yee, Yuki Fujiwara, Kaitlyn Dickinson, Zhiwei Sun, Junyi Hu, Yuwen Zhu

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Adoptive transfer of membrane-restricted IL-12-TCR T cells promotes antigen spreading and elimination of antigen-negative tumor variants by James L Gulley, Ling Zhang, Christian S Hinrichs, John S Davies, Andrew Sinkoe, Wiem Lassoued, Farrah Karimipour, Philip Homan, Daniel Burnett, Scott M Norberg, Alex Kuznetsov, Margaret Cam, Ping Xue

“…The tumor-bearing mice then underwent 5.5 Gy total body irradiation, followed by adoptive transfer of OT-I TCR-T cells engineered with or without caIL-12.Results TCR-T cells (OT-I) delivered caIL-12 to the B16-U-OVA tumor sites and induced robust tumor control and survival benefits in mice bearing a heterogeneous tumor with OVA-negative variants. caIL-12 exerted its effect on OVA-negative B16 variants primarily by priming and activating endogenous antitumor CD8 T cells via antigen spreading. …”
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An integral membrane constitutively active heparanase enhances the tumor infiltration capability of NK cells by Sofia Liborio-Ramos, Isaac Quiros-Fernandez, Neta Ilan, Soaad Soboh, Malik Farhoud, Ruken Süleymanoglu, Michele Bennek, Sara Calleja-Vara, Martin Müller, Israel Vlodavsky, Angel Cid-Arregui

Subjects: “…Adoptive cell transfer…”
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Regenerative and hepatospecific activity of total RNA from xenogenic bone marrow cells by N. A. Onishchenko, A. O. Nikolskaya, Z. Z. Gonikova, L. A. Kirsanova, M. Yu. Shagidulin, V. I. Sevastianov

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IL-2/α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment. by Benedikt Mahr, Lukas Unger, Karin Hock, Nina Pilat, Ulrike Baranyi, Christoph Schwarz, Svenja Maschke, Andreas Michael Farkas, Thomas Wekerle

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Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cells by Gregory B Lesinski, Chrystal M Paulos, Hannah M Knochelmann, Megan M Wyatt, Guillermo O Rangel Rivera, Anna C Cole, Megen C Wittling

“…Background How distinct methods of host preconditioning impact the efficacy of adoptively transferred antitumor T helper cells is unknown.Methods CD4+ T cells with a transgenic T-cell receptor that recognize tyrosinase-related peptide (TRP)-1 melanoma antigen were polarized to the T helper 17 (Th17) phenotype and then transferred into melanoma-bearing mice preconditioned with either total body irradiation or chemotherapy.Results We found that preconditioning mice with a non-myeloablative dose of total body irradiation (TBI of 5 Gy) was more effective than using an equivalently dosed non-myeloablative chemotherapy (cyclophosphamide (CTX) of 200 mg/kg) at augmenting therapeutic activity of antitumor TRP-1 Th17 cells. …”
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NIVO-TIL: combination anti-PD-1 therapy and adoptive T-cell transfer in untreated metastatic melanoma: an exploratory open-label phase I trial by Jean-Matthieu L'Orphelin, Ugo Lancien, Jean-Michel Nguyen, Francisco J.S. Coronilla, Soraya Saiagh, Julie Cassecuel, Lise Boussemart, Anne Dompmartin, Brigitte Dréno

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Adoptive cell therapy with tumor-infiltrating lymphocytes in combination with nivolumab in patients with advanced melanoma by D. König, B. Kasenda, M. Sandholzer, A. Chirindel, A. Zingg, R. Ritschard, H. Thut, K. Glatz, E.A. Kappos, D. Schaefer, C. Kettelhack, J. Passweg, K. Baur, A. Holbro, A. Buser, D. Lardinois, L.T. Jeker, N. Khanna, F. Stenner, M.S. Matter, N. Rodrigues Mantuano, M. Binder, A. Zippelius, H. Läubli

“…Results: Between 2020 and 2022, we enrolled 11 patients and 9 underwent a TIL transfer (median transfused cell number: 66.25 × 109). …”
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NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors by Cheng Wei, Xin Huang, Tianlong Xu, Yinan Fang, Fabao Wang, Qiaolin He, Peiyuan Zhang, Qianjin Yu, Ying Zhang, Binjiao Zheng, Yue Gao, Yongping Chen, Qichuan Zhuge, Ai Zhao, Jimin Gao, Jimin Gao, Jinhong Jiang, Jinhong Jiang

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