Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphoma by Linyu Yang, Qiang Qiu, Jie Wang, Yi Wen, He Li, Rui Liang, Yunyu Feng, Fang Wang, Xiaojing Lin, Minghai Tang, Jianhong Yang, Heying Pei, Peng Zhao, Jishi Wang, Jin Xiang, Jia Miao, Li Zheng, Ke Tan, Yongsheng Wang, Yiguo Hu, Lijuan Chen, Weili Zhao, Ting Niu

“…Purinostat mesylate (PM), a highly selective HDAC I/II binhibitor, exhibits excellent antitumor activity in MM and lymphoma cell lines and mouse models, outperforming the pan-HDAC inhibitor panobinostat or first-line/second-line multi-drug combinations. …”
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Selection of Prediction Method of Basic Statistical Work Parameters of N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department by B. L. Kurilin, V. Y. Kisselevskaya-Babinina, N. A. Karasyov, I. V. Kisselevskaya-Babinina, E. V. Kislukhkina, V. A. Vasilyev

“…The application of the Holt–Winters model, which takes into account the exponential trend (the trend of time series indicators) and additive season (periodic fluctuations observed in the time series), is most suitable for processing statistical data and forecasting for long-term, medium-term and short-term periods taking the specifics of a hospital providing emergency care into account. 3. …”
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Patient satisfaction and its associated factors in selected primary healthcare facilities in Kono District, Sierra Leone: a cross-sectional study by Julia Higgins, Zeleke Abebaw Mekonnen, Samuel I Watson, Joia Mukherjee, Yusupha Dibba, Stefanie Joseph, Foday Boima, Jean Gregory Jerome, Lyzberthe Chery, Vivian Chung, Kilongo Papy Mulailwa

“…Objective To assess patient satisfaction (PS) with services and its associated factors across selected primary care facilities in Kono district, Sierra Leone.Design Facility-based cross-sectional study.Setting Five primary healthcare facilities (Wellbody, Sewafe, Kombayendeh, Gandorhun and Kayima) located in Kono district, Sierra Leone. …”
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Study of biotransformation of new selective carbonic anhydrase II inhibitor 4-(2-methyl-1,3-oxazole-5-yl)-benzenesulfonamide by A. L. Khokhlov, I. I. Yaichkov, A. A. Shetnev, S. A. Ivanovskiy, M. K. Korsakov, O. A. Gasilina, N. N. Volkhin, S. S. Petukhov

“…The aim of the study was to determine biotransformation products of a new selective carbonic anhydrase II inhibitor – 4-(2-methyl-1,3-oxazole-5-yl)-benzenesulfonamide.Materials and methods. …”
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Stress resilience in Coffea arabica and Coffea canephora under harsh drought and/or heat conditions: selected genes, proteins, and lipid integrated responses by José C. Ramalho, José C. Ramalho, Isabel Marques, Isabel P. Pais, Isabel P. Pais, Jean Armengaud, Duarte Gouveia, Ana P. Rodrigues, Danielly Dubberstein, Danielly Dubberstein, Danielly Dubberstein, António E. Leitão, António E. Leitão, Miroslava Rakočević, Paula Scotti-Campos, Paula Scotti-Campos, Sónia Martins, Sónia Martins, Magda C. Semedo, Magda C. Semedo, Fábio L. Partelli, Fernando C. Lidon, Fábio M. DaMatta, Ana I. Ribeiro-Barros, Ana I. Ribeiro-Barros

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Investigating Roasted Açaí (<i>Euterpe oleracea</i>) Seed Powder as a Coffee Substitute: Effects of Water Temperature, Milk Addition, and In Vitro Digestion on Phenolic Content and... by Rayssa Cruz Lima, Carini Aparecida Lelis, Jelmir Craveiro de Andrade, Carlos Adam Conte-Junior

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Inter-reader agreement and additive benefit of SPECT or SPECT/CT modality with [99mTc]Tc-pertechnetate scintigraphy imaging for the assessment of thyroid nodules in a tertiary care... by Emil Novruzov, Dominik Schmitt, Katalin Mattes-György, Julian Kuhlmann, Mareike Muchalla, Matthias Schott, Christina Antke, Frederik L. Giesel, Eduards Mamlins

“…Three readers with varying experience level selected a target nodule within thyroid gland and evaluated its functionality, ACR TI-RADS categorization and additive benefit of SPECT(-/CT) imaging. …”
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Pioneering Role of Nanopore Single-Molecule Sensing in Environmental and Food Surveillance by Wenqiang Tian, Xu Wang, Yan Zhang, Ting Weng, Tlili Chaker, Xiaohan Chen, Qingke Kong, Deqiang Wang

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Understanding the effect of pre-sintering scanning strategy on the relative density of Zr-modified Al7075 processed by laser powder bed fusion by Nicolas Nothomb, Ignacio Rodriguez-Barber, María Teresa Pérez-Prado, Norberto Jimenez Mena, Grzegorz Pyka, Aude Simar

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Study on the mechanical properties of Ti-6Al-4V alloy with minimal surface structures: effects of different heat treatment temperatures by Kai Qian, Shuangyu Liu, Fulong Zhang, Guihua Hang, Bo Cui, Ziwei Guo, Qiushi Zhang, Wang Binhua

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Design and Evaluation of the Mechanical Performance of Hollow BCC Truss AlSi10Mg Lattice Structures by Wanqi Ma, Yangwei Wang, Qingtang Li, Bingyue Jiang, Jingbo Zhu

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Combined Effects of Dual-Scale Modified Surface with Micro- and Nanostructures on the Cellular Biocompatibility, Osteoinduction, and Antibacterial Properties of Titanium Implants by Shaheer Maher, Nenad L. Ignjatović, Miloš Lazarević, Sanja Petrović, Andrijana Žekić, Dusan Losic

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Development of interpretable intelligent frameworks for estimating river water turbidity by Amin Gharehbaghi, Salim Heddam, Saeid Mehdizadeh, Sungwon Kim

“…USGS 14206950 and USGS 14211720) were selected as a case study. 70% and 30% of whole data were utilized as the training and validation datasets when developing the models, respectively. …”
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Design and Optimization of a Gripper Clamp by Mariana Cunha, Sofia Alves, Jose Costa

“…To produce sustainable and competitive products, component material and design selection is an essential and critical topic in the industry. …”
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Method of direct synthesis of electric filters on elements with distributed parameters by A. A. Svirydzenka

“…This method for the first time allows designing frequency selective microwave circuits using the features of classical theory. …”
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Application of the Analytic Hierarchy Process Method to Select the Final Solution for Multi-Criteria Optimization of the Structure of a Hybrid Generation System with Energy Storage by Andrzej Tomczewski, Stanisław Mikulski, Jan Szymenderski

“…The AHP method was used to select the final solution, which allows determination of the ranking of solution variants, taking into account selected additional criteria. …”
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Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3‐O‐UGT2 by Qiushuang Ji, Yirong Liu, Huanyu Zhang, Yan Gao, Yixin Ding, Yuanyuan Ding, Jing Xie, Jianyu Zhang, Xinghua Jin, Bin Lai, Cheng Chen, Juan Wang, Wenyuan Gao, Kunrong Mei

“…Pq3‐O‐UGT2, an important UDP‐dependent glycosyltransferase (UGT), catalyzes the production of Ginsenoside Rg3 and Rd by extending the glycan chain of Ginsenoside Rh2 and F2, respectively, with higher selectivity for F2. However, the mechanism underlying its substrate recognition remains unclear. …”
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Simultaneous Content Determination of Mono-, Di-, and Fructo-oligosaccharides in Citrus Fruit Juices Using an FTIR-PLS Method Based on Selected Absorption Bands by Yurika Yajima, Hideyuki Wakabayashi, Ken-ichiro Suehara, Takaharu Kameoka, Atsushi Hashimoto

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A Fuzzy Group Decision Making for a Material Handling Equipment Selection Problem by VIKOR and Monte Carlo Simulation: A Case Study by Saeed Dehnavi-Arani, Hadi Mokhtari

“…The selection of material handling equipment is crucial for companies as it significantly impacts productivity in manufacturing and service operations. …”
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Investigating Motion Data Selections Based on Patient-Specific Respiration Pattern at External Surrogates Radiotherapy Using Cyberknife Synchrony Respiratory Tracking System by Seyed Amirreza Dastyar, Ahmad Esmaili Torshabi

“…Results: The number of training and updating data points can be intelligently optimized depending on the breathing pattern of each patient. In addition, by developing recognition algorithm, the shooting time for motion data selection is converted from conventional strategy to intelligent approach, accordingly. …”
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