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A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy
Published 2025-02-01“…Pathogenic potential was assessed using disease phenotype predictors and CADD scores, while allele frequency data from gnomAD contextualized mutation prevalence. Additionally, aggregation propensity, frustration analysis, and post-translational modification sites were analyzed for functional disruptions.ResultsOf the 184 substitutions analyzed, 50 were identified as deleterious, with 41 predicted to be pathogenic. …”
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162
Pulse-Width-Modulation For A Modified Hybrid 2/3-Level Converter
Published 2016-12-01Get full text
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163
The ferroelectric PLZT type ceramics as a material for transducers
Published 2014-01-01Get full text
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164
RLSuccSite: succinylation sites prediction based on reinforcement learning dynamic with balanced reward mechanism and three-peaks enhanced method for physicochemical property score...
Published 2025-06-01“…Abstract Recent progress in computational biology has driven the development of machine learning models for predicting protein post-translational modification sites. …”
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165
Facile synthesis, characterization, molecular and dynamic optical properties of metronidazole and sulfamethoxazole adducts of tricarbonyl(1-5-η-2-methoxycyclohexadienylium)iron
Published 2025-04-01“…Here, we synthesized new tricarbonyl [1,4-η-5-(4-amino-N-(5-methyl-1,2-oxazol-3yl)benzenesulfonamide) cyclohexa-1,3-diene]iron (1SF) and tricarbonyl[1,4-η-5-(2-(2-methyl-5-nitroimidazol-1-yl)ethanol)cyclohexa-1,3-diene] iron (1MF) by the modification of sulfamethoxazole (1S) and metronidazole (1 M) via their nucleophilic addition to 2-methoxydienyliumiron cation ([(1-5-η-2-MeOC6H6)Fe(CO)3] [PF6]. …”
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Mission Sequence Model and Deep Reinforcement Learning-Based Replanning Method for Multi-Satellite Observation
Published 2025-03-01“…Extensive simulations demonstrate that our method significantly outperforms state-of-the-art approaches, achieving a 15.27% higher request insertion revenue rate and a 3.05% improvement in overall mission revenue rate, while maintaining a 1.17% lower modification rate and achieving faster computational speeds. …”
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168
Low power IoT device communication through hybrid AES-RSA encryption in MRA mode
Published 2025-04-01“…The enhanced RSA algorithm replaces the traditional dual-prime system with a triple-prime system, increasing the number of primes while reducing the bit length of each prime. This modification optimizes computational efficiency and strengthens security.Furthermore, we investigate the feasibility of integrating the RSA and AES algorithms and propose a novel RSA-AES hybrid algorithm MRA. …”
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169
VM-UNet++ research on crack image segmentation based on improved VM-UNet
Published 2025-03-01“…On the other hand, while Transformers are powerful in handling long-range dependencies, their high computational cost remains a significant challenge. To effectively address these issues, this paper proposes an innovative modification to the VM-UNet model. …”
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170
Beyond conditional averages: Estimating the individual causal effect distribution
Published 2025-05-01Get full text
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171
Efficient and privacy-preserving certificateless data aggregation in Internet of things–enabled smart grid
Published 2019-04-01“…The proposed scheme can resist replay attacks, modification attacks, and impersonation attacks. In the process of collecting data, computation of encryption and signature generation do not need expensive bilinear pairings. …”
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172
An open source FEM code for solving coupled thermo-poroelastoplastic processes
Published 2024-06-01“…The code is freely available to the general community for use and modification. …”
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Modulating Osteoclast Activity and Immune Responses with Ultra-Low-Dose Silver Nanoparticle-Loaded TiO<sub>2</sub> Nanotubes for Osteoporotic Bone Regeneration
Published 2025-05-01“…In addition, Ag@TiO<sub>2</sub>-NTs facilitated the polarization of macrophages toward the M2 phenotype. …”
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175
Electrically Controlled Meta-Switch With Nonvolatile Functionality
Published 2019-01-01Get full text
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176
A U-net based reconstruction of high-fidelity simulation results for flow around a ship hull based on low-fidelity inviscid flow simulation
Published 2025-01-01“…To create the training dataset, a variety of hull forms are generated from six baseline hull forms using parametric modification function techniques. Inviscid and viscous flow data for each hull are obtained through potential flow analysis and computational fluid dynamics - simulations, respectively. …”
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177
Dynamic Mapping and 3D Perception Using Voxel Grid and Modified Artificial Potential Fields for Indoor Locomotion
Published 2025-01-01“…Voxel grid filtering enhances computational efficiency, reducing processing time per iteration by up to 73% - from 0.247 seconds (raw LiDAR) to 0.067 seconds (voxel size of 0.9) - while maintaining obstacle detection accuracy. …”
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178
FORMAL REPRESENTATION OF THE PIXEL-BY-PIXEL CLASSIFICATION PROCESS USING A MODIFIED WANG-MENDEL NEURAL NETWORK
Published 2020-09-01“…The proposed IFST2, on the one hand, provide a formalization of more additional degrees of uncertainty compared to FST1, on the other hand, are "implemented" in the development of fuzzy systems (models) and have less computational complexity, compared to fuzzy sets of the second type (FST2).…”
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179
Script-Based Material and Geometrical Modeling of Steel–Concrete Composite Connections for Comprehensive Analysis Under Varied Configurations
Published 2025-03-01“…The Python-based parametric model allows for easy modification of design parameters, ensuring efficiency and minimizing modeling errors. …”
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