A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements by Astrid D. Haase

“…Mechanisms of piRNA silencing are most readily studied in Drosophila melanogaster, which serves as a model to delineate molecular concepts and as a reference for mammalian piRNA systems. PiRNA pathways utilize two major strategies to handle the challenges of transposon control: (1) the hard-wired molecular memory of prior transpositions enables recognition of mobile genetic elements and discriminates transposons from host genes; (2) a feed-forward adaptation mechanism shapes piRNA populations to selectively combat the immediate threat of transposon transcripts. …”
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Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation. by Ryan Centini, Mark Tsang, Terri Iwata, Heon Park, Jeffrey Delrow, Daciana Margineantu, Brandon M Iritani, Haiwei Gu, H Denny Liggitt, Janella Kang, Lim Kang, David M Hockenbery, Daniel Raftery, Brian M Iritani

“…Whereas kidney-specific deletion of the Bhd gene in mice is known to result in polycystic kidney disease (PKD) and renal cell carcinoma, the roles of Fnip1 in renal cell development and function are unclear. In this study, we utilized mice with constitutive deletion of the Fnip1 gene to show that the loss of Fnip1 is sufficient to result in renal cyst formation, which was characterized by decreased AMPK activation, increased mTOR activation, and metabolic hyperactivation. …”
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Host Cell Signalling and Leishmania Mechanisms of Evasion by Marina Tiemi Shio, Kasra Hassani, Amandine Isnard, Benjamin Ralph, Irazu Contreras, Maria Adelaida Gomez, Issa Abu-Dayyeh, Martin Olivier

“…These signalling alterations contribute to the inactivation of critical macrophage functions (e.g., Nitric oxide, IL-12, and TNF-α). Additionally, to interfere with IFN-γ receptor signalling, Leishmania also alters several LPS-mediated responses. …”
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Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies by Nikola Dordevic, Clemens Dierks, Essi Hantikainen, Vadim Farztdinov, Fatma Amari, Vinicius Verri Hernandes, Alessandro De Grandi, Francisco S. Domingues, Orr Shomroni, Kathrin Textoris-Taube, Vivien Bahr, Hannah Schmid, Ilja Demuth, Florian Kurth, Michael Mülleder, Peter Paul Pramstaller, Johannes Rainer, Markus Ralser

“…Abstract Background The study of circulating blood proteins in population cohorts offers new avenues to explore lifestyle-related and genetic influences describing and shaping human health. Methods Utilizing high-throughput mass spectrometry, we quantified 148 highly abundant proteins, functioning in the innate and adaptive immune system, coagulation and nutrient transport in 3632 blood plasma, and 500 serum samples from the CHRIS and BASE-II cross-sectional population studies, respectively. …”
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Establishing a core outcome set for creatine transporter deficiency and guanidinoacetate methyltransferase deficiency by Zahra Nasseri Moghaddam, Emily K. Reinhardt, Audrey Thurm, Beth K. Potter, Maureen Smith, Celeste Graham, Beth H. Tiller, Steven A. Baker, Deborah A. Bilder, Regina Bogar, Jacobus Britz, Rachel Cafferty, Daniel P. Coller, Ton J. DeGrauw, Vicky Hall, Gerald S. Lipshutz, Nicola Longo, Saadet Mercimek-Andrews, Judith S. Miller, Marzia Pasquali, Gajja S. Salomons, Andreas Schulze, Celine P. Wheaton, Kayla F. Williams, Sarah P. Young, Jasmine Li, Sofia Balog, Theresa Selucky, Sylvia Stöckler-Ipsiroglu, Heidi Wallis

“…The COS developed includes seven outcomes (“Adaptive Functioning”, “Cognitive Functioning”, “Emotional Dysregulation”, “MRS Brain Creatine”, “Seizure/Convulsions”, “Expressive Communication”, and “Fine Motor Functions”) for both CTD and GAMT, and an additional outcome for GAMT (“Serum/Plasma Guanidinoacetate”) that are important to stakeholders and consequently should be considered for measurement in every clinical trial. …”
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Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications by Adina Alberts, Andreea Gabriela Bratu, Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu

“…The important processes by which collagen promotes healing (e.g., promoting angiogenesis, encouraging cell proliferation, and offering structural support) are discussed to clarify its function in tissue regeneration. The effectiveness and adaptability of collagen dressings are demonstrated via clinical applications investigated in acute and chronic wounds. …”
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Large Language Model-Assisted Deep Reinforcement Learning from Human Feedback for Job Shop Scheduling by Yuhang Zeng, Ping Lou, Jianmin Hu, Chuannian Fan, Quan Liu, Jiwei Hu

“…Therefore, a human feedback-based large language model-assisted deep reinforcement learning (HFLLMDRL) framework is proposed to solve this problem, in which few-shot prompt engineering by human feedback is utilized to assist in designing instructive reward functions and guiding policy convergence. …”
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Closed-Loop Clustering-Based Global Bandwidth Prediction in Real-Time Video Streaming by Sepideh Afshar, Reza Razavi, Mohammad Moshirpour

“…Unlike local models, GFMs apply the same function to all traces enabling cross-learning, and leveraging relationships among traces to address the performance issues seen in current SBP algorithms. …”
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The impacts of different eyes, individual differences, and different time points in healthy rats on the variability of visual electrophysiological examination indicators by Hong Chen, Yu Cheng, Ke Diao, YiFan Wang, Jing An, Haijiang Zhang, RongRong Li, Dan Zhang, SuMian Cheng, Minglian Zhang, LiFei Wang

“…At different time points (1 d, 7 d), Roland visual electrophysiological device was utilized to record in FVEP P2 peak time and N2-P2 amplitude, peak time and amplitude of dark-adapted 0.01 ERG b-wave, peak time and amplitude of dark-adapted 3.0 ERG a- and b-waves, OPs OS2 amplitude, peak time and amplitude of light-adapted 3.0 ERG a- and b-waves, and N1-P1 amplitude of light-adapted 3.0 flash ERG. …”
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Damping profile learning for human-robot collaboration using Bayesian optimization with a task success rate model by Liem Duc TRAN, Tasuku YAMAWAKI, Masahito YASHIMA

“…In the realm of human-robot collaboration, impedance and admittance control are widely utilized techniques to regulate the interaction dynamics between humans and robots. …”
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A Novel Multi-Objective Fuzzy Deep Learning Framework for Predictive Maintenance in Industrial Internet of Things by Jiangang Feng, Jicheng Kan

“…However, traditional PdM methods often struggle with handling complex high-dimensional data and managing uncertainty, leading to limitations in predictive accuracy and adaptability. This paper introduces MO-FCNN, a novel PdM model that integrates fuzzy logic with deep convolutional neural networks (DCNN) to manage data uncertainty and utilizes non-dominated sorting biogeography-based optimization (NSBBO) to improve the overall maintenance decision-making process. …”
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Variable-Parameter Impedance Control of Manipulator Based on RBFNN and Gradient Descent by Linshen Li, Fan Wang, Huilin Tang, Yanbing Liang

“…To address the computationally intensive nature of current hybrid force/position control methods, a variable-parameter impedance control method for manipulators, utilizing a gradient descent method and Radial Basis Function Neural Network (RBFNN), is proposed. …”
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Uso de Métodos Monte Carlo na Modelagem de Fontes Radioativas Naturais by Gutemberg Luiz Sales Claudino, José Vieira, Viriato Leal Neto, Fernando Lima, José Santos

“…Essentially, if tried improve the way the photons are sampled in the plan, taking in account the probability density function (PDF) that describes the problem, the runtime simulation and dosimetric results. …”
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A Novel Multistep Wavelet Convolutional Transfer Diagnostic Framework for Cross-Machine Bearing Fault Diagnosis by Lujia Zhao, Yuling He, Hai Zheng, Derui Dai

“…Nevertheless, the majority of current transfer-learning-based fault diagnosis approaches focus primarily on adapting to varying conditions within the same machine. …”
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An improved multiclass classification of acute lymphocytic leukemia using enhanced glowworm swarm optimization by Saranya N, Kalamani M

“…A subset of most vital features were selected by utilizing nature inspired metaheuristic Enhanced Glowworm Swarm Optimization (EGSO) algorithm. …”
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Non-Conventional Lane Design and Control Coordination Optimization at Urban Road Intersections: Review and Prospects by Yizhe Wang, Xiaoguang Yang

“…Optimally configuring the number and turning functions of intersection approach and exit lanes to adapt to changing traffic demands, along with optimal traffic signal timing, is key to ensuring smooth, safe, and efficient urban road intersections. …”
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VOLTAGE PROFILE IMPROVEMENT WITH APPLICATION OF DIFFERENTLY OPTIMIZED FACTS CONTROLLERS by Joel R. SUTTER, John N. NDERU, Ariel M. MUTEGI

“…This research work presents a novel individual and Hybrid MGA and IGWO was utilized to develop FACTS-controlled optimization model for improvement of bus voltage profiles. …”
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Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong by Reena Rajasuriar, Syaza Hisham, John Son Lim, Jean Yi Cheong, Wen Ying Ho, Siew Hwei Yap, Nurul Syuhada Zulhaimi, Malinee Neelamegam, Catherine Cheung, Vivian Wong, Ruhana Che Yusof, Kejal Hasmukharay, Shahrul Bahyah Kamaruzzaman, Sharifah Faridah Syed Omar, Meng Li Chong, Pui Li Wong, Grace Chung‐Yan Lui

“…Abstract Introduction WHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age‐associated vulnerabilities. …”
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A Comprehensive Review of Multifunctional Nanozymes for Degradation and Detection of Organophosphorus Pesticides in the Environment by Jijia Liang, Zhongtian Dong, Ning Xu, Tao Chen, Jie Liang, Mingzhu Xia, Fenghe Wang

“…Nanozymes inherit both the unique properties of nanomaterials and catalytic functions, which could overcome the limitations inherent in natural enzymes and have great versatile and adaptable application prospects. …”
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Mass cytometry analysis reveals a cross-tissue immune landscape in Actinobacillus pleuropneumoniae-induced pneumonia by Yanyan Tian, Xuan Jiang, Chuntong Bao, Tamin Abdelaal, Dexi Chen, Wenjing Wang, Fengyang Li, Liancheng Lei, Na Li

“…Meanwhile, the specific functions of APP infection-related immune subsets were explored. …”
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