Comprehensive profiling of candidate biomarkers and immune infiltration landscape in metabolic dysfunction-associated steatohepatitis by Zhangliu Jin, Jianyun Cao, Zhaoxun Liu, Mei Gao, Hailan Liu

“…Furthermore, the biological processes and molecular functions of the IR-DEGs were analyzed. To characterize the hub IR-DEGs, we employed a protein-protein interaction network. …”
Get full text

Safety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial. by Steven Perrin, Shafeeq Ladha, Nicholas Maragakis, Michael H Rivner, Jonathan Katz, Angela Genge, Nicholas Olney, Dale Lange, Daragh Heitzman, Cynthia Bodkin, Omar Jawdat, Namita A Goyal, Jeffrey D Bornstein, Carmen Mak, Stanley H Appel, Sabrina Paganoni

“…Exploratory endpoints assessed the pharmacokinetics of tegoprubart as well as anti-drug antibody (ADA) responses, changes in disease progression utilizing the Revised ALS Functional Rating Scale (ALSFRS-R), CD154 target engagement, changes in pro-inflammatory biomarkers, and neurofilament light chain (NFL). …”
Get full text

Markers of intracellular energy supply under conditions of hypoxia in premature babies by O.S. Godovanets

“…This results in impaired adaptation in the neonatal period and a high risk of developing functional and chronic pathology in the future. …”
Get full text

Unlocking wellness: the comprehensive impact of community-based exercise programs on older adults by Ronal Surya Aditya, Ah Yusuf, Qory Tifani Rahmatika, Achmad Masfi, Muhammad Putra Ramadhan, Eri Yanuar Akhmad Budi Sunaryo, Nurma Afiani, Nurul Evi, Yhenti Widjayanti, Neni Fidya Santi, Domingos Soares, Reem Iafi AlMutairi

“…Result: The analysis revealed several key themes: Improvement in Physical Function (increased mobility, strength, balance, and endurance), Enhanced Exercise Self-Efficacy (confidence in physical abilities, positive attitude toward exercise, self-management of health), Social and Emotional Benefits (social connections, emotional support, motivation from group dynamics, reduced loneliness), Psychological and Cognitive Benefits (increased mental alertness, stress reduction, improved mood), Overcoming Initial Challenges (physical barriers, psycholog-ical hesitations, adapting to new routines), Long-Term Commitment and Behavior Change (continued participation, development of healthy habits, increased awareness of health), and Program Design and Facilitators' Role (tailored exercises, positive influence of instructors, accessibility of the program). …”
Get full text

Effects of high-intensity interval training and moderate-intensity continuous training on mitochondrial dynamics in human skeletal muscle by Yuqing Li, Yuqing Li, Yuqing Li, Wanjun Zhao, Qi Yang

“…Exercise and physical activity confer health advantages, in part, by enhancing skeletal muscle mitochondrial respiratory function. The objective of this study is to analyze the impacts of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the dynamics and functionality of the mitochondrial network within skeletal muscle. 20 young male participants were assigned to either HIIT or MICT group. …”
Get full text

A Blockchain-Oriented Task Scheduling and Allocation System for ROS Enabled Mobile Robots by Mehmed Oguz Sen, Fatih Okumus, Adnan Fatih Kocamaz

“…In the application, Hyperledger Fabric (HLF) has been utilized as the blockchain platform due to its advantages. …”
Get full text

A Robust Cross-Platform Solution With the Sense2Quit System to Enhance Smoking Gesture Recognition: Model Development and Validation Study by Anarghya Das, Juntao Feng, Maeve Brin, Patricia Cioe, Rebecca Schnall, Ming-Chun Huang, Wenyao Xu

“…The app was developed using the Flutter framework to ensure seamless functionality across Android and iOS platforms, with robust synchronization between the smartwatch and smartphone for real-time monitoring. …”
Get full text

Chlorophyll a/b-binding Overexpression 2 regulates nitric oxide signaling in Arabidopsis response to sulfur deficiency by Oluwaseun Olayemi Aluko, Zhixin Liu, Yaping Zhou, Hao Liu, Aizhi Qin, Qianli Zhao, Mengfan Li, Chunyang Li, Luyao Kong, Lulu Yan, Vincent Ninkuu, Jean-David Rochaix, Lam-Son Phan Tran, Xuwu Sun

Get full text

Genome-wide identification and expression profiles of NAC transcription factors in Poncirus trifoliata reveal their potential roles in cold tolerance by Tian Fang, Yue Wang, Haowei Chen, Jing Qu, Peng Xiao, Yilei Wang, Xin Jiang, Chunlong Li, Ji-Hong Liu

Get full text

Understanding therapeutic tolerance through a mathematical model of drug-induced resistance by Jana L. Gevertz, James M. Greene, Samantha Prosperi, Natacha Comandante-Lou, Eduardo D. Sontag

“…Abstract There is growing recognition that phenotypic plasticity enables cancer cells to adapt to various environmental conditions. An example of this adaptability is the ability of an initially sensitive population of cancer cells to acquire resistance and persist in the presence of therapeutic agents. …”
Get full text

Spatiotemporal transcriptome and metabolome landscapes of cotton fiber during initiation and early development by Xuwu Sun, Aizhi Qin, Xingxing Wang, Xiaoyang Ge, Zhixin Liu, Chenxi Guo, Xiaole Yu, Xianliang Zhang, Yao Lu, Jincheng Yang, Jiuming He, Yaping Zhou, Yumeng Liu, Mengke Hu, Hao Liu, Zihao Zhao, Guanjing Hu, Wei Li, Xinshan Zang, Shuai Dai, Susu Sun, Lenin Yong-Villalobos, Luis Herrera-Estrella, Lam-Son Phan Tran, Xiongfeng Ma

Get full text

Heterogeneous transfer learning model for improving the classification performance of fNIRS signals in motor imagery among cross-subject stroke patients by Jin Feng, YunDe Li, ZiJun Huang, Yehang Chen, SenLiang Lu, RongLiang Hu, QingHui Hu, YuYao Chen, XiMiao Wang, Yong Fan, Jing He

“…IntroductionMotor imagery functional near-infrared spectroscopy (MI-fNIRS) offers precise monitoring of neural activity in stroke rehabilitation, yet accurate cross-subject classification remains challenging due to limited training samples and significant inter-subject variability. …”
Get full text

Pangenome analysis of transposable element insertion polymorphisms reveals features underlying cold tolerance in rice by Yongqing Qian, Zuwen Zhou, Tianmin Ouyang, Dongao Li, Ru Li, Ping Gan, Renfei Qiao, Yingying Tan, Mingchao Qian, Liezhao Liu, Jiana Li, Kun Lu, Jijing Luo, Ling-Ling Chen, Jia-Ming Song

Get full text

Response of streamflow components and evapotranspiration to changes in tree species composition in a subboreal permafrost watershed in the Greater Khingan Mountains of Northeastern... by Peng Hu, Zhipeng Xu, Xiuling Man, Liangliang Duan, Tijiu Cai

“…The findings reveal the sensitivity of subboreal permafrost hydrology to forest composition changes and offer critical insights for climate adaptation strategies. Additionally, they emphasize the importance of restoring Larix gmelinii forests to enhance the hydrological function.…”
Get full text

Hierarchical Reinforcement Learning for Quadrupedal Robots: Efficient Object Manipulation in Constrained Environments by David Azimi, Reza Hoseinnezhad

“…This design minimizes the computational demands while maintaining adaptability and robust functionality. Simulated trials conducted in NVIDIA Isaac Sim, utilizing ANYbotics quadrupedal robots, demonstrated a high manipulation accuracy, with a mean positioning error of 11 cm across object–target distances of up to 10 m. …”
Get full text

Green communication and networking for Carbon-peaking and Carbon-neutrality: challenges and solutions by Zhisheng NIU, Sheng ZHOU, Yuxuan SUN

“…Driven by the Carbon-peaking and Carbon-neutrality strategic goals, future mobile communication and networks need to drastically reduce energy consumption while satisfying the growing traffic demand.Therefore, it is necessary to study the theories and technologies used to send more information bits with less energy (SMILE).To meet the challenge, it was far from enough to rely solely on the improvements of wireless transmission technologies and hardware.It was necessary to explore efficient energy utilization mechanisms from the perspective of the system and network.Both energy saving and renewable energy utilization approaches were proposed, and solutions for the growing computing energy consumption were provided.Specifically, by introducing hyper-cellular network, agile coverage and elastic access were realized, and thus service base stations and edge servers could enter the sleeping mode to save energy when the traffic volume was low.Meanwhile, by the introduction of renewable energy and the smart adaption of energy flow and information flow, the energy consumption of the power grid could be greatly reduced.Furthermore, green computing and artificial intelligence could be realized through network function virtualization, energy-efficient coordination of communication and compute resources, and distributed computing and coordination approaches of moving agents.…”
Get full text

Closed-Loop Spinal Cord Stimulation in Chronic Pain Management: Mechanisms, Clinical Evidence, and Emerging Perspectives by Nicholas Mangano, Andrew Torpey, Catherine Devitt, George A. Wen, Christopher Doh, Abhishek Gupta

“…<b>Results</b>: Clinical trials, including the Avalon and Evoke studies, have demonstrated that closed-loop spinal cord stimulation provides superior pain relief, functional improvement, and reduced opioid dependence compared to traditional open-loop systems. …”
Get full text

Biological protection of plants in agricultular landscape—state of the art, problems and ways of their decision by Sokolov M S, Kolombet L V

“…</bold> Present-day bioprotection is based on agrolandscape approaches. The major global function of the agrolandscape involves utilization of maximum quantity of solar energy. …”
Get full text

Impact of green and blue spaces on ecosystem services in Beijing: spatiotemporal dynamics and driving mechanisms by Chaonan Cheng, Yang Hu, Feng Li, Ming Zhao, Pei Wang

“…However, urban expansion has led to pronounced fragmentation of peri-urban GBS, suggesting potential degradation of their ecosystem service support functions. These findings emphasize the need for adaptive GBS management strategies that balance ecological conservation with sustainable urban growth in rapidly developing cities. …”
Get full text

medAL-suite: A software solution for creating and deploying complex clinical decision support algorithms by Ludovico Gennaro Cobuccio, Vincent Faivre, Rainer Tan, Alan Vonlanthen, Fenella Beynon, Emmanuel Barchichat, Alain Fresco, Quentin Girard, Sinan Ucak, Sylvain Schaufelberger, Ibrahim Evans Mtebene, Peter Agrea, Emmanuel Kalisa, Gillian A. Levine, Martin Norris, Sabine Renggli, Alix Miauton, Lisa Cleveley, Kristina Keitel, Julien Thabard, Valérie D’Acremont, Alexandra V. Kulinkina

“…Important future developments and adaptations as the software evolves should emphasize interoperability and scalability, primarily via integrating CDSS functionality into electronic medical records for a streamlined user experience that supports improved service quality at the point-of-care. …”
Get full text