Baxdrostat and finerenone: new aldosterone synthase-aldosterone-mineralocorticoid receptor hormonal system inhibitors for the drug treatment of resistant arterial hypertension by O. B. Kuzmin, N. V. Buchneva, V. V. Belyanin, V. V. Zhezha, M. V. Stolbova

“…Its assumed that in this pathological process, in addition to aldosterone, is also involved the small Rho GTFase Rac1 — regulatory G-protein, which can enter into a direct ligand-independent interaction with mineralcorticoid receptors, performing the function of a powerful nonsteroidal activator of the transmission of their intracellular signals. …”
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Confronting the Gap between Classroom Ideals and the Reality of Clinical Culture: A Student’s Perspective by Isabelle Band, Krishna Chokshi

“…Role-playing, real-world case discussions, and debates in safe spaces without fear of judgment can foster readiness and courage. • Active Role Modeling and Mentorship: Educators should demonstrate moral courage and reflect openly on their own experiences with ethical challenges. …”
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Effects of Different Physical Field Treatment Technologies on the Quality of Freeze-dried Mango Powder by Kewei LIN, Zijian LI, Linjing LI, Feng WANG, Lukai MA, Gengsheng XIAO

“…By measuring physical indicators such as color, water activity, and solubility, along with chemical indicators including total phenols, vitamin C content, and antioxidant activity, the quality changes of freeze-dried mango powder were analyzed, and the optimal treatment parameters for each group were determined. …”
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CRISPR-Hybrid: A CRISPR-Mediated Intracellular Directed Evolution Platform for RNA Aptamers by Qiwen Su-Tobon, Jiayi Fan, Michael Goldstein, Kevin Feeney, Hongyuan Ren, Patrick Autissier, Peiyi Wang, Yingzi Huang, Udayan Mohanty, Jia Niu

“…Abstract Recent advances in gene editing and precise regulation of gene expression based on CRISPR technologies have provided powerful tools for the understanding and manipulation of gene functions. …”
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Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers by Kazuya Terasawa, Kazuharu Shimizu, Gozoh Tsujimoto

“…RNA interference (RNAi) is a powerful tool for studying gene function owing to the ease with which it can selectively silence genes of interest, and it has also attracted attention because of its potential for therapeutic applications. …”
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Machine learning and complex network analysis of drug effects on neuronal microelectrode biosensor data by Manuel Ciba, Marc Petzold, Caroline L. Alves, Francisco A. Rodrigues, Yasuhiko Jimbo, Christiane Thielemann

“…Abstract Biosensors, such as microelectrode arrays that record in vitro neuronal activity, provide powerful platforms for studying neuroactive substances. …”
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A large field-of-view, single-cell-resolution two- and three-photon microscope for deep and wide imaging by Aaron T. Mok, Tianyu Wang, Shitong Zhao, Kristine E. Kolkman, Danni Wu, Dimitre G. Ouzounov, Changwoo Seo, Chunyan Wu, Joseph R. Fetcho, Chris Xu

“…Abstract In vivo imaging of large-scale neuronal activity plays a pivotal role in unraveling the function of the brain's circuitry. …”
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Underwater Sounds Classification for Effective Smart Marine Monitoring Systems by Michele Nappi, Fabio Narducci, Benedetto Simone

“…Underwater sound classification is commonly referred to the process of identifying and categorizing different types of sounds in underwater environments, such as those produced by marine animals, human activities, or natural phenomena. Deep learning models have revealed to be able to powerfully classify underwater sounds when conditions are particularly favorable. …”
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Detection and Prevention of Medical Fraud using Machine Learning by Ceyda Ünal, Gökçe Sinem Erbuğa

“…Machine learning is considered one of the most powerful and optimal approaches to prevent medical fraud. …”
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Improving catalysts and operating conditions using machine learning in Fischer-Tropsch synthesis of jet fuels (C8-C16) by Parisa Shafiee, Bogdan Dorneanu, Harvey Arellano-Garcia

“…Fischer-Tropsch synthesis (FTS) offers a promising route for producing sustainable jet fuels from syngas. However, optimizing catalyst design and operating conditions for the ideal C8-C16 jet fuel range is challenging. …”
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A Novel Efficient Method for Extraction and Purification of Recombinant Phenylalanine Dehydrogenase

“…Briefly, we described the application of ATPS as an interesting and powerful technique for purifying and recovery of recombinant PheDH.…”
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Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy by Yi Li, Yuang Zhang, Yiqin Tao, Xianpeng Huang, Chao Yu, Haibin Xu, Jiangjie Chen, Kaishun Xia, Kesi Shi, Yongxiang Zhang, Jingkai Wang, Jiawei Shu, Feng Cheng, Shaoke Wang, Chengzhen Liang, Fangcai Li, Xiaopeng Zhou, Qixin Chen

“…Herein, metabolic glycoengineering (MGE) is an easy but powerful technology for remodeling the structure of glycan. …”
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Investigation of the Cyanothece nitrogenase cluster in Synechocystis: a blueprint for engineering nitrogen-fixing photoautotrophs by Deng Liu, Anindita Bandyopadhyay, Michelle Liberton, Himadri B. Pakrasi, Maitrayee Bhattacharyya-Pakrasi

“…We demonstrate that besides the structural genes nifHDK, nifBSUENPVZTXW, as well as hesAB, are important for optimal nitrogenase function in a phototroph. We also show that optimal expression of these genes is crucial for efficient nitrogenase activity. …”
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Priority directions of institutional provision of regional development in the conditions of war by Yu.Р. Kharchenko

“…Obstacles to the integration of certain popular services into administrative service provision centers remain due to excessive centralization of powers to provide them.…”
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Machine learning developed immune-related exosome signature for prognosis and immunotherapy benefit in bladder cancer by Xiaoting Luo, Yi Luo

“…Results The RSF + Enet (alpha = 0.2) algorithm-based signature was considered as the optimal IES as it had a highest average C-index of 0.75. …”
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Abnormalities of the endocannabinoid system produce piercing nuclear hernias in migrating cerebral neurons by Yury M. Morozov, Pasko Rakic

“…This indicates that deviations from optimal functioning of the endocannabinoid system in under- or over-activity may trigger analogous mechanisms increasing intranuclear pressure and chromatin herniation. …”
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Molecularly engineered supramolecular fluorescent chemodosimeter for measuring epinephrine dynamics by Yudan Zhao, Yuxiao Mei, Zhichao Liu, Jing Sun, Yang Tian

“…Abstract Accurately visualizing epinephrine (EP) activity is essential for understanding its physiological functions and pathological processes in brain. …”
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Health dashboard for information management in cervical cancer screening by Adriana Aparecida Paz, Alloma Christine de Madureira Paula, Ananda Miranda de Lima, Gisele Lopes Castro, Mayara Casagrande Batista da Silva, Lunara Teles Silva

“…The model is reusable, which makes it a powerful tool for opportunistic and organized screening activities in the context of Primary Health Care. …”
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Modeling of the processes of functioning of an organizational and technical system based on Markov random processes by A. O. Zheleznyakov, R. A. Zhilin

“…The considered approaches to modeling the processes of functioning of an organizational and technical system are a powerful tool for making informed and effective management decisions, they allow you to take into account many factors, conduct scenario analysis and optimize solutions, as well as use computers for more accurate and complex calculations.…”
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Motor Unit Sampling From Intramuscular Micro-Electrode Array Recordings by Agnese Grison, Jaime Ibanez Pereda, Dario Farina

“…Through systematic offline analyses of these recordings, we tested different electrode configurations to identify optimal setups for accurately capturing motor unit activity. …”
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