Geochemical and microbial factors driving crustacean assemblages in adjacent aquifer units within the same aquifer by T. Di Lorenzo, T. Di Lorenzo, T. Di Lorenzo, T. Di Lorenzo, S. Amalfitano, S. Amalfitano, D. M. P. Galassi, M. Melita, M. Melita, M. Melita, A. Zoppini, D. Parrone, S. Ghergo, D. Rossi, A. Tabilio Di Camillo, A. Tabilio Di Camillo, E. Preziosi

“…We unveiled significant differences in both the taxonomic and functional composition of groundwater crustaceans across the three AUs, and these patterns remained consistent throughout the survey period. …”
Get full text

Organic substitution regulated the soil microbial communities by modifying nutrient limitations in saline-alkaline soils by Yue Han, Zhanli Ma, Rui Chen, Yue Wen, Yonghui Liang, Jinzhu Zhang, Wenhao Li, Zhenhua Wang

“…Organic amendment strategies significantly influence soil microbial community structure and functional activity, particularly in salt-affected agroecosystems. …”
Get full text

The dynamic role of ferroptosis in cancer immunoediting: Implications for immunotherapy by Jiarui Lan, Dan Cai, Shuang Gou, Yulin Bai, Huaqing Lei, Yan Li, Yu Chen, Yueshui Zhao, Jing Shen, Xu Wu, Mingxing Li, Meijuan Chen, Xiaobing Li, Yuhong Sun, Li Gu, Wanping Li, Fang Wang, Chi Hin Cho, Yan Zhang, Xin Zheng, Zhangang Xiao, Fukuan Du

“…Targeting ferroptosis is an emerging area in cancer immunotherapy, and our findings reveal that the antioxidant systems associated with ferroptosis possess dual roles, functioning differently across the three phases of cancer immunoediting. …”
Get full text

Youth co-production for sustainable engagement and empowerment in health (YiPEE): protocol for a cluster-randomised controlled trial of an intervention for mental health promotion... by Josefien van Olmen, Pilvikki Absetz, Mark Tomlinson, Carina King, Edwin Wouters, Josefien van Olmen, G J Melendez-Torres, Jeroen De Man, Stefan Swartling Peterson, Suresh Kumar, Mariam Claeson, Monika Martens, Frances Mathews, Christina A Laurenzi, Yoona Kim, Yeukai Chideya, Maria Niemi, Vijaya Raghavan, Jill Åhs, Anu Linnansaari, Fredric Azariah, Moitreyee Sinha, Upasana Sharma, Orlaith O’Sullivan, Yoo Na Kim, Akshaya Rajesh, Samyukta Saravanan, Nivetha Vasanthan, N P Haritha, Lander Willem, Jeroen de Man, Christina Laurenzi, GJ Melendez Torres, Matt Hughsam, Maureen Gikonyo, Joyce Arita

“…The intervention consists of: an 8-week classroom-based component, a 12-week teacher-focused component and a board comprising members from across the whole school. All children attending Grade 7 (aged 12–15) will be exposed to the classroom component, and teachers who actively teach Grade 7 will be invited to participate in the teacher component. …”
Get full text

Comprehensive multi‐tissue epigenome atlas in sheep: A resource for complex traits, domestication, and breeding by Deyin Zhang, Jiangbo Cheng, Xiaolong Li, Kai Huang, Lvfeng Yuan, Yuan Zhao, Dan Xu, Yukun Zhang, Liming Zhao, Xiaobin Yang, Zongwu Ma, Quanzhong Xu, Chong Li, Xiaojuan Wang, Chen Zheng, Defu Tang, Fang Nian, Xiangpeng Yue, Wanhong Li, Huibin Tian, Xiuxiu Weng, Peng Hu, Yuanqing Feng, Peter Kalds, Zhihua Jiang, Yunxia Zhao, Xiaoxue Zhang, Fadi Li, Weimin Wang

“…Abstract Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic functional annotation of the sheep genome is lacking. …”
Get full text

Overall Layout Method of Frame Structure Plane Based on Generative Adversarial Network by ZHONG Yan, LEI Xin, LONG Danbing, FANG Changjian, KANG Yongjun

“…The model’s generated frame columns met functional requirements, were well-placed, and had appropriate size and density. …”
Get full text

Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features by Milin Kim, Nitin Sharma, Esten H. Leonardsen, Saige Rutherford, Geir Selbæk, Karin Persson, Nils Eiel Steen, Olav B. Smeland, Torill Ueland, Geneviève Richard, Aikaterina Manoli, Sofie L. Valk, Dag Alnæs, Christian F. Beckman, Andre F. Marquand, Ole A. Andreassen, Lars T. Westlye, Thomas Wolfers, Torgeir Moberget

Get full text

Integrative Transcriptome‐Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibilit... by Yan Liang, Xiang‐Yu Xiong, Guo‐Wang Lin, Xiaomeng Bai, Fugui Li, Josephine Mun‐Yee Ko, Yun‐He Zhou, An‐Yi Xu, Shu‐Qiang Liu, Shuai He, Pan‐Pan Wei, Qiu‐Yan Chen, Lin‐Quan Tang, Vivien Ya‐Fan Wang, Hai‐Qiang Mai, Chun‐Ling Luo, Yanni Zeng, Maria Li Lung, Mingfang Ji, Jin‐Xin Bei

“…Functional assays demonstrate that VAMP8 exerts a tumorigenic role in NPC, enhancing cell proliferation, migration, and tumor growth. …”
Get full text

Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study by Chenxi Wang, He Xie, Binjia Sun, Kexin Tang, Haiou Wang, Zelin Zhao, Qinxiang Zheng, Jie Wu, Qi Zhang, Baihua Chen, He Dong, Jizhong Yang, Hai Liu, Feng Wen, Tao Sun, Jinsong Xue, Shaozhen Zhao, Limin Chen, Zhirong Liu, Yanning Yang, Xunlun Sheng, Pengcheng Wu, Yuping Han, Wei Qiang, Qi Xie, Yingnan Xu, Hui Liu, Man Yu, Linying Huang, Huiping Li, Ruifen Wei, Minye Wang, Gang Chen, Yan Cheng, Wei Chen

Get full text

Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state by Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran, Faith Aloboudi, May G Chan, Enzo Peroni, Grace Pereira, Alba López-Moraga, Anna Pallé, Eyal Y Kimchi, Nancy Padilla-Coreano, Romy Wichmann, Kay M Tye

“…Engaging in social interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However, the identity, interconnectivity, and functional encoding of social information within these circuits remains poorly understood. …”
Get full text

Clinical characteristics and prognosis of acute stroke in pregnancy and puerperium (ASPP) patients and their offspring: a retrospective, observational, nationwide, multicenter stud... by Zhongji Zhang, Zihan Yin, Tong Liu, Xiaolin Zhang, Qihang Zhang, Junlin Lu, Long Mu, Yang Dong, Juning Liu, Yi Xiao, Yanming Chen, Chenyang Song, Zengguang Wang, Yuheng Liu, Wei Ding, Li Zhang, Huaizhang Shi, Jingtao Qi, Bin Tang, Fei Wang, Pin Guo, Yongjun Tang, Mingsheng Yu, Wenjian Zheng, Qinglong He, Jian Yu, Aihua Zhu, Dazhao Fang, Gang Li, Yu Bai, Yushuang Zhang, Jiaxi Li, Yuli Wang, Faliang Gao, Yonggang Ma, Yifan Liu, Li Ma, Bao Yang, Yahui Zhao, Xun Ye, Qian Zhang, Yan Zhang, Xingju Liu, Jizong Zhao, on behalf of the ASPP Study Group

“…Primary outcomes include unfavorable functional outcomes (mRS > 2 or EQ-5D index score < 0.7) at follow-up for Aim 1, recurrent strokes (neuroimaging-confirmed) for Aim 2, and neonatal asphyxia (Apgar scoring) and future development (ASQ-3) of offspring for Aim 3. …”
Get full text

Comparative effectiveness of epilepsy surgery versus additional anti-seizure medications for Lennox–Gastaut syndrome: study protocol for a multicenter, mixed-methods study by Sandi Lam, Sandi Lam, Marc Rosenman, Marc Rosenman, Tracy Dixon-Salazar, Kelly G. Knupp, Liu Lin Thio, Taylor J. Abel, Taylor J. Abel, William P. Welch, William P. Welch, Laurel Reed, Laurel Reed, Stephanie C. Randle, Stephanie C. Randle, Rebecca Garcia-Sosa, Rebecca Garcia-Sosa, Jason S. Hauptman, Carolyn C. Foster, Carolyn C. Foster, Elizabeth R. Alpern, Elizabeth R. Alpern, Lu Zhang, Lu Zhang, Nicole Villalba, Nicole Villalba, Maura Carroll, Anup D. Patel

“…Aim 2 will describe the real-world utilization of these treatments across multiple healthcare institutions in the United States. …”
Get full text

95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa by Alessandra Orfano, Awa Cisse, Zizhang Sheng, Yicheng Guo, Leeah Han, Laty G. Thiam, Khadidiatou Mangou, Adam J. Moore, Aboubacar Ba, Rebecca Li, Mariama N. Pouye, Fatoumata Diallo, Seynabou D. Sene, Elhadji Malick Ngom, Bacary D. Sadio, Alassane Mbengue, Christopher Membi, Thomas Bazié, Fabrice Anyirékun Somé, Natalie Olson, Saurabh Patel, Lawrence Shapiro, Sunil Parikh, Brian Foy, Michael Cappello, Zul Premji, Roch K. Dabiré, Jean-Bosco Ouedraogo, Amy K. Bei

“…Further research exploring the functional implications of these variations will be important to elucidate their role in malaria transmission.…”
Get full text

Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
Get full text

Supporting African communities to increase resilience and mental health of kids with developmental disabilities and their caregivers using the World Health Organization’s Caregiver... by Melissa Washington-Nortey, Vibian Angwenyi, Mekdes Demissie, Eva Mwangome, Tigist Eshetu, Hanna Negussie, Kimberley Goldsmith, Andrew Healey, Merga Feyasa, Girmay Medhin, Amanuel Belay, Temesgen Azmeraw, Medhanit Getachew, Rahel Birhane, Carophine Nasambu, Tsegereda Haile Kifle, Angela Kairu, Beatrice Mkubwa, Fikirte Girma, Rehana Abdurahman, Ruth Tsigebrhan, Liya Tesfaye, Leonard Mbonani, Nadine Seward, Tony Charman, Andrew Pickles, Erica Salomone, Chiara Servili, Edwine Barasa, Charles R. Newton, Charlotte Hanlon, Amina Abubakar, Rosa A. Hoekstra

“…We aim to recruit 544 child-caregiver dyads, evenly distributed across the two arms and countries. The co-primary outcomes are the child-focused Child Behavior Checklist (assessing emotional and behavioural problems) and the caregiver-focused Pediatric Quality of Life Inventory (assessing caregiver quality of life), both assessed at endpoint. …”
Get full text

Genome sequencing of ‘Fuji’ apple clonal varieties reveals genetic mechanism of the spur-type morphology by Yudong Cai, Xiuhua Gao, Jiangping Mao, Yu Liu, Lu Tong, Xilong Chen, Yandong Liu, Wenyan Kou, Chuanjun Chang, Toshi Foster, Jialong Yao, Amandine Cornille, Muhammad Mobeen Tahir, Zhi Liu, Zhongye Yan, Siyi Lin, Fengwang Ma, Juanjuan Ma, Libo Xing, Na An, Xiya Zuo, Yanrong Lv, Zhengyang Zhao, Wenqiang Li, Qianjin Li, Caiping Zhao, Yanan Hu, Hangkong Liu, Chao Wang, Xueyan Shi, Doudou Ma, Zhangjun Fei, Yu Jiang, Dong Zhang

“…Several putative functional somatic variants have been identified, including a spur-type-specific deletion in the promoter of the TCP transcription factor gene MdTCP11. …”
Get full text

Unlocking data: Decision-maker perspectives on cross-sectoral data sharing and linkage as part of a whole-systems approach to public health policy and practice by Emily Tweed, Kristina Cimova, Peter Craig, Mirjam Allik, Denise Brown, Mhairi Campbell, David Henderson, Charlie Mayor, Petra Meier, Nick Watson

“…This covered three key overarching themes: differing understandings of evidence; diverse functions of evidence; and factors affecting use (such as technical, political and institutional, workforce and governance). …”
Get full text

Daily Mobility in Metropolitan Areas by Marcela Soto Caro

“…Such day-to-day activities are further shaped by more dynamic and perhaps more subtle influences such as the changing functions of the urban space, increasing socioeconomic fragmentation and segmentation and the inequitable provision of public transport across what is a topographically complex area. …”
Get full text

Prospects of Predicting the Polar Motion Based on the Results of the Second Earth Orientation Parameters Prediction Comparison Campaign by Tomasz Kur, Justyna Śliwińska‐Bronowicz, Malgorzata Wińska, Henryk Dobslaw, Jolanta Nastula, Aleksander Partyka, Santiago Belda, Christian Bizouard, Dale Boggs, Sara Bruni, Lue Chen, Mike Chin, Sujata Dhar, Robert Dill, PengShuo Duan, Jose M. Ferrandiz, Junyang Gou, Richard Gross, Sonia Guessoum, Songtao Han, Robert Heinkelmann, ChengLi Huang, Christopher Irrgang, Jacek Kudrys, Jia Li, Marcin Ligas, Lintao Liu, Weitao Lu, Volker Mayer, Wei Miao, Maciej Michalczak, Sadegh Modiri, Michiel Otten, Todd Ratcliff, Shrishail Raut, Jan Saynisch‐Wagner, Matthias Schartner, Erik Schoenemann, Harald Schuh, M. Kiani Shahvandi, Benedikt Soja, Xiaoqing Su, Daniela Thaller, Maik Thomas, Guocheng Wang, Yuanwei Wu, CanCan Xu, Xueqing Xu, Xinyu Yang, Xin Zhao, Zhijin Zhou

“…Predictions of PMy are usually more accurate and have a smaller spread across all submitted files when compared to PMx. We present an analysis of similarity between the participants to indicate what methods and input data give comparable output. …”
Get full text

Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…The intervention, its intensity and follow-up period varied across studies. Most studies had short follow-ups (maximum of 12–18 months). …”
Get full text