Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties by Jan Šťastný, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Tomáš Skala, Andrea Bernardos, Andrea Bernardos, Andrea Bernardos, Petr Maršík, Araceli Lérida-Viso, Araceli Lérida-Viso, Araceli Lérida-Viso, Jaroslav Matějka, Anna Mascellani Bergo, María Dolores Marcos, María Dolores Marcos, María Dolores Marcos, Ramón Martínez-Máñez, Ramón Martínez-Máñez, Ramón Martínez-Máñez, Ivan Jablonský, Pavel Klouček

“…Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. Besides exploration of the most active components in different species or genotypes, new formulation techniques are in development. …”
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Tracking neural activity patterns during rapid high-altitude transitions by Ji-Yu Xie, Yi Zhang, Wei Shen, Liying Wu, Quanhao Yu, Zhen Lyu, Liangyuan Song, Rui Yang, Shuyi Ning, Wenwen Duan, Ying Li, Yimeng Liu, Xuemin Wang, Liping Chen, Jie Weng, Yonglan Du, Xiao Li, Taicheng Huang, Hailin Ma, Quansheng Gao, Haitao Wu, Ti-Fei Yuan

“…Extensive studies have observed human behavior and brain activity in a stable environment, but there is still a lack of understanding of how our brain's functional activity drives behavioral changes when the natural environment changes. …”
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Multi-dimensional Exposure Characteristics and Health Benefits Differentiation of Green Spaces within Community Life Circle by Hailin HONG, Qing CHANG

“…The green space metrics comprise four types of green spaces (residential green space, park green space, street green space, and other green spaces) across two dimensions (passive exposure and active exposure). …”
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Realidad virtual inmersiva y su influencia en parámetros fisiológicos de personas sanas (Immersive virtual reality and its influence on physiological parameters in healthy people)... by Gustavo Rodriguez-Fuentes, Pablo Campo-Prieto, Xose Carlos Souto, Jose Maria Cancela Carral

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Interaction effect of comorbid depression and proactive positivity coping strategy on the 1-year survival of patients with advanced cancer: a nationwide multicentre study in South... by Ju Youn Jung, Je-Yeon Yun, Jung Hun Kang, Su-Jin Koh, Yu Jung Kim, Seyoung Seo, Jung Hoon Kim, JaeKyung Cheon, Eun Joo Kang, Eun-Kee Song, Eun Mi Nam, Ho-Suk Oh, Hye Jin Choi, Jung Hye Kwon, Woo-Kyun Bae, Jung Eun Lee, Kyung Hae Jung, EunKyo Kang, Young Ho Yun

“…A total of 144 patients who were aware of their cancer diagnosis were recruited from 12 tertiary hospitals across South Korea between October 2017 and October 2018. …”
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The triple-helix model as foundation of innovative entrepreneurial ecosystems by Klaus Bruno Schebesch, Horațiu Florin Șoim, Radu Lucian Blaga

“…This study aims at leveraging the city-based view on entrepreneurial ecosystems, to enable new ways of boosting the functionality of triple-helix minded programs, especially so for emerging economies and their cross-border regions. …”
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The agricultural plastic paradox: Feeding more, harming more? by Kai Wang, Xuejun Liu, David R. Chadwick, Changrong Yan, Michaela Reay, Tida Ge, Fan Ding, Jingkuan Wang, Ruimin Qi, Mouliang Xiao, Rui Jiang, Yanling Chen, Ji Ma, Charlotte Lloyd, Richard P. Evershed, Yongming Luo, Yongguan Zhu, Fusuo Zhang, Davey L. Jones

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Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility by Jiao Gong, Huiru Sun, Kaiyuan Wang, Yanhui Zhao, Yechao Huang, Qinsheng Chen, Hui Qiao, Yang Gao, Jialin Zhao, Yunchao Ling, Ruifang Cao, Jingze Tan, Qi Wang, Yanyun Ma, Jing Li, Jingchun Luo, Sijia Wang, Jiucun Wang, Guoqing Zhang, Shuhua Xu, Feng Qian, Fang Zhou, Huiru Tang, Dali Li, Chinese Pangenome Consortium (CPC), Fritz J. Sedlazeck, Li Jin, Yuting Guan, Shaohua Fan

“…Our results suggest that the GSDMD SV could serve as a rapid and cost-effective biomarker for assessing the risk of cisplatin-induced acute kidney injury. The functional conservation from human to mouse and widespread signals of positive natural selection suggest that both SVs likely influence local adaptation, phenotypic diversity, and disease susceptibility across diverse human populations.…”
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Surface display of Lys0859, a Streptococcus suis prophage lysin, on Bacillus subtilis spores and its antibacterial activity against Streptococcus suis by Linkang Wang, Linkang Wang, Linkang Wang, Xiaochao Duan, Xiaochao Duan, Xiaochao Duan, Xiaochao Duan, Mengyuan Zhu, Mengyuan Zhu, Mengyuan Zhu, Haiyan Wang, Haiyan Wang, Haiyan Wang, Haiyan Wang, Xinxin Li, Xinxin Li, Xinxin Li, Xinxin Li, Dayue Hu, Dayue Hu, Dayue Hu, Dayue Hu, Xiangmin Li, Xiangmin Li, Xiangmin Li, Xiangmin Li, Ping Qian, Ping Qian, Ping Qian, Ping Qian

“…In vivo, spore treatment reduced S. suis SC19 colonization by 0.47–1.96 log units (p < 0.05) across all tissues compared with PBS controls.DiscussionThis study achieved functional display of prophage lysin Lys0859 on B. subtilis spores through CotG anchoring, demonstrating potent in vitro anti-streptococcal activity. …”
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TROLL 4.0: representing water and carbon fluxes, leaf phenology, and intraspecific trait variation in a mixed-species individual-based forest dynamics model – Part 2: Model evaluat... by S. Schmitt, S. Schmitt, S. Schmitt, F. J. Fischer, J. G. C. Ball, N. Barbier, M. Boisseaux, D. Bonal, B. Burban, X. Chen, G. Derroire, G. Derroire, G. Derroire, J. W. Lichstein, D. Nemetschek, N. Restrepo-Coupe, S. Saleska, G. Sellan, P. Verley, G. Vincent, C. Ziegler, J. Chave, I. Maréchaux

“…In a companion paper, we describe how the model represents the physiological and demographic processes that control the tree life cycle in a 1 m resolution spatially explicit scene and uses plant functional traits measurable in the field to parameterize such processes across species and individuals (Maréchaux et al., 2025). …”
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Impact of short-term aircraft noise on cardiovascular disease risk in the area surrounding London Heathrow airport: the RISTANCO epidemiological study by Xiangpu Gong, Nicole Itzkowitz, Calvin Jephcote, Kathryn Adams, Glory O Atilola, John Gulliver, Marta Blangiardo, Anna Hansell

“…We first looked at how aircraft noise varies across the day in areas affected by noise from aircraft arriving at and departing from London Heathrow airport. …”
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Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Further research is needed to address the technical limitations, evaluate broader cognitive functions, and extend durations to evaluate its therapeutic potential. …”
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Addressing Challenges in Simulating Inter–Annual Variability of Gross Primary Production by Ranit De, Shanning Bao, Sujan Koirala, Alexander Brenning, Markus Reichstein, Torbern Tagesson, Michael Liddell, Andreas Ibrom, Sebastian Wolf, Ladislav Šigut, Lukas Hörtnagl, William Woodgate, Mika Korkiakoski, Lutz Merbold, T. Andrew Black, Marilyn Roland, Anne Klosterhalfen, Peter D. Blanken, Sara Knox, Simone Sabbatini, Bert Gielen, Leonardo Montagnani, Rasmus Fensholt, Georg Wohlfahrt, Ankur R. Desai, Eugénie Paul‐Limoges, Marta Galvagno, Albin Hammerle, Georg Jocher, Borja Ruiz Reverter, David Holl, Jiquan Chen, Luca Vitale, M. Altaf Arain, Nuno Carvalhais

“…Both models simulated hourly GPP and were parameterized for (a) each site–year, (b) each site with an additional constraint on IAV (CostIAV), (c) each site, (d) each plant–functional type, and (e) globally. This was followed by forward runs using calibrated parameters, and model evaluations using Nash–Sutcliffe efficiency (NSE) as a model‐fitness measure at different temporal scales across 198 eddy‐covariance sites representing diverse climate–vegetation types. …”
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Geriatric Nutritional Risk Index Assessment in Patients Undergoing Transcatheter Edge-to-Edge Repair by Kenichi Shibata, PT, Masanori Yamamoto, MD, Ai Kagase, MD, Takahiro Tokuda, MD, Hiroshi Tsunamoto, MD, Testuro Shimura, MD, Azusa Kurita, MD, Ryo Yamaguchi, MD, Mike Saji, MD, Masahiko Asami, MD, Yusuke Enta, MD, Masaki Nakashima, MD, Shinichi Shirai, MD, Masaki Izumo, MD, Shingo Mizuno, MD, Yusuke Watanabe, MD, Makoto Amaki, MD, Kazuhisa Kodama, MD, Junichi Yamaguchi, MD, Toru Naganuma, MD, Hiroki Bota, MD, Yohei Ohno, MD, Masahiro Yamawaki, MD, Daisuke Hachinohe, MD, Hiroshi Ueno, MD, Kazuki Mizutani, MD, Toshiaki Otsuka, MD, Shunsuke Kubo, MD, Kentaro Hayashida, MD

“…Kaplan–Meier curves showed significantly better prognoses for the entire cohort, functional MR, and degenerative MR across the 4 groups (P < 0.001). …”
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Surgical management and postoperative outcomes of orbital cavernous malformations: A systematic literature review by the EANS skull base section by Edoardo Agosti, Vittorio Ricciuti, Giorgio Mantovani, Giorgia De Rosa, Pier Paolo Panciani, Marco Maria Fontanella, Cesare Zoia, Moncef Berhouma, Michaël Bruneau, Luigi Maria Cavallo, Jan Frederick Cornelius, Sebastien Froelich, Emmanuel Jouanneau, Diego Mazzatenta, Torstein R. Meling, Mahmoud Messerer, Dimitris Paraskevopoulos, Pierre-Hugues Roche, HenryWS. Schroeder, Marcos Tatagiba, Idoya Zazpe, Roy Thomas Daniel

“…Research objective: This systematic review aims to compare the resection rates, postoperative complications, and clinical outcomes across various surgical approaches for OCM management. …”
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European survey on CAR T-Cell analytical methods from apheresis to post-infusion immunomonitoring by Biagio De Angelis, Maria Luisa D’Amore, Pacôme Lecot, Kerstin Neininger, Margot Lorrain, Laetitia Gambotti, Caroline Dreuillet, Elise Courcault, Sampurna Chatterjee, Sampurna Chatterjee, Julio Delgado, Anne Galy, Paul Franz, Juan Roberto Rodriguez-Madoz, Yolanda Cabrerizo, Anne Richter, Charis Girvalaki, Maddalena Noviello, Elena Tassi, Carmen Sanges, Maik Luu, Michael Hudecek, Andreas Kremer, Franco Locatelli, Franco Locatelli, Helene Negre, Concetta Quintarelli, Concetta Quintarelli

“…Notably, a minority of respondents conducted phenotypical characterization of T-cell subsets in the drug product and assessed activation/exhaustion T cell profiles.ConclusionThe survey underscored the necessity to standardize CAR T-cell functional potency assays and identify predictive biomarkers for response, relapse, and toxicity. …”
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Interplay of health-related quality of life and comorbidities in people with type 2 diabetes mellitus treated in primary care settings in Austria: a countrywide cross-sectional stu... by Faisal Aziz, Martin Clodi, Michael Resl, Julia K Mader, Harald Kojzar, Susanne Kaser, Harald Sourij, Peter Fasching, Norbert Joachim Tripolt, Kehkishan Azhar, Caren Sourij, Bernhard Ludvik, Gersina Rega-Kaun, Claudia Ress, Lars Stechemesser, Harald Stingl, Thomas Wascher

“…Linear regression was used to assess the association of HRQoL domain scores with clinical covariates and comorbidities.Setting A countrywide study was conducted on individuals with established T2DM (N=635) attending primary healthcare services for various conditions across nine federal states of Austria from 2021 to 2023.Participants A total of 635 individuals, aged above 50 years and diagnosed with T2DM, were recruited by the attending physician to evaluate their HRQoL in relation to T2DM and its associated comorbidities.Results The mean SF-36 scores for physical functioning (69±28), role-physical (62±42), mental health (72±20), role-emotional (73±41), social functioning (79±25), bodily pain (67±28) and vitality (55±22) were satisfactory, except for general health (41±10). …”
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R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial by Elizabeth Kibwana, Caroline Bundi, Domtila Kimani, Lydia Nyamako, Kelvias Keter, Agnes Mutiso, Rodney Ogwang, Duncan Bellamy, Katerina Rapi, Amelia Bajer, Samuel Provstgaard-Morys, Lisa Stockdale, Olivia Munoz, Mehreen S. Datoo, Alison Lawrie, Fernando Ramos-Lopez, Rachel Roberts, Mainga Hamaluba, Mainga Hamaluba, Adrian V. S. Hill, Philip Bejon, Philip Bejon, Katie J. Ewer, Melissa Kapulu, Melissa Kapulu

“…Humoral immunity was evaluated by quantifying antigen specific antibody subtypes and subclasses via ELISA, alongside functional antibody properties including avidity and complement fixation elicited by vaccination and challenge. …”
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Multicentre pragmatic embedded stepped wedge cluster randomised trial comparing glucose 5% with sodium chloride 0.9% as the default drug diluent in the ICU: the sweet-water trial p... by Alexander Zarbock, Kai-Uwe Eckardt, Claudia Spies, Felix Balzer, Martin Witzenrath, Philipp Enghard, Björn Tampe, Oliver Hunsicker, Steffen Weber-Carstens, Bjoern Weiss, Jens Nee, Christian Strauss, Heiko Schenk, Jan-Hendrik Bernhard Hardenberg, Ricarda Merle Hinz, Mareen Pigorsch, Alexander Uhrig, Holger Müller-Redetzky, Tim Schroeder, Ulrike Trost, Daniel Zickler, Rainer Borgstedt, Mariam Abu-Tair, Uta Hildebrand, Dario von Wedel

“…Hypernatraemia adversely affects various physiological functions and is associated with delirium, prolonged length of stay and increased ICU and post-discharge mortality. …”
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Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis by Jing Yang, Jing Yang, Jing Yang, Wenyi Li, Wenyi Li, Wenyi Li, Mei Tian, Mei Tian, Mei Tian, Lei Zhang, Fengping Du, Fengping Du, Fengping Du, Xin Li, Xin Li, Xin Li, Qi Liu, Qi Liu, Qi Liu, Rui Li, Rui Li, Rui Li, Zhenzhong Li, Zhenzhong Li, Zhenzhong Li, Hui Dong, Hui Dong, Hui Dong, Yaling Liu, Yaling Liu, Yaling Liu

“…After controlling for age and sex, the ALS group had thinner cortexes in multiple clusters across the brain than the control group. Further analyses revealed that cortical thickness in the right superior temporal and lingual gyrus regions was inversely correlated with ΔFS scores. …”
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