Discovery of functional factorless internal ribosome entry site-like structures through virome mining. by Subash Chapagain, Nicolas Salcedo-Porras, Amir Abdolahzadeh, Yaohua Zhang, Higor Sette Pereira, Stephane Flibotte, Kevin Low, Christina Young, Yuhang Wu, Shao Wang, Soh Ishiguro, Nozomu Yachie, Trushar Patel, Artem Babaian, Eric Jan

“…Using a bioinformatics pipeline to examine the diversity and function of IRESs across RNA viromes, we searched for IRES-like RNA structures using RNA covariance models for multiple IRES sub-types, and tested functional IRES by using a dual-fluorescent lentiviral library reporter screen. …”
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Identification of Road Black Spots Based on the Sliding Window Optimization and Safety Performance Function Development by Shahin Shabani, Jalal Ayoubinejad, Nassir Baradaran Rahmanian

“…Next, a Safety Performance Function is developed to calculate the predicted and expected number of crashes, as well as the Potential Safety Improvement, for each window movement across all selected scenarios within the segment. …”
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A standardized method for collection of human placenta samples in the age of functional magnetic resonance imaging by Victoria HJ Roberts, Jessica E Gaffney, Katherine S Lewandowski, Matthias C Schabel, Terry K Morgan, Antonio E Frias

“…Current methods for placental tissue collection assess a delivered organ without direct functional correlates; therefore, the four-quadrant biopsy protocol utilized by many researchers may provide reasonable representation of tissue across a large organ, and offer a snapshot for molecular analysis of the placenta. …”
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Integrative analysis of SEPN1 in glioma: Prognostic roles, functional implications, and potential therapeutic interventions. by Zisong Wang, Danwen Wang, Xuanyu Wang, Yihang Xu, Yunhe Yuan, Yuxin Chen, Zhiqiang Li, Xiaoping Liu

“…This study aims to investigate the expression, prognostic significance, and tumor microenvironment (TME) relevance of SEPN1 across pan-cancer, with a particular focus on glioma.…”
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Multiple Mechanisms to Regulate Actin Functions: “Fundamental” Versus Lineage-Specific Mechanisms and Hierarchical Relationships by Taro Q. P. Uyeda, Yosuke Yamazaki, Saku T. Kijima, Taro Q. P. Noguchi, Kien Xuan Ngo

“…Additionally, while certain mechanisms are fundamental and ubiquitous across eukaryotes, others are lineage-specific. Here, we emphasize the fundamental importance and functional significance of the following actin regulatory mechanisms: the biochemical regulation of actin nucleators, the ATP hydrolysis-dependent aging of actin filaments, thermal fluctuation- and mechanical strain-dependent conformational changes of actin filaments, and cooperative conformational changes induced by actin-binding proteins.…”
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Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles by Deok-Hyeon Cheon, Sheejune Park, Jihyun Park, MinSeo Koo, Hyun-Hyung Kim, Seol Han, Hyung Jin Choi

“…The LH is characterized by high heterogeneity and functional complexity, with many aspects still unexplored. …”
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Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning by Etienne Combrisson, Ruggero Basanisi, Matteo Neri, Guillaume Auzias, Giovanni Petri, Daniele Marinazzo, Stefano Panzeri, Andrea Brovelli

“…Higher-order synergistic interactions were characterized by long-range relationships centered in the ventromedial and orbitofrontal cortices, which served as key receivers in the broadcast of information gain across cortical circuits. Overall, this study provides evidence that information gain is encoded through synergistic and higher-order functional interactions and is broadcast to prefrontal reward circuits.…”
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SuperEdgeGO: Edge-supervised graph representation learning for enhanced protein function prediction. by Shugang Zhang, Yuntong Li, Wenjian Ma, Qing Cai, Jing Qin, Xiangpeng Bi, Huasen Jiang, Xiaoyu Huang, Zhiqiang Wei

“…The implementation of edge supervision in SuperEdgeGO resulted in enhanced graph representations for protein function prediction, as demonstrated by its superior performance across all the evaluated categories. …”
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The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. by Ursula Straschil, Arthur M Talman, David J P Ferguson, Karen A Bunting, Zhengyao Xu, Elizabeth Bailes, Robert E Sinden, Anthony A Holder, Elizabeth F Smith, Juliet C Coates, Rita Tewari

“…Using homology modelling, bioinformatics analysis and complementation studies in Chlamydomonas, we show that some regions of the PF16 protein are highly conserved across all eukaryotes, whereas other regions may have species-specific functions. …”
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Rectified Tangent Activation (RTA): A Novel Activation Function for Enhanced Deep Learning Performance by Gaurav Kumar Pandey, Sumit Srivastava

“…In deep learning, activation functions (AFs) influence a model’s performance, convergence rate, and generalization capability. …”
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The Effect of Grazing on Central Anatolian Steppe Vegetation: A Modeling Approach Using Functional Traits by Anıl Bahar, Çağatay Tavşanoğlu

“…Our simulations incorporated a range of plant functional traits to predict changes across five different vegetation types in Central Anatolia, including woodland steppes and treeless steppes. …”
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Predictive Utility of the Functional Movement Screen and Y-Balance Test: Current Evidence and Future Directions by Adam C. Eckart, Pragya Sharma Ghimire, James Stavitz, Stephen Barry

“…This review analyzes the Functional Movement Screen (FMS) and the Y-Balance Test (YBT) landscape. …”
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Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury by Armin Iraji, Hanbo Chen, Natalie Wiseman, Robert D. Welch, Brian J. O’Neil, E. Mark Haacke, Tianming Liu, Zhifeng Kou

“…Three hundred fifty-eight brain landmarks that preserve structural and functional correspondence of brain networks across individuals were used to investigate longitudinal brain connectivity. …”
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Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization analysis by Bing Zhou, Minping Hong, Liqin Jin, Keng Ling

“…Our MR analysis further supported this finding, demonstrating no significant association between creatine levels and six indicators assessing renal function (IVW, all with p values exceeding 0.05). Similar p values were consistently observed across other MR methods, confirming the absence of a statistical correlation.Conclusions This MR study offers compelling evidence indicating that creatine levels are not statistically associated with renal function, suggesting the potential to alleviate concerns within the fitness community and emphasizing the significance of evidence-based decision-making when considering nutritional supplementation.…”
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Educational multimedia design principles affect local and global information processing in functional brain networks by Mohammadhossein Ostadi, Masoumeh Golmohamadian, Alireza Bosaghzadeh, S. Hamid Amiri, Reza Ebrahimpour

“…Two distinct multimedia programs were constructed using identical auditory content but differing visual designs: one adhered to five guidelines for optimizing multimedia instruction, referred to as principal multimedia, while the other intentionally violated these guidelines, referred to as non-principal multimedia. Cortical functional brain networks were then extracted from EEG data to evaluate local and global information processing across the two conditions. …”
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Compositional and functional characterization of cucumber and watermelon seed powders and their application in fortified dairy-based dessert by Richa Bhtoya, Ankita Dobhal, Shweta Joshi, Ravneet Kaur

“…The growing emphasis on sustainable nutrition has encouraged the exploration of underutilized plant by-products for functional food development. This study evaluated the nutritional, phytochemical, and techno-functional attributes of cucumber (Cucumis sativus L.) and watermelon (Citrullus lanatus) seed powders, and their application in dairy-based dessert. …”
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Influence of Elevated Potassium Fertilization on Structural and Functional Properties of Sweet Potato Root Tuber Starch by Ke Guo, Shuai Liu, Long Zhang, Qian Zhang, Yang Yu, Peiyong Ma, Zhaodong Jia, Cunxu Wei, Xiaofeng Bian

“…The structural and functional properties of the starches were subsequently analyzed. …”
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Neural Posterior Estimation for Cataloging Astronomical Images with Spatially Varying Backgrounds and Point Spread Functions by Aakash Patel, Tianqing Zhang, Camille Avestruz, Jeffrey Regier, The LSST Dark Energy Science Collaboration

“…This result suggests that a single NPE network can generalize across spatial variations, eliminating the need for retraining on each observational condition.…”
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Lactate-induced metabolic signaling is the potential mechanism for reshaping the brain function - role of physical exercise by Xueqiang Zhu, Wenjia Chen, Ricardo A. Pinho, Anand Thirupathi

“…This review examines how exercise-induced lactate formation acts as both an energy substrate and signaling molecule to reshape brain function, focusing on its metabolic and molecular mechanisms across different neural cell types. …”
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Carob Pod Nanoparticles: enhancing physicochemical, antioxidant, and antibacterial properties of innovative functional frozen yogurt by Amro Abdelazez, Ghada Abady, Monira Basiony, Atef A. Abd El-Rahman, Sally M. A. El-Shafei, Emad S. Shaker, Garsa Alshehry, Eman Algarni, Huda Aljumayi, Amina Mahmoud Hassan

“…Over a 45-day storage period, the chemical properties remained stable across all groups, with no significant differences observed (p < 0.05). …”
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