Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer by He J, Akhtar A, Li J, Wei Q, Yuan Y, Ran J, Ma Y, Chen D

“…Next, we applied bulk RNA-seq deconvolution algorithms to estimate the abundance of this subpopulation across breast cancer cohorts. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were employed to identify genes associated with the IGKC+ T cell population. …”
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Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment – A post-hoc analysis from the phase 2B FORWARD study by Felix Eckstein, Susanne Maschek, Wolfgang Wirth, Christoph Ladel, Asger Reinstrup Bihlet, Chris Knight, Kenneth Somberg, Luping Zhao

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Atomic layer deposition of SnO2 and TiO2 on electrodeposited BiOI thin films for efficient light-driven peroxymonosulfate activation by Laura Huidobro, Mahmoud Abid, Haitham Maslouh, Arnaud Demore, Mikhael Bechelany, Elvira Gómez, Albert Serrà

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FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma by Yuan Hepei, Zeng Jun, Khan Muhammad, Wang Baiyao, Hu Xiaoshan, Wei Hao, Wang Zhaotong, Yuan Yawei

“…Single-cell RNA-seq confirmed differential PRG expression across tumor, stromal, and immune cells. Among the PRG risk genes, FNDC5 and ACOX1 were identified as key biomarkers. …”
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Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes by Wenxu Wang, Wenxu Wang, Jincheng Lu, Jincheng Lu, Ningyun Pan, Ningyun Pan, Huiying Zhang, Jingcen Dai, Jie Li, Cheng Chi, Liumei Zhang, Liang Wang, Mengying Zhang, Mengying Zhang

“…We further performed gene set variation analysis (GSVA), functional enrichment analysis, and immune cell infiltration analysis to investigate differences between the identified AD subtypes. …”
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Comorbid anxiety, loneliness, and chronic pain as predictors of intervention outcomes for subclinical depressive symptoms in older adults: evidence from a large community-based stu... by Stephanie Ming Yin Wong, Dara Kiu Yi Leung, Tianyin Liu, Zuna Loong Yee Ng, Gloria Hoi Yan Wong, Wai Chi Chan, Terry Yat Sing Lum

“…Those with non-remission and non-response showed more depression-related functional impairments and poorer health-related quality of life post-intervention. …”
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Introducing the dataset for measuring centrality for sustainability—A case study of Pecinci municipality, SerbiaMendeley DataMendeley Data by Tatjana Mrđenović

“…The current theories and practices of planning central activities in Serbia primarily rely on functional factors of network flow. However, this approach aims to enhance the current practice of data utilisation for the sustainable development of central activities and integrative central places. …”
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Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis by Sadique Hussain, Gaurav Gupta, Moyad Shahwan, Pooja Bansal, Harpreet Kaur, Mahamedha Deorari, Kumud Pant, Haider Ali, Sachin Kumar Singh, Venkata Sita Rama Raju Allam, Keshav Raj Paudel, Kamal Dua, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…GPX4, as the principal orchestrator of ferroptosis, has garnered significant attention across cancer, cardiovascular, and neuroscience domains over the past decade. …”
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Analysis of endophytic bacterial diversity of Puerariae thomsonii from different production areas and their correlation with secondary metabolites by Yang Xu, Yang Xu, Lihua Zeng, Lihua Zeng, Zheng Peng, Zheng Peng, Nana Chang, Nana Chang, Ye Wang, Ye Wang, Lingling Zheng, Lingling Zheng, Yan Ren, Yan Ren, Hui Li, Hui Li, Hui Li, Tielin Wang, Tielin Wang

“…In addition, differences in endophytic bacteria across the samples from different productions were analyzed using LEfSe analysis. …”
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Optimization of phenolic extraction method and in vitro bioaccessibility of microencapsulated pigmented rice bran extracts and their antioxidant and anticancer properties by Rhowell Navarro Tiozon, Jr., Glenn Vincent P. Ong, Kristel June D. Sartagoda, Sheba Mae M. Duque, Saleh Alseekh, Aldrin P. Bonto, Shem Gempesaw, Jr., Vipin Pratap, Florencio C. Reginio, Jr., Jonina Marie J. Tengco, Christian Seagan, Joel H G Tolentino, Dennis Marvin O. Santiago, Alisdair R. Fernie, Nese Sreenivasulu

“…The results support the integration of rice bran extracts into the rice value chain, promoting their use in functional health applications.…”
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Genome-wide characterization of GRAS gene family and their expression profiles under diverse biotic and abiotic stresses in Amorphophallus konjac by Haoliang Shi, Ming Yang, Zhongsi Liu, Jianrong Zhao, Ying Qi, Jianwei Guo, Penghua Gao, Feiyan Huang, Jiani Liu, Lei Yu, Lifang Li

“…Six pairs of duplicated genes were identified within the AkGRAS gene family. Protein-protein functional associations analysis suggested that the top three functionally associated proteins were RGA, PAT1-2, and NSP2 in Arabidopsis thaliana. …”
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Assessment of psychosocial aspects in adults in post-COVID-19 condition: the EURONET-SOMA recommendations on core outcome domains for clinical and research use by Stefan Salzmann, Lars de Vroege, Petra Engelmann, Per Fink, Susanne Fischer, Stephan Frisch, Lise Kirstine Gormsen, Katharina Hüfner, Willem J. Kop, Ferenc Köteles, Nadine Lehnen, Bernd Löwe, Christoph Pieh, Victor Pitron, Charlotte Ulrikka Rask, Markku Sainio, Rainer Schaefert, Meike Shedden-Mora, Anne Toussaint, Roland von Känel, Ursula Werneke, Winfried Rief, on behalf of the EURONET-SOMA Group

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Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma by Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili

“…<b>Results</b>: Radioligand binding results highlighted that the derivatives bearing a terminal butyl chain showed structure–activity relationships different from those with a benzyl terminal. From functional studies performed on the best derivatives <b>12</b> and <b>16</b>, the response profiles of both compounds were more robust in antagonist mode, with derivative <b>16</b> showing higher antagonist potency than <b>12</b> across all three transducers. …”
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Single−cell transcriptomic landscape of sciatic nerve after transection injury by Yiben Ouyang, Mingqian Yu, Tieyuan Zhang, Haofeng Cheng, Liang Zuo, Haolin Liu, Yanjun Guan, Ao Liu, Jiajie Chen, Ruichao He, Sice Wang, Tianqi Su, Yixiao Tan, Yuhui Cu, Xiaochun Zhang, Xiaoyang Fu, Junli Wang, Jinjuan Zhao, Jiang Peng, Yu Wang

“…Abstract Peripheral nerve injuries, particularly those affecting the sciatic nerve, often result in incomplete functional recovery due to the limited regenerative capacity of adult peripheral nerves. …”
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Twenty‐Four‐Hour Post‐Thrombolysis NIHSS Score As the Strongest Prognostic Predictor After Acute Ischemic Stroke: ENCHANTED Study by Shoujiang You, Yanan Wang, Xia Wang, Toshiki Maeda, Menglu Ouyang, Qiao Han, Qiang Li, Lili Song, Yang Zhao, Chen Chen, Candice Delcourt, Xinwen Ren, Cheryl Carcel, Zien Zhou, Yongjun Cao, Chun‐Feng Liu, Danni Zheng, Hisatomi Arima, Thompson G. Robinson, Xiaoying Chen, Richard I. Lindley, John Chalmers, Craig S. Anderson

“…The 24‐hour NIHSS score (≤3) was the best predictor of 90‐day excellent functional recovery (mRS score 0–1). Findings were consistent across subgroups, including sex, race, baseline NIHSS score, stroke subtype, and age. …”
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Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, Xinjiang by Jingru Yang, Jingru Yang, Jingru Yang, Zhuang Qiang, Zhuang Qiang, Zhuang Qiang, Dandan Zhang, Dandan Zhang, Dandan Zhang, Huimin Hao, Huimin Hao, Huimin Hao, Jie Wei, Jie Wei, Jie Wei, Hamid Syeda Maira, Hamid Syeda Maira, Hamid Syeda Maira, Weimin Wang, Weimin Wang, Zhulan Nie, Zhulan Nie, Zhulan Nie

“…Shotgun metagenomics was employed to profile the gut microbiota and functional potential. Taxonomic and functional annotations were analyzed, including identification of dominant taxa, biomarkers (LEfSe), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for metabolic functions, and Carbohydrate-Active enZymes (CAZy) database annotations. …”
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Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis by Rutao Li, Na Li, Qianqian Yang, Xing Tong, Wei Wang, Chang Li, Jun Zhao, Dong Jiang, Haitao Huang, Chen Fang, Kai Xie, Jiamin Yuan, Shaomu Chen, Guangbin Li, Haitao Luo, Zhibo Gao, Dongfang Wu, Xiaoli Cui, Wei Jiang, Lingchuan Guo, Haitao Ma, Yu Feng

“…Additionally, public bulk and single-cell RNA-sequencing (scRNA-seq) datasets were analyzed, and in vitro and in vivo functional studies were conducted. Results Spatial transcriptional reprogramming and dynamic cell signaling pathways that determined ESCC progression were delineated. …”
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Abundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index by Jonathan Trujillo-Viera, Mona C. Wittmann, Daniel Lam, Yang Shen, Adhideb Ghosh, Falko Noé, Anne Hoffmann, Coralie Viollet, Alec Dick, Matthias Blüher, Jiawei Zhong, Lucas Massier, Christian Wolfrum, Holger Klein, Heike Neubauer, Bradford Hamilton

“…Objective: The cellular composition and functionality of adipose tissue are key determinants of metabolic diseases associated with adipose tissue dysregulation, such as obesity. …”
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Characterizing spatial immune architecture in metastatic melanoma using high-dimensional multiplex imaging by Joel Eliason, Santhoshi Krishnan, Yasunari Fukuda, Matias A. Bustos, Dan Winkowski, Sungnam Cho, Akshay Basi, Akshay Basi, Regan Baird, Elizabeth A. Grimm, Michael A. Davies, Dave S. B. Hoon, Arvind Rao, Arvind Rao, Arvind Rao, Arvind Rao, Jared K. Burks, Jared K. Burks, Suhendan Ekmekcioglu

“…Using imaging mass cytometry (IMC) and multiplex immunofluorescence (mIF), we characterized the phenotypic, functional, and spatial properties of the TIME. Cellular neighborhoods were defined by inflammatory marker expression, and spatial interactions between immune and tumor cells were quantified using nearest-neighbor functions (G-cross). …”
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SIBES: Long-term and large-scale monitoring of intertidal macrozoobenthos and sediment in the Dutch Wadden Sea by Allert I. Bijleveld, Paula de la Barra, Hailley Danielson-Owczynsky, Livia Brunner, Anne Dekinga, Sander Holthuijsen, Job ten Horn, Anne de Jong, Loran Kleine Schaars, Adrienne Kooij, Anita Koolhaas, Hidde Kressin, Felianne van Leersum, Simone Miguel, Luc G. G. de Monte, Dennis Mosk, Amin Niamir, Dorien Oude Luttikhuis, Myron A. Peck, Theunis Piersma, Reyhaneh Roohi, Léon Serre-Fredj, Marten Tacoma, Evaline van Weerlee, Bas de Wit, Roeland A. Bom

“…Macrozoobenthic invertebrates perform key ecological functions within intertidal areas by regulating nutrient cycles, decomposing organic matter, and providing food for fish, birds and humans. …”
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