Flexible host–microbe interaction aid adaptation of black-necked crane to seasonal shifts by Ruifeng Ma, Shujuan Ma, Yujia Zhang, Lei Hu, Keyi Tang, Hongyi Liu, Ke He, Yudong Li, Suolangduoerji, Ying Zhu

“…According to Simpson's indexes, the gut microbiota was also positively associated with the plant-based diet across the seasons. The plant diet–microbe co-occurrence network was more complex than the animal diet–microbe network. …”
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Helminth Coinfections Modulate Disease Dynamics and Vaccination Success in the Era of Emerging Infectious Diseases by Brice Armel Nembot Fogang, Linda Batsa Debrah, Michael Owusu, George Agyei, Julia Meyer, Jonathan Mawutor Gmanyami, Manuel Ritter, Kathrin Arndts, Derrick Adu Mensah, Tomabu Adjobimey, Achim Hörauf, Alexander Yaw Debrah

“…However, they can exacerbate disease outcomes in most bacteria and blood-borne viral conditions by impairing immune functions, such as neutrophil recruitment and antibody response, leading to more severe infections and higher viral loads. …”
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Mitochondrial genome of Lonicera macranthoides: features, RNA editing, and insights into male sterility by Zhong Chen, Wei Zhuo, Yuqi Wang, Junpeng Qi, Li Liu, Sheng’E. Lu, Han Wang, Tao Sun, Liqiang Wang, Fengming Ren, Fengming Ren

“…Notably, RNA editing events varied across different plant tissues, with 357 editing sites in 30 PCGs in leaves, 138 sites in 24 PCGs in flowers, and 68 sites in 13 PCGs in stems. …”
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Frequency-dependent changes in the amplitude of low-frequency fluctuations in post stroke apathy: a resting-state fMRI study by Ying Liu, Ying Liu, Yi-Kuang Hsien, Yi-Kuang Hsien, Wenlong Su, Wenlong Su, Zhiqing Tang, Zhiqing Tang, Hui Li, Junzi Long, Junzi Long, Xingxing Liao, Xingxing Liao, Hao Zhang, Hao Zhang, Hao Zhang

“…Apathy was measured using the Apathy Evaluation Scale (AES). Resting-state functional magnetic resonance imaging (rs-fMRI) was utilized to investigate spontaneous brain activity. …”
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Reassembly of a tropical rainforest: A new chronosequence in the Chocó tested with the recovery of tree attributes by Sebastián Escobar, Felicity L. Newell, María‐José Endara, Juan E. Guevara‐Andino, Anna R. Landim, Eike Lena Neuschulz, Ronja Hausmann, Jörg Müller, Karen M. Pedersen, Matthias Schleuning, Constance J. Tremlett, Edith Villa‐Galaviz, H. Martin Schaefer, David A. Donoso, Nico Blüthgen

“…Hence, our chronosequence can be used to determine the time for recovery and stability (resistance and resilience) of different taxa and ecosystem functions, including species interaction networks. …”
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Mentalization-based treatment versus bona fide treatment for patients with borderline personality disorder in Germany (MAGNET): study protocol of a prospective, multi-centre random... by Sophie Hauschild, Svenja Taubner, Thorsten Vidalón Blachowiak, Ulrike Dinger, Harald Gündel, Sabine C. Herpertz, Jörg Rademacher, Bernhard Strauss, Timo Storck, Ralitsa Vassileva, Ina Burghaus, Manuel Herbst, Simiao Chen, Christoph Nikendei, Sebastian Euler, Jana Volkert

“…Secondary, MBT’s efficacy will be investigated with regard to cost-effectiveness within the German health care system, general and interpersonal functioning, BPD and general symptom severity, social adjustment, quality of life, reduction in psychotropic medication and therapy retention. …”
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Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation by Yu Wang, Hui Xue, Xiaohui Zhu, Dong Lin, Zheng Chen, Xin Dong, Junru Chen, Mingchen Shi, Yuchao Ni, Jonathan Cao, Rebecca Wu, Connie Kang, Xinyao Pang, Francesco Crea, Yen‐Yi Lin, Colin C. Collins, Martin E. Gleave, Abhijit Parolia, Arul Chinnaiyan, Christopher J. Ong, Yuzhuo Wang

“…Distinct TF profiles for adenocarcinoma and NEPC are unveiled, identifying 126 shared TFs, 46 adenocarcinoma‐TFs, and 56 NEPC‐TFs, validated across multiple cohorts. Gene Ontology is employed to validate their biological and functional roles in PCa progression. …”
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Cognition and behavior in adults with neurofibromatosis type 1 by Anja Bos-Roubos, Anja Bos-Roubos, Anja Bos-Roubos, Hanneke van Leeuwen, Hanneke van Leeuwen, Hanneke van Leeuwen, Ellen Wingbermühle, Ellen Wingbermühle, Ellen Wingbermühle, Ellen Wingbermühle, Louisa van den Bosch, Lindsey Ossewaarde, Walter Taal, Walter Taal, Laura de Graaff, Laura de Graaff, Laura de Graaff, Jos Egger, Jos Egger, Jos Egger, Jos Egger, Jos Egger

“…The present study describes the neuropsychological phenotype of adults with NF1 based on comprehensive clinical examination of cognition and behavior across multiple functions.MethodsParticipants were 62 adults with NF1 (mean age 38.2 years; SD 13.4). …”
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Vitamin D Deficiency Is Common in Ghana despite Abundance of Sunlight: A Multicentre Comparative Cross-Sectional Study by Samuel Asamoah Sakyi, Maxwell Hubert Antwi, Linda Ahenkorah Fondjo, Edwin Ferguson Laing, Richard K. Dadzie Ephraim, Alexander Kwarteng, Benjamin Amoani, Seth Christopher Appiah, Bright Oppong Afranie, Stephen Opoku, Tonnies Abeku Buckman

“…Vitamin D is a steroid hormone important for the normal functioning of the body. It is produced through skin exposure to sunlight and from the diet. …”
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Treatment decision-making and care among older adults with kidney failure: protocol for a multicentre, prospective observational cohort study with nested substudies and linked qual... by Martin Gallagher, Vasi Naganathan, Gian Luca Di Tanna, Celine Foote, Angela Makris, Chris Gianacas, Nicholas A Gray, Isaac Yeboah Addo, Amanda Siriwardana, Chenlei Kelly Li, Kenneth Yong, Yachna Mehta, Jannel Ramos, Sarah Roxburgh

“…There are limited data on several key outcomes for the elderly population including survival, quality of life, symptom burden, changes in physical functioning and experienced burden of healthcare. Patients, caregivers and clinicians consequently face significant uncertainty when making life-impacting treatment decisions. …”
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Structural variants linked to Alzheimer’s disease and other common age-related clinical and neuropathologic traits by Ricardo A. Vialle, Katia de Paiva Lopes, Yan Li, Bernard Ng, Julie A. Schneider, Aron S. Buchman, Yanling Wang, Jose M. Farfel, Lisa L. Barnes, Aliza P. Wingo, Thomas S. Wingo, Nicholas T. Seyfried, Philip L. De Jager, Chris Gaiteri, Shinya Tasaki, David A. Bennett

“…While genome-wide association studies (GWAS) have identified numerous risk loci for late-onset AD (LOAD), the functional mechanisms underlying most of these associations remain unresolved. …”
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Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell r... by Victoria Jennings, Alan Melcher, Fiona Errington-Mais, Victoria Roulstone, Kevin J Harrington, Galabina Bozhanova, Shane Foo, Martin McLaughlin, Malin Pedersen, John Bell, Pablo Nenclares, Joan Kyula, Lizzie Appleton, Edward Armstrong, Masahiro Ono, Matthew K L Chiu, Anton Patrikeev, Nitya Mohan, Julia Hoebart, Emmanuel Patin

“…Background Over the past decade, cancer immunotherapies have revolutionized the treatment of melanoma; however, responses vary across patient populations. Recently, baseline tumor size has been identified as an independent prognostic factor for overall survival in patients with melanoma receiving immune checkpoint inhibitors. …”
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WRF-ELM v1.0: a regional climate model to study land–atmosphere interactions over heterogeneous land use regions by H. Huang, Y. Qian, G. Bisht, J. Wang, T. Chakraborty, D. Hao, J. Li, T. Thurber, B. Singh, Z. Yang, Y. Liu, P. Xue, P. Xue, W. J. Sacks, E. Coon, R. Hetland

“…In general, the coupled WRF-ELM model has reasonably captured the spatial distribution of surface state variables and fluxes across the GLR, particularly over the natural vegetation areas. …”
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Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosing by Ahmed Gamal Abd-Elsatar, Hamada Elsayed, Onat Basak, Kamalan Mosas, Aleksandra Nowicka, Hana Kaňková, Akansha Mehta, Jozef Rahel, Jozef Kraxner, Dušan Galusek, Enrico Bernardo

“…P-IET is a cost-effective, innovative, long-lasting, and industrially scalable process designed to improve the performance of Type I borosilicate glass across various pharmaceutical packaging forms and structures. …”
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Profiling of rhizosphere-associated microbial communities in North Alabama soils infested with varied levels of reniform nematodes by Sowndarya Karapareddy, Varsha C. Anche, Sowjanya R. Tamatamu, Madhusudhana R. Janga, Kathy Lawrence, Leopold M. Nyochembeng, Antonette Todd, Lloyd T. Walker, Venkateswara R. Sripathi

“…On the other hand, the close association of Ascomycota and Basidiomycota suggesting that they have different ecological roles but occupy similar niches and contribute similar functions within the microbial community. The abundant microbial communities identified in this study had a role in nutrient recycling, soil health, plant resistance to some environmental stress and pests including nematodes, and biogeochemical cycles. …”
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Integrin beta‐like 1 is regulated by DNA methylation and increased in heart failure patients by Lauren Kerrigan, Kevin Edgar, Adam Russell‐Hallinan, Oisin Cappa, Nadezhda Glezeva, Carlos Galan‐Arriola, Eduardo Oliver, Borja Ibanez, John Baugh, Patrick Collier, Mark Ledwidge, Ken McDonald, David Simpson, Sudipto Das, David J. Grieve, Chris J. Watson

“…Single nuclei RNA sequencing was carried out on heart tissue from angiotensin‐II infused mice to establish the expression profile of Itgbl1 across cardiac cell populations. Subsequent in vitro analyses were conducted to elucidate a role for ITGBL1 in human cardiac fibroblasts. …”
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Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway by Ang Li, Ang Li, Ang Li, Man Luo, Xiyao Liu, Hongjiao Wu, Hongjiao Wu, Hongjiao Wu, Xiaoguang Liu, Zhi Zhang, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang

“…This study aims to investigate the role of TLR3 in LUAD by examining its expression levels, prognostic significance, and impact on immune signaling pathways.MethodsWe analyzed the impact of TLR3 expression on the prognosis of lung adenocarcinoma patients using data from the Cancer Genome Atlas (TCGA) database and four additional cohorts (GSE72094, GSE30219, GSE50081 and GSE31210). Functional enrichment analyses were performed to compare molecular features between low and high TLR3 expression groups using gene set variation analysis (GSVA). …”
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Urban Tree Canopy Mapping and Analysis Using Iterative Annotation Method and Deep Learning: A Case Study in Beijing by Yulong Ding, Ximin Cui, Zhengchao Chen, Zeqing Wang, Debao Yuan, Xiang Meng, Xuan Yang, Yue Xu, Xiangyu Tian

“…Urban trees have significant ecological and social functions, and generating urban tree canopy (UTC) maps is an effective method for understanding their distribution. …”
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Genome-wide identification and gene expression analysis of the malate dehydrogenase (MDH) gene family in Eucalyptus grandis by Yifan Xing, Yifan Xing, Huiming Xu, Deming Yang, Lichuan Deng, Guolong Li, Guolong Li, Zhixin Zhao, Zhixin Zhao, Zhaohua Lu, Liuyin Ma, Guangyou Li

“…Malate dehydrogenases are pivotal in plant metabolism and stress responses, yet their evolutionary dynamics and functional diversification in woody angiosperms remain underexplored. …”
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Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

“…In vivo, MEVs biodistributed across mice organs, including the brain, liver, stomach, and spleen. …”
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