Multidimensional analysis suggests that ZNF433 is a promising biomarker for the diagnosis and prognosis of human cancers by Lingyu Xie, Lingyu Xie, Xin Zeng, Xin Zeng, Hui Luo, Hui Luo, Bin Xie, Xuefeng Wang, Nan Wu, Junrong Zou, Junrong Zou, Junrong Zou, Guoxi Zhang, Guoxi Zhang, Guoxi Zhang, Xiaofeng Zou, Xiaofeng Zou, Xiaofeng Zou, Hui Xu, Hui Xu, Hui Xu

“…Despite the growing body of research on KRAB-ZFPs, the role of ZNF433, a relatively less studied member of this family, remains poorly understood in the context of cancer.MethodsWe conducted multi-dimensional analyses using publicly available databases, including TCGA and GTEx, to evaluate ZNF433’s expression patterns, genetic mutations, survival outcomes, immune microenvironment interactions, and diagnostic potential across different cancers. Functional enrichment and protein interaction network analyses were also performed to explore its potential involvement in cancer-related pathways.ResultsOur findings revealed that ZNF433 is significantly downregulated in most cancer types, with stage-dependent expression patterns observed in KIRC and KIRP. …”
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International Consensus on Evidence Gaps and Research Opportunities in Extracorporeal Cardiopulmonary Resuscitation for Refractory Out‐of‐Hospital Cardiac Arrest: A Report From the... by Laurie J. Morrison, Elizabeth A. Hunt, Brian Grunau, Thomas P. Aufderheide, Clifton Callaway, Joseph E. Tonna, Comilla Sasson, Audrey Blewer, Bryan F. McNally, Demetris Yannopoulos, Jan Belohlavek, Jason Bartos, Alain Combes, Ahamed Idris, Raina M. Merchant, Leith States, Emily Tinsley, Renee Wong, Scott T. Youngquist, George Sopko, Karl B. Kern

“…In addition, well‐designed efficacy trials, recruiting across different regions of care evaluating long‐term follow‐up, including patient reported outcomes, cost effectiveness, and equity measures, would contribute significantly to the body of science. …”
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Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease by Wouter Dheedene, Stefaan Verhulst, Louise Demuynck, Bram Callewaert, Willeke de Haan, Stefan Vinckier, Jore Van Wauwe, Petra Vandervoort, Marleen Lox, Mathias Stroobants, Renaud Lavend’homme, Wilfred F. J. van IJcken, Elizabeth A. V. Jones, An Zwijsen, Marc Jacquemin, Leo A. van Grunsven, Kimberly Martinod, Danny Huylebroeck, Eskeatnaf Mulugeta, Aernout Luttun

“…In healthy and steatotic wild-type livers, Zeb2 was ubiquitously and similarly expressed across blood-vascular EC types. LSEC RNA sequencing revealed ZEB2 deficiency-triggered expression changes greatly overlapping with those evoked by WD-feeding. …”
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Large-scale EM data reveals myelinated axonal changes and altered connectivity in the corpus callosum of an autism mouse model by Guoqiang Zhao, Guoqiang Zhao, Ao Cheng, Jiahao Shi, Jiahao Shi, Peiyao Shi, Jun Guo, Chunying Yin, Hafsh Khan, Hafsh Khan, Jiachi Chen, Jiachi Chen, Pengcheng Wang, Pengcheng Wang, Jiao Chen, Jiao Chen, Ruobing Zhang

“…However, given the structural focus of this study, further research integrating functional assessments is necessary to establish a direct link between these morphological changes and ASD-related neural dysfunction.…”
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Single-cell landscape of immunological responses in patients with juvenile idiopathic arthritis by Yun Liu, Xiwen Luo, Liuqing Yang, Qiang Luo, Xiya Luo, Li Xu, Yating Wang, Yunfei An, Yupeng Cun, Xuemei Tang

“…Reclustering analysis of myeloid cells highlighted interferon-related functions predominantly in non-classical monocytes of sJIA patients. …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

“…Experiments are designed to illustrate the following properties of CFPSs that can aid clinicians in narrowing down their search space: a CFPS can 1) classify syndromes accurately, 2) generalize to novel syndromes, and 3) preserve the relatedness of genetic diseases, meaning that clusters of phenotypically similar disorders reflect functional relationships between genes. The proposed model consists of three main components: an encoder based on GDL optimizing distances between groups of individuals in the CFPS, a decoder enhancing classification by reconstructing faces, and a singular value decomposition layer maintaining orthogonality and optimal variance distribution across dimensions. …”
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Combining discotic mesogens with AIE luminogens for advanced optoelectronic applications: Design, synthesis, mesomorphism, self-assembly and optical properties of tetraphenylethyle... by Hang Lin, Ke-Xiao Zhao, Bi-Qin Wang, Ping Hu, Ke-Qing Zhao, Bertrand Donnio

“…The combination of different molecular entities with their own and specific functionalities within a single molecule enables the generation of potentially original multifunctional materials with unique properties and a broad range of applications across various fields. …”
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Mitigating T-cell mitochondrial dysfunction in CLL to augment CAR T-cell therapy: evaluation in an immunocompetent model by Wael Gamal, Nienke B. Goedhart, Helga Simon-Molas, Melanie Mediavilla-Varela, Angimar Uriepero-Palma, Fleur S. Peters, Kamira Maharaj, Julio C. Chavez, John Powers, Alyssa Obermayer, Timothy I. Shaw, José R. Conejo-Garcia, Paulo C. Rodriguez, Eva Sahakian, Javier Pinilla-Ibarz, Arnon P. Kater

“…Integrated metabolic and functional analyses revealed impaired, depolarized mitochondria across all T-cell subsets in untreated patients with CLL, leading to further ex vivo and in vivo mouse studies on the underlying signaling alterations. …”
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A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up – towards an international prognostication guideline by Marijn Albrecht, Maayke Hunfeld, Annemieke Arkesteijn-Muit, Karolijn Dulfer, Matthijs de Hoog, Gabry de Jong, Rogier de Jonge, Aldert Lamoré, Vinay Nadkarni, Corinne Buysse, Nikki Schoenmaker, Annelies van Zwol, Geanne Krabben-de Vlaam, Nicole de la Haye, Jennifer Walker

“…Methods: The Pediatric Resuscitation Prognostication and Outcomes Registry (ClinicalTrials.gov ID: NCT06938009) collects data on pediatric cardiac arrest across Dutch pediatric intensive care units, extending the pediRES-Q collaborative. …”
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Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma by Bing Liu, Wei Tao, Xuantong Zhou, Li-Di Xu, Yanrui Luo, Xin Yang, Qingjie Min, Miao Huang, Yuge Zhu, Xinrun Cui, Yaqi Wang, Tongyang Gong, Enli Zhang, Yu S. Huang, Weizhi Chen, Shi Yan, Nan Wu

“…Integrated analyses were conducted to disclose molecular characteristics and explore molecular subtyping. Functional validation of key molecules was carried out through in vitro and in vivo experiments. …”
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A multicenter validation and calibration of automated software package for detecting anterior circulation large vessel occlusion on CT angiography by Kyu Sun Yum, Jong-Won Chung, Sue Young Ha, Kwang-Yeol Park, Dong-Ick Shin, Hong-Kyun Park, Yong-Jin Cho, Keun-Sik Hong, Jae Guk Kim, Soo Joo Lee, Joon-Tae Kim, Woo-Keun Seo, Oh Young Bang, Gyeong-Moon Kim, Myungjae Lee, Dongmin Kim, Leonard Sunwoo, Hee-Joon Bae, Wi-Sun Ryu, Beom Joon Kim

“…The diagnostic performance was evaluated using area under the curve (AUC), sensitivity, and specificity across the entire study population and specifically in patients with isolated middle cerebral artery (MCA)-M2 occlusion. …”
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The impact of mentoring relationships on professional identity formation in medical education: a systematic review by Lalit Kumar Radha Krishna, Nila Ravindran, Hannah Yi Fang Kwok, Xuan Yu Tan, Jasper Soh, Elizabeth Yong Mei Leong, Darius Wei Jun Wan, Tiat Yan Low, Aiden Wei-Jun Chan, Nicholas Chong Jin Lim, Yen Kit Ng, Arthena Anushka Thenpandiyan, Jun Rey Leong, Adele Yi Dawn Lim, Elaine Li Ying Quah, Leia Ning Tse, Sriram PL, Sri Priyanka Rajanala, Jun Kiat Lua, Varsha Rajalingam, Victoria Jia En Fam, Ranitha Govindasamy, Nur Amira Binte AbdulHamid, Crystal Lim, Eng Koon Ong, Shin Wei Sim, Stephen Mason, Simon Yew Kuang Ong

“…Results 248 articles were identified across four databases and snowballing of key articles. …”
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Domestication of different varieties in the cheese-making fungus Geotrichum candidum by Bennetot, Bastien, Vernadet, Jean-Philippe, Perkins, Vincent, Hautefeuille, Sophie, Rodríguez de la Vega, Ricardo C., O’Donnell, Samuel, Snirc, Alodie, Grondin, Cécile, Lessard, Marie-Hélène, Peron, Anne-Claire, Labrie, Steve, Landaud, Sophie, Giraud, Tatiana, Ropars, Jeanne

“…Commercial starter strains were scattered across the cheese clade, thus not constituting a single clonal lineage. …”
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Construct and Predictive Validity of the Kansas City Cardiomyopathy Questionnaire in Adult Congenital Heart Disease by Ryan D. Byrne, MD, Ajith P. Nair, MD, Stephen J. Dolgner, MD, Swati Choudhry, MD, Edward J. Hickey, MD, Alexis C. Wood, PhD, Savitri Fedson, MD, Biykem Bozkurt, MD, PhD, Christopher R. Broda, MD

“…KCCQ scores were compared across ACHD complexity categories, disease characteristics and physiologic failure, and within 2 primary composite outcomes: death or all-cause hospitalization (DH) and death or interventional cardiac procedures (DP). …”
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Effects of Haematococcus pluvialis powder in the diet of golden pompano (Trachinotus ovatus) on the growth performance, pigmentation, hepatic and intestinal health, antioxidant cap... by Jieping Liu, Ziqiao Wang, Yongkang Chen, Yucai Guo, Xiaoming Li, Yanmei Li, Peinan Zhang, Xiangyan Hou, Chun Luo, Wei Zhao, Jin Niu

“…Haematococcus pluvialis enriched natural astaxanthin is widely used as a functional additive in the farming industry. The objective of this study was to evaluate the effects of dietary supplementation with H. pluvialis powder on growth performance, pigmentation, hepatic and intestinal morphology, antioxidant capacity, and immunity of golden pompano (Trachinotus ovatus). …”
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Starch α-glucan microparticles trigger hemocyte activation in Cherax quadricarinatus crayfish by Crystal Guluarte, Alí Pereyra, Maya Pérez-Echeverria, María Fernanda López-Galicia, Eda Patricia Tenorio, Eleazar Ramírez Hernández, Romina Rodríguez-Sanoja, Silvia Moreno-Mendieta, Carlos Angulo, Edgar Zenteno, José Luis Sánchez-Salgado

“…Semigranular cells exhibited reduced GalNAc expression and increased α-2,6-linked sialic acid expression across all stimuli. Granular cells showed decreased Gal and GalNAc expression, while α-2,3- and α-2,6-linked sialic acid expression increased in response to SMP and bacterial stimuli.Our results indicate that SMP, like Vp or Ec, serves as an effective stimulus for activating both cellular and humoral immune mechanisms. …”
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Virtual human retina: Simulating neural signalling, degeneration, and responses to electrical stimulation by Keith Ly, Michael L. Italiano, Mohit N. Shivdasani, David Tsai, Jia-Yi Zhang, Chunhui Jiang, Nigel H. Lovell, Socrates Dokos, Tianruo Guo

“…The comprehensive three-dimensional model includes photoreceptors, horizontal cells, bipolar cells, amacrine cells, and midget and parasol retinal ganglion cells, with comprehensive network connectivity across various eccentricities (1 mm–5 mm from the fovea) in the human retina. …”
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Efficacy of Rikkunshito on Chemotherapy-Induced Nausea and Vomiting in Patients With Uterine Corpus or Cervical Cancer Treated With Cisplatin-Based Regimen-Placebo-controlled, Doub... by Yosuke Konno MD, Shunsuke Ohnishi MD, Shinichiro Minobe PhD, Eiji Nomura PhD, Takayuki Nagasawa PhD, Etsuko Fujimoto MD, Tatsuru Ohara PhD, Shin Nishio MD, Hisamori Kato PhD, Yoshihito Yokoyama PhD, Etsuko Miyagi PhD, Hideki Tokunaga PhD, Koji Nishino MD, Akira Kikuchi PhD, Yoshio Yoshida PhD, Takashi Iwata PhD, Daito Noguchi MD, Wataru Kudaka PhD, Shunsuke Oyamada PhD, Keisuke Ariyoshi PhD, Kota Kihara PhD, Hidemichi Watari MD

“…Rikkunshito, a Japanese traditional herbal medicine, has been shown to improve cisplatin-induced anorexia and functional dyspepsia, and our exploratory study found that rikkunshito has an additive beneficial effect on CINV in patients with uterine corpus and cervical cancer receiving cisplatin containing chemotherapy (JORTC KMP-02). …”
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Parvoviruses NS1 oncolytic attributes: mechanistic insights and synergistic anti-tumor therapeutic strategies by Abdul Haseeb, Wafa Yousaf, Zhigang Cao, Kuohai Fan, Kuohai Fan, Na Sun, Panpan Sun, Yaogui Sun, Huizhen Yang, Wei Yin, Hua Zhang, Zhenbiao Zhang, Jia Zhong, Jianzhong Wang, Hongquan Li

“…NS1 possesses a distinctive structure; however, it differs across different parvovirus species. It is comprised of three fundamental domains: the N-terminal origin binding, helicase domain, and C-terminal domain, all crucial for significant functions. …”
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Anthropogenic Effects on Green Infrastructure Spatial Patterns in Kisangani City and Its Urban–Rural Gradient by Julien Bwazani Balandi, Jean-Pierre Pitchou Meniko To Hulu, Kouagou Raoul Sambieni, Yannick Useni Sikuzani, Jean-François Bastin, Charles Mumbere Musavandalo, Timothée Besisa Nguba, Roselande Jesuka, Carlo Sodalo, Léa Mukubu Pika, Jan Bogaert

“…These results raise concerns regarding the functions, services, and opportunities provided by mature and short forests in the context of global change. …”
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