Bridging aging, immunity, and atherosclerosis: novel insights into senescence-related genes by Yan Lu, Rong Yuan, Rong Yuan, Qiqi Xin, Qiqi Xin, Keji Chen, Keji Chen, Weihong Cong, Weihong Cong

“…The immune cell infiltration and biological functions of the diagnostic genes were assessed by CIBERSORT and single-sample gene set enrichment analysis (ssGSEA). …”
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Mycorrhizal and nutrient controls of carbon sequestration in tropical rainforest soil by Jie Chen, Xin Tang, Han Xu, Yanpeng Li, Adriana Corrales, Yide Li, Yakov Kuzyakov, Zhanfeng Liu, Shirong Liu

“…This study characterized the performances of AM and ECM trees, SOC content, and soil microbial functions under variable soil nitrogen (N) and phosphorus (P) content across an intact tropical rainforest based on the spatial dataset from a 60-ha dynamic plot and fitted statistical models to examine the mycorrhizal and nutrient controls on SOC stocks. …”
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Unveiling ammonia-induced cell death: a new frontier in clear cell renal cell carcinoma prognosis by Peize Yu, Peize Yu, Qikai Zhong, Qikai Zhong, Xinlei Wang, Xinlei Wang, Yifang Liu, Qiang Liu, Qiang Liu, Yuqiang Zhang, Jiawei Lu, Yang Dong, Cong-hui Han, Cong-hui Han

“…High-risk (HR) patients exhibited immunosuppressive microenvironments, elevated tumor mutational burden (TMB), and genomic instability. In vitro functional assays confirmed that ATP1A1 knockdown significantly enhanced the proliferative, migratory, and invasive capabilities of renal carcinoma cells (A498 and 786-O), suggesting a suppressive role for ATP1A1 in malignant tumor progression. …”
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Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions by Tarikul I. Milon, Titli Sarkar, Titli Sarkar, Yixin Chen, Jordan M. Grider, Feng Chen, Jun-Yuan Ji, Seetharama D. Jois, Konstantin G. Kousoulas, Vijay Raghavan, Wu Xu

“…(iv) Intra-residual keys revealed two distinct Tyr clusters characterized by specific triangle geometries.ConclusionThis study presents an advanced computational approach that not only quantifies and interprets conformational changes in protein backbones, entire structures, or individual amino acids, but also facilitates the search for substructures induced by molecular binding across protein datasets. In some instances, a direct correlation between structures and functions was successfully established.…”
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Combined nomogram for differentiating adrenal pheochromocytoma from large-diameter lipid-poor adenoma using multiphase CT radiomics and clinico-radiological features by Zujuan Shan, Xinzhang Zhang, Yiwen Zhang, Shuailong Wang, Junfeng Wang, Xin Shi, Lin Li, Zhenhui Li, Liuyang Yang, Hao Liu, Wenliang Li, Junfeng Yang, Liansheng Yang

“…Adenomas are typically non-functional tumors managed through observation or medication, with some cases requiring surgical removal, which is generally safe. …”
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An integrated, multidisciplinary management team intervention to improve patient-centeredness, HIV, and maternal-child outcomes in Lesotho: formative research on participatory impl... by Laura K. Beres, Mammatli Chabela, Matseliso Masitha, Zachary Catanzarite, Vincent J. Tukei, Lynne Mofenson, Appolinaire Tiam, Lauren Greenberg, Majoalane Mokone, Ramatlapeng Thabelo, Masepeli Nchephe, Tsietso Mots’oane, Laura Guay, Amy R. Knowlton

“…The coordination, monitoring and cross-cadre communication functions of the MDTs supported implementation of other interventions, and may serve as a valuable platform for improving patient-centered care practices in similar settings and for other health services. …”
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AI-driven pharmacovigilance: Enhancing adverse drug reaction detection with deep learning and NLP by Dr. Bharti Khemani, Dr. Sachin Malave, Samyukta Shinde, Mandvi Shukla, Razzaq Shikalgar, Harshita Talwar

“…BERT and GPT, were also employed to provide the functionality of textual interactions over medical data. • Performance metrics such as accuracy, precision, recall, and F1-score were systematically applied to evaluate each model’s performance. …”
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The prevalence and correlates of low resilience in patients prior to discharge from acute psychiatric units in Alberta, Canada by Ernest Owusu, Wanying Mao, Reham Shalaby, Hossam Eldin Elgendy, Belinda Agyapong, Ejemai Eboreime, Mobolaji A. lawal, Nnamdi Nkire, Yifeng Wei, Peter H. Silverstone, Pierre Chue, Xin-Min Li, Wesley Vuong, Arto Ohinmaa, Valerie Taylor, Carla T. Hilario, Andrew J. Greenshaw, Vincent I. O. Agyapong

“…Methods Respondents for this study were recruited from nine psychiatric in-patient units across Alberta. Demographic and clinical information were collected via a REDCap online survey. …”
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Clinical Prediction of Secondary Bloodstream Infections in Patients with Cerebral Infarction: A Nomogram-Driven Risk Assessment Model Based on LASSO Regression by Zhang L, Li X, Cai D, Mei C, Lu L

“…The LASSO analysis identified four predictors: The following variables were found to have a statistically significant relationship to the occurrence of the primary complication: peripherally inserted central venous catheters (PICC) (odds ratio [OR] = 2.791, 95% confidence interval [CI] =1.514– 5.148), use of ventilators(VA) (OR = 2.771, 95% CI=1.410– 5.443), Indwelling urinary catheters(CAU) (OR = 1.800, 95% CI= 0.990– 3.276), and hypoalbuminemia (OR = 3.643, 95% CI=2.195– 6.046).The nomogram demonstrated an AUC of 0.789 in the training set and 0.778 in the test set, indicating a satisfactory model fit across data sets. Good model fit based on Hosmer-Lemeshowp-values(Hosmer-LemeshowP=0.338/0.170).DCA indicated a net clinical benefit at risk thresholds of 0– 15%.Conclusion: Secondary BSI in patients with cerebral infarction can seriously affect the quality of medical care.The developed nomogram functions as a pragmatic instrument for the preliminary identification of patients at high risk. …”
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Proof-of-concept MALDI-TOF-MS assay for the detection of Toxin B enzymatic activity in Clostridioides difficile infection by Josef Dvorak, Lukáš Fojtík, Ljubina Adámková, Katerina Vlkova, Vendula Studentova, Katerina Chudejova, Lenka Geigerová, Michael Volny, Petr Novak, Jaroslav Hrabak, Petr Pompach

“…In our work, we focused on the functional detection of Clostridioides difficile, an important nosocomial human pathogen that is responsible for diarrhea and can lead to life-threatening colitis, as a model diagnostic problem. …”
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Effects of integrated exercise approach on total testosterone levels in eumenorrheic women: a randomized controlled trial by Wajiha Shahid, Rabiya Noor

“…This immediate increase in testosterone levels can lead to increased strength, cognition and sexual functions in females. Trial registration number. This clinical trial was submitted by Dr. …”
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The effect of chronic yoga interventions on sleep quality in people with sleep disorders: a scoping review by Mohammad Alghosi, Mohammad Alghosi, Maryam Sharifi, Sanam Namavari, Neda Rajamand, Faezeh Bamorovat, Narges Norouzi, Mohammad Alimoradi, Andreas Konrad

“…BackgroundPoor or insufficient sleep adversely affects various physiological and psychological functions, impacting body systems such as the endocrine, metabolic, and immune systems.ObjectivesDespite available pharmacological and non-pharmacological treatments, the impact of chronic yoga interventions on sleep quality in individuals with sleep problem syndrome remains underexplored. …”
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Good-Quality mHealth Apps for Endometriosis Care: Systematic Search by Diksha Sirohi, Cecilia HM Ng, Niranjan Bidargaddi, Helen Slater, Melissa Parker, M Louise Hull, Rebecca O'Hara

“…These apps provided symptom-tracking functions and self-management support. A total of 17 apps were designed for community use, while 2 apps provided a digital endometriosis classification tool to clinicians. …”
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Evaluating the role of training data origin for country-scale cropland mapping in data-scarce regions: A case study of Nigeria by Joaquin Gajardo, Michele Volpi, Daniel Onwude, Thijs Defraeye

“…Handling class imbalance was also critical, with weighted loss functions improving accuracy by up to 0.071 for the single-headed LSTM. …”
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Integrating multi-omics data to optimize immunotherapy in endometrial cancer: a comprehensive study by Xin Guan, Rongchuan Cao, Longbi Liu, Lin Ma, Ning Gao, Yanfei Yang, Mingyue Xiao, Rui Du, Yuzhe Su, Zhen Wang, Xiaofeng Liu, Lu Han

“…The study employed functional enrichment and gene set variant analysis to discern noteworthy disparities in biological pathways across various groups. …”
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Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer by Sen Zhang, Jianrui Pan, Huina Guo, Xiaoya Guan, Chenxu Yan, Lingling Ji, Xiansha Wu, Hui Huangfu

“…Conclusions This study identified two key prognostic biomarkers, RENBP and OLR1, and characterized TME differences across risk groups, offering novel insights into the diagnosis and treatment of LC.…”
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Host-specific microbiome-rumination interactions shape methane-yield phenotypes in dairy cattle by Alejandro Castaneda, Nagaraju Indugu, Kathryn Lenker, Kapil Narayan, Sarah Rassler, Joseph Bender, Linda Baker, Ojas Purandare, David Chai, Xin Zhao, Dipti Pitta

“…Microbial analysis revealed conserved methanogen diversity across the rumen, bolus, and fecal microbiomes, though functional differences were evident. …”
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Evidence adaptation and tailored implementation of family bereavement support in specialised palliative care: A multi-method study by Myrta Kohler, Qëndresa Thaqi, Silke Kuske, Torsten Schwalbach, Marco Riguzzi, Rahel Naef

“…Results: The study resulted in an adapted bereavement support pathway with three core functions of evidence-informed practices delivered during dying, at death, three-to-six, and if necessary nine-to-twelve months post-loss: screening and assessing family needs and risks, intervention and support activities for families, and team collaboration and coordination within and across providers. …”
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Elevated pulse wave velocity as a marker of arterial stiffness and its association with mortality in US adults by Kai Liu, Zhang Lin, Ying Chen, Huashan Hong

“…Restricted cubic spline (RCS) functions were used to visualize the association between estimated pulse wave velocity (ePWV) and mortality risk. …”
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Multidimensional bioinformatics analysis reveals the potential carcinogenic role of acrylamide in colorectal cancer by Xiaopeng Yu, Junjie Niu, Jinyang Hu

“…Conclusion: Acrylamide may drive CRC progression through dysregulated signaling and immune modulation. Validation across cohorts and experimental models is needed to confirm key targets and inform precision prevention. …”
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