Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-bl... by Jie Li, Feitong Liu, Yuemei Luo, Anisha Wijeyesekera, Shan Wang, Xiaojiao Chen, Yamei Lv, Jing Jin, Huafang Sheng, Guopan Wang, Yuanan Wei, Zhuang Li, Muxuan Chen, Hongwei Zhou

“…However, the clinical effects on glycemic metabolism across different populations remain uncertain. In this study, we conducted a randomized, double-blind investigation to examine the impact of inulin and fructooligosaccharides (FOS) on glycemic metabolism in overweight/obese and healthy adults. …”
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The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma by Laura Hruby, Katerina Schaal, Alberto Delaidelli, Daniel Picard, Christopher Dunham, Oksana Lewandowska, Tobias Reiff, Magalie Larcher, Celio Pouponnot, Poul HB Sorensen, Barak Rotblat, Guido Reifenberger, Marc Remke, Gabriel Leprivier

“…Survival analyses highlighted that high EIF4EBP1 mRNA expression was associated with reduced overall and event-free survival across all MB patients and in Group 3/Group 4 MB patients. …”
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hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery by Xin Chen, Hong An, Yongbiao Du, Hao Zhong, Fangfang Zhang, Xiaomei Zeng, Fen Lv, Zhihua Tian, Zaixue Jiang, Qi Peng, Zengbao Li, Siping Li, Baimao Zhong, Xiaomei Lu, Yinghua Zhu

“…Proteomic profiling, pharmacological inhibition, and functional assays were employed to identify critical exosomal components. …”
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Overview of Operational Global and Regional Ocean Colour Essential Ocean Variables Within the Copernicus Marine Service by Vittorio E. Brando, Rosalia Santoleri, Simone Colella, Gianluca Volpe, Annalisa Di Cicco, Michela Sammartino, Luis González Vilas, Chiara Lapucci, Emanuele Böhm, Maria Laura Zoffoli, Claudia Cesarini, Vega Forneris, Flavio La Padula, Antoine Mangin, Quentin Jutard, Marine Bretagnon, Philippe Bryère, Julien Demaria, Ben Calton, Jane Netting, Shubha Sathyendranath, Davide D’Alimonte, Tamito Kajiyama, Dimitry Van der Zande, Quentin Vanhellemont, Kerstin Stelzer, Martin Böttcher, Carole Lebreton

“…From 2019 onwards, new EOVs have been introduced, focusing on phytoplankton functional groups, community structure, and primary production. …”
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Barriers and Facilitators to Adherence to Exercise-Based Cardiac Rehabilitation Among Coronary Artery Disease Patients: A Scoping Review by Zhao X, Zhang S, Zhang F, Wu X, Zhang Z, Liu Y, Jiang J, Li Z, Li S, Zheng S, Yang X, Ju X, Li H, Gong L, Kong D

“…These factors were mapped onto the Behaviour Change Wheel, and the APEASE criteria were applied to determine appropriate intervention functions. Finally, Behaviour Change Techniques were matched to these intervention functions.Results: Seventeen studies were included, identifying multiple core domains of the Theoretical Domains Framework influencing EBCR adherence. …”
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iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Contro... by Christy Au-Yeung, Helen Thai, Michael Best, Christopher R Bowie, Synthia Guimond, Katie M Lavigne, Mahesh Menon, Steffen Moritz, Myra Piat, Geneviève Sauvé, Ana Elisa Sousa, Elisabeth Thibaudeau, Todd S Woodward, Martin Lepage, Delphine Raucher-Chéné

“… BackgroundCognitive impairments are a key aspect of schizophrenia spectrum disorders (SSDs), significantly affecting clinical and functional outcomes. The COVID-19 pandemic has heightened concerns about mental health services and cognitive stimulation opportunities. …”
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Socioeconomic inequalities in patient-reported outcome measures among total hip and knee arthroplasty patients: a comprehensive analysis of instruments and domains by Joshua M. Bonsel, Max Reijman, Erin M. Macri, Jan A. N. Verhaar, Liza N. van Steenbergen, Gouke J. Bonsel

“…Differences in PROM scores between SES groups, and how these differences compared across PROMs, were similar in THA patients. Overall, the EQ-5D-5L produced similar patterns compared to the EQ-5D-3L. …”
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Genomic insights into the population structure, antimicrobial resistance, and virulence of Brachyspira hyodysenteriae from diverse geographical regions by Maria Hakimi, Fangshu Ye, Anugrah Saxena, Xiao Hu, Huigang Shen, Paarthiphan Elankumaran, Chloe C. Stinman, Nubia Macedo, Orhan Sahin, Eric R. Burrough, Ganwu Li

“…Multilocus sequence typing identified 69 sequence types (STs), including 20 novel STs across 251 genomes. Association between specific lineages, STs, and geographical regions was evident, highlighting evolutionary and regional patterns. …”
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Evaluation of Simulated Weightlessness Model of Hindlimb Unloading Miniature Pigs and Their Tissue Damage by TU Yingxin, JI Yilan, WANG Fei, YANG Dongming, WANG Dongdong, SUN Zhixin, DAI Yuexin, WANG Yanji, KAN Guanghan, WU Bin, ZHAO Deming, YANG Lifeng

“…Additionally, western blotting was employed to detect the expression levels of skeletal muscle atrophy-related proteins, including muscle-specific RING finger protein 1 (MuRf-1) and muscle atrophy F-box (MAFbx, as known as Atrogin-1), while immunohistochemistry was used to detect the expression of glial fibrillary acidic protein (GFAP), an indicator of astrocyte activation in the brain, reflecting the pathophysiological functional changes across systems. Results After hindlimb unloading, the experimental group showed significant decreases in body weight (P<0.001) and blood volume (P<0.01). …”
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Strategies for Digital Economy Operation of Urban Parks Guided by Gamification Methods by Zhaochen WANG

“…ObjectiveIn the mid-to-late stages of China’s urbanization process, the high-quality development of existing urban areas has placed higher demands on the functions and benefits of park green spaces, making operations a new focus for the renewal and construction of urban parks. …”
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Induction of more severe central sensitization in a medication overuse headache model mice through active ingestion of rizatriptan by Zhenjie Ma, Chenhao Li, Wenhao Bai, Wei Xie, Mingjie Zhang, Han Xiao, Cancan Chen, Yang Li, Wenwen Zhang, Deqi Zhai, Yingyuan Liu, Dengfa Zhao, Wenjing Tang, Zhao Dong, Ruozhuo Liu, Shengyuan Yu

“…Quantitative data from c-Fos immunostaining across 25 specific brain regions were subjected to Z score normalization, followed by three-tiered computational analyses: 1) hierarchical clustering (complete linkage) to characterize activation patterns, 2) Pearson correlation analysis for functional connectivity mapping, and 3) graph-theoretical network analysis (Cytoscape 3.2.1) to identify hub regions and their topological relationships. …”
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Pathological and non-pathological hikikomori: social media use, digital engagement, and therapeutic implications by Jeff Gavin, Jeff Gavin, Mark Brosnan, Mark Brosnan, Richard Joiner

“…IntroductionHikikomori is traditionally defined as a form of pathological social withdrawal marked by extreme social isolation in one’s home, leading to significant functional impairment or distress. However, shifts in working and study habits since COVID-19 have introduced the concept of ‘non-pathological hikikomori’ to describe individuals who are isolated in their homes but do not experience functional impairment or distress. …”
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Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-Release Tablets on Somatic Symptoms of Major Depressive Disorder: A Prospective, Single-Arm, Multicenter Clinical... by Wang Y, He M, Zhang H, Luo Y, Sun X, Yao Z, Tang H, Yan R, Du X, Li Z, Peng D, Wang Z

“…Yun Wang,1,&amp;ast; Mengxin He,2,&amp;ast; Huifeng Zhang,1 Yanli Luo,2 Xia Sun,2 Zhijian Yao,3 Hao Tang,3 Rui Yan,3 Xiangdong Du,4 Zhe Li,4 Daihui Peng,1 Zhen Wang1 1Mood Disorders Department, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Psychology Department, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Psychiatry Department, Nanjing Brain Hospital, Nanjing University School of Medicine, Nanjing, People’s Republic of China; 4Psychiatry Department, Suzhou Guangji Hospital, Suzhou, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Daihui Peng, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People’s Republic of China, Email pdhsh@126.com Zhen Wang, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People’s Republic of China, Email wangzhen@smhc.org.cnImportance: Depression is a significant global public health issue, with somatic symptoms being a common and challenging aspect of its management.Objective: This study aimed to evaluate the efficacy and safety of toludesvenlafaxine hydrochloride sustained-release tablets (Roxylin®) for somatic symptoms of major depressive disorder (MDD).Design, Setting, and Participants: Prospective, single-arm, multicenter clinical study conducted between June 1, 2023 and May 1, 2024, enrolling patients diagnosed with MDD with somatic symptoms at four hospitals across China.Intervention: All participants received toludesvenlafaxine hydrochloride monotherapy for 8 weeks.Main Outcomes and Measures: The primary outcomes were improvements in somatic depression symptoms measured by PHQ-15 and SSS-CN at baseline and weeks 2, 4, and 8, while secondary outcomes included changes in depressive symptoms (HAMD-17), pain intensity (VAS), fatigue (MFI-20), and functional impairment (SDS), with adverse events monitored.Results: Out of 72 screened patients, 61 were enrolled. …”
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Chronic Tic Disorders in Youth: Clinical Phenotypes and Response to Pharmacological Treatment with Aripiprazole by Francesca Falcone, Stefano Berloffa, Gianluca Sesso, Antonio Narzisi, Elena Valente, Valentina Viglione, Gabriele Masi, Annarita Milone, Pamela Fantozzi

“…Patients treated with Aripiprazole showed significant improvement across all scales during follow-up. ADHD was identified as a negative predictor of reduced tic severity on the YGTSS. …”
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Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration by Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan

“…Abstract Background Cortical atrophy is a common manifestation in behavioral variant frontotemporal degeneration (bvFTD), exhibiting spatial heterogeneity across various genetic subgroups, which may be driven by distinct biological mechanisms. …”
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Decentralized biobanking platform for organoid research networks by Marielle Gross, Marielle Gross, Ananya Dewan, Mario Macis, Mario Macis, Eve Budd, M. Eifler, Olayinka Odeniran, Jeff Kahn, Jeff Kahn, Jeff Kahn, Robert Clell Miller, Robert Clell Miller, William Sanchez

“…We design, develop, and demonstrate a functional de-bi platform for a real-world organoid biobank.MethodsEthnography of the organoid biobanking ecosystem was performed in 2022–2023, with site visits, interviews, focus groups, and structured observations of stakeholder interactions. …”
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Optimizing health-related quality of life assessments for stroke survivors: a validation study of psychometric properties for the Vietnamese version of stroke impact scale 3.0 by Thao Thi Phuong Nguyen, Thao Thi Phuong Nguyen, Hai Bui Hoang, Hai Bui Hoang, Huyen Thi Thanh Vu, Huyen Thi Thanh Vu, Seung Won Lee, Seung Won Lee, Seung Won Lee, Seung Won Lee

“…BackgroundEnsuring lifelong health among aging populations necessitates comprehensive assessments of functional recovery and quality of life, particularly for vulnerable groups such as older adult stroke survivors. …”
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Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study by Huijing Shao, Chang Xu, Haoran Wang, Nan Lu, Hang Gu, Caihong Zhang, Lirong Li, Qianqian Sun, Rui Guan, Beibei Xuan

“…Cross-trait pleiotropic analysis identified shared loci and genes, while functional annotation and tissue-specific analysis revealed relevant biological pathways and tissues. …”
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A machine learning-based risk prediction model for diabetic oral ulceration by Wang Xiaoling, Wang BingQian, Zhu Zhenqi, Li Wen, Gu Shuyan, Chen Hanbei, Xin Feng, Chenglong Yang, Jutang li, Guoyao Tang, Jie Wei

“…Future research should focus on validating the model across larger, multicenter cohorts and further exploring the long-term impact of ML-guided interventions on DOU management.…”
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Distinct bone metabolic networks identified in Phospho1−/− mice vs. wild type mice using [18F]FDG total-body PET by Abigail F. Hellman, Paul S. Clegg, Colin Farquharson, José Luis Millán, Carlos J. Alcaide-Corral, Carlos J. Alcaide-Corral, Karla J. Suchacki, Karla J. Suchacki, Adriana A. S. Tavares, Adriana A. S. Tavares

“…The skeletal system provides a good model for applying network analysis to total-body PET, as bone serves many classical whole-body functions as well as being an endocrine regulator of metabolism. …”
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