Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response by Alistair Perry, Laura E. Hughes, Natalie E. Adams, Michelle Naessens, Niels A. Kloosterman, Matthew A. Rouse, Alexander G. Murley, Duncan Street, P. Simon Jones, James B. Rowe

“…The consequences of frontotemporal lobar degeneration include changes in prefrontal cortical neurophysiology, with abnormalities of neural dynamics reported in the beta frequency range (14–30 Hz) that correlate with functional severity. We examined beta dynamics in two clinical syndromes associated with frontotemporal lobar degeneration: the behavioral variant of frontotemporal dementia (bvFTD) and progressive supranuclear palsy (PSP). …”
Get full text

Transcriptomics Reveals the Differences in mRNA Expression Patterns in Yak Uterus of Follicular, Luteal, and Pregnant Phases by Shaohui Beng, Daoliang Lan, Yueyue Li, Deping Li, Yuehuan Zhang, Zelang Ma, Jianbo Zhu, Shunyang Liu, Kechao Chen, Jian Li, Peng Wang, Wei Fu

“…However, the molecular mechanism regulating yak uterine functions remains to be explored. This study utilized transcriptomics to identify differentially expressed genes (DEGs) in yaks across uteruses undergoing the follicular phase (UFP) (<i>n</i> = 3/group), luteal phase (ULP) (<i>n</i> = 3/group), and pregnant phase (UPP) (<i>n</i> = 3/group), aiming to depict and compare their transcriptomic characteristics. …”
Get full text

The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…The human RNASET2 protein has demonstrated both oncosuppressive and immunoregulatory functions across various cancer types, yet its role as an oncosuppressor or alarmin-like molecule in prostate cancer (PCa) is unexplored. …”
Get full text

Macrogenomics-based analysis of rumen microbial composition and their metabolic pathways in yaks under different dietary concentrate-to-forage ratios by Fajie Gou, Fajie Gou, Yincang Han, Yincang Han, Yonggang Sun, Yonggang Sun, Weiqing Ding, Weiqing Ding, Shenwei Jin, Shenwei Jin, Yaqian Liu, Yaqian Liu, Jianyu Chen, Jianyu Chen

“…The C35 group exhibited higher activity in functional pathways related to starch and sucrose metabolism, fructose and mannose metabolism, cellulose degradation, and methanolysis. …”
Get full text

Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis by Zhicong Chen, Yanqing Gong, Fukai Chen, Hyeon Jeong Lee, Jinqin Qian, Jing Zhao, Wenpeng Zhang, Yamin Li, Yihui Zhou, Qiaobing Xu, Yu Xia, Liqun Zhou, Ji‐Xin Cheng

“…Methods The potential interactions between SCD and FADS2 were explored by bioinformatics analyses across multiple cancer cohorts, which guided subsequent functional and mechanistic investigations. …”
Get full text

Preparation and investigation of structural, optical, and dielectric properties of PVA/PVP blend films boosted by MWCNTs/AuNPs for dielectric capacitor applications by Abdu Saeed, Amal Mohsen Alghamdi, Maha Aiiad Alenizi, Reem Alwafi, G.M. Asnag, Eman Alzahrani, Randa A. Althobiti, Ahmed N. Al-Hakimi, Aeshah Salem, S.A. Al-Ghamdi

“…The capacitors exhibited stable high capacitance across a broad frequency spectrum, making them alternatives for energy storage solutions.…”
Get full text

Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis by Yu Liu, Weijie Li, Lei Lei, Yaoliang Zhou, Mingcheng Huang, Yide Li, Xiaoying Zhang, Yingyu Jiang, Haiqi Wu, Zhihua Zheng, Kongyang Ma, Chun Tang

“…Additionally, microarray and single-cell RNA sequencing data integration, including gene set enrichment analysis (GSEA), KEGG and GO functional enrichment analysis, immune infiltration analysis, and single-cell sequencing analysis, were performed to elucidate the role of PGK1 in sepsis.ResultsOur results revealed a significant upregulation of PGK1 in sepsis patients, with the area under the ROC curve (AUC) exceeding 0.9 across multiple datasets, indicating PGK1’s strong potential as a diagnostic biomarker. …”
Get full text

Impact of treatment suspension on health-related quality of life in the EMBARK trial: a post hoc analysisResearch in context by Stephen J. Freedland, Ugo De Giorgi, Antti Rannikko, Fred Saad, Miguel Ramirez-Backhaus, Anchen F. Nasr, Jasmina I. Ivanova, Arijit Ganguli, Pavol Kral, Arlene L. Reisman, Neal D. Shore

“…Separate models were used to assess four patient-reported outcome (PRO) instruments—Brief Pain Inventory – short form, Functional Assessment of Cancer Therapy – Prostate, QoL Questionnaire – Prostate 25, and European QoL 5-Dimensions 5-Levels health questionnaire—with predefined clinically meaningful thresholds. …”
Get full text

Weighted Gene Co-Expression Network Analysis Identifies Hub Genes Governing Resistance to <i>Fusarium oxysporum</i> f. sp. <i>niveum</i> in Watermelon (<i>Citrullus lanatus</i>) by Chen Zhang, Xufeng Fang, Jing Zhang, Xinying Wang, Zhao Liu, Shusen Liu, Zhengfeng Song, Peng Gao, Feishi Luan

“…Differential expressions of these genes across infection stages likely underpin the observed phenotypic disparities. …”
Get full text

SMART accelerates rate of cognitive gains in service members with mTBI and PTSD by Erin Venza, Jeffrey S. Spence, Jennifer Zientz, Cole Devlin, Jason Bailie, Jason Bailie, Jason Bailie, Andrew Darr, Andrew Darr, Andrew Darr, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Bond Chapman

“…Also of note, training-based cognitive gains were consistent across PTSD severity levels, suggesting CR is a potentially reliable tool for populations with mTBI plus concomitant PTSD. …”
Get full text

Association studies for leaf rust resistance earmark differential genomic regions for silicon (Si) responsiveness in bread wheat (Triticum aestivum L.) by Prashanth Babu, Manjunath Prasad, R. Nirmalaruban, Sudhir Kumar, Rajbir Yadav, Manjeet Kumar, Kiran B. Gaikwad, Naresh Kumar Bainsla, S. Bhaskar Reddy, Nasreen Saifi, Amit Kumar Mazumder, Meda Alekya, Gaurav Kaushik, Palaparthi Dharamteja, Meghashri S. Patil, Shiv Kumar Singh, Dunna Vijay, Ranjeet Ranjan Kumar

“…The identified Si-responsive QTLs, once validated across diverse wheat populations, hold significant promise for developing Si-responsive genotypes with improved resistance. …”
Get full text

In vivo evaluation of phage therapy against Klebsiella pneumoniae using the Galleria mellonella model and molecular characterization of a novel Drulisvirus phage species by Gustavo Quispe-Villegas, Gabriela I. Alcántara-Lozano, Diego Cuicapuza, Raúl Laureano, Brenda Ayzanoa, Pablo Tsukayama, Jesús Tamariz

“…The phage demonstrated stability across a wide range of temperatures (8°C–40°C) and pH levels (4–8). …”
Get full text

Fine mapping genetic variants affecting birth weight in sheep: a GWAS of 3007 individuals using low-coverage whole genome sequencing by Ran Li, Yuheng Bai, Maqiang Zhao, Xinyue Zhang, Haiyan Wang, Bo Feng, Shuo Zhang, Huanhuan Zhang, Gang Ren, Xihong Wang, Yu Jiang

“…The chromosome 9 QTL encompassed a regulatory region functionally linked to PLAG1 expression through expression quantitative trait locus (eQTL) mapping. …”
Get full text

The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy by I-Na Lu, Louisa Müller-Miny, Carolin Krekeler, Phyllis Fung-Yi Cheung, Georgia Antonopoulou, Astrid Jeibmann, Andreas Schulte-Mecklenbeck, Kornelius Kerl, Simon Call, Christian Reicherts, Annalen Bleckmann, Matthias Stelljes, Georg Lenz, Heinz Wiendl, Gerd Meyer zu Hörste, Oliver M. Grauer

“…Control samples were obtained from patients with idiopathic intracranial hypertension, functional neurological disorders, and multiple sclerosis. …”
Get full text

The Coral Reefs and Fishes of St. Brandon, Indian Ocean Archipelago: Implications for Sustainable Fisheries by Melanie Ricot, Sruti Jeetun, Shakeel Yavan Jogee, Deepeeka Kaullysing, Nawsheen Taleb-Hossenkhan, Maina Joseph Mbui, Beatriz Estela Casareto, Yoshimi Suzuki, Diah Permata Wijayanti, Ranjeet Bhagooli

“…The three channel sites composed a cluster. Coral species across eight families were identified, with significant variability (<i>p</i> < 0.05) observed in their benthic cover, particularly live coral cover (LCC). …”
Get full text

Deep learning of the particulate and mineral-associated organic carbon fractions using a compositional transform and mid-infrared spectroscopy by Mingxi Zhang, Zefang Shen, Lewis Walden, Farid Sepanta, Zhongkui Luo, Lei Gao, Oscar Serrano, Raphael A. Viscarra Rossel

“…The SHAP values reflected the compositional modelling and identified important organic and inorganic functional groups that differed by fraction and land use. …”
Get full text

Dose-dependent effects of capsaicin on intestinal morphology and microbiota composition in mice: Structural, immunohistochemical, and microbial insights by Kai Li, Jianghai Xu, Siying Chen, Aifei Du, Shaohua Feng, Shibin Yuan, Bangyuan Wu

“…While low-dose administration supports mucosal integrity and promotes beneficial microbial functions, higher doses disrupt epithelial architecture and induce dysbiosis. …”
Get full text

fNIRS reproducibility varies with data quality, analysis pipelines, and researcher experience by Meryem A. Yücel, Robert Luke, Rickson C. Mesquita, Alexander von Lühmann, David M. A. Mehler, Michael Lührs, Jessica Gemignani, Androu Abdalmalak, Franziska Albrecht, Iara de Almeida Ivo, Christina Artemenko, Kira Ashton, Paweł Augustynowicz, Aahana Bajracharya, Elise Bannier, Beatrix Barth, Laurie Bayet, Jacqueline Behrendt, Hadi Borj Khani, Lenaic Borot, Jordan A. Borrell, Sabrina Brigadoi, Kolby Brink, Chiara Bulgarelli, Emmanuel Caruyer, Hsin-Chin Chen, Christopher Copeland, Isabelle Corouge, Simone Cutini, Renata Di Lorenzo, Thomas Dresler, Adam T. Eggebrecht, Ann-Christine Ehlis, Sinem B. Erdoğan, Danielle Evenblij, Talukdar Raian Ferdous, Victoria Fracalossi, Erika Franzén, Anne Gallagher, Christian Gerloff, Judit Gervain, Noy Goldhamer, Louisa K. Gossé, Ségolène M. R. Guérin, Edgar Guevara, SM Hadi Hosseini, Hamish Innes-Brown, Isabell Int-Veen, Sagi Jaffe-Dax, Nolwenn Jégou, Hiroshi Kawaguchi, Caroline Kelsey, Michaela Kent, Roman Kessler, Nadeen Kherbawy, Franziska Klein, Nofar Kochavi, Matthew Kolisnyk, Yogev Koren, Agnes Kroczek, Alexander Kvist, Chen-Hao Paul Lin, Andreas Löw, Siying Luan, Darren Mao, Giovani G. Martins, Eike Middell, Samuel Montero-Hernandez, Murat Can Mutlu, Sergio L. Novi, Natacha Paquette, Ishara Paranawithana, Yisrael Parmet, Jonathan E. Peelle, Ke Peng, Tommy Peng, João Pereira, Paola Pinti, Luca Pollonini, Ali Rahimpour Jounghani, Vanessa Reindl, Wiebke Ringels, Betti Schopp, Alina Schulte, Martin Schulte-Rüther, Ari Segel, Tirdad Seifi Ala, Maureen J. Shader, Hadas Shavit, Arefeh Sherafati, Mojtaba Soltanlou, Bettina Sorger, Emma Speh, Kevin D. Stubbs, Katharina Stute, Eileen F. Sullivan, Sungho Tak, Zeus Tipado, Julie Tremblay, Homa Vahidi, Maaike Van Eeckhoutte, Phetsamone Vannasing, Gregoire Vergotte, Marion A. Vincent, Eileen Weiss, Dalin Yang, Gülnaz Yükselen, Dariusz Zapała, Vit Zemanek

“…This is especially relevant for functional Near-Infrared Spectroscopy (fNIRS), a rapidly growing technique for assessing brain function in naturalistic settings and across the lifespan, yet one that still lacks standardized analysis approaches. …”
Get full text

RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer by Qin Li, Ziteng Li, Bing Chen, Jingjing Zhao, Hongwu Yu, Jia Hu, Hongyan Lai, Hena Zhang, Yan Li, Zhiqiang Meng, Zhixiang Hu, Shenglin Huang

“…Here, we perform a thorough analysis of RNA splicing junctions in 34,775 samples across multiple sample types. We identified 29,051 tumor-specific transcripts (TSTs) in pan-cancer, with a majority of these TSTs being unannotated. …”
Get full text

Reducing greenhouse gas emissions via harvest residue management in eucalyptus afforestation on Brazilian sandy soils by Jackson Freitas Brilhante de São José, Bruno Britto Lisboa, Frederico Costa Beber Vieira, Josiléia Acordi Zanatta, Elias Frank Araujo, Juscilaine Gomes Martins, Andressa Classer Bender, Eduardo Carniel, Cimelio Bayer, Luciano Kayser Vargas

“…The soil consistently functioned as a methane sink across all management systems, with CH4 fluxes ranging from –2.56 to –3.91 kg C-CH4 ha−1 year−1. …”
Get full text