Genomic signatures of SnRKs highlighted conserved evolution within orchids and stress responses through ABA signaling in the Cymbidium ensifolium by Ruiyue Zheng, Kai Zhao, Jiemin Chen, Xuanyi Zhu, Yukun Peng, Mingli Shen, Zhong-Jian Liu, Donghui Peng, Yuzhen Zhou

“…Moreover, distinct functional domains beyond the kinase domain differentiated the subfamilies. …”
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Clinical Trial Readiness in Limb Girdle Muscular Dystrophy R1 (LGMDR1): A GRASP Consortium Study by Stephanie M. Hunn, Lindsay N. Alfano, Aileen Jones, Amanda Butler, Linda P. Lowes, Megan A. Iammarino, Natalie F. Reash, Lindsay Pietruszewski, Sandhya Sasidharan, Melissa Currence, Jeffrey M. Statland, Talia Strahler, Robert Will, Matthew Wicklund, Stacy Dixon, Renee Augsburger, Tahseen Mozaffar, Katie M. Laubscher, Shelley R. H. Mockler, Katherine D. Mathews, Nikia Stinson, Doris G. Leung, Molly M. Stark, Rebecca A. Horton, Peter B. Kang, Meredith K. James, Amanda Clause, Conrad C. Weihl, Nicholas E. Johnson, GRASP‐LGMD Consortium

“…ABSTRACT Objective Identifying functional measures that are both valid and reliable in the limb girdle muscular dystrophy (LGMD) population is critical for quantifying the level of functional impairment related to disease progression in order to establish clinical trial readiness in the context of anticipated therapeutic trials. …”
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Integrating genome and transcriptome analysis to decipher balanced structural variants in unsolved cases of neurodevelopmental disorders by Simona Mellone, Alice Spano, Denise Vurchio, Giulia Borgonovi, Giulia Borgonovi, Alessandro Ugonotti, Giulia Paglino, Alba Bianco, Sara Ronzani, Maurizio Sciancalepore, Flavia Prodam, Flavia Prodam, Amanda Papa, Maurizio Viri, Umberto Dianzani, Umberto Dianzani, Mara Giordano, Mara Giordano

“…Whole-genome sequencing (WGS) allows for base-pair resolution of structural variants across the entire genome, making it a powerful tool to detect cryptic chromosomal rearrangements and refine breakpoint mapping. …”
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T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome by Cansu Cimen Bozkus, Matthew Brown, Leandra Velazquez, Marcus Thomas, Eric A. Wilson, Timothy O’Donnell, Anna Kaminska, Denis Ruchnewitz, Douglas Geertz, Yonina Bykov, Julia Kodysh, Kasopefoluwa Y. Oguntuyo, Vladimir Roudko, David Hoyos, Komal D. Srivastava, Giulio Kleiner, Hala Alshammary, Neha Karekar, Christopher McClain, Ramya Gopal, Kai Nie, Diane Del Valle, Daniela Delbeau-Zagelbaum, Denise Rodriguez, Jessica Setal, Emily Carroll, Margrit Wiesendanger, Percio S. Gulko, Alexander Charney, Miriam Merad, Seunghee Kim-Schulze, Benhur Lee, Ania Wajnberg, Viviana Simon, Benjamin D. Greenbaum, Diego Chowell, Nicolas Vabret, Marta Luksza, Nina Bhardwaj

“…Conservation analysis across human coronaviruses and in silico alanine scanning highlighted the functional importance of mutationally constrained immunodominant regions. …”
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Biogeographic patterns and adaptive strategies of microbial carbon metabolic profiles in paddy soils in the Chinese Mollisol region by Xiaojing Hu, Haidong Gu, Mikhail Semenov, Yongbin Wang, Jinyuan Zhang, Zhenhua Yu, Yansheng Li, Junjie Liu, Jian Jin, Xiaobing Liu, Guanghua Wang

“…Here, we employed gene- and genomic-centric metagenomic approaches to explore soil microbial biogeographic patterns and functional traits regulating C metabolisms across 120 soils derived from 30 paddy fields in Chinese Mollisols. …”
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State of nature 2023 terrestrial and freshwater animal dataset for the United Kingdom and its constituent countriesZenodo by Fiona Burns, Simone Mordue, Nida Al-Fulaij, Philipp Boersh-Supan, Katherine L. Boughey, Philip Briggs, Mark A. Eaton, Colin Harrower, Angus C. Jackson, Steve Langton, Francesca Mancini, David Noble, Chris R. Shortall, Chloë A. Smith, Robin J. Pakeman

“…Trend data for long- (1970–2020/21) and short-term (2010–2020) periods have been calculated by fitting statistical models to measures of abundance (753 species) or occupancy (4979 species) across the UK. Trend data was also calculated for each constituent country: England, Northern Ireland, Scotland and Wales for reduced sets of species.Trends in abundance data were generally created from the analysis of repeat counts at specific sites. …”
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The lamprey habenula provides an extreme example for the temporal regulation of asymmetric development by Lucile Guichard, Ronan Lagadec, Léo Michel, Hélène Mayeur, Michaël Fuentès, Jordan Pain, Noah Heier, Quentin Rougemont, Maria Celina Rodicio, Antón Barreiro-Iglesias, Antón Barreiro-Iglesias, Patrick Blader, Michael Schubert, Sylvie Mazan

“…By their phylogenetic position and their marked epithalamic asymmetries, lampreys are relevant models for understanding the formation and evolution of this trait across vertebrates. In this study, we use a transcriptomic approach to identify novel signature markers to characterize the highly asymmetric, bipartite organization of habenulae in lampreys. …”
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The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution by Xiuchao Wang, Quanbin Dong, Pan Huang, Shuai Yang, Mengke Gao, Chengcheng Zhang, Chuan Zhang, Youpeng Deng, Zijing Huang, Beining Ma, Yuwen Jiao, Yan Zhou, Tingting Wu, Huayiyang Zou, Jing Shi, Yanhui Sheng, Yifeng Wang, CGVR Consortium, Liming Tang, Shixian Hu, Yi Duan, Wei Sun, Wei Chen, Qixiao Zhai, Xiangqing Kong, Lianmin Chen

“…However, existing viral genomes are mainly derived from Western populations, limiting our understanding of global gut viral diversity and functional variations necessary for personalized medicine and addressing regional health disparities. …”
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Genome-Wide Identification and Expression Analysis of the HSP90 Gene Family in Relation to Developmental and Abiotic Stress in Ginger (<i>Zingiber officinale</i> Roscoe) by Daoyan Xiao, Yajun Jiang, Zhaofei Wang, Xingyue Li, Hui Li, Shihao Tang, Jiling Zhang, Maoqin Xia, Meixia Zhang, Xingfeng Deng, Hong-Lei Li, Huanfang Liu

“…This suggests that the HSP90 gene family in ginger possesses both conserved functions and species-specific adaptations to optimize stress responses. …”
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Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis by Kornelius Schulze, Tim Daniel Rose, Lorenz Adlung, Manuela Peschka, Francesca Pagani, Joao Gorgulho, Thorben W. Fründt, Ismail Labgaa, Philipp K. Haber, Carolin Zimpel, Darko Castven, Arndt Weinmann, Teresa Garzia-Lezana, Moritz Waldmann, Thomas Renné, Hannah Voß, Manuela Moritz, Dorian Orlikowski, Hartmut Schlüter, Jan Baumbach, Myron Schwartz, Ansgar W. Lohse, Samuel Huber, Bruno Sangro, Rocio I.R. Macias, Laura Izquierdo-Sanchez, Jesus M. Banales, Henning Wege, Jens U. Marquardt, Augusto Villanueva, Josch Konstantin Pauling, Johann von Felden

“…In vitro knockdown confirmed a functional role in proliferation and migration, as exemplified for PYCR2. …”
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Quality of life in patients with metastatic colorectal cancer receiving cytotoxic and cytotoxic plus targeted therapy by Hong Tham Pham, Tuan Anh Nguyen, Thao Le Ba, Vo Ngoc Minh Tran, Ronald L. Castelino, Kim-Huong Truong-Nguyen, Bao Khanh Nguyen, Megan K. Fischer, Viet Dung Tran, Minh-Hoang Tran

“…Conclusion Compared with those on CyT alone, patients with mCRC receiving Cy-TaT showed improved overall H/QoL, functional scales, and symptom scales/items. These benefits were consistent across most subgroups of chemotherapy, with the greatest improvements in H/QoL observed in the CAPEOX-TaT and mFOLFOX-7-TaT groups.…”
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Evaluating Degenerative Lumbar Disease with Markerless 3D Motion Capture: Reliability and Validity in Sit-to-Stand Test by Yi-Ting Huang, Szu-Hua Chen, Chao-Ying Chen, Shiu-Min Wang, Pei-Yuan Wu, Dar-Ming Lai, Wei-Li Hsu

“…Markerless motion capture offers a portable alternative, yet its functional assessment applications in DLD remain underexplored. …”
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Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD in Aspergillus by Heungyun Moon, Mi-Kyung Lee, Junha Shin, Sung Chul Park, Julio C. Rivera Vazquez, Daniel Amador-Noguez, Nancy P. Keller, Hee-Soo Park, Kap-Hoon Han, Jae-Hyuk Yu

“…This study provides the first genome-wide comparative map of NsdD-mediated GRNs in filamentous fungi and highlights how evolutionary rewiring allows a conserved TF to acquire distinct regulatory functions across species.IMPORTANCEMultifunctional TFs are central in coordinating development and metabolism in filamentous fungi. …”
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WAYS OF USING CLOUD SERVICES FOR TRAINING IT BACHELORS by Pavlo Pavlyha

“…The purpose of this study is to outline the ways cloud technologies can be applied in the preparation of IT bachelors across various specializations, compile a list of relevant cloud services, and provide exam- ples of their use in the educational process. …”
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A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging by Peggy Ler, Jonathan K. L. Mak, Chandra A. Reynolds, Alexander Ploner, Nancy L. Pedersen, Juulia Jylhävä, Anna K. Dahl Aslan, Deborah Finkel, Ida K. Karlsson

“…We examined the bidirectional, longitudinal association between changes in BMI and biological aging, measured by frailty index (FI) and functional aging index (FAI), across late life. Methods This longitudinal cohort study used data from the Swedish Twin Registry substudies, GENDER, OCTO‐Twin and SATSA, collected via in‐person assessments from 1986 to 2014 at 2‐ to 4‐year intervals. …”
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Association between daily living activities and quality of life in post-COVID-19 patients: a cross-sectional study by Shameem Ahammad, Ruksana Akter, Md. Abdul Koddus, Md. Kabir Hossain, Ehsanur Rahman, Tofajjal Hossain, Mohammad Mohinul Islam, Khin Nyein Yin, Md. Feroz Kabir, Md. Iqbal Kabir Jahid

“…After the acute period of COVID-19, many people still face considerable difficulties in carrying out activities of daily living (ADLs), which are essential for independent functioning and overall quality of life (QoL). Objective This study aimed to prompt how these persistent symptoms affect individuals’ ability to perform ADLs-basic tasks essential for self-care and daily functioning and how these limitations, in turn, influence overall QoL. …”
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Mitochondrial genome characterization, evolution and intron dynamics of the entomopathogenic genus Cordyceps by Jinlong Jia, Jinlong Jia, Jinlong Jia, Chengpeng Li, Mei Tang, Mei Tang, Mei Tang, Hefa Liao, Hefa Liao, Hefa Liao, Zhuliang Yang, Zhuliang Yang, Yanan Wang, Ming Li, Wenbo Zeng, Yuanbing Wang, Yuanbing Wang

“…The rps3 gene appears to be under relaxed selection pressure across Cordyceps species. The non-conserved PCGs, such as homing endonucleases and proteins of unknown functions, show dynamic evolutionary patterns, highlighting the genetic diversity among the species. …”
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Associations of SEMA7A, SEMA4D, ADAMTS10, and ADAM8 with KRAS, NRAS, BRAF, PIK3CA, and AKT Gene Mutations, Microsatellite Instability Status, and Cytokine Expression in Colorectal... by Błażej Ochman, Piotr Limanówka, Sylwia Mielcarska, Agnieszka Kula, Miriam Dawidowicz, Wiktor Wagner, Dorota Hudy, Monika Szrot, Jerzy Zbigniew Piecuch, Jerzy Piecuch, Zenon Czuba, Elżbieta Świętochowska

“…The potential immunomodulatory functions of these molecules and their suitability as therapeutic targets require further investigation.…”
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Machine learning approach effectively discriminates between Parkinson’s disease and progressive supranuclear palsy: Multi-level indices of rs-fMRI by Weiling Cheng, Xiao Liang, Wei Zeng, Jiali Guo, Zhibiao Yin, Jiankun Dai, Daojun Hong, Fuqing Zhou, Fangjun Li, Xin Fang

“…Therefore, we aimed to discriminate between PD and PSP based on multi-level indices of resting-state functional magnetic resonance imaging (rs-fMRI) via the machine learning approach. …”
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Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation by Isabell Int-Veen, Beatrix Barth, Ramona Täglich, Betti Schopp, Hans-Christoph Nuerk, Christian Plewnia, Stefanie De Smet, Marie-Anne Vanderhasselt, Andreas J. Fallgatter, Ann-Christine Ehlis, David Rosenbaum

“…Functional Near-Infrared Spectroscopy (fNIRS) was used to assess neural changes. …”
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