Deciphering the role of heat shock protein HSPA1L: biomarker discovery and prognostic insights in Parkinson's disease and glioma by Hong Cheng, Jing Wang, Yingjie Zhao, Xiaoli Hou, Fang Ling, Yixia Wang, Yasen Cao

“…Gene Set Variation Analysis (GSVA) was performed to explore functional profiles, while LASSO regression was employed to screen potential PD biomarkers. …”
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Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome by Tamar Rubin, Stéphane Bernier, Lily Siok Hoon Lim, Michael S. Salman, Edward Leung, Aziz Mhanni, Sandra Marles, Cheryl Greenberg, Anna Perez, Yichun Sun, Isabelle Angers, Donald C. Vinh, Donald C. Vinh, Donald C. Vinh, Donald C. Vinh, Lucie Roussel

“…This also reiterates the importance of molecular and functional assessments of genomic variants identified by sequencing.…”
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Performance of Ankle Exoskeletons on Irregular Terrains: Key Design Principles and Benchmarking Tests by L. Liguori, G. Mariani, J. Taborri, I. Mileti, D. Torricelli, L. Mattioli, E. Palermo, F. Patane, S. Rossi

“…Specifically, the first prototype (S-RANK) accommodates a single DoF in the sagittal plane, whereas the second prototype (M-RANK) extends the functionality to include ankle inversion/eversion and internal/external rotation. …”
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Genomic characterization and antibiotic susceptibility of biofilm-forming Borrelia afzelii and Borrelia garinii from patients with erythema migrans by Giorgia Fabrizio, Giorgia Fabrizio, Ilaria Cavallo, Francesca Sivori, Mauro Truglio, Daniela Kovacs, Massimo Francalancia, Giovanna D’Agosto, Elisabetta Trento, Grazia Prignano, Arianna Mastrofrancesco, Eva Ruzič-Sabljič, Fulvia Pimpinelli, Enea Gino Di Domenico

“…Surface adhesion gene profiles exhibited significant variation across species, suggesting potential functional differences in host adaptation. …”
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The role of gut microbiota in a generalist, golden snub-nosed monkey, adaptation to geographical diet change by Yuhang Li, Yujie Yan, Haojie Wu, Yiyi Men, Yi Yang, Hengguang Fu, Derek Dunn, Xiaowei Wang, Genggeng Gao, Peng Zhang, Guixin Dong, Liyuan Hao, Jia Jia, Baoguo Li, Songtao Guo

“…Variations in gut microbiota composition across distinct populations mirror the disparities in macronutrient intake, with a notable emphasis on carbohydrate. …”
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Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer by Haruka Suzuki, Kohei Hamada, Junzo Hamanishi, Akihiko Ueda, Ryusuke Murakami, Mana Taki, Rin Mizuno, Koichi Watanabe, Hanako Sato, Yuko Hosoe, Hiroaki Ito, Koji Yamanoi, Hiroyuki Yoshitomi, Nobuyuki Kakiuchi, Ken Yamaguchi, Noriomi Matsumura, Seishi Ogawa, Hideki Ueno, Masaki Mandai

“…Our findings indicate that the functions and prognostic implications of TLSs may vary with their locations, and dTLSs may serve as prognostic factors and predictors of treatment efficacy. …”
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Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall by Madhumeeta Chadha, Sara Iadecola, Andrew Jenks, Valeriya Pankova, Yuen Bun Tam, Jessica Burns, Amani Arthur, Christopher P. Wilding, Liang Chen, Priya Chudasama, Dario Callegaro, Dirk C. Strauss, Khin Thway, Alessandro Gronchi, Robin L. Jones, Rosalba Miceli, Sandro Pasquali, Paul H. Huang

“…Conclusions Risk stratification of patient with STS is defined by distinct biological pathways across a range of cancer hallmarks. Incorporation of SPM6 protein signature improves prognostic risk stratification of the Sarculator nomogram. …”
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Kolmogorov–Arnold–Enhanced Nonlinear Expansions for Fine-Grained Feature Amplification in Robust Near-Shore SAR Vessel Discrimination by Hankang Wang, Gaopeng Huang, Zhao Huang, Xingru Huang, Zhaoyang Xu, Zhiwen Zheng, Shanwei Liu, Shiqing Wei, Jin Liu, Xiaoshuai Zhang

“…This structure preserves small-target details by propagating enriched semantic information across detection layers, mitigating feature loss during downsampling. …”
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Effects of Three Different Bee Pollen on Digestion, Immunity, Antioxidant Capacity, and Gut Microbes in <i>Apis mellifera</i> by Xin-Meng Li, Ying Wang, Li Lei, Ge Zhang, Bao-Hua Xu

“…Additionally, notable differences in amino acid composition were observed across the three pollen types. Feeding assays demonstrated that honeybees consumed significantly more sunflower bee-collected pollen than maize bee-collected pollen or lotus bee-collected pollen. …”
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Are cocoa plantations suitable habitats? Network between parasites (Diptera: Hippoboscidea) and hosts (Mammalia: Chiroptera) in cocoa-dominated landscapes of the Brazilian Amazon by Samantha Valente Dias, Rafaela Jemely Rodrigues Alexandre, Letícia Lima Correia, Ludmilla M. S. Aguiar, Gustavo Graciolli, Daniel Maximo Correa Alcantara, Thiago Bernardi Vieira, Thiago Bernardi Vieira

“…In the Amazon, various forms of disturbance contribute to ecosystem imbalance, potentially leading to the local extinction and disruption of ecological functions. Cacao cultivation has been expanding in the Amazon, but studies on its impacts on bat diversity are still limited, hindering the development of effective conservation strategies. …”
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Exploring Work Engagement and Cynicism in Industry: A Preliminary Investigation in a Central Italian Engineering Company by Luca Di Giampaolo, Teresa Galanti, Michela Cortini, Simone De Sio, Claudia Giurgola, Federica Marino, Piergiorgio Astolfi, Rossella Martelli, Daria Ziccardi, Paola Borrelli, Laura Forcella, Maria Elisa Maiolo, Luca Coppeta

“…High levels of engagement are associated with improved organizational functioning and a stronger sense of belonging among employees. …”
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Meta-analysis of Germline Whole-exome Sequencing in 1435 Cases of Testicular Germ Cell Tumour to Evaluate Disruptive Mutations Under Dominant, Recessive, and X-linked Inheritance M... by Zeid Kuzbari, Charlie F. Rowlands, Isaac Wade, Alice Garrett, Chey Loveday, Subin Choi, Beth Torr, Kevin Litchfield, Alison Reid, Robert Huddart, Peter Broderick, Richard S. Houlston, Clare Turnbull

“…We performed gene-level association testing of protein-truncating variants and nonsynonymous disruptive variants across six candidate gene sets (733 genes) potentially biologically related to TGCT. …”
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Impact assessment of differential chlormequat chloride exposure on soil fungal community dynamics by Qiujun Lin, Qiujun Lin, Xianxin Wu, Xianxin Wu, Lina Li, Lina Li, Tianshu Peng, Tianshu Peng, Xun Zou, Xun Zou, Guang Li, Guang Li, Jianzhong Wang, Jianzhong Wang, Chunjing Guo, Chunjing Guo

“…Basidiomycota displayed relative stability across treatments. Functional guild analysis identified significant shifts: pathogenic fungi like Neonectria spp. declined drastically (from 92.08% in CK to 25.84% under D treatment), whereas saprophytic fungi such as Plectosphaerella spp. proliferated markedly (28.68% in D; 22.82% in G vs. 2.26% in CK).DiscussionThese findings establish clear dose–response relationships between CC exposure levels and fungal community parameters. …”
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The impact of biofeedback in enhancing chronic pain rehabilitation: A systematic review of mechanisms and outcomes by Andrea Calderone, Vincenza Maura Mazzurco Masi, Rosaria De Luca, Antonio Gangemi, Mirjam Bonanno, Daniela Floridia, Francesco Corallo, Giovanni Morone, Angelo Quartarone, Maria Grazia Maggio, Rocco Salvatore Calabrò

“…The evidence that was examined shows that it is effective in improving how pain is perceived, increasing functional results, and boosting overall quality of life among a variety of patient groups.…”
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Socioeconomic status and lifestyle as factors of multimorbidity among older adults in China: results from the China Health and Retirement Longitudinal Survey by Wei Gong, Wei Gong, Wei Gong, Xiaoxiao Hu, Huimin Cui, Huimin Cui, Yuxin Zhao, Yuxin Zhao, Hong Lin, Hong Lin, Hong Lin, Peng Sun, Peng Sun, Jianjun Yang, Jianjun Yang

“…SHapley Additive exPlanations (SHAP) were used to interpret model outputs.ResultsXGBoost achieved the best predictive performance (AUC = 0.788 on the test set), outperforming both linear and non-linear models across most evaluation metrics. SHAP analysis revealed that education level, activities of daily living (ADL), work status, self-assessed health status, and per capita income were the top factors associated with of multimorbidity. …”
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Effect of Exercise or Combined Exercise and Diet Intervention on Sleep and Fatigue in Kidney Transplant Recipients by Tim J. Knobbe, Daan Kremer, Monica L. van der Meulen, Frederike J. Bemelman, Stefan P. Berger, Gerjan Navis, Stephan J.L. Bakker, Eva Corpeleijn, Tim J. Knobbe, Daan Kremer, Dorien M. Zelle, Gerald Klaassen, Desie Dijkema, Iris M.Y. van Vliet, Paul B. Leurs, Frederike J. Bemelman, Maarten H.L. Christiaans, Stefan P. Berger, Gerjan Navis, Stephan J.L. Bakker, Eva Corpeleijn

“…Introduction: Physical functioning and diet may be promising targets to improve sleep and reduce fatigue among kidney transplant recipients (KTRs). …”
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Argatroban in patients with acute ischemic stroke with early neurological deterioration: a cost-effectiveness analysis from the perspective of Chinese healthcare system by Yu Xie, Liping Hu, Ping Xu, Xianbin Guo, Junxiu Cai, Min Pan, Jie Tang, Qingtao Gong, Rong Su, Yake Lou, Yan Liu, Li Wang, Ying Yu

“…Background and ObjectiveStudies have shown that argatroban improves 90-day functional outcomes in patients with acute ischemic stroke (AIS) with early neurological deterioration (END). …”
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Intercropping-driven effects on soil organic carbon mineralization and its temperature sensitivity are associated with soil C-N-P stoichiometry and carbon-acquiring microorganisms... by Ziyu Yang, Jinmeng Hu, Xiaowei Chen, Yuping Zhang, Yizhe Wang, Jianwei Peng, Jiangchi Fei, Gongwen Luo, Chaolin Liao

“…The carbon–nitrogen-phosphorus (C-N-P) stoichiometry of soil and microbiome, C-acquiring enzyme activities, and the abundances of 15 functional genes relating to SOC mineralization were employed to identify their relationships with SOC mineralization rate and its Q10. …”
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Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands by Jessica A. Greven, Joshua R. Wydra, Rory A. Greer, Cynthia Zhi, David A. Price, Jordyn D. Svoboda, Christopher L. M. Camitta, Mya Washington, Daisy W. Leung, Yuhua Song, Jen Alexander-Brett, Tom J. Brett

“…Our findings imply that pharmaceutical strategies targeting these surfaces might be effective to modulate TREM2 functions.…”
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Effects of soil water on fungal community composition along elevational gradients on the northern slope of the Central Kunlun Mountains by Yongguang Zhang, Yongguang Zhang, Chaonan Li, Zhihao Zhang, Chenhong Li, Bo Zhang, Hongchen Jiang, Waqar Islam, Xiangzhen Li, Fanjiang Zeng

“…Results indicated that the dominant phyla identified across the seven elevational gradients were Basidiomycota and Ascomycota, displaying a unimodal pattern and a U-shaped pattern in relative abundance, respectively. …”
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