Characterization of Spectrin Family Genes and Their Evolutionary Roles in Domestication and Breeding of the Silkworm <i>Bombyx mori</i> by Kunpeng Lu, Chengyu Zhan, Jianghong Shen, Chao Zhi, Jun Deng, Kerui Lai, Minjin Han, Hai Hu, Xiaoling Tong, Fangyin Dai

“…The spectrin family genes play critical roles in cytoskeletal organization and cellular integrity, yet their evolutionary and functional significance in non-classical model organisms remains poorly explored. …”
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Characteristic of motor-related cortical network during stimulating at the affected or bilateral limbs of stroke patients by acupuncture by Ziwen Yuan, Fei Mao, Zimo Liu, Shubo Xing, Liu Yang, Wenping Wu, Weiwei Xu, Jingyuan Deng, Gang Wang

“…Some evidence suggests bilateral stimulation more effectively engages networks across both hemispheres compared to the affected side only. …”
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Exploring the optimal lower blood pressure boundary during endovascular thrombectomy in patients with large vessel occlusion by Yu-Ming Chang, Chun-Min Wang, Kang-Po Lee, Po-Chun Shen, Po-Yu Lin, Chi-Hung Liu, Sheng-Hsiang Lin, Chih-Hung Chen, Meng-Tsang Hsieh, Pi-Shan Sung

“…This study aims to delve into the correlation between various targets of lower boundary for systolic and diastolic BP (SBP and DBP) during EVT and 3-month functional outcomes. Methods: A cohort study was conducted across two EVT-capable centers, enrolling patients with large artery occlusion undergoing EVT within 8 h of stroke onset. …”
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The stifling burden of climate change on African public healthcare systems by Jack Ogony, Jack Ogony, Judith Mangeni, George Ayodo, Esther Amulen, Florenc Scopas, Tusubila Juma, Michael Wagaba, Amos Deogratius Mwaka, Lena Nwanja, Sambila Princewill, Ben Oyugi, Arthy Yongo, Sitraka Rakotosolofo, Alberto Francioli, Eunison Mugamu, Julia Davies, Simon Karanja, Corrie Hannah

“…It disrupts the physical environment, natural and human systems, and the functionality of healthcare systems, acting as a multiplier threat that jeopardizes and potentially reverses decades of health gains. …”
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AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates by William J. Smiles, Ashley J. Ovens, Dingyi Yu, Naomi X. Y. Ling, Andrea C. Poblete Goycoolea, Kaitlin R. Morrison, Emmanuel O. Murphy, Astrid Glaser, Sophie F. Monks O’Byrne, Scott Taylor, Alistair M. Chalk, Carl R. Walkley, Luke M. McAloon, John W. Scott, Bruce E. Kemp, Ashfaqul Hoque, Christopher G. Langendorf, Janni Petersen, Sandra Galic, Jonathan S. Oakhill

“…Whether AMPK contains other functional mTORC1 substrates is unknown. Using mass spectrometry, we generated precise stoichiometry profiles of phosphorylation sites across all twelve AMPK complexes expressed in proliferating human cells and identified seven sites displaying sensitivity to pharmacological mTORC1 inhibition. …”
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A bacterial and viral genome catalogue from Atlantic salmon highlights diverse gut microbiome compositions at pre- and post-smolt life stages by Varsha Kale, Germana Baldi, Martin Beracochea, Cecilie Clausen, Alejandra Escobar-Zepeda, Sabina Leanti La Rosa, Laurène A. Lecaudey, Sen Li, Sarah S. T. Mak, Michael D. Martin, Garazi Martin Bideguren, Louisa A. Pless, Jacob A. Rasmussen, Alexander B. Rogers, Harald Sveier, Arturo Vera-Ponce de León, Ana Verissimo, M. Thomas P. Gilbert, Lorna Richardson, Morten T. Limborg, Robert D. Finn

“…We profiled the salmon gut microbiome across 540 salmon samples in differing conditions with a view to capture the genomic diversity that can be resolved from the salmon gut. …”
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Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies by Xiaoming Zhang, Yibing Guo, Kun Fang, Xiangqian Huang, Duo Lan, Mengqi Wang, Lina Jia, Xunming Ji, Ran Meng, Da Zhou

“…Methods: A comprehensive literature search was conducted across multiple databases to identify studies investigating the effects of MSC-Exos on rodent models of IS. …”
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Kombucha: An Old Tradition into a New Concept of a Beneficial, Health-Promoting Beverage by Dhuelly Kelly Almeida Andrade, Boying Wang, Emília Maria França Lima, Sergei Konstantinovich Shebeko, Alexey Mikhailovich Ermakov, Valentina Nikolaevna Khramova, Iskra Vitanova Ivanova, Ramon da Silva Rocha, Manuela Vaz-Velho, Anthony Nhamo Mutukumira, Svetoslav Dimitrov Todorov

“…Its origins trace back to China, from where it spread across Asia and Europe before reaching the modern global market. …”
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Geographic Distribution Pattern Determines Soil Microbial Community Assembly Process in <i>Acanthopanax senticosus</i> Rhizosphere Soil by Mingyu Wang, Xiangyu Xing, Youjia Zhang, Xin Sui, Chunying Zheng

“…PICRUSt 2.0 and FUNGuild were used to predict the potential functions of soil bacterial and fungal microbiota, respectively, during different land use patterns. …”
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TIMP-1 associates with myelin membrane and preserves myelin in injured peripheral nerve by Hanbum Joe, Hyungseok Seo, Jennifer Dolkas, Megh Jawala, Swathi K. Hullugundi, Yang Hoon Chung, Hemal H. Patel, Andrei V. Chernov, Veronica I. Shubayev

“…Myelin enables rapid impulse propagation in axons across long distances. Following peripheral nerve injury, Schwann cells provide trophic, metabolic, and immune support to damaged neurons. …”
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Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium by Oliver Labrenz, Oliver Labrenz, Lucie Waedel, Lucie Waedel, Michael Kölch, Michael Kölch, Susanne Lezius, Christina Wacker, Antonia Fröhlich, Antonia Fröhlich, Kerstin Paschke, Rainer Thomasius, Olaf Reis, Olaf Reis

“…BackgroundDigital media use disorder (DMUD) is a prevalent problem among young people, which can result in adverse consequences and functional impairments across multiple domains of life due to a persistent inability to regulate one’s use, which can lead to the development of psychological problems. …”
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Effect of Intravenous Tirofiban Versus Placebo on Excellent Outcome in Patients With Acute Ischemic Stroke: The Multicenter, Randomized INSTANT Trial Protocol by Fan Zhang, Minghui Xiao, Cong Zhang, Guangxiong Yuan, Zhiyong Xie, Yi Yin, Ruize Zhou, Shanggui Yuan, Genxiang Xiao, Donghuan Mei, Xiaobing Zeng, Huashi Liu, Huadong Li, Hongwen Liu, Jinchang Tan, Bin Chen, Qingqing Fu, Bin Li, Jinxing Lai, Wei Sun, Shuhua Xie, Zhaohui Lai, Zhongming Qiu, Zidian Jiang, Xianghong Liu, Guoyong Zeng

“…The primary efficacy end point is excellent functional status, defined as a score of 0 or 1 on the modified Rankin Scale at 90 days after randomization. …”
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Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…Next, an innovative classification system was implemented, classifying 10,905 compounds into a 3-tier hierarchy across 141 classes, based on functional group weighting. …”
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Treatment resistance in schizophrenia and depression as an interactive kind: Mapping the development of a classification through Meta-Narrative review by Leighton Schreyer, Csilla Kalocsai, Oshan Fernando, Melanie Anderson, Vanessa Lockwood, Sophie Soklaridis, Gary Remington, Araba Chintoh, Suze Berkhout

“…Despite ongoing attempts to delineate and name treatment resistance (TR) in psychiatry, the term is increasingly deployed across diagnostic categories. Still, what it is that constitutes TR remains unclear and in flux. …”
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Advanced vat photopolymerization 3D printing of silicone rubber with high precision and superior stability by Zhongying Ji, Bingang Xu, Zhiyong Su, Xiaochen Wang, Yang Lyu, Sen Liu, Tao Wu, Xiaolong Wang

“…Silicone rubber (SR) is a versatile material widely used across various advanced functional applications, such as soft actuators and robots, flexible electronics, and medical devices. …”
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Differences in care delivery for children and adolescents with cancer in Europe – Results from the SIOPE OCEAN project by Maria Otth, Teresa de Rojas, Kerstin K. Rauwolf, Miguel Martins, Uta Dirksen, Delphine Heenen, Lejla Kameric, Pamela Kearns, Ruth Ladenstein, Cormac Owens, Caroline Queiroz, Richard Sullivan, Carmelo Rizzari, Gilles Vassal

“…Results: The cancer incidence across Europe was 15/100’000 and 26/100’000 in those aged 0–14 and 15–24 years respectively in 2022. …”
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Physical Activity, Sleep, and Quality of Life in Pulmonary Arterial Hypertension: Novel Insights From Wearable Devices by Andrew M. Hughes, Alisha Lindsey, Jeffrey Annis, Kelly Burke, Hiral Master, Luke G. Silverman‐Lloyd, Jonah D. Garry, Michael J. Blaha, Erika S. Berman Rosenzweig, Robert P. Frantz, Paul M. Hassoun, Evelyn M. Horn, Jane A. Leopold, Franz P. Rischard, Brett Larive, Nicholas S. Hill, Serpil C. Erzurum, Gerald J. Beck, Anna R. Hemnes, Evan L. Brittain

“…ABSTRACT Reduced functional capacity and poor sleep quality are common in pulmonary arterial hypertension (PAH). …”
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Hearing problems in humans and mouse models with rare copy number variants associated with schizophrenia: a scoping review protocol [version 2; peer review: 2 approved, 1 approved... by Noushin Saadullah Khani, Maria Richards-Brown, Jennifer F Linden, Lauren Varney, Elvira Bramon, Stephen Murtough, Chen Lu, Daniele Panconesi, Marius Cotic, Rosemary Abidoph, Alvin Richards-Belle, Daisy Mills

“…Conclusions To our knowledge, this will be the first scoping review to explore auditory functioning across all CNVs that confer high schizophrenia risk. …”
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Thermal sensitivity and niche plasticity of generalist and specialist leaf-endophytic bacteria in Mangrove Kandelia obovata by Rajapakshalage Thashikala Nethmini, Huaxian Zhao, Lianghao Pan, Xinyi Qin, Jiongqing Huang, Qing He, Xiaofang Shi, Gonglingxia Jiang, Qinghua Hou, Qingxiang Chen, Xiaolei Li, Ke Dong, Lingling Xie, Nan Li

“…Soil nutritional factors, particularly phosphate for generalists and total organic carbon for specialists are critical in shaping the functional profiles. Interestingly, temperature has a limited impact on functional profiles. …”
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Adherence to Adjuvant Endocrine Therapy in Patients With Nonmetastatic Estrogen Receptor–Positive Breast Cancer: A Comprehensive Brazilian Real-World Data Study by Daniele Assad-Suzuki, Danielle Laperche-Santos, Heloisa Resende, Fernanda Cesar Moura, Sulene Cunha Sousa Oliveira, Andrea Kazumi Shimada, Renata Arakelian, Anna Luiza Zapalowski Galvão, Bruno Santos Wance de Souza, Amanda Guimarães Castro Custódio, Monalisa Ceciliana Freitas Moreira de Andrade, Yuri Cardoso Rodrigues Beckedorff Bittencourt, Maria Cristina Figueroa Magalhães, Cristiano de Pádua Souza, Carlos Eduardo Paiva, Poliana Albuquerque Signorini, Daniela Jessica Pereira, Angélica Nogueira-Rodrigues, Daniela Dornelles Rosa, Romualdo Barroso-Sousa

“…Factors associated with adherence were nonuse of ovarian suppression (P = .004), use of anti–human epidermal growth factor receptor 2 therapy (P = .007), high European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 scores on global health status (P = .0004), role functioning (P = .03), emotional functioning (P = .0007), cognitive functioning (P < .001), and social functioning (P = .0005), and EORTC BR23 scores on body image (P < .001) and future perspective domains (P = .0198).CONCLUSIONMore than one third of the patients evaluated were not adherent to ET. …”
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