Impact of Poly(Lactic Acid) and Graphene Oxide Nanocomposite on Cellular Viability and Proliferation by Karina Torres Pomini, Júlia Carolina Ferreira, Laira Mireli Dias da Silva, Paulo Gabriel Friedrich Totti, Monique Gonçalves Alves, Eliana de Souza Bastos Mazuqueli Pereira, Marcelo Melo Soares, Durvanei Augusto Maria, Rose Eli Grassi Rici

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INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma by Simin Zhao, Yu Zhang, Xiaoqin Meng, Ye Wang, Yahui Li, Hao Li, Xingyu Zhao, Pishan Yang, Shaopeng Liu, Chengzhe Yang

“…Moreover, INHBA+Mac in ODSCC presented stronger immune-suppressive functions than that in NODSCC. iCAF differentially highly expressed INHBA and enriched in immune-related pathways and collagen/ECM pathways across CAF subsets, and possessed stronger immune-suppressive functions, as shown by up-regulated gene expression of TDO2, IDO1 and DUSP4 in ODSCC versus in NODSCC. …”
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Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry by Aikaterini Anastasiou, Alex Brehm, Johannes Kaesmacher, Adnan Mujanovic, Marta de Dios Lascuevas, Tomás Carmona Fuentes, Alfonso López-Frías, Blanca Hidalgo Valverde, Ansgar Berlis, Christoph J. Maurer, Thanh N. Nguyen, Mohamad Abdalkader, Piers Klein, Guillaume Thevoz, Patrik Michel, Bruno Bartolini, Marius Kaschner, Daniel Weiss, Andrea M. Alexandre, Alessandro Pedicelli, Paolo Machi, Gianmarco Bernava, Shuntaro Kuwahara, Kazutaka Uchida, Jason Wenderoth, Anirudh Joshi, Grzegorz Karwacki, Manuel Bolognese, Agostino Tessitore, Sergio Lucio Vinci, Amedeo Cervo, Claudia Rollo, Ferdinand Hui, Aaisha Siddiqua Mozumder, Daniele Giuseppe Romano, Giulia Frauenfelder, Nitin Goyal, Vivek Batra, Violiza Inoa, Christophe Cognard, Matúš Hoferica, Riitta Rautio, Daniel P. O. Kaiser, Johannes C. Gerber, Julian Clarke, Michael R. Levitt, Marcel N. Wolf, Ahmed E. Othman, Luca Scarcia, Erwah Kalsoum, Diana Melancia, Diana Aguiar de Sousa, Maria Porzia Ganimede, Vittorio Semeraro, Flavio Giordano, Massimo Muto, Aristeidis Katsanos, Umesh Bonala, Anil M. Tuladhar, Sjoerd F. M. Jenniskens, Victoria Hellstern, Ilka Kleffner, Paolo Remida, Susanna Diamanti, Leonardo Renieri, Elena Ballabio, Luca Valvassori, Nikki Rommers, Mira Katan, Victor Schulze-Zachau, Marios-Nikos Psychogios

“…Design: Retrospective cohort study across 34 international centers. Methods: Patients with large vessel occlusion and RS after failed thrombectomy (2019–2023) were included. …”
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Design and Application of GISC Beijing Global Cache by Gu Wenjing, Guo Ping, Zhang Laien, Xue Lei, Han Xinqiang, Gao Feng, He Wenchun, Wang Huaile, Wang Peng, Wang Bo

“…The global data cache's overall architecture is introduced, including its core functionalities and the underlying technical implementation. …”
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Is a single calibration for the TloadDback cognitive fatigue induction task reliable? by Jeromy Michael Hrabovecky, Jeromy Michael Hrabovecky, Xavier De Tiège, Xavier De Tiège, Chloé Samyn, Guillermo Borragán, Philippe Peigneux, Mélanie Strauss, Hichem Slama, Hichem Slama

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Simple ecological indicators benchmark regeneration success of Amazonian forests by André L. Giles, Juliana Schietti, Milena F. Rosenfield, Rita C. Mesquita, Daniel Luis Mascia Vieira, Ima C. G. Vieira, Lourens Poorter, Pedro H. S. Brancalion, Marielos Peña-Claros, João Siqueira, Luis Oliveira Junior, Mário Marcos do Espírito-Santo, Priscila Sanjuan de Medeiros Sarmento, Joice N. Ferreira, Erika Berenguer, Jos Barlow, Fernando Elias, Henrique Luis Godinho Cassol, Richarlly C. Silva, Sabina Cerruto Ribeiro, Natália Medeiros, André B. Junqueira, Paulo Massoca, Marciel Jose Ferreira, Markus Gastauer, Leandro V. Ferreira, Danilo Roberti Alves de Almeida, Luiz E. O. C. Aragão, Catarina C. Jakovac

“…However, the vast variability in regeneration rates across environmental gradients and over time poses considerable challenges for assessing regeneration success and ecosystem services provision in human-modified landscapes. …”
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Spin excitations and flat electronic bands in a Cr-based kagome superconductor by Zehao Wang, Yucheng Guo, Hsiao-Yu Huang, Fang Xie, Yuefei Huang, Bin Gao, Ji Seop Oh, Han Wu, Jun Okamoto, Ganesha Channagowdra, Chien-Te Chen, Feng Ye, Xingye Lu, Zhaoyu Liu, Zheng Ren, Yuan Fang, Yiming Wang, Ananya Biswas, Yichen Zhang, Ziqin Yue, Cheng Hu, Chris Jozwiak, Aaron Bostwick, Eli Rotenberg, Makoto Hashimoto, Donghui Lu, Junichiro Kono, Jiun-Haw Chu, Boris I. Yakobson, Robert J. Birgeneau, Guang-Han Cao, Atsushi Fujimori, Di-Jing Huang, Qimiao Si, Ming Yi, Pengcheng Dai

“…We also observe low-energy magnetic excitations evolving across the low-temperature transition, largely consistent with the FB shift. …”
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Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China by Zhenglong Guo, Wenke Yang, Qiongrui Zhao, Yuwei Zhang, Xin Wang, Jinming Wang, Ruili Wang, Ruili Wang, Bingtao Hao, Shixiu Liao

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Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression by Li Yuan, Libin Pan, Yunzhe Wang, Jing Zhao, Luo Fang, Ying Zhou, Ruihong Xia, Yubo Ma, Zhengchen Jiang, Zhiyuan Xu, Can Hu, Yanan Wang, Shengjie Zhang, Bo Zhang, Haiying Ding, Mengxuan Chen, Haibo Cheng, Ajay Goel, Zhao Zhang, Xiangdong Cheng

“…Abstract As a critical component of the tumour immune microenvironment (TIME), the resident microbiota promotes tumorigenesis across a variety of cancer types. Here, we integrated multiple types of omics data, including microbiome, transcriptome, and metabolome data, to investigate the functional role of intratumoral bacteria in gastric cancer (GC). …”
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Cross-species single-cell transcriptomic atlas of retinal photoreceptors reveals molecular signatures underlying color vision adaptation by Zhibin Li, Chengkai Yan, Yubao Lu, Yaqing Shu, Shilin Wu, Xi Cheng, Yuge Wang, Shishi Shen, Hui Yang, Gang Cao, Jianping Ji, Liangming Zhang, Jian Sun, Dongchang Xiao, Shasha Li, Wei Qiu

“…Summary: The retina exhibits conserved structural and functional features across species, yet the evolutionary mechanisms underlying color vision remain unclear. …”
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Changes in auditory cortex subregions and their prediction for sound therapy outcomes in patients with tinnitus by Ling Wang, Yu Zhang, Rui Zhao, Yan Huang, Xinghao Wang, Yuyou Huang, Jiancheng Zhang, Han Lv, Pengfei Zhao, Zhenghan Yang, Qian Chen, Zhenchang Wang

“…We compared gray matter volume, fractional anisotropy(FA), amplitude of low-frequency fluctuations(ALFF), fractional ALFF(fALFF), regional homogeneity(ReHo) within AC subregions, and functional connectivity(FC) between each subregion and other brain voxels, across the three groups. …”
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High performance relaxor ferroelectric textured ceramics for electrocaloric refrigeration by Xuexin Li, Jinglei Li, Yang Li, Xuechen Liu, Shuai Yang, Jie Wu, Dingwei Hou, Jinjing Zhang, Haijun Wu, Yang Zhang, Xiangdong Ding, Jun Sun, Shujun Zhang, Hongliang Du, Fei Li

“…Notably, the ΔT variation remains within ±10% across a temperature range of 30 °C to 80 °C, demonstrating a promising material for the design and application of electrocaloric cooling devices. …”
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Prognostic Value of the Goutallier Scale for Paravertebral Muscle Atrophy in Predicting Disability and Pain Outcomes in Degenerative Lumbar Spinal Stenosis: A Longitudinal Cohort S... by Giuseppe Corazzelli, Sergio Corvino, Chiara Di Domenico, Federico Russo, Vincenzo Meglio, Settimio Leonetti, Valentina Pizzuti, Marco Santilli, Alessandro D’Elia, Francesco Ricciardi, Sergio Paolini, Raffaele de Falco, Oreste de Divitiis, Vincenzo Esposito, Gualtiero Innocenzi

“…However, postoperative functional outcomes are variable and influenced by factors beyond neural compression alone. …”
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Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures by Alexandra M. Lish, Nancy Ashour, Richard V. Pearse, II, Paige C. Galle, Gwendolyn A. Orme, Sarah E. Heuer, Courtney R. Benoit, Kellianne D. Alexander, Elyssa F.L. Grogan, Gizem Terzioglu, Allegra Scarpa, Andrew M. Stern, Nicholas Seyfried, Vilas Menon, Tracy L. Young-Pearse

“…Comparing monocultures and tricultures, we demonstrate how cell-cell interactions shape transcriptional and functional states across all three cell types. Neurons in triculture exhibit increased spine density and activity, while astrocytes and microglia show altered responses to proinflammatory stimulation. …”
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A chromosome-level reference genome for the critically endangered Southern Corroboree frog (Pseudophryne corroboree) [version 1; peer review: 2 approved] by Lee Berger, Tiffany A. Kosch, Deon Gilbert, Andrew J. Crawford, David Hunter, Damian Goodall, Linelle Abueg, Michael McFadden, Giulio Formenti, Joanna Collins, Nivesh Jain, Tatiana Tilley, Conor Whelan, Brian O'Toole, Matthieu Muffato, Ira Cooke, Olivier Fedrigo, Bethan Yates, Erich D. Jarvis, Jennifer Balacco, Lee F. Skerratt

“…This species has been driven to functional extinction by the introduction of the fungal disease, chytridiomycosis. …”
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The PAZ pocket and dimerization drive CpAgo’s guide-independent and DNA-guided dual catalysis by Yuchan Liu, Jiasu Zhang, Ji Liu, Shengchun Zhang, Linfeng An, Wenbing Xie, Kaiming Zhang, Shanshan Li

“…Abstract Argonaute proteins (Agos) play essential roles in nucleic acid targeting across life domains. While eukaryotic Agos (eAgos) utilize small-interfering RNAs (siRNAs) or microRNAs (miRNAs) for RNA interference, the mechanisms driving prokaryotic Agos (pAgos) in bacterial defense remain underexplored. …”
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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening by Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan

“…Here, we describe a method that reproducibly generates thousands of organoids across multiple hiPSC lines. These High Quantity brain organoids (Hi-Q brain organoids) exhibit reproducible cytoarchitecture, cell diversity, and functionality, are free from ectopically active cellular stress pathways, and allow cryopreservation and re-culturing. …”
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Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in Gram‐negative bacteria by Audrey Goman, Bérengère Ize, Katy Jeannot, Camille Pin, Delphine Payros, Cécile Goursat, Léa Ravon‐Katossky, Kazunori Murase, Camille V. Chagneau, Hélène Revillet, Frédéric Taieb, Sophie Bleves, Laure David, Etienne Meunier, Priscilla Branchu, Eric Oswald

“…The cprA gene is conserved across Pseudomonas aeruginosa clades and its expression is directly regulated by the two‐component system PmrAB. …”
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Observation of metal-organic interphase in Cu-based electrochemical CO2-to-ethanol conversion by Yan Shen, Nan Fang, Xinru Liu, Yu Ling, Yuming Su, Tian Tan, Feng Chen, He Lin, Boxuan Zhao, Jin Wang, Duanhui Si, Shunji Xie, Ye Wang, Da Zhou, Teng Zhang, Rong Cao, Cheng Wang

“…Using an automated platform, 1080 CO2RR experiments with 180 molecular modifiers identify functional groups affecting selectivity for ethanol and multi-carbon (C2+) products. …”
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Strain-induced lead-free morphotropic phase boundary by Reza Ghanbari, Harikrishnan KP, Kinnary Patel, Hua Zhou, Tao Zhou, Rui Liu, Liyan Wu, Aarushi Khandelwal, Kevin J. Crust, Sankalpa Hazra, John Carroll, Cedric J. G. Meyers, Jiayue Wang, Sergey Prosandeev, Huimin Qiao, Young-Hoon Kim, Yoji Nabei, Miaofang Chi, Dali Sun, Nina Balke, Martin Holt, Venkatraman Gopalan, Jonathan E. Spanier, David A. Muller, Laurent Bellaiche, Harold Y. Hwang, Ruijuan Xu

“…The coexistence of energetically competing phases facilitates field-driven polarization rotation and phase transitions, giving rise to a multi-state polarization switching pathway and large enhancements in dielectric susceptibility and tunability across a broad frequency range. Our results open new possibilities for engineering lead-free thin films with enhanced functionalities for next-generation applications.…”
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