Molecular cloning of TPM3 gene in qinchuan cattle and its effect on myoblast proliferation and differentiation by Juntao Guo, Jianfang Wang, Ke Zhang, Zhimei Yang, Bingzhi Li, Yueting Pan, Hengwei Yu, Shengchen Yu, Sayed Haidar Abbas Raza, Belete Kuraz Abebea, Linsen Zan

“…This protein demonstrated high conservation across species while displaying a predominant α-helix secondary structure despite being an unstable acidic protein. …”
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AlphaMissense Predictions and ClinVar Annotations: A Deep Learning Approach to Uveal Melanoma by David J. Taylor Gonzalez, MD, Mak B. Djulbegovic, MD, MSc, Meghan Sharma, MD, MPH, Michael Antonietti, BS, Colin K. Kim, BS, Vladimir N. Uversky, PhD, DSc, Carol L. Karp, MD, Carol L. Shields, MD, Matthew W. Wilson, MD

“…We explore the use of a novel deep learning tool to assess the functional impact of genetic mutations in UM. Design: A cross-sectional bioinformatics exploratory data analysis of genetic mutations from UM cases. …”
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Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibitor mitigate Aβ oligomer-induced neurotoxicity in Alzheimer’s disease by Jing Ma, Yu Tian, Chengzhong Du, Yang Zhu, Wen Huang, Chenyu Ding, Penghui Wei, Xuehan Yi, Zhangya Lin, Wenhua Fang

“…In an Aβ1-42 oligomer-induced AD mouse model, systematic administration of NM@PB-Ce (320 μg/mL, 0.01 mL/g/day for 14 days) significantly improved cognitive performance across multiple behavioral paradigms, including the Morris water maze, Y-maze, and open field tests. …”
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The ADAMTS2 metalloproteinase inhibits tumor growth by regulating the innate immune system by Loïc Joannes, Laura Dupont, Louis Stock, Esther Arpigny, Pascale Hubert, Marie Ancion, Margaux Luyckx, Joan Abinet, Wen Peng, Didier Calaldo, Agnes Noel, Thomas Marichal, Michael Herfs, Christophe Deroanne, Alain Colige

“…These data identify ADAMTS2 as a cancer regulator with antagonistic functions, limiting initial progression but promoting efficient metastatic dissemination.…”
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Comparison of the efficacy of one-stage revision surgery guided by precise pathogen diagnosis and conventional two-stage revision for chronic knee periprosthetic joint infection by Zhengwei Xiao, Jinyuan Zeng, Zeyu Zhang, Baijian Wu, Zihao Hong, Yufeng Guo, Chengguo Huang, Zida Huang, Zhaoyang Wu, Wenming Zhang, Xinyu Fang, Wenbo Li

“…Clinical characteristics, pathogen detection rates, targeted antibiotic therapy, reinfection rates, and functional outcomes were compared between patients who underwent one-stage and two-stage revision surgeries. …”
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Constructing a novel mitochondrial metabolism-related genes signature to evaluate tumor immune microenvironment and predict survival of colorectal cancer by Hou Wang, Hou Wang, Kai Zhang, Guang Ning, Guang Ning

“…Core mitochondrial metabolism-related gene, TMEM86B was identified and its functions validated through cell-based assays and in vivo mouse models.ResultsFifteen mitochondrial metabolism-related genes were identified, including HSD3B7, ORC1, GPSM2, NDUFA4L2, CHDH, LARS2, TMEM86B, FABP4, TNFAIP8L3, HMGCL, GDE1, ACOX1, ARV1, HDC, and GSR. …”
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Distribution patterns of fungal community diversity in the dominant tree species Dacrydium pectinatum and Vatica mangachapoi in tropical rainforests by Kepeng Ji, Yaqing Wei, Xin Wang, Yu Liu, Rui Sun, Yuwu Li, Guoyu Lan

“…This compartment-aware perspective enhances our ability to leverage microbial functions to improve the resilience of endangered trees in the face of climate change.…”
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Comparative study of the characteristics of the energy flow and food web structure in the Laizhou Bay ecosystem based on the Ecopath and LIM-MCMC models by Cui Wenhui, Xu Bingqing, Dong Xiuqiang, Yang Jisong, Li Min, Zhang Depu, Li Shengfu, Lv Zhenbo, Li Fan, Ren Zhonghua

“…The ecosystem was divided into 22 functional groups with trophic levels ranging from 1.00 to 3.48 and a large proportion of predator groups. …”
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Pelagic fish camouflage in shallow waters from the humboldt current system through intracellular structures and reflectance mechanisms by Caroline S. Montes, Ricardo F. Soto, Mario I. Sanhueza, Ignacio Sanhueza, Danny Luarte, Sebastián E. Godoy, Sergio N. Torres, Rosario Castillo, Rubén Escribano, Mauricio A. Urbina

“…Accordingly, Fourier analysis indicated that silvery fish are capable of scattering light uniformly across the visible spectrum. In contrast, the Mote sculpin shows a stronger scattering of red light, distinguishing it from silvery fish.…”
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Effects of Biochar on Cadmium Availability, Nitrification and Microbial Communities in Soils with Varied pH Levels by Wei Zhao, Xiaoxu Cao, Hong Pan, Yanhong Lou, Hui Wang, Quangang Yang, Yuping Zhuge

“…Biochar has shown promise in immobilizing Cd and enhancing microbial functions, yet its pH-dependent mechanisms remain underexplored. …”
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Phase angle as a predictor of prolonged length of hospital stay and adverse outcomes in elderly medical inpatients: a retrospective cohort study by Jia Liu, Jia Liu, Song Hu, Shan Wang, Tongxiao Luan, Tongxiao Luan, Yuting Duan, Yuting Duan, Jing Zhou, Li Jia, Nina An, Yongjun Mao

“…PhA can serve as a valuable indicator for monitoring malnutrition in hospitalized elderly patients and functions as a reliable independent predictor of prognosis.…”
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Impact of a pharmacist driven antimicrobial stewardship program on inpatient antibiotic consumption in a Chinese Tertiary Hospital: a 5-year retrospective study by Can Qian, Ting Yuan, Fuyong Zhang, Shiyuan Gou, Chunmei Jiang, Xuebing Chen, Ya Huang, Xiaolin Zhao, You Du, Chenglong Li, Yangyun Han, Huaiyu Su

“…We evaluated the impact of the program on relevant indicators of antimicrobial consumption in inpatient.ResultsCompared to the pre-implementation year of 2020, the annual Antibiotic Use Density for inpatients across the hospital decreased by 22.28% in 2024, reaching 36.26 defined daily doses/100 patient days. …”
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Establishing a Staging System for Adjacent Segment Disease and Exploring Its Significance in Guiding Surgical Decisions: A Retrospective Study by Changpeng Qu, Jianwei Guo, Hao Tao, Chuanli Zhou, Kai Zhu, Yihao Sun, Lei Li, Zhiming Liu, Hao Zhang, Xuexiao Ma

“…Specifically, Groups B, C, and D showed earlier functional recovery compared to Group A, with Groups B and C experiencing more rapid relief from low back pain. …”
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Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis by Monika Golinska, Monika Golinska, Aleksander Rycerz, Matylda Sobczak, Jedrzej Chrzanowski, Konrad Stawiski, Wojciech Fendler, Wojciech Fendler, Wojciech Fendler

“…EEM: CPA3, logFC = 1.54, p < 0.0001; KIT, logFC = 0.74, p < 0.001). Functional enrichment analysis highlighted complement and coagulation, inflammation, angiogenesis, and extracellular matrix remodeling as drivers of endometriosis. …”
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In-depth characterization of accessory gene regulator loci and associated virulence factors in tcdA+B+ Clostridioides difficile isolates by Mansoor Kodori, Zohreh Ghalavand, Abbas Yadegar, Gita Eslami, Masoumeh Azimirad, Mohammad Reza Zali

“…This study also provides novel phenotypic insights into tcdA+B+ C. difficile isolates from Iranian patients, paving the way for more comprehensive functional and clinical studies of agr loci.…”
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Edaphic and climatic effects on soil water dynamics and infiltration patterns in tropical rainforests by Xin Zou, Ankit Shekhar, Yuxuan Mo, Ashutosh Kumar Singh, Xiaojin Jiang, Wenjie Liu

“…The preservation of forests’ hydrological functions is pivotal for alleviating land degradation and enhancing ecosystem services. …”
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The reliability of witness memories: a review of the factors influencing accuracy in the forensic context by João Miguel Alves Ferreira, Sergii Tukaiev

“…We conducted searches across various renowned databases, such as PsycINFO, PubMed, EMBASE, Web of Science, Cochrane, Google, and CINAH. …”
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Interlacing biology and engineering: An introduction to textiles and their application in tissue engineering by S. Scholpp, L.A. Hoffmann, E. Schätzlein, T. Gries, C. Emonts, A. Blaeser

“…Finally, we analyze how these textile and fiber structures are utilized in TE, organized by the use of textiles in TE across major organ systems, including the nervous, skin, cardiovascular, respiratory, urinary, digestive, and musculoskeletal systems.…”
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Glial and immune dysregulation in glaucoma independent of retinal ganglion cell loss: a human post-mortem histopathology study by Akanksha Salkar, Viswanthram Palanivel, Devaraj Basavarajappa, Mehdi Mirzaei, Angela Schulz, Peng Yan, Vivek Gupta, Stuart Graham, Yuyi You

“…This gliotic response differed across conditions, with astrocyte activation being more prominent in DM and microglial activation predominating in AMD. …”
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The intersection between circulatory microRNAs and biomarkers of neurodegeneration by Amber Yaqub, Rima Mustafa, M. Arfan Ikram, Mohsen Ghanbari

“…Abstract Background MicroRNAs (miRNAs) are small non-coding RNAs with a vast array of biological functions, including the regulation of gene expression. …”
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