Phospholipid-Rich DC-Vesicles with Preserved Immune Fingerprints: A Stable and Scalable Platform for Precision Immunotherapy by Ramon Gutierrez-Sandoval, Francisco Gutierrez-Castro, Natalia Muñoz-Godoy, Ider Rivadeneira, Adolay Sobarzo, Luis Alarcón, Wilson Dorado, Andy Lagos, Diego Montenegro, Ignacio Muñoz, Rodrigo Aguilera, Jordan Iturra, Francisco Krakowiak, Cristián Peña-Vargas, Andres Toledo

“…<b>Conclusions</b>: DC-Vesicles demonstrate structural resilience and functional retention across storage conditions. Their cold-chain-independent compatibility, immune-targeting profile, and potential regulatory classification as Non-New Chemical Entities (NCEs) support their advancement as candidates for precision immunotherapy in resistant solid tumors.…”
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Genomic Survey of Genes Encoding Major Intrinsic Proteins (MIPs) and Their Response to Arsenite Stress in Pepper (<i>Capsicum annum</i>) by Syed Muhammad Azam, Kaixuan Huang, Jiaxin Yuan, Yanqing Bai, Qiaolin Chen, Panpan Dang, Hend Alwathnani, Hajar Fahad Bin Zayid, Renwei Feng, Christopher Rensing

“…Major intrinsic proteins (MIPs) are a super family of proteins that mediate the bidirectional concentration-dependent flux of water in particularly small solutes in fraction and some metalloids across the cell membrane. This article reports the genome-wide study of pepper genes encoding MIPs and their expression analysis. …”
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A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma by Jiale Fang, Siyuan Yu, Wei Wang, Wei Wang, Cheng Liu, Xiaojia Lv, Jiaqi Jin, Xiaomin Han, Xiaomin Han, Xiaomin Han, Fang Zhou, Yukun Wang

“…A comprehensive machine learning approach, utilizing ten distinct algorithms, facilitated the creation of a TILB-related index (BRI) across the TCGA, GSE31210, and GSE72094 datasets. …”
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Effect of CCNA2 on Prognosis of Colon Cancer by Regulating Immune Microenvironment of Tumor Cells by Peng YANG, Ziyi QIU, Lingling WANG, Yuan HU, Zhengzhen CHEN, Meizhen ZHONG, Feiyue YU, Rongyuan QIU

“…Gene Set Enrichment Analysis (GSEA) was used to assess the potential molecular functions of CCNA2 in colon cancer. CIBERSORT algorithm was applied to calculate the correlation between CCNA2 and immune-cell infiltration in colon cancer. …”
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Comparative transcriptomics analysis of the Oleidesulfovibrio alaskensis G20 biofilms grown on copper and polycarbonate surfaces by Priya Saxena, Dipayan Samanta, Payal Thakur, Vinoj Gopalakrishnan, Rajesh K. Sani

“…Sulfate-reducing bacterial (SRB) biofilms are prevalent across diverse environments, playing key roles in biogeochemical sulfur cycling while also contributing to industrial challenges such as biofouling and biocorrosion. …”
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Biochar amendment mitigates negative effects of controlled irrigation on paddy soil structure: Insights from micro-pore network analysis by Jiazhen Hu, Shihong Yang, Wim M. Cornelis, Qian Huang, Suting Qi, Zewei Jiang, Haonan Qiu, Yi Xu

“…CA increased porosity across various effective pore diameters, while CB and CC primarily increased the proportion of porosity for diameters > 250μm. …”
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Trial Conduct, Baseline Characteristics, and Symptom Burden of Patients in the ARISE Study by Charles L. Daley, James D. Chalmers, Patrick A. Flume, David E. Griffith, Naoki Hasegawa, Kozo Morimoto, Kevin L. Winthrop, Chau-Chyun Sheu, Korkut Avsar, Dario Andrisani, Luigi Ruffo Codecasa, Dayton W. Yuen, Mariam Hassan, Marie-Laure Nevoret, Kevin Mange

“…Symptom burden was assessed using QOL-B, PROMIS F SF-7a, and Functional Assessment of Chronic Illness Therapy (FACIT) questionnaires. …”
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Genome-Wide Identification and Abiotic Stress Response Analysis of C2H2 Zinc Finger Protein Genes in Foxtail Millet (<i>Setaria italica</i>) by Qian Zhao, Yingxin Zhang, Xiangyu Xing, Shuyao Li, Ruidong Sun, Weilong Zhang, Jun Zhang, Liangyu Jiang, Zhenyuan Zang, Ming Gao, Jian Zhang

“…Here, we performed a comprehensive genome-wide analysis of <i>C2H2-ZFPs</i> in foxtail millet (<i>Setaria italica</i> v2.0), identifying 67 members that were unevenly distributed across all nine chromosomes. Most SiC2H2 proteins were predicted to be alkaline, stable, and nuclear-localized, with the exception of <i>SiC2H2-11</i> and <i>SiC2H2-66</i>, which were chloroplast-targeted. …”
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The influence of microwave-assisted osmotic dehydration in coconut meat preservation technique by Mahfujul Alam, Mipahur Jannat, Nayon Datta, Mir Meahadi Hasan, Asraful Alam, Md. Ashrafuzzaman Zahid, Md. Shakir Moazzem, Mohammad Mainuddin Molla, Mrityunjoy Biswas

“…Coconut is cultivated in tropical and subtropical areas across the globe because of its diverse applications, particularly in terms of its nutritional and therapeutic benefits. …”
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Health-related quality of life with bemarituzumab plus mFOLFOX6 in patients with FGFR2b-overexpressing, advanced gastric or gastroesophageal junction cancer by Z.A. Wainberg, P.C. Enzinger, S. Qin, K. Yamaguchi, J. Wang, X. Zhou, A. Gnanasakthy, K. Taylor, A. Yusuf, I. Majer, A. Jamotte, Y.-K. Kang

“…Results: PRO scale scores at baseline and compliance rates across PRO assessments over time were similar between the bemarituzumab and placebo arms. …”
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Cooperation between coagulase and von willebrand factor binding protein in Staphylococcus aureus fibrin pseudocapsule formation by Dominique C.S. Evans, Amanda B. Khamas, Alex Payne-Dwyer, Adam J.M. Wollman, Kristian S. Rasmussen, Janne K. Klitgaard, Birgitte Kallipolitis, Mark C. Leake, Rikke L. Meyer

“…However, it is unclear how Coa and vWbp contribute differently to the localisation and dynamics of clot assembly in growing biofilms.Here, we address this question using high-precision time-resolved confocal microscopy of fluorescent fibrin to establish the spatiotemporal dynamics of fibrin clot formation in functional biofilms. We also use fluorescent fusion proteins to visualise the locations of Coa and vWbp in biofilms using both confocal laser scanning and high resolution highly inclined and laminated optical sheet microscopy. …”
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Chaperonin containing TCP1 subunit 5 as a novel pan-cancer prognostic biomarker for tumor stemness and immunotherapy response: insights from multi-omics data, integrated machine le... by Jiajun Li, Nuo Xu, Leyin Hu, Jiayue Xu, Yifan Huang, Deqi Wang, Feng Chen, Yi Wang, Jiani Jiang, Yanggang Hong, Huajun Ye

“…Nevertheless, its comprehensive roles in pan-cancer progression, underlying biological functions, and potential as a predictor of immunotherapy response remains poorly understood. …”
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Amplification of Higher-Order Salivary Gland Volume Effects from External Beam Radiotherapy in Normal Tissue Complication Probability Modeling of Radiopharmaceutical Therapy by Chunming Gu, Robert F. Hobbs, Ana P. Kiess, Junghoon Lee, Todd McNutt, Harry Quon, Zhuoyao Xin, Tahir I. Yusufaly

“…In EBRT, salivary glands are usually assumed to be parallel organs, with QUANTEC guidelines based on <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>D</mi><mrow><mi>m</mi><mi>e</mi><mi>a</mi><mi>n</mi></mrow></msub></semantics></math></inline-formula>, but this is known to be a gross over-simplification of the full complexity of the underlying functional organization. The goal of this work is to combine machine learning of EBRT dose–outcome data with stylized small-scale RPT dosimetry to discover more reliable normal tissue complication probability (NTCP) models of xerostomia across both modalities. …”
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The role of mangroves in early-life trophic interactions supporting fishery production in the Galapagos by José Pontón-Cevallos, José Pontón-Cevallos, Anna-Maria Vafeiadou, Nicolas Moity, Jorge Ramírez-González, María José Rendón, Mercy J. Borbor-Cordova, Tom Moens, Jorge R. Bermudez-Monsalve, Peter Goethals

“…We used Bayesian mixing models to assess the relative importance of food sources across six protected shorelines on Santa Cruz and Isabela Islands, representing different biogeographic origins. …”
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Positive association between foliar silicon and extrafloral nectar in Vicia faba with application of methyl jasmonate by Chelsea Megan Gowton, Dennis Chiu, Isaac John Peetoom Heida, Juli Carrillo

“…Plants have evolved direct and indirect defences against herbivores, which may come at a cost to other plant functions. Many plants can uptake and deposit large amounts of silicon within plant tissue, creating structures which can reduce herbivore performance. …”
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The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort by Mengqi Wu, Xin Zhou, Saiping Chen, Yuqing Wang, Bin Lu, Aiping Zhang, Yanqin Zhu, Min Huang, Jiarui Wang, Junyi Liu, Fenggui Zhu, Hong Liu, Riyang Lin, Riyang Lin

“…The DKD+NDRD group was uniquely enriched in Prevotella_9. Functional prediction highlighted elevated pyruvate metabolism and bacterial toxin pathways in DKD, contrasting with enhanced linoleic acid metabolism in DM and attenuated endotoxin-related pathways in DKD+NDRD.ConclusionsThis study delineates gut microbiota profiles and functional shifts across DKD, DM, and DKD+NDRD. …”
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Global analysis of protein lysine lactylation profiles in the marine bacterium Photobacterium damselae subsp. damselae by Yongxiang Yu, Yongxiang Yu, Haozhe Liu, Chunyuan Wang, Yingeng Wang, Yingeng Wang, Xiaojun Rong, Xiaojun Rong, Meijie Liao, Meijie Liao, Bin Li, Bin Li, Xingling Yi, Zheng Zhang, Zheng Zhang

“…Lysine lactylation (Klac) is a recently discovered post-translational modification (PTM) widespread across species, playing a crucial role in cellular processes and associated with pathological conditions. …”
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Air pollution and prostate cancer: Unraveling the connection through network toxicology and machine learning by Yuqi Li, Tao Zhou, Zhiyu Liu, Xinyao Zhu, Qilong Wu, Chunyang Meng, Qingfu Deng

“…Protein-protein interaction (PPI) analysis and visualization were conducted for the intersecting genes, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses to explore potential mechanisms. …”
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Effects of the <i>Agrobacterium rhizogenes rolC</i> Gene Insertion on Secondary Metabolites Profile and In Vitro Biological Activity of <i>Acmella oleracea</i> (L.) R.K. Jansen by Priscilla Paola Bettini, Martina Imbesi, Patrizia Bogani, Valentina Maggini, Filippo Firenzuoli, Fabio Firenzuoli, Domenico Trombetta, Antonella Smeriglio

“…LC−DAD−ESI−MS analysis identified a diverse metabolite profile, with AP being notably rich in flavonoids (48.65%) and alkylamides (32.43%), including spilanthol. Functional assessments across antioxidant and anti−inflammatory assays demonstrated that R extracts exhibited stronger bioactivity compared to AP extracts, as indicated by lower IC₅₀ values (0.004–2.18 mg/mL for R vs. 0.007–7.24 mg/mL for AP). …”
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Right ventricular outflow tract morphology and its clinical significance for invasive procedures by Marcin Jakiel, Rafał Jakiel, Jakub Batko, Edyta Dyngosz, Maria Kurek, Karolina Gutkowska, Jakub Hołda, Filip Bolechała, Marcin Strona, Mateusz K. Hołda

“…In conclusion, this study provides a detailed definition, along with anatomical and structural analysis of the RVOT, highlighting its complex morphology and its significant role in cardiac functionality and clinical interventions.…”
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