Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models by Romain Sigaud, Anja Stefanski, Florian Selt, Daniela Kocher, Diren Usta, Daniel Picard, Isabel Büdenbender, Marc Remke, Stefan M. Pfister, David T. W. Jones, Tilman Brummer, Olaf Witt, Till Milde

“…Trametinib treatment inhibited MAPK activity, OIS and SASP signatures across all omics levels, functionally underscored by reduced sensitivity towards senolytic drugs. …”
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The Involvement of <i>MGF505</i> Genes in the Long-Term Persistence of the African Swine Fever Virus in Gastropods by Sona Hakobyan, Nane Bayramyan, Zaven Karalyan, Roza Izmailyan, Aida Avetisyan, Arpine Poghosyan, Elina Arakelova, Tigranuhi Vardanyan, Hranush Avagyan

“…African swine fever virus (ASFV), a highly contagious and lethal virus affecting domestic and wild pigs, has raised global concerns due to its continued spread across Europe and Asia. While traditional transmission pathways involve suids and soft ticks, this study investigates the potential role of freshwater gastropods as environmental reservoirs capable of sustaining ASFV. …”
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Nutrition and Antioxidant Potential of Three Cauliflower (Brassica oleracea L. Var. Botrytis) Cultivars Cultivated in Southern Part of Bangladesh by Mousumi Jahan Sumi, Sharmin Akter Serity, Tusar Kanti Roy, Keya Akter, Shishir Rasul, Mostofa Jaman Depro, Md. Masum Abdullah, Md. Nesar Uddin

“…The findings highlight the potential of Carotena and Valentena for health-conscious consumers seeking nutrient-rich, antioxidant benefits in functional meals.…”
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Standardized low-resolution brain electromagnetic tomography does not improve EEG Alzheimer's disease assessment by Wolfgang Frühwirt, Martin Mairhofer, Andreas Hahn, Heinrich Garn, Markus Waser, Reinhold Schmidt, Thomas Benke, Peter Dal-Bianco, Gerhard Ransmayr, Dieter Grossegger, Stephen Roberts, Georg Dorffner

“…Thousands of distinct quantitative EEG markers of slowing, complexity, and functional connectivity were computed and regressed against disease severity, with rigorous control for multiple testing. …”
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Green synthesis and characterization of silver-doped ZnO nanoparticles using tobacco leaf extract: A novel hydrothermal approach for antibacterial and antifungal applications by Jebel Haji Mahamud, Abebe Belay Gemta, Alemu Kebede Hordofa, Getachew Abebe Argaw, Umer Sherefedin, Muktar Ahmed, Tesfaye Feyisa Hurrisa, Gurumurthi T.

“…Two-way ANOVA revealed significant differences in the zone of inhibition across varying concentrations and Ag doping levels (p < 0.005). …”
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Deep-Learning-Based Land Cover Mapping in Franciacorta Wine Growing Area by Girma Tariku, Isabella Ghiglieno, Andres Sanchez Morchio, Luca Facciano, Celine Birolleau, Anna Simonetto, Ivan Serina, Gianni Gilioli

“…Land cover mapping is essential to understanding global land-use patterns and studying biodiversity composition and the functioning of eco-systems. The introduction of remote sensing technologies and artificial intelligence models made it possible to base land cover mapping on satellite imagery in order to monitor changes, assess ecosystem health, support conservation efforts, and reduce monitoring time. …”
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Differential methylation patterns in cord blood associated with prenatal exposure to neighborhood crime: an epigenome-wide association study and regional analysis by Chantel L. Martin, Jiawen Chen, Alena S. D’Alessio, Cavin K. Ward-Caviness, Ai Ye, Evans K. Lodge, Lea Ghastine, Radhika Dhingra, Dereje D. Jima, Susan K. Murphy, Cathrine Hoyo

“…Our results suggest potential links between prenatal neighborhood crime exposure and offspring DNAm; however, additional research is needed in larger cohorts across wider geographic areas to confirm our results.…”
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A Comprehensive Deep Learning System With MGRF Modeling for Predicting Breast Cancer Response to Neoadjuvant Chemotherapy by Ahmed Sharafeldeen, Fatma Taher, Norah Saleh Alghamdi, Eman Alnaghy, Reham Alghandour, Khadiga M. Ali, Sameh Shamaa, Abdelrahman Gamal, Mohammed Ghazal, Sohail Contractor, Ayman El-Baz

“…First, tumor regions are delineated across MRI modalities and then modeled using a translation-invariant Markov-Gibbs random field (MGRF) with analytical parameter estimation to capture modality-specific spatial appearance patterns correlated with NAC response. …”
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Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma by Youyi Wu, Chen Lin, Chen Lin, Yuchen Qian, Xiaowei Huang, Yajing Xu, Jiayi Li, Youdi He, Congying Xie, Huafang Su

“…This model was verified using the IMvigor210 dataset, and we functionally validated the immune risk score model in vitro.ResultsThe results revealed significant correlations between CD8+ T cell-related genes and immune-related pathways. …”
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Classification of SERS spectra for agrochemical detection using a neural network with engineered features by Mateo Frausto-Avila, Monserrat Ochoa-Elias, Jose Pablo Manriquez-Amavizca, María del Carmen González-López, Gonzalo Ramírez-García, Mario Alan Quiroz-Juárez

“…Notably, we performed feature engineering to optimize the input data; specifically, we derived 20 key features from transformation functions applied to the SERS spectra. The model demonstrates strong predictive performance, achieving high precision and recall values across all classes, with an overall classification accuracy of 98.5% for organophosphate pesticides and their mixtures. …”
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Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study by Misbah Unnisa, Mahya Faghih, Asbjørn Mohr Drewes, Vikesh K. Singh, Dhiraj Yadav, Rupjyoti Talukdar, Søren Schou Olesen, Anna Evans Phillips

“…Conclusion: There appear to be demographic, etiological, and quality of life differences in the experience of CP across different populations. Reasons for these differences, including potential cultural and societal forces, need to be further explored.…”
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Microplastics, invasive species and fungal stressors modulate antioxidative mechanisms, rhizosphere enzymes and microbial dynamics in alfalfa by Muhammad Anas, Muhammad Riaz, Meng-Ting Yan, Yi-Fan Liu, Ying Li, Shan- Shan Qi, Zhi-Cong Dai, Dao-Lin Du

“…PCoA explained 44.61 % of total variation across PC1 and PC2, clearly separating treatments. …”
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Detailed Investigation of Cobalt-Rich Crusts in Complex Seamount Terrains Using the Haima ROV: Integrating Optical Imaging, Sampling, and Acoustic Methods by Yonghang Li, Huiqiang Yao, Zongheng Chen, Lixing Wang, Haoyi Zhou, Shi Zhang, Bin Zhao

“…To enhance surveys of cobalt-rich crusts (CRCs) on complex seamount terrains, the 4500-m-class Haima ROV integrates advanced payloads, such as underwater positioning systems, multi-angle cameras, multi-functional manipulators, subsea shallow drilling systems, sediment samplers, and acoustic crust thickness gauges. …”
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Substrate-Induced Structural Dynamics and Evolutionary Linkage of Siderophore-Iron ABC Transporters of <i>Mycobacterium tuberculosis</i> by Aisha Farhana, Abdullah Alsrhani, Hasan Ejaz, Muharib Alruwaili, Ayman A. M. Alameen, Emad Manni, Zafar Rasheed, Yusuf Saleem Khan

“…We also analyzed the stability of substrate binding to the domains of the two transporters across varying temperature and pH ranges, revealing significant shifts in their activity under different conditions. …”
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Identification of the putative regulatory regions and candidate genes associated with backfat thickness and intramuscular fat content traits in Xiang pigs by Xia Chen, Yundi Zheng, Fengbin Hu, Xiaoli Liu, Wei Wang, Fenfang Qi, Xi Niu, Shihui Huang, Jiafu Wang, Xueqin Ran

“…These findings enhance our understanding of the genetic mechanisms underlying fat deposition in Xiang pigs and provide a theoretical framework for future functional studies and genomic selection.…”
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Orthokeratology for myopia control: a three-year longitudinal study on axial length modulation influenced by baseline age and spherical equivalent by Xiaoxue Hu, Zixun Wang, Boxuan Sun, Xiang Wan, Feng Chang, Weiping Lin, Ruihua Wei

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Effect of different perioperative music interventions on anxiety and blood pressure levels during intravitreal injections by Fuyan Song, Zixun Wang, Xiaoling Zhang, Zhenjie Yu, Zhiqing Li

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Enhancing physical activity in older type 2 diabetic adults through remote patient monitoring: a pre-post study in Taiwan by Cheng-Fu Lin, Hui-Min Chang, Chiann-Yi Hsu, Chao-Tung Yang, Shih-Yi Lin

“…Remote monitoring led to a significant and consistent increase in daily step counts across all tracking periods (p < 0.001). Conclusions The study found that digital mobile health monitoring improved daily step counts over time in older diabetic patients, and baseline physical functions, and nutritional status were related to the changes. …”
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Salivary lactoferrin levels in Down Syndrome: a case-control study by Desireé Antequera, Lucía Sande, Eliane García Mato, Deborah Romualdi, Laura Carrero, Cristina Municio, Pedro Diz, Eva Carro

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Innovative strategies for bone organoid: Synergistic application and exploration of advanced technologies by Xu Lou, Qirong Zhou, Zhenglin Dong, Long Bai, Jiacan Su, Hua Yue

“…Assembloids enable the assembly of multicellular systems to better replicate bone tissue microenvironments, whereas gene editing refines disease modeling and functional modifications. Despite these advancements, challenges remain, including the lack of vascularization, insufficient mechanical stimulation, and standardization issues across different models. …”
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