Genome-Wide Identification, Evolutionary Expansion, and Expression Analyses of Aux/IAA Gene Family in <i>Castanea mollissima</i> During Seed Kernel Development by Yujuan Tian, Jingmiao Huang, Jinxin Wang, Dongsheng Wang, Ruimin Huang, Xia Liu, Haie Zhang, Jingzheng Zhang, Xiangyu Wang, Liyang Yu

“…Auxin/induced-3-acetic acid (Aux/IAA) serves as a key regulator in the auxin signaling pathway of plants, which exhibits crucial functions in the development of plants. However, the Aux/IAA gene family has not yet been characterized in the genome of <i>Castanea mollissima</i>, an important food source in the Northern Hemisphere. …”
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scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury by Lufei Shao, Yueliang Chang, Jinfang Liu, Leilei Lin, Long Chang, Jialin Zhang, Zhibin Lan, Honglai Zhang, Xiaolei Chen

“…The current study aims to identify specific microglial subtypes and investigate their responses and functional differences in SCI recovery across different age groups. …”
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Heterologous Expression and Biochemical Characterization of a New α-Amylase from <i>Nocardiopsis aegyptia</i> HDN19-252 of Antarctic Animal Origin by Fuhao Liu, Xiangnan Zheng, Wenhui Liao, Xingtao Ren, Chuanteng Ma, Guojian Zhang, Qian Che, Tianjiao Zhu, Wenxue Wang, Tao Zhang, Feng Han, Dehai Li

“…Recombinant Alphaz exhibited optimal activity at 40 °C/pH 8.0 while maintaining stability across 0–30 °C and pH 6.6–9.6. Its distinctive halotolerant properties included full activity retention in 0.6 M NaCl and >60% efficiency in salt-free conditions. …”
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A Telephone-based Physiotherapy Intervention for Patients with Osteoarthritis of the Knee by Adesola C Odole, Oluwatobi D. Ojo

“…Within group comparison showed significant improvements across baseline, and at weeks two, four, and six for both TG and CG’s pain intensity and physical function. …”
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Estrogen rescues muscle regeneration impaired by DUX4 in a humanized xenograft mouse model by Silvia Maiullari, Giada Mele, Patrizia Calandra, Giorgia di Blasio, Sonia Valentini, Alessio Torcinaro, Isabella Manni, Emanuela Teveroni, Fabio Mancino, Luca Proietti, Fabio Maiullari, Maria Pesavento, Ludovica Giorgini, Sabrina Putti, Roberto Rizzi, Sara Bortolani, Ferdinando Scavizzi, Marcello Raspa, Enzo Ricci, Giulia Piaggio, Cesare Gargioli, Alfredo Pontecorvi, Siro Luvisetto, Massimiliano Mazzone, Giancarlo Deidda, Fabiola Moretti

“…Inducible lentiviral expression of the pathogenic FSHD gene, DUX4, in human cells impaired the structural and functional recovery of murine muscle, providing a humanized mouse model of DUX4-mediated pathogenicity and proving that the biological effect of DUX4 spreads across the neighbouring murine nuclei. …”
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Lmx1a is essential for marginal cell differentiation and stria vascularis formation by Justine M. Renauld, Igor Y. Iskusnykh, Ebenezer N. Yamoah, Richard J. H. Smith, Corentin Affortit, David Z. He, Huizhan Liu, David Nichols, Judith Bouma, Mahesh K. Nayak, Xin Weng, Tianli Qin, Mai Har Sham, Victor V. Chizhikov, Bernd Fritzsch

“…Lmx1a dreher (Lmx1adr/dr), a recessive null mutation, results in non-functional Lmx1a expression, which expands from the outer sulcus to the stria vascularis and Reissner’s membrane. …”
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Unveiling the Causes of Acute and Non-Acute Myocardial Ischemic Syndromes: The Role of Optical Coherence Tomography by Angela Buonpane, Alberto Ranieri De Caterina, Giancarlo Trimarchi, Francesca Maria Di Muro, Domenico Galante, Samuela Zella, Fausto Pizzino, Marco Ciardetti, Umberto Paradossi, Giovanni Concistrè, Sergio Berti, Antonio Maria Leone, Filippo Crea, Carlo Trani, Francesco Burzotta

“…In Non-Acute Myocardial Ischemic Syndromes, OCT assists in evaluating stenosis severity, plaque morphology, vulnerability, and healing, and may contribute to the diagnosis of Ischemia with Non-Obstructive Coronary Arteries, identifying myocardial bridge and epicardial spasm alongside conventional functional assessment of intermediate stenoses. This narrative review outlines the expanding clinical applications of OCT across the full spectrum of ischemic syndromes, emphasizing its role in bridging obstructive and non-obstructive pathophysiology and supporting a more comprehensive diagnostic approach to ischemic heart disease.…”
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The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity by Shiba M. Esfand, Francesca R. Querdasi, Naomi N. Gancz, Paul W. Savoca, Siyan Nussbaum, Jennifer A. Somers, Julia Ditzer, Matthew B. Figueroa, Kristen Chu, Emily Towner, Bridget L. Callaghan

“…Across three waves, spread approximately 12–18 months apart, youth with and without previous experiences of caregiving-related adversity completed self-report measures of mental and physical health, provided stool, saliva, hair, and blood samples, and completed an MRI scan. …”
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The DoGA consortium expression atlas of promoters and genes in 100 canine tissues by Matthias Hörtenhuber, Marjo K. Hytönen, Abdul Kadir Mukarram, Meharji Arumilli, César L. Araujo, Ileana Quintero, Pernilla Syrjä, Niina Airas, Maria Kaukonen, Kaisa Kyöstilä, Julia Niskanen, Tarja S. Jokinen, Faezeh Mottaghitalab, Işıl Takan, Noora Salokorpi, Amitha Raman, Irene Stevens, Antti Iivanainen, Masahito Yoshihara, Oleg Gusev, Danika Bannasch, Antti Sukura, Jeffrey J. Schoenebeck, DoGA Consortium, Sini Ezer, Shintaro Katayama, Carsten O. Daub, Juha Kere, Hannes Lohi

“…Unlike many model organisms, the dog genome has a comparatively poor functional annotation, which hampers gene discovery for development, morphology, disease, and behavior. …”
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Comprehensive Assessment of Potentially Toxic Element (PTE) Contamination in Honey from a Historically Polluted Agro-Industrial Landscape: Implications for Agricultural Sustainabil... by Ioana Andra Vlad, Szilárd Bartha, Győző Goji, Ioan Tăut, Florin Alexandru Rebrean, Laviniu Ioan Nuțu Burescu, Călin Gheorghe Pășcuț, Petrică Tudor Moțiu, Adrian Tunduc, Claudiu Ion Bunea, Florin-Dumitru Bora

“…Honey is increasingly recognized not only as a functional food but also as a potential bioindicator of environmental pollution. …”
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Genome-wide detection of selective signatures in a Jinhua pig population by Zhong XU, Hao SUN, Zhe ZHANG, Qing-bo ZHAO, Babatunde Shittu OLASEGE, Li Qiu-meng, Yang YUE, Pei-pei MA, Xiang-zhe ZHANG, Qi-shan WANG, Yu-chun PAN

“…A total of 26 161 core regions spanning 636.42 Mb were identified, which occupied approximately 28% of the genome across all autosomes, and 1 158 significant (P<0.01) core haplotypes were selected. …”
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Transcriptomic profiling reveals SARS-CoV-2-infected humanized MHC mice recapitulate human post vaccination immune responses by Siyue Li, Siyue Li, Xuelian Han, Ruolan Hu, Ruolan Hu, Keyu Sun, Min Li, Yuan Wang, Guangyu Zhao, Mengzhe Li, Huahao Fan, Huahao Fan, Huahao Fan, Huahao Fan, Qi Yin

“…MethodsThis study systematically characterized immune responses in SARS-CoV-2-challenged hMHC mice lung tissues through comparative transcriptomic profiling, combined with functional enrichment and PPI network analyses.ResultsKey findings demonstrate that hMHC mice exhibit enhanced immunological activation relative to wild-type controls, particularly in IFN-γ signaling pathways and neutrophil mobilization dynamics that closely parallel human post-vaccination responses. …”
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Cooling devices used to avoid warm ischemia time injury during kidney transplantation. Systematic review and meta-analysis by Marco A. Arizmendi-Villarreal, Alejandro Diaz Gonzalez-Colmenero, Jorge A. Cantú-Hernández, Javier Sanchez-Maldonado, Gerardo E. Muñoz-Maldonado, Edelmiro Perez-Rodriguez, Homero A. Zapata-Chavira, Rene Rodriguez-Gutierrez, Rene Rodriguez-Gutierrez, Francisco J. Reyna-Sepulveda

“…However, post-transplant urinary output was significantly higher in the cooling device groups (SMD 0.49; 95% CI 0.10 to 0.88).DiscussionThe overall risk of bias across included studies was high. Cooling devices effectively lower graft temperature and may improve early functional outcomes. …”
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Identification of glycolysis-related molecular subtypes and prognostic model in intrahepatic cholangiocarcinoma by Yue Wang, Pengxiang Wang, Hui Liu, Haokang Feng, Muzi Cao, Zefan Zhang, Keqiang Rao, Jia Fan, Xiutao Fu, Yunfan Sun

“…This study aims to identify glycolysis-related molecular subtypes, explore their functional heterogeneity, and develop a prognostic model for iCCA. …”
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Integrated Omics Reveal <i>Dendrobium nobile</i> Lindl.’s Anti-Diabetic Mechanisms via Arginine/Proline and Glycerophospholipid Pathways by Zhibo Wang, Xian Wang, Sifan Guo, Ying Cai, Dandan Xie, Yujuan Wang, Aihua Zhang, Jun Dai, Shi Qiu

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Technical considerations for using intravenous gadolinium-based-contrast-agent (GBCA) based MRI approaches to study cerebrospinal fluid (CSF) circulation and clearance by Jun Hua, Yuanqi Sun, Yinghao Li, Xinyi Zhou, Yuhan Bian, Adrian Paez, Briana Meyer, Swati Rane Levendovszky

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Genome-Wide Characterization and Haplotype Module Stacking Analysis of the <i>KTI</i> Gene Family in Soybean (<i>Glycine max</i> L. Merr.) by Huilin Tian, Zhanguo Zhang, Shaowei Feng, Jia Song, Xue Han, Xin Chen, Candong Li, Enliang Liu, Linli Xu, Mingliang Yang, Qingshan Chen, Xiaoxia Wu, Zhaoming Qi

“…Additionally, the <i>GmKTI</i> family demonstrated evolutionary conservation, with its functions likely linked to light induction, biotic stress, and growth development. …”
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Crustacean zooplankton communities as indicators of game fish occurrence and abundance in Québec lakes by Cindy Paquette, Stéphanie Gagné, Maxime Gaudet-Boulay, Véronique Leclerc, Paschale Noël Bégin, Zofia E. Taranu, Beatrix E. Beisner, Vincent Fugère

“…Here, we used a dataset including game fish abundance, crustacean zooplankton community composition and associated habitat variables in 94 north temperate lakes across the province of Quebec, Canada. Our study aimed to uncover whether zooplankton taxonomic and functional community properties were related to walleye, brook trout, and lake trout occurrence and abundance. …”
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Dynamic and Stable Core Microbiota Assist Plants in Enriching Selenium and Reducing Cadmium Absorption by Zheng Lei, Hua Zhang, Wenju Liu, Jiandong Sheng, Huan Zhang, Yin Wang, Yanni Tang, Huaxing Wang, Cuicui Ding, Wanqi Qiao, Yonghui Zhu, Guoyin Yang, Yihan Zhang, Zhuoyi Liu, Nanyu Zhou, Chengxiao Hu, Xiaohu Zhao

“…Microbiome analysis, metagenomics, genomic analysis, strain isolation, and functional validation are performed to investigate these relationships. …”
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Fruit quality evaluation of different mulberry varieties by Jie Tian, Haichao Wen, Bingxiang Liu, Xinyuan Tian, Yibo Wu, Jingyan Yang, Bingying Zhang, Hongjiao Li

“…Overall, varieties such as ‘Jiang Mi Guo Sang’, ‘Bai Shen 2’, ‘Ji Gui Hua’, ‘Xiao Bai E’, ‘Da Bai E’, and ‘Da Yi Bai’ stand out in terms of comprehensive quality. Regarding functional components, the four varieties—’Lv Shen Zi’, ‘Hei Zhen Zhu’, ‘He Lan Sang’, and ‘Da 10’—are prominent across all indicators. …”
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