Distinct brain activity patterns associated with traditional Chinese medicine syndromes: a task-fMRI study of mild cognitive impairment by Zhaoying Li, Shanyu Liu, Yuling Shen, Huan Zhao, Zhenwei Chen, Rui Tan, Zhuoling Li, Ling Quan, Dongdong Yang, Min Shi

“…Neuropsychological assessments were performed, and fMRI scans were acquired during an episodic memory task involving the recognition of new and old vocabulary. Brain activity across different stages of episodic memory was analyzed using SPM12 and DPABI 7.0 software.ResultsA total of 57 aMCI patients (34 with SKD and 23 with PCO) and 54 healthy controls were involved in the final task-based fMRI analysis. …”
Get full text

A Model-Driven Approach Employing DSL and Generation Templates to Accelerate the Development of Conversational Agents for Smart Tourism by Charaf Ouaddi, Lamya Benaddi, Adnane Souha, Hamza Abdelmalek, Abdeslam Jakimi, Rachid Saadane

“…Conversational agents are intelligent, ubiquitous software applications widely used across various sectors, such as commerce, tourism, and more. …”
Get full text

BertADP: a fine-tuned protein language model for anti-diabetic peptide prediction by Xueqin Xie, Changchun Wu, Yixuan Qi, Shanghua Liu, Jian Huang, Hao Lyu, Fuying Dao, Hao Lin

“…Notably, BertADP exhibited remarkable sequence length adaptability, maintaining stable performance across both standard and short peptide sequences. …”
Get full text

Chromosome-scale genome assembly and annotation of two geographically distinct strains of malaria vector Anopheles albimanus by Dieunel Derilus, Gareth D. Weedall, Michael W. Vandewege, Dhwani Batra, Mili Sheth, Lori A. Rowe, Ananias A. Escalante, Audrey Lenhart, Lucy Mackenzie Impoinvil

“…Abstract Anopheles albimanus is one of the principal malaria vectors in the Americas and exhibits phenotypic variation across its geographic distribution. High-quality reference genomes from geographically distant populations are essential to deepen our understanding of the biology, evolution, and genetic variation of this important malaria vector. …”
Get full text

A lightweight triple-modal fusion network for progressive mild cognitive impairment prediction in Alzheimer's disease by Xiangyu Shen, Xiangyang Hu, Renfeng Zhang, Yunzhan Fu, Jiamin Xu, Degang Lyu, Hongbiao Xie, Hongbiao Xie, Deen Shi, Changsheng Shi, Lisi Li, Yuantong Gao

“…Although multimodal neuroimaging and clinical data provide complementary information, existing fusion models often face challenges such as high computational complexity and limited interpretability.MethodsTo address these limitations, we introduce TriLightNet, an innovative lightweight triple-modal fusion network designed to integrate structural MRI, functional PET, and clinical tabular data for predicting MCI-to-AD conversion. …”
Get full text

Quantitative lipidomic analysis of modified liquid egg: Effects of combined high-pressure homogenization and heat treatment by Gan Hu, Jing Pu, Wenlong Xu, Zhifeng Zhao, Jinqiu Wang, Fang Geng

“…Quantitative lipidomics analysis using LC-MS/MS identified 894 lipid molecules across 25 subclasses, with minimal changes in total lipid abundance after modification. …”
Get full text

Exploring the perspectives of phytobiotics and their role in aquaculture: Present status and future trends by Bala Akhila Pudota, Neeraja Tambireddy, Rajanidhi Chennu, Lavanya Chethurajupalli, Haseena Shaik, Ranjit Kumar Nadella, Niladri Sekhar Chatterjee, Anand Prasad Paturi

“…The purpose of this review is to synthesize recent advances on the use of phytobiotics in aquaculture, focusing on their biological functions, mechanisms of action, and practical applications. …”
Get full text

Genomic Characterization of Probiotic Purple Nonsulfur Bacteria <i>Cereibacter sphaeroides</i> Strains S3W10 and SS15: Implications for Enhanced Shrimp Aquaculture by Chollachai Klaysubun, Nattarika Chaichana, Sirikan Suwannasin, Kamonnut Singkhamanan, Thunchanok Yaikhan, Duangporn Kantachote, Rattanaruji Pomwised, Monwadee Wonglapsuwan, Komwit Surachat

“…The genomic insights in this study provide a deeper understanding of the strains’ adaptability and functional potential, aligning with previous in vitro and in vivo studies and highlighting their potential for use in shrimp cultivation.…”
Get full text

Evidence and perspectives on miRNA, circRNA, and lncRNA in myocardial ischemia-reperfusion injury: a bibliometric study by Xiaowen Bo, Qiuyu Li, Siyuan Chen, Tian Zhou, Ning Yin, Wenpeng Song, Donghui Zhao, Jinghua Liu, Qian Fan

“…The “Analyze Results” and “Citation Report” functions in WOS were utilized to compile the annual publication and citation counts in this field. …”
Get full text

Optimized Nitrogen Foam Flooding System for Enhanced Oil Recovery: Development and Field Test in Mu146 Block Medium-High Permeability Reservoir, China by Jia-Yang Luo, Zhen-Jun Wang, Xin-Yuan Zou, Quan Xu, Bo Dong, Song-Kai Li, Zhu-Feng Wang, Jie-Rui Liu, Xian-Feng Wang, Xiao-Hu Xue

“…The technology demonstrates dual functionality in conformance control and enhanced recovery, effectively improving both oil productivity and ultimate recovery factors.…”
Get full text

Machine learning-assisted multi-dimensional transcriptomic analysis of cytoskeleton-related molecules and their relationship with prognosis in hepatocellular carcinoma by Yuxuan Li, Mingbo Cao, Xiaorui Su, Gaoyuan Yang, Yupeng Ren, Zhiwei He, Zheng Shi, Ziyi Hu, Guirong Liang, Qi Zhang, Zhicheng Yao, Meihai Deng

“…A robust five-gene prognostic model (ARPC1A, CCNB2, CKAP5, DCTN2, TTK) was developed using LASSO regression and validated across cohorts. The model was integrated into a clinical nomogram, demonstrating good calibration and utility. …”
Get full text

Analysis of Coupled and Coordinated Development of Cultivated Land Multifunction and Agricultural Mechanization in China by Yuan Qin, Zhongbo Li, Enwei Huang, Dale Lu, Shiming Fang, Xin Duan, Lulu Gao, Yinuo Zhao, Hanzhe Kang, Zixuan Liu, Zhen Yang

“…The CLM level in western regions was significantly lower than in eastern and central regions, with regional differences in AM development gradually expanding. (2) Driving factors of coupled and coordinated development varied significantly across regions: eastern regions were primarily driven by technological innovation, central regions were influenced by production efficiency and social security, and western regions were mainly constrained by ecological functions. (3) Natural conditions such as cultivated land area, quality, and land flatness significantly impact the coordinated development of AM and CLM. …”
Get full text

The Trehalose-6-Phosphate Synthase and Trehalose-6-Phosphate Phosphatase in Cocoa (Theobroma cacao L.): Genome-Wide Identification and Expression Analysis by Quy Phuong Nguyen, Phi Bang Cao, Ngoc Thi Bich Chu, Lan Thi Mai Tran, Man Thi Le, Hang Thi Luong, Quynh Thi Ngoc Le, Gioi Huy Dong, Ha Duc Chu

“…Five TcTPP and eight TcTPS genes were identified using the latest cocoa genome assembly, distributed unevenly across nine of the ten chromosomes. Detailed physicochemical characterization revealed significant variability in amino acid length, molecular weight, isoelectric point, and hydrophilicity among these proteins, suggesting functional diversity. …”
Get full text

Dynamic Changes in the Gut Microbiota During Peripartum in Jennies by Xinyue Wang, Yang Shao, Xiaoling Zhou, Zheng Li, Jingze Liu, Mingyao Tang, Yixin Yang, Liang Deng

“…Sequencing of the V4 hypervariable regions of the 16S rRNA genes was carried out using fecal samples to identify the differences in the microbiome across the peripartum period. Bacteroidota and Firmicutes were the most abundant bacterial phyla in the feces. …”
Get full text

Genome-Wide Analysis of the Polygalacturonase Gene Family in Macadamia and Identification of Members Involved in Fruit Abscission by Yu-Chong Fei, Yi Mo, Jiajing Xu, Kai Lin, Liang Tao, Xiyong He, Meng Li, Zeng-Fu Xu

“…In this study, 56 <i>PG</i> gene family members, which were unevenly distributed across 13 of the 14 chromosomes, were identified in the macadamia genome. …”
Get full text

Transcatheter aortic valve replacement in quadricuspid aortic valve: a systematic review and meta-analysis by Mostafa A. Khalifa, Hashim Talib Hashim, Aya Ahmed Shimal, Fathima Raahima Riyas Mohamed, Srinithi Ragunathan, Ahmed Sermed Al Sakini, Mohamed H. Elbadawi, Mohammed Rushdhi Irfan, Ibrahim Moqbel, Marwah Mohammed Almualed, Mohammedbaqer Al-Ghuraibawi, Batool S. Al-Aboudi

“…This review analyzes current evidence to guide clinicians in managing aortic stenosis in this complex valve morphology.MethodFollowing PRISMA guidelines, a comprehensive literature search was conducted across multiple databases up to August 15, 2024. A random-effects model was used for meta-analysis, focusing on 30-day mortality and procedural success, with secondary outcomes including paravalvular leak incidence, pacemaker insertion, hemodynamic changes, and NYHA functional class improvement.ResultsA total of 11 case reports/series were analyzed, involving 17 adult patients with QAV. …”
Get full text

Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis by Ipek Pervaz, Lilly Thurn, Cecilia Vezzani, Luisa Kaluza, Anne Kühnel, Nils B. Kroemer

“…Background: Transcutaneous vagus nerve stimulation (tVNS) has emerged as a promising technique to modulate autonomic functions, and pupil dilation has been recognized as a promising biomarker for tVNS-induced monoaminergic release. …”
Get full text

Genome-Wide Characterization of <i>9-Cis-Epoxycarotenoid Dioxygenase</i> Genes in Luffa Identifies <i>LcNCED2</i> as Being Associated with ABA Levels During Seed Germination by Pingping Fang, Xifeng Li, Haoxin Mu, Jing Wei, Ting Zhang, Xueyan Wang, Qinwei Guo, Qunfeng Lou

“…In this study, we identified four <i>LaNCED</i> genes in <i>Luffa acutangula</i> and four <i>LcNCED</i> genes in <i>Luffa cylindrica</i>, distributed across four chromosomes in each species. Phylogenetic analysis classified these genes into two subgroups. …”
Get full text

PAQR5 drives the malignant progression and shapes the immunosuppressive microenvironment of hepatocellular carcinoma by activating the NF-κB signaling by Ruida Yang, Huanhuan Wang, Cong Wu, Yu Shi, Hanqi Li, Xinyue Bao, Yuqian Yang, Shaoshan Han, Xue Yang, Jie Tao, Hao Sun, Shaobo Wu, Liankang Sun

“…Utilizing data from bulk, single-cell, and spatial transcriptomics cohorts, this study systematically assessed the expression patterns, immune landscape, and functional characteristics of PAQR5 across different levels of resolution in HCC. …”
Get full text

Study protocol of sustaining home palliative care for patients with Heart Failure (HF) and their family caregivers in rural Appalachia: a mixed methods randomized clinical trial by Ubolrat Piamjariyakul, Stephanie Young, Angel Smothers, Sijin Wen, R. Osvaldo Navia, George Sokos, Ann E. Hendrickson, Peggy Fink, Diana Niland, Matthew Hottle, Angelo C. Giolzetti, Carol E. Smith

“…The intervention group received 2 home visits, 3 biweekly telephone calls and telephone reinforcement across 12 months. Data collection for both groups was conducted at baseline and at 3, 6, 9, and 12 months. …”
Get full text