Single-cell transcriptomics and tissue metabolomics uncover mechanisms underlying wooden breast disease in broilers by Di Zhao, Zehe Song, Li Shen, Tian Xia, Qingyuan Ouyang, Haihan Zhang, Xi He, Kelang Kang

“…Additionally, we found six key differential metabolites across 22 pathways. When WB occurs, myocytes and endothelial cells undergo apoptosis, macrophages are activated and exert immune functions, satellite cells participate in muscle rebuilding and repair, and the content of metabolites undergoes significant changes. …”
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Integrative Approaches to Muscle Recovery: The Impact of Protein, Micronutrients, and Cold-Water Immersion on Performance and Health by Zofia Goliszek, Jakub Szarłowicz, Michał Mazur, Dorota Waz, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła

“…The findings support the use of these strategies across various population groups, including athletes, older adults, and clinical patients. …”
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Biosimilars in Focus: Evaluating Their Role Compared to Adalimumab in Clinical Practice by Dorota Waz, Michał Mazur, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła

“…Materials and Methods: A comprehensive literature review was conducted to evaluate the structural, functional, and clinical parity of adalimumab biosimilars with the reference product. …”
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Toll‐Like Receptors in the Immunotherapy Era: Dual‐Edged Swords of Tumor Immunity and Clinical Translation by Nueraili Maihemuti, Yueli Shi, Kaiyue Zhang, Xinyuan Jiang, Jiahe Chu, Yun Xu, Zhiyong Xu, Kai Wang

“…Despite their importance, the mechanisms underlying their dual functions remain poorly understood, creating a gap in current research. …”
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Beyond single company climate risk disclosure: event-based physical risk reporting by Victor Wattin Håkansson, Simona Meiler, Sarah Hülsen, Leonie Villiger, Mathilde Bossut, Jamie W McCaughey, Chahan M Kropf, David N Bresch

“…However, the lack of standardization has led to the use of varied risk metrics from different data sources, making it difficult to compare physical risks across companies and preventing investors from aggregating risks at the portfolio level. …”
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Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection by Giacomo Vezzani, Giacomo Vezzani, Viola Viviani, Martina Audagnotto, Alessandro Rossi, Paolo Cinelli, Nicola Pacchiani, Chiara Limongi, Laura Santini, Fabiola Giusti, Sara Tomei, Giulia Torricelli, Elisa Faenzi, Chiara Sammicheli, Simona Tavarini, Adriana Efron, Alessia Biolchi, Oretta Finco, Isabel Delany, Elisabetta Frigimelica

“…We identified three functional classes within the PorB HumAbs, through binding and in silico docking experiments, likely to be elicited from distinct epitopes on PorB and highlighting this antigen as a multi-epitope immunogenic OMV component responsible for distinct cross-protection across multiple MenB strains. …”
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Enhanced production of gamma-aminobutyric acid (GABA) in Mang Buk Brown rice via optimal fermentation conditions with Lactobacillus brevis, Lactobacillus pentosus, and Lactobacillu... by Ho Thi Ngoc Tram, Pham Van Thinh, Truong Ngoc Minh, Dang Thuy Mui, Ngoc Duc Vu, Binh An Pham, Dung Thuy Nguyen Pham, Le Hong Phu, Cao Xuan Thuy

“…The optimized process presents an opportunity for expanding the production of functional foods with enhanced nutritional value.…”
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Bioinformatics-Driven Structural and Pharmacological Analysis of SLITRK1 in Tourette Syndrome: Impact of S656M Mutation Using Molecular Dynamics, Docking, and Reinforcement Learnin... by Emre Aktaş, Alirıza İslim, Kevser Kübra Kırboğa, Derya Yıldız, Nehir Özdemir Özgentürk, Mithun Rudrapal, Johra Khan, Raghu Ram Achar, Ekaterina Silina, Natalia Manturova, Victor Stupin

“…Structural analyses revealed that the S656M mutation significantly alters SLITRK1’s 3D conformation, biological functions, and drug binding profiles. Among the tested drugs, Aripiprazole exhibited the highest binding affinity across various SLITRK1 variants, with reinforcement learning highlighting a notable interaction with the S659K mutation. …”
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Reductive Supramolecular In Situ Construction of Nano‐Platinum Effectively Couples Cathodic Hydrogen Evolution and Anodic Alcohol Oxidation by Rui Bai, Qiao Ye, Cuiyu Li, Haijian Wang, Yan Zhao, Yicheng Zhang, Yingtang Zhou, Xue Zhao

“…The resulting Pt/BNHCSs catalyst demonstrates the ability to facilitate electrocatalytic water splitting for hydrogen production across multiple scenarios while simultaneously accelerating the anodic methanol oxidation kinetics, significantly outperforming commercial Pt/C catalyst in various aspects. …”
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FtsZ as a novel target for antibiotics development: Promises and challenges by Ming-Wei Wang, Kaini Hang, Wei Han, Xin Li, Qingtong Zhou, Dehua Yang

“…Filamenting temperature-sensitive mutant Z (FtsZ), a protein essential for bacterial cell division, is highly conserved across bacterial species but absent in humans, positioning it as a strategic target for the development of antibiotics. …”
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Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota by Huan Wang, Ye Li, Rui Wang, Huaifei Ji, Chenyang Lu, Xiurong Su

“…Merrillii (Taxace, Torreya) is mainly distributed across the hilly areas of subtropical China and is well known for its nutritional value. …”
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Shared and distinct neural signatures of feature and spatial attention by Anmin Yang, Jinhua Tian, Wenbo Wang, Liqin Zhou, Ke Zhou

“…Our study challenges traditional network-centric models of attention, emphasizing distributed brain functioning in attention, and provides comprehensive evidence for shared and distinct neural mechanisms underlying FA and SA.…”
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Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases by Daniela Michlmayr, Theodore R Pak, Adeeb H Rahman, El‐Ad David Amir, Eun‐Young Kim, Seunghee Kim‐Schulze, Maria Suprun, Michael G Stewart, Guajira P Thomas, Angel Balmaseda, Li Wang, Jun Zhu, Mayte Suaréz‐Fariñas, Steven M Wolinsky, Andrew Kasarskis, Eva Harris

“…We present a multiscale network that summarizes all observed modulations across cellular and transcriptomic levels and their interactions with clinical outcomes, providing a uniquely global view of the biomolecular landscape of human CHIKV infection.…”
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Pharmacological effects, molecular mechanisms and strategies to improve bioavailability of curcumin in the treatment of neurodegenerative diseases by Gang Wang, Gang Wang, Xueyuan Zhou, Xueyuan Zhou, Xiaoyan Pang, Xiaoyan Pang, Ke Ma, Ke Ma, Lu Li, Lu Li, Yuexin Song, Yuexin Song, Dongxia Hou, Dongxia Hou, Xiaohua Wang, Xiaohua Wang

“…This article systematically reviews the pathogenesis of NDs and the knowledge on curcumin including pharmacological effects, neuroprotective mechanisms, functions across specific NDs and advanced strategies to enhance the bioavailability, with the aim of promoting the development and clinical translation of curcumin-based therapeutics for NDs.…”
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Advancing nonadiabatic molecular dynamics simulations in solids with E(3) equivariant deep neural hamiltonians by Changwei Zhang, Yang Zhong, Zhi-Guo Tao, Xinming Qin, Honghui Shang, Zhenggang Lan, Oleg V. Prezhdo, Xin-Gao Gong, Weibin Chu, Hongjun Xiang

“…This framework offers a reliable and efficient approach for conducting accurate NAMD simulations across various condensed materials.…”
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Biogeographic patterns reveal the extensive adaptation of forest soil myxobacteria along environmental gradients by Yang Zhou, Xianjiao Zhang, Qing Yao, Honghui Zhu

“…Considering that tolerance to physicochemical factors is an attribute of microbial lineages and functional groups, it seems necessary to figure out how well each taxon’s adaptation and sensitivity to different environments, especially for the prediction model of microbial response to climate change. …”
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Contribution of mushroom farming to mitigating food scarcity: Current status, challenges and potential future prospects in Pakistan by Asif Khan, Waheed Murad, Salahuddin, Sajid Ali, Syed Sikandar Shah, Sobia Ahsan Halim, Asaad Khalid, Hamdy Kashtoh, Ajmal Khan, Ahmed Al-Harrasi

“…Mushrooms are not only a rich nutritional source of functional food all over the world, but also have highly significant bioactive compounds that are considered nutraceuticals, cosmeceuticals, and mycotherapeutics across the globe. …”
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Uncovering potential biomarkers of endometriosis: transcriptomic and single-cell analysis by Yuqiu Liu, Guanwen Gao, Guanwen Gao, Guanwen Gao, Wei Tian, Qingfeng Lv, Degao Liu, Degao Liu, Changzhong Li, Changzhong Li

“…This study aims to identify potential biomarkers in EMS associated with both PCD and mitochondrial functions.MethodsThis analysis incorporates datasets related to EMS, PCD-related genes (PCD-RGs), and mitochondria-related genes (MRGs) sourced from public repositories. …”
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Genome-wide identification and analysis of SmRR gene family in eggplant (Solanum melongena L.) and their response to abiotic stress and auxin by Wenjing Li, Hui Li, Yanyu Lin, Yutong Li, Xiaofang Xie, Xuefang Zheng, Weiren Wu, Yuanchang Zhou, Yan Zheng

“…While numerous RR families have been identified, comprehensive characterization and functional studies of RR genes in eggplant have not been reported. …”
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Controlled Coffee Intake Enhances Erythrocyte Deformability, Na,K-ATPase Activity, and GSH/GSSG Ratio in Healthy Young Adults by Dominika Radosinska, Tomas Jasenovec, Alzbeta Golianova, Ivan Szadvari, Rastislav Vazan, Ivona Kovacicova, Denisa Snurikova, Norbert Vrbjar, Jana Radosinska

“…Erythrocyte deformability improved across a range of shear stress values typical of human circulation. …”
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