The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancer by Julia Kallenbach, Mahdi Rasa, Mehdi Heidari Horestani, Golnaz Atri Roozbahani, Katrin Schindler, Aria Baniahmad

“…Functional assays reveal that MIR503HG promotes PCa cell proliferation and inhibits SAL-mediated cellular senescence, partly through miR-424-5p. …”
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IMPACT OF ENERGY PRICES ON PRICES OF BASIC TOURISM SERVICES IN THE EURO AREA by Lachezar Borisov

“…The primary objective of this study is to ascertain the causal relationship between energy inflation and inflation in the hotel and restaurant sector across various periods of crises and external influences on the sector. …”
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Measuring and Improving the Efficiency of Python Code Generated by LLMs Using CoT Prompting and Fine-Tuning by Ramya Jonnala, Jeong Yang, Young Lee, Gongbo Liang, Zechun Cao

“…The evaluation metrics encompass execution time, memory utilization, and peak memory consumption, while maintaining the functional correctness of the generated code. Leveraging the EffiBench benchmark datasets within the Google Vertex AI Workbench environment, across a spectrum of machine configurations, the study implemented a consistent seed parameter to ensure experimental reproducibility. …”
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TRIP13-induced NUSAP1 upregulation promotes CcRCC progression through EMT and PI3K/AKT/mTOR pathway by Xiaolong Chen, Qing Wang, Zhiqiang Zhu, Zheng Peng, Kunyuan Huang, Guanyun Deng, Kehua Jiang, Kun Chen, Fa Sun

“…This study aimed to explore the functional role and mechanisms of TRIP13 in ccRCC progression and its potential as a therapeutic target. …”
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Heterogeneity of CD8αα intraepithelial lymphocytes is transcriptionally conserved between TCRαβ and TCRγδ cell lineages by Kaito A. Hioki, Kaito A. Hioki, Kaito A. Hioki, Xueting Liang, Xueting Liang, Adam C. Lynch, Adam C. Lynch, Adam C. Lynch, Ravi Ranjan, Elena L. Pobezinskaya, Leonid A. Pobezinsky, Leonid A. Pobezinsky

“…Further transcriptional analysis revealed shared profiles between TCRαβ+ and TCRγδ+ small intestinal IEL subsets, suggesting conserved functional roles across these populations. Finally, our analysis indicated that TCRαβ+ memory-like IELs arise from Tcf7+ double-negative (DN) precursors, and that effector-like IELs subsequently differentiate from the memory-like population. …”
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Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery by Runzi Guo, Zhenzhen Zhang, Shuyi Zhang, Tingting Gai, Huizhu Yu, Li Su, Heng Yin, Xiuhui Wang, Yafeng Zhang

“…Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological barriers, targeting and security. …”
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Revisiting the effective connectivity within the distributed cortical network for face perception by Roman Kessler, Kristin M. Rusch, Kim C. Wende, Verena Schuster, Andreas Jansen

“…The classical core system of face perception consists of the occipital face area (OFA), fusiform face area (FFA), and posterior superior temporal sulcus (STS). The functional interaction within this network, more specifically the effective connectivity, was first described by Fairhall and Ishai (2007) using functional magnetic resonance imaging and dynamic causal modeling. …”
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Integrating environmental, nutritional, and economic dimensions in Food choices: A case study on legume vs. meat-based burger patties by Abhishek Dattu Narote, Andrea Casson, Valentina Giovenzana, Alessia Pampuri, Alessio Tugnolo, Roberto Beghi, Riccardo Guidetti

“…This study applies Life Cycle Assessment (LCA) to analyze three burger patties (legume, chicken, and beef) across these dimensions, aiming to provide a holistic view of their impacts. …”
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Who seeks treatment for gaming? Characteristics of young and adult patients seeking treatment for gaming disorder by Per Bore, Per Bore, Mitchell Andersson, Mitchell Andersson, Sara Nilsson, Kajsa Oehm, Matti Cervin, Matti Cervin, Anders Håkansson, Anders Håkansson, Emma Claesdotter-Knutsson, Emma Claesdotter-Knutsson

“…Treatment should not only address gaming behavior but also support patients in improving functioning across important areas of life, such as school, work, and relationships.…”
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Predicting clinical outcomes in a blended care intervention for early psychosis: Acceptance and Commitment Therapy in Daily-Life (ACT-DL) by Rafaël A. Bonnier, Joanne R. Beames, Glenn Kiekens, Evelyne van Aubel, Frederike Schirmbeck, Lieuwe de Haan, Machteld Marcelis, Mark van der Gaag, Ruud van Winkel, Therese van Amelsvoort, Thomas Vaessen, Ulrich Reininghaus, Ginette Lafit, Inez Myin-Germeys

“…Outcomes included psychotic distress, negative symptoms, global functioning, and psychological flexibility. Using multivariate-multilevel models, we evaluated the effects of sociodemographics, personality, and childhood trauma across baseline, post-intervention, and six- and 12-month follow-ups. …”
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Charting the spatial transcriptome of the human cerebral cortex at single-cell resolution by Songren Wei, Meng Luo, Pingping Wang, Rui Chen, Xiyun Jin, Chang Xu, Chenyang Li, Xiaoyu Lin, Zhaochun Xu, Hongxin Liu, Rui Cheng, Wenyi Yang, Yideng Cai, Guangfu Xue, Peng Huang, Zhigang Liu, Haoxiu Sun, Jiangping Xu, Qinghua Jiang

“…The atlas, integrated with functional networks, highlights correlations between neural cell types and cortical functions, uncovering cell-cell interactions and ligand-receptor patterns with regional differences in neuron-glia communication. …”
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Baseline-dependent network reactivity to visual input in children with autism spectrum disorder: a magnetoencephalography study by Tetsu Hirosawa, Tetsu Hirosawa, Daiki Soma, Masuhiko Sano, Masafumi Kameya, Yuko Yoshimura, Yuko Yoshimura, Sumie Iwasaki, Sanae Tanaka, Mitsuru Kikuchi, Mitsuru Kikuchi

“…MEG signals were mapped to 68 cortical regions using the Desikan–Killiany atlas, and functional connectivity was assessed using the phase lag index across five frequency bands (delta, theta, alpha, beta, and gamma). …”
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Uncovering Social States in Healthy and Clinical Populations Using Digital Phenotyping and Hidden Markov Models: Observational Study by Imogen E Leaning, Andrea Costanzo, Raj Jagesar, Lianne M Reus, Pieter Jelle Visser, Martien J H Kas, Christian F Beckmann, Henricus G Ruhé, Andre F Marquand

“…The result in the AD group was very robust across HMM variations, whereas the result in the memory complaints group was less robust. …”
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Dietary Protein-Induced Changes in Archaeal Compositional Dynamics, Methanogenic Pathways, and Antimicrobial Resistance Profiles in Lactating Sheep by Maida Mushtaq, Xiaojun Ni, Muhammad Khan, Xiaoqi Zhao, Hongyuan Yang, Baiji Danzeng, Sikandar Ali, Muhammad Hammad Zafar, Guobo Quan

“…Dietary protein levels greatly influence gut microbial ecosystems; however, their effects on gut archaea and associated functions in ruminants require further elucidation. …”
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Perception and Consumption of Organic Food in a Group of Organic and Conventional Fruit Growers—A Pilot Study (CO-FRESH Project) by Hubert Dobrowolski, Justyna Obidzińska, Ewa Rembiałkowska, Renata Kazimierczak, Dariusz Włodarek

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Hotspots of genetic change in Yersinia pestis by Yarong Wu, Youquan Xin, Xiaoyan Yang, Kai Song, Qingwen Zhang, Haihong Zhao, Cunxiang Li, Yong Jin, Yan Guo, Yafang Tan, Yajun Song, Huaiyu Tian, Zhizhen Qi, Ruifu Yang, Yujun Cui

“…These HRs are distributed non-randomly across Y. pestis phylogenetic lineages and are primarily linked to regulatory genes, underscoring their potential functional significance. …”
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Spatial Patterns and Drivers of Nonperennial Flow Regimes in the Contiguous United States by John C. Hammond, Margaret Zimmer, Margaret Shanafield, Kendra Kaiser, Sarah E. Godsey, Meryl C. Mims, Samuel C. Zipper, Ryan M. Burrows, Stephanie K. Kampf, Walter Dodds, C. Nathan Jones, Corey A. Krabbenhoft, Kate S. Boersma, Thibault Datry, Julian D. Olden, George H. Allen, Adam N. Price, Katie Costigan, Rebecca Hale, Adam S. Ward, Daniel C. Allen

“…Geological Survey watersheds across the contiguous United States from 1979 to 2018. …”
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Pre-clinical model of dysregulated FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis by Amanda K. Casey, Nathan M. Stewart, Naqi Zaidi, Hillery F. Gray, Hazel A. Fields, Masahiro Sakurai, Carlos A. Pinzon-Arteaga, Bret M. Evers, Jun Wu, Kim Orth

“…The bi-functional enzyme FicD catalyzes AMPylation and deAMPylation of the endoplasmic reticulum chaperone BiP to modulate ER homeostasis and the unfolded protein response (UPR). …”
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Machine learning integrates region-specific microbial signatures to distinguish geographically adjacent populations within a province by Li Luo, Li Luo, Bangwei Chen, Bangwei Chen, Shengyin Zeng, Shengyin Zeng, Yaxin Li, Yaxin Li, Xiaolin Chen, Xiaolin Chen, Jianguo Zhang, Xiangjie Guo, Shujin Li, Lei Ruan, Shida Zhu, Cairong Gao, Cuntai Zhang, Tao Li

“…To obtain the optimal model that can distinguish geographically close populations, three machine learning (ML) algorithms based on microbiota or functions were employed.ResultsSignificant differences in microbial α diversity and β diversity were observed. …”
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JAG modulates sepal flatness by regulating cell growth direction, interacts with AS2, and is antagonized by TCP24 by Xi He, Shouling Xu, Avilash Singh Yadav, Ruoyu Liu, Heng Zhou, Yiru Xu, Dan Xiang, Yuhan He, Juan Xu, Adrienne H.K. Roeder, Lilan Hong

“…Summary: Flat plant organs are crucial for optimal organ functionality. Polarity establishment and growth coordination between tissues are key factors in maintaining organ flatness. …”
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