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Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice
Published 2024-12-01“…The most potent analogue of the panel across all functional assays was α’-methyl etonitazene. …”
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14044
Recycled Sericin Biopolymer in Biotechnology and Bioelectronics
Published 2025-05-01“…Furthermore, preparing and studying new environmentally friendly functional polymers with attractive physicochemical properties can open new opportunities for developing next-generation materials and composites. …”
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14045
Trio-based whole-exome sequencing reveals mutations in early-onset high myopia
Published 2024-05-01“…Subsequently, computational methodologies were employed for functional annotations and pathogenicity assessments.Results Our investigation identified 7 genes and 10 variants associated with HM across 7 families, including a novel mutation in the ARR3 gene (c.139C>T, p.Arg47*) and two mutations in the P3H2 gene (c.1865T>C, p.Phe622Ser and c.212T>C, p.Leu71Pro). …”
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14046
Net2Brain: a toolbox to compare artificial vision models with human brain responses
Published 2025-05-01“…Net2Brain provides functionalities in four key areas. First, it offers access to over 600 DNNs trained on diverse tasks across multiple modalities, including vision, language, audio, and multimodal data, organized through a carefully structured taxonomy. …”
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14047
Lithic industries, modern tools, and language: An evolutionary perspective through fMRI
Published 2025-09-01“…Participants performed a tool evaluation task, in which they assessed the functionality of both tool types across three levels of complexity designed to reflect embedded constraints. …”
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14048
Multi-channel spatio-temporal graph attention contrastive network for brain disease diagnosis
Published 2025-02-01“…Specifically, we first construct dynamic brain functional networks from fMRI data with sliding windows, and embed the structural connectivity derived from diffusion tensor imaging (DTI) to the dynamic functional connectivity graph representation to construct multi-modal brain network. …”
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14049
Xyloglucan endotransglucosylase/hydrolase 25 positively regulates the lead tolerance in Raphanus sativus
Published 2025-06-01“…Gene structure analysis revealed the presence of eight conserved motifs, along with variations in exon-intron organization and chromosomal distribution across all chromosomes. Phylogenetic analysis of XTH genes from R. sativus, Arabidopsis thaliana and Oryza sativa grouped them into five distinct clades, suggesting their evolutionary conservation and potential functional diversification. …”
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14050
Comprehensive Analysis of the <i>UGT</i> Gene Superfamily in <i>Spodoptera frugiperda</i>
Published 2025-06-01“…These findings provide a foundation for further exploration of the biological functions of the <i>UGT</i> gene family.…”
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14051
Longitudinal transitions in frailty and health-related quality of life investigated by a 5-year community study
Published 2025-04-01“…Significant trends toward higher scores on the physical component summary (PCS), role/social component summary (RCS), and subscales of physical functioning, role-physical, vitality, social functioning, and role-emotional were detected across groups with improvements in their frailty status from 2014 to 2019. …”
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14052
Actionable Wearables Data for the Neurology Clinic: A Proof‐of‐Concept Tool
Published 2025-08-01“…Results During development, 25 clinicians and four engineers across eight clinical settings provided feedback. …”
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14053
Revolutionizing pharmacology: AI-powered approaches in molecular modeling and ADMET prediction
Published 2025-12-01“…The convergence of AI with quantum chemistry and density functional theory (DFT) is illustrated through surrogate modeling and reaction mechanism prediction. …”
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14054
Does preeclampsia impact the gut microbiota of preterm offspring during early infancy?
Published 2025-01-01“…The gut virome analysis showed no significant differences among the groups. Functional analysis revealed distinct metabolic pathway activities across the groups, suggesting that early disturbances due to PE impact the establishment of healthy gut microbiota. …”
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14055
Evaluation of familial phenotype deviation to measure the impact of de novo mutations in autism
Published 2025-08-01“…Results We observed that ASD probands with disruptive DNVs exhibited greater behavioral symptoms and lower adaptive functioning relative to their within-family unaffected members. …”
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14056
HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer
Published 2025-04-01“…Functional experiments were carried out on the AGS and HGC-27 GC cell lines. …”
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14057
Genotype-specific rhizosphere microbiome assembly and its impact on soybean (Glycine max (L.) Merri.) yield traits
Published 2025-04-01“…However, the genotype-specific dynamics and functional influence of these microbial communities on soybean (Glycine max (L.) …”
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14058
Genome-wide analyses reveal intricate genetic mechanisms underlying egg production efficiency in chickens
Published 2025-08-01“…By combining the signals of Singleton Density Score (SDS), which is a population-genetic statistic designed to detect recent selection by leveraging the distribution of singletons, and association analyses, multiple egg-laying traits related to egg production efficiency were found to have experienced polygenic selection. Consistently, functional analysis of associated genes demonstrates that egg production efficiency benefits from multiple physiological functions. …”
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14059
Unraveling Fish Community Diversity and Structure in the Yellow Sea: Evidence from Environmental DNA Metabarcoding and Bottom Trawling
Published 2025-04-01“…The use of environmental DNA (eDNA) metabarcoding to analyze fish species diversity across different aquatic ecosystems is well documented. …”
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14060
Analysis of histone modifications in key cellular subpopulations in the context of azoospermia using spermatogenic single-cell RNA-seq data
Published 2025-07-01“…HDAC2, a pivotal regulator of histone acetylation, exhibited significant upregulation. Functional pathway analysis implicated these genes in critical biological processes, including nuclear transport, RNA splicing, and autophagy. …”
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