Elucidating the role of KCTD10 in coronary atherosclerosis: Harnessing bioinformatics and machine learning to advance understanding by Xiaomei Hu, Fanqi Liang, Man Zheng, Juying Xie, Shanxi Wang

“…Among 10 DEGs linked with KCTD10, 13 were identified as hub genes through LASSO and SVM-RFE analyses. Functional assays highlighted KCTD10’s role in enhancing viral defense mechanisms, cytokine production, and immune cascades. …”
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High-performance ZrNiSn-based half-Heusler thermoelectrics with hierarchical architectures enabled by reactive sintering by Xin Ai, Yu Wu, Haiyan Lyu, Lars Giebeler, Wenhua Xue, Andrei Sotnikov, Yumei Wang, Qihao Zhang, Denys Makarov, Yuan Yu, G. Jeffrey Snyder, Kornelius Nielsch, Ran He

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The relationship between immune cell infiltration and necroptosis gene expression in sepsis: an analysis using single-cell transcriptomic data by Shouyi Wang

“…Differentially expressed genes (DEGs) were identified using the limma package, and functional enrichment analysis was performed using the clusterProfiler package for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. …”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

“…The novel approach of utilizing microbial-derived PDRN opens new avenues for therapeutic applications in oxidative stress management, tissue regeneration, and immune modulation, paving the way for a paradigm shift in PDRN sourcing and functionality.…”
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Neurotoxicity associated with cancer chemotherapy: the first study in the Palestinian healthcare system by Roqaya Warrad, Aya Abushar, Abdullah Qubbaj, Sultan Mosleh, Razan Odeh, Ahmad Abuhassan, Ramzi Shawahna

“…Neurotoxicity was evaluated using a comprehensive 65-item functional neurotoxicity scale. Results A total of 196 cancer patients were included in the study. …”
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Identification and validation of hub genes associated with biotic and abiotic stresses by modular gene co-expression analysis in Oryza sativa L. by Izreen Izzati Razalli, Muhammad-Redha Abdullah-Zawawi, Rabiatul Adawiah Zainal Abidin, Sarahani Harun, Muhamad Hafiz Che Othman, Ismanizan Ismail, Zamri Zainal

“…A modular gene co-expression (mGCE) analysis was conducted, followed by gene set enrichment analysis to evaluate the upregulation of module activity across different stress conditions. Over-representation analysis was conducted to determine the functional association of each gene module with stress-related processes and pathways. …”
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Hierarchic Branch Morphology, Needle Chlorophyll Content, and Needle and Branch Non-Structural Carbohydrate Concentrations (NSCs) Imply Young <i>Pinus koraiensis</i> Trees Exhibit... by Bei Li, Wenkai Li, Sudipta Saha, Xiao Ma, Yang Liu, Haibo Wu, Peng Zhang, Hailong Shen

“…Research on young trees’ adaptation to shade has predominantly focused on leaf-level responses, overlooking critical structural and functional adaptations in branch systems. In this study, we address this gap by investigating hierarchical branch morphology–physiology integration in 20-year-old <i>Pinus koraiensis</i> specimens across four distinct light conditions classified by photosynthetic photon flux density (PPFD): three in the understory (low light, LL: 0–25 μmol/m²/s; moderate light, ML: 25–50 μmol/m²/s; and high levels of light, HL: 50–100 μmol/m²/s) and one under full light as a control (FL: 1300–1700 μmol/m²/s). …”
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A Convolutional Neural Network Model for Classifying Resting Tremor Amplitude in Parkinson&#x2019;s Disease by Augusto Ielo, Serena Dattola, Lilla Bonanno, Paolo De Pasquale, Alberto Cacciola, Angelo Quartarone, Maria Cristina De Cola

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Mucosal microbiota signatures reveal diagnostic insights in chronic liver disease by Sadık Dinçer, Yakup Ülger, Anıl Delik

“…The intestinal microbiota acts as a bioreactor for autonomous metabolic and immunological functions in regulating the host’s response to external stimuli in the intestinal microbiota. …”
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Bidirectional Two-Sample Mendelian Randomization Study Reveals Causal Associations Between Aging and Endometriosis by Chen L, Yan H, Nie J

“…Additionally, validation was performed using independent GWAS meta-analysis datasets.Results: Inverse variance-weighted (IVW) analysis revealed a significant association between longer LTL and an increased risk of endometriosis (OR-IVW = 1.276, 95% CI: 1.143 to 1.424, FDR-adjusted P = 7.00E-5), with consistent findings across multiple MR methods. Sensitivity analysis using an independent GWAS meta-analysis dataset did not confirm the LTL-endometriosis association (OR-IVW = 1.128, 95% CI: 0.140 to 9.115, P = 0.910). …”
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Rotor Location During Atrial Fibrillation: A Framework Based on Data Fusion and Information Quality by Miguel A. Becerra, Diego H. Peluffo-Ordoñez, Johana Vela, Cristian Mejía, Juan P. Ugarte, Catalina Tobón

“…The novelty of this approach lies in evaluating the IQ across signal-processing stages and optimizing it through data fusion to enhance rotor tip position estimation. …”
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Comprehensive identification, stress responses and protein-protein interactions of the ferredoxin gene family in the fast-growing tree species Paulownia fortunei by Xin Mao, Haibo Yang, Mengmeng Ji, Pingluo Xu, Guoqiang Fan

“…In this study, bioinformatics analysis was utilized to identify eight members of the ferredoxin gene family in Paulownia fortunei, categorized into four subfamilies distributed across eight different chromosomes. All members contain a 2Fe-2 S domain and light-responsive elements, displaying high conservation among subfamily members. …”
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Host genetic factors and vaccine-induced immunity to hepatitis B virus infection. by Branwen J Hennig, Katherine Fielding, John Broxholme, Mathurin Diatta, Maimuna Mendy, Catrin Moore, Andrew J Pollard, Pura Rayco-Solon, Giorgio Sirugo, Marianne A van der Sande, Pauline Waight, Hilton C Whittle, Syed M Zaman, Adrian V Hill, Andrew J Hall

“…<h4>Methods</h4>We analyzed 715 SNP across 133 candidate genes in 662 infant vaccinees from The Gambia, assessing peak vaccine-induced anti-HBs level and core antibody (anti-HBc) status, whilst adjusting for covariates. …”
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DNA methylation of food sensitization in a French-Canadian population by Bénédicte L. Tremblay, Anne-Marie Madore, Catherine Laprise

“…Conclusions To our knowledge, this is a unique association study between FS and DNA methylation using targeted bisulfite sequencing across the genome. This approach provides high-resolution assessment of genome-wide functional methylome that yields valuable understandings to this field of research. …”
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clonevdjseq: A workflow and bioinformatics management system for sequencing, archiving, and analysis of VDJ sequences from clonal libraries by Keith Mitchell, Samuel Hunter, Lutz Froenicke, Karl Murray, Matthew Settles, James S. Trimmer

“…The pipeline is built upon a robust, high-throughput library prep protocol, upon which processed data has been verified across thousands of monoclonal antibodies. The results of this effort has yielded sequences used to develop functional recombinant monoclonal antibodies and single chain variable fragments as a part of the NeuroMabSeq initiative where thousands of hybridoma samples were processed (Mitchell et al. in Sci Rep 13(1):16200, 2023) as well as provide additional modeling and extensibility to other modalities. …”
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Dynamic Assessment of Population Exposure to Urban Flooding Considering Building Characteristics by Shaonan Zhu, Xin Yang, Jiabao Yang, Jun Zhang, Qiang Dai, Zhenzhen Liu

“…The implemented model systematically evaluates transient population exposure through spatiotemporal superposition analysis of flood characteristics and human occupancy patterns across different urban functional zones in Lishui City, China. …”
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FCN3 Can Serve as A Potential Biomarker for Prognosis and 
Immunotherapy of Lung Squamous Cell Carcinoma by Wei LI, LinglingZU, Song XU

“…The aim of this study was to explore the potential biological functions and prognostic significance of FCN3 in LUSC. …”
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Perception of medical students at public universities in Uganda on their education environment: a cross-sectional study by David Jolly Muganzi, Timothy Mwanje Kintu, Racheal Mukisa Nakandi, Linda Atulinda, Immaculate Kaducu Atim, Francis Mwaka, Blair Kizza, Joseph Ngonzi

“…Abstract Background The healthcare workforce is one of the six core components of a well-functioning and sufficient health system. The WHO highlights that improving education and training of the health workforce is critical to improving health systems. …”
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Effectiveness of sensorimotor training on pain, cervical joint position sense, range of motion, balance, and disability in chronic neck pain: A systematic review by Sahar Zaidi, Sohrab Ahmad Khan, Saima Zaki, Habiba Sundus, Md Farhan Alam, Shibili Nuhmani

“…Results: SMT significantly reduced pain, improved CJPS, enhanced CROM, and boosted balance and functional outcomes across diverse protocols. Combined SMT approaches targeting proprioception, oculomotor control, and balance produced sustained benefits over 12 months. …”
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Preliminary efficacy of eye movement desensitization and reprocessing for children aged 1.5–8 years with PTSD: a multiple baseline experimental design (N = 19) by Carlijn de Roos, Julia Offermans, Samantha Bouwmeester, Ramón Lindauer, Frederike Scheper

“…These symptoms can cause severe impairment to a child’s functioning and, if left untreated, have negative long-term consequences. …”
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