Development trend of primary healthcare after health reform in China: a longitudinal observational study by Hui Li, Jie Feng, Zuxun Lu, Yanhong Gong, Xuan Zhou, Guopeng Zhang, Xiaoxv Yin, Jianxiong Wu

“…We evaluated the development of primary healthcare based on the absolute values of health resources allocation and health service provision and evaluated the status of primary healthcare throughout the health system based on the composition ratios of the indicators across the health system. The Cochran-Armitage trend test and linear trend test were used to identify the indicators’ trends over time.Results From 2009 to 2018, the amounts of health resources allocation and health service provision of Chinese primary healthcare institutions showed a significant upward trend (p<0.001). …”
Get full text

Development and Application of a Crosslinked Gelatin Foam Dressing for Wound Recovery by Meng‐Yi Bai, Yu‐Ting Liu, Ying‐Ting Yeh, Yi‐Ling Hong, Yi‐Ju Tsai, Yu‐Chi Wang, Masahi Kurashina, Mikito Yasuzawa, Sung‐Ling Tang

“…We conducted cell viability analyses on four cell lines (3T3, L929, Hs68, CG1519) exposed to the fluids released from the crosslinked gelatin foam dressing, with excellent biocompatibility demonstrated across all cell lines. In wound healing studies performed in BALB/cByJNarl mice, the crosslinked gelatin foam dressing exhibited a pronounced effect in promoting functional tissue regeneration and skin repair at the wound site. …”
Get full text

Foams‐Induced Hierarchy for Multiscale Photonics on Flat Substrates: Lasing and Mie‐Bragg Diffraction as Case Studies. by Luisina Forzani, Pedro Tartaj, Yurena Luengo, Ramazan Dalmis, Pedro Moronta, Alvaro Blanco, Cefe López

“…Abstract Densely packed arrays of monodisperse dielectric spheres exhibit strong optical diffraction down to the single‐layer limit, making them highly attractive for the implementation of order‐ and disorder‐based functionalities in photonic devices. Colloidal techniques are among the most convenient methods for creating these densely packed arrays, performing well on flat substrates. …”
Get full text

Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing by Wenwen Li, Huihui Zhang, Lianglong Chen, Chaoyang Huang, Ziwei Jiang, Hai Zhou, Xinxi Zhu, Xiaoyang Liu, Zesen Zheng, Qiuyi Yu, Yufang He, Yanbin Gao, Jun Ma, Lei Yang

“…Recent advances in NV-based therapies have demonstrated their potential across multiple biomedical applications. Although challenges persist in terms of standardization, storage stability, and clinical translation, the combination of natural cell-derived functions with artificial modification potential positions NVs as a promising platform for next-generation therapeutic delivery systems, thereby offering new possibilities in wound healing applications. …”
Get full text

Tuning the electronic and optical properties of dumbbell quantum dot via electric field by N.Y. Yengibaryan, G.A. Mantashian, T.A. Sargsian, C. Garoufalis, S. Baskoutas, D.B. Hayrapetyan

“…In this study, we investigate the impact of an external electric field on the electronic and optical properties of dumbbell-shaped quantum dots using the finite element method to calculate the electron energy spectrum and wave functions in the framework of the effective mass approximation. …”
Get full text

Nanocellulose derived from agricultural biowaste by-products–Sustainable synthesis, biocompatibility, biomedical applications, and future perspectives: A review by Md. Meraj Ansari, Yunji Heo, Kyoungtag Do, Mrinmoy Ghosh, Young-Ok Son

“…Moreover, the strategic integration of nanocellulose into composites and its structural functionalization enable customizing its properties for specific functions, further expanding its utility. …”
Get full text

REMR: Identification of RNA Editing-mediated MiRNA Regulation in Cancers by Xu Zhou, Haizhou Liu, Fei Hou, Zong-Qing Zheng, Xinyu Cao, Quan Wang, Wei Jiang

“…Through analyses of functional enrichment, transcriptional regulatory networks, and protein-protein interaction (PPI) networks, we showed that RNA editing-mediated miRNA regulation potentially affects critical cancer-related functions, such as apoptosis, cell cycle, drug resistance, and immunity. …”
Get full text

Single‐Cell Analysis of Alternative Splicing and Gene Regulatory Network Reveals Remarkable Expression and Regulation Dynamics During Human Early Embryonic Development by Jiwei Chen, Gaigai Wei, Fangge Sun, Yunjin Li, Shuang Tang, Geng Chen

“…Additionally, we identified functionally important specific gene regulatory modules for each stage and revealed dynamic usage of transcription factor binding motifs (TFBMs). …”
Get full text

Adaptation of Diqing Tibetan pigs to hypoxic and cold environments through extramedullary hematopoiesis and uncoupled thermogenesis in the liver by Xinpeng Li, Xinxing Dong, Shuhong Zhao, Yunlong Ma, Siqi Jin, Chunlu Zhou, Yi Lan, Shuyuan Luo, Bin Ni, Hongjiang Wei, Dawei Yan

“…Results This study employed single-nucleus RNA sequencing to profile and conduct bioinformatic analyses on the liver tissues of Diqing Tibetan pigs across 5 developmental stages (embryonic day 25, embryonic day 55, day of birth, development to 30 days, and development to 90 days). …”
Get full text

Nitrogen sensitivity of soil microorganism community in alpine desert steppe is not always higher than that in alpine steppe by Zhishu Wang, Jianyu Xiao, Fusong Han, Shaolin Huang, Chengqun Yu

“…Nitrogen sensitivity of soil bacterial community in the AS was higher than that in the ADS at 10 g N m⁻² y⁻¹ nitrogen addition rate, while the result was reversed at 20–40 g N m⁻² y⁻¹ ; the fungal community was more sensitive than bacterial community in the ADS at 5 g N m⁻² y⁻¹ nitrogen addition rate, while the result was reversed 20–40 g N m⁻² y⁻¹ ; the nitrogen sensitivity of the bacterial community's β-diversity in AS varied across species, functional, and phylogenetic dimensions. …”
Get full text

A pilot study on physiological indicators of expertise in pre-hospital emergency medical services (EMS) providers during endotracheal intubation by Gabriel Gazetta, Yaoyu Fu, Kaori Tanaka, Brian M. Clemency, Anirban Dutta, Matthew Hackett, Jack Norfleet, Rahul, Suvranu De, Steven Schwaitzberg, Lora Cavuoto

“…Results: Twenty-seven out of 30 participants successfully intubated the manikin across all repetitions, and expert clinicians finished the task on average 11.6s faster than intermediate clinicians. …”
Get full text

Availability and Key Characteristics of National Early Warning Systems for Emerging Profiles of Antimicrobial Resistance in High-Income Countries: Systematic Review by Jessica Iera, Claudia Isonne, Chiara Seghieri, Lara Tavoschi, Mariateresa Ceparano, Antonio Sciurti, Alessia D'Alisera, Monica Sane Schepisi, Giuseppe Migliara, Carolina Marzuillo, Paolo Villari, Fortunato D'Ancona, Valentina Baccolini

“…The systems were established quite recently; in most cases, they covered both community and hospital settings, but their main characteristics varied widely across countries in terms of the organization and microorganisms under surveillance, with also different definitions of emerging AMR and alert functioning. …”
Get full text

Effect of Alkali Source on Crystal Regulation and Ethanol Gas Sensing Properties of Nano-ZnO by Yinying Liao, Lu Qiu, Yunfei Ouyang, Dayang Feng, Shiyi Huang, Zhaoyang Zhang, Xinyao Xie, Junwei Ke, Tianhao Liu, Xiangxiang Chen, Hongshan Bi, Weiran Zuo

“…To elucidate the underlying mechanisms, density functional theory (DFT) calculations combined with electron depletion layer theory were applied to assess charge transfer processes and identify the most sensitive ZnO crystal planes for ethanol detection. …”
Get full text

Insights into the physiological and metabolic features of Thalassobacterium, a novel genus of Verrucomicrobiota with the potential to drive the carbon cycle by Xin-Yun Tan, Xin-Jiang Liu, De-Chen Lu, Yu-Qi Ye, Xin-Yu Liu, Fan Yu, Hui Yang, Fan Li, Zong-Jun Du, Meng-Qi Ye

“…ABSTRACT Verrucomicrobiota are widely distributed across various habitats but are difficult to culture. …”
Get full text

Histological morphology and gene expression in the digestive system of Procambarus clarkii by Zonglin Yang, Jingjing Hao, Yufei Liu, Xugan Wu, Xiaowu Chen

“…To unravel the intricate morphological structure and functional aspects of the digestive system in Procambarus clarkii, this study employed histology and transcriptome sequencing techniques for a comprehensive analysis of its digestive system. …”
Get full text

Dynamical patterns of EEG connectivity unveil Parkinson’s disease progression: insights from machine learning analysis by Caroline L Alves, Loriz Francisco Sallum, Francisco Aparecido Rodrigues, Thaise G L de O Toutain, Patrícia Maria de Carvalho Aguiar, Michael Moeckel

“…Statistical validation confirmed the significance of these connections across disease stages. Early-stage PD exhibited neural connectivity patterns similar to HCs, while advanced stages showed distinct connectivity changes. …”
Get full text

Orally Dissolving Film-Based Influenza Vaccines Confer Superior Protection Compared to the Oral Administration of Inactivated Influenza Virus by Keon-Woong Yoon, Jie Mao, Gi-Deok Eom, Su In Heo, Ki Back Chu, Mi Suk Lee, Fu-Shi Quan

“…Each group received equivalent antigen doses across three immunizations. Humoral responses and antibody functionality were assessed using sera collected post-immunization. …”
Get full text

Construction and validation of a cell-in-cell related prognostic signature for hepatocellular carcinoma by Hao Zhong, Dong Wang, Yisheng Chen, Danhong Zhan, Chenxi Wang, Rongqi Lin, Wen Li, Qiang Sun, Ruizhi Wang, Meifang He

“…A selection of fifty CICGs was compiled from the literature, revealing their association with CIC development through functional studies. Six predictive genes were ultimately identified through univariate Cox proportional hazards regression (Cox) and least absolute shrinkage and selection operator (LASSO) analyses. …”
Get full text

Melatonin bridges timekeeping and survival: coordinating diurnal rhythms, autophagy, and energy balance in upland cotton by Laha Supriya, Deepika Dake, Nyanthanglo Woch, Kritika Chauhan, Richa Lobiyal, Mehanathan Muthamilarasan, Gudipalli Padmaja

“…Melatonin is widely recognized for its regulatory role in animal circadian rhythms, but its functional significance in plant chronobiology, especially its integration with energy metabolism and autophagy, remains poorly understood. …”
Get full text

Patterns of Variation in the Usage of Fatty Acid Chains among Classes of Ester and Ether Neutral Lipids and Phospholipids in the Queensland Fruit Fly by Shirleen S. Prasad, Matthew C. Taylor, Valentina Colombo, Heng Lin Yeap, Gunjan Pandey, Siu Fai Lee, Phillip W. Taylor, John G. Oakeshott

“…We describe 421 lipids across 15 classes of ester neutral lipids and phospholipids and ether neutral lipids and phospholipids. …”
Get full text