An Increase in Functional Visual Loss: Another Side-Effect of the COVID-19 Pandemic? by Andrea Lembo, Ilia Bresesti, Sofia Ginelli, Irene Schiavetti, Paolo Nucci

“…<b>Background</b>: Functional visual loss (FVL), also known as Non-Organic Visual Loss (NOVL), is a condition characterized by visual impairment without an identifiable organic cause. …”
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CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential by Sophia Clune, Paul Awolade, Hector Esquer, Qiong Zhou, Daniel V. LaBarbera

“…Its overexpression correlates with metastasis, therapy resistance, and poor prognosis across many solid tumors. This review covers CHD1L’s structure, oncogenic functions, and developmental origins, and highlights emerging therapeutic strategies that target CHD1L as a druggable vulnerability in cancer.…”
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Differences in the functional use of two migratory stopovers by humpback whales (Megaptera novaeangliae). by Raphael Mayaud, Joshua N Smith, David Peel, Craig Wilson, Wally Franklin, Tim Stevens, Susan Bengtson Nash

“…Moreton Bay is a newly identified migratory stopover for Australia's east coast humpback whale population. Understanding the functional roles of stopovers is essential for a holistic understanding of population dynamics and connectivity. …”
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Organic Farming to Improve Soil Quality and the Functional Structure of Soil Microbial Communities by Ruilong Huang, Wei Li, Mengting Niu, Bo Hu

“…Using high-throughput sequencing technology, we analyzed soil microbial communities associated with organic (orange lands) and conventional (coffee and maize lands) farming practices in the Gaoligong Mountains (GLGM) region, with the aim of revealing differences in soil properties, microbial community structure, and functional composition across different agricultural management practices. …”
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The functional near infrared spectroscopy applications in children with developmental diseases: a review by Jing Wang, Zhuo Zou, Haoyu Huang, Jinting Wu, Xianzhao Wei, Shuyue Yin, Yingjuan Chen, Yun Liu

“…This review provides a comprehensive synthesis of the application of functional near-infrared spectroscopy (fNIRS) in pediatric developmental disorders, with a particular emphasis on its potential for clinical translation. fNIRS is a portable and non-invasive brain imaging technique that detects the relative concentration changes of oxyhemoglobin (HbO2), deoxyhemoglobin (HbR), and total hemoglobin in the cerebral cortex. …”
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Lateralized Resting-State Functional Brain Network Organization Changes in Heart Failure. by Bumhee Park, Bhaswati Roy, Mary A Woo, Jose A Palomares, Gregg C Fonarow, Ronald M Harper, Rajesh Kumar

“…However, the status of such connectivity or functional organization is unknown in HF. Determination of that status was the aim here, and we examined region-to-region FC and brain network topological properties across the whole-brain in 27 HF patients compared to 53 controls with resting-state functional MRI procedures. …”
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The multifaceted functions of SPC25 in cancer: from molecular pathways to targeted therapy by Yigang Jin, Minjie Chen, Fei Chen, Zhaofeng Gao, Xiaoping Li, Lingyu Hu, Dandan Cai, Siqi Zhao, Zhengwei Song

“…Furthermore, we discuss its prognostic significance across different cancer types and its potential impact on therapy resistance. …”
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Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease by Eswar Kumar Nadendla, Rebecca E. Tweedell, Gary Kasof, Thirumala-Devi Kanneganti

“…Given the clinical relevance of caspases across multiple diseases, improved understanding of these proteins and their structure–function relationships is critical for developing effective treatment strategies.…”
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Functioning of Neurotypical Siblings of Individuals with Autism Spectrum Disorder: A Systematic Review by Brenda Cervellione, Calogero Iacolino, Alessia Bottari, Chiara Vona, Martina Leuzzi, Giovambattista Presti

“…A systematic search was conducted across EBSCO, PubMed, and Google Scholar, covering studies published between 2013 and 2024. …”
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The Historical Evolution and Significance of Multiple Sequence Alignment in Molecular Structure and Function Prediction by Chenyue Zhang, Qinxin Wang, Yiyang Li, Anqi Teng, Gang Hu, Qiqige Wuyun, Wei Zheng

“…Multiple sequence alignment (MSA) has evolved into a fundamental tool in the biological sciences, playing a pivotal role in predicting molecular structures and functions. With broad applications in protein and nucleic acid modeling, MSAs continue to underpin advancements across a range of disciplines. …”
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Functional divergence between the two cerebral hemispheres contributes to human fluid intelligence by Xinyu Liang, Junhao Luo, Qiuhui Bi, Yaya Jiang, Liyuan Yang, Deniz Vatansever, Elizabeth Jefferies, Gaolang Gong

“…Applying this framework to a large cohort (N = 777), we identified high functional divergence across the two hemispheres within the frontoparietal network. …”
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Functional Study of Opsin Genes in <i>Pardosa astrigera</i> (Araneae: Lycosidae) by Shuxin Zhai, Boqi Ren, Xinghua Zhang, Fangyu Shen, Min Ma, Xinmin Li, Rui Li

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Widely Targeted Metabolomics Revealed the Metabolic Basis of Physiological Function and Flavor of Natto by Xiaolong Yin, Xiaona Wang, Lili Xu, Jianzhi Zhao, Can Li, Jianqiang Lin

“…However, due to the absence of large-scale and systematic investigations into its metabolite profile, the mechanisms governing the biological functions and flavor characteristics of natto remain incompletely elucidated. …”
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Elevated Ambient Temperature Associated With Reduced Infectious Disease Test Positivity Rates: Retrospective Observational Analysis of Statewide COVID-19 Testing and Weather Across... by Nicholas Wing-Ping Kwok, Joshua Pevnick, Keith Feldman

“…A mixed-effects beta-regression model was used to estimate daily COVID-19 test positivity rate as a function of ambient temperature, population, and estimates of COVID prevalence, with nested random effects for a day of the week within unique counties across the state. …”
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The Plantaris Muscle Is Not Vestigial: Developmental, Comparative, and Functional Evidence for Its Sensorimotor Role by Łukasz Olewnik, Ingrid C. Landfald, Bartosz Gonera, Aleksandra Szabert-Kajkowska, George Triantafyllou, Maria Piagkou

“…Rather than indicating postnatal regression, it suggests a stable polymorphism rooted in prenatal development. Across mammalian species, the PM varies in presence and function, correlating with locomotor specialization from proprioception in primates to propulsion in carnivores, and absence in ungulates. …”
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Sb-PiPLU: A Novel Parametric Activation Function for Deep Learning by Ayan Mondal, Vimal K. Shrivastava, Ayan Chatterjee, Raghavendra Ramachandra

“…The choice of activation function&#x2014;particularly non-linear ones&#x2014;plays a vital role in enhancing the classification performance of deep neural networks. …”
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Mapping plant functional types through phenological insights: a novel approach by Agradeep Mohanta, Sandhya Kiran Garge, PankajKumar C. Prajapati, Shrishti Rajput, Kavi Oza, Ramandeep Kaur M. Malhi, Prashant Kumar Srivastava, Sanjay Shitole

“…Analysing 130 tree species in Shoolpaneshwar Wildlife Sanctuary reveals unique PhFTs with distinct phenological signatures linked to ecological functions. Using advanced remote sensing, especially the Enhanced Vegetation Index (EVI), enables detailed temporal and spatial analyses across large geographic scales. …”
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The Role of a Conserved Arg-Asp Pair in the Structure and Function of Tetanus Neurotoxin by Elizabeth A. Wilson, Ashtyn N. Bevans, Michael R. Baldwin

“…This is achieved, in part, through pH-triggered membrane insertion of the translocation (HCT) domain, which delivers the catalytic light-chain (LC) domain to the cytosol. While the function of HCT is well defined, the mechanism by which it accomplishes this task is largely unknown. …”
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A multimodal functional structure-based graph neural network for fatigue detection by Dongrui Gao, Zhihong Zhou, Zongyao Peng, Haokai Zhang, Shihong Liu, Manqing Wang, Hongli Chang

“…Recent studies have attempted to enhance detection performance through multimodal information fusion, yet they largely overlook the impact of functional connectivity among multimodal signals. To address this limitation, we propose a novel multimodal fatigue classification framework integrating electroencephalogram (EEG) and electrocardiogram (ECG) signals. …”
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Genetic analyses and functional validation of ruminant SLAMs reveal potential hosts for PPRV by Xi Wei, Kejia Lu, Zhengwu Chang, Hanwei Guo, Qinfeng Li, Binxuan Yuan, Chen Liu, Zengqi Yang, Haijin Liu

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