Microbial diversity and biogeography across gastrointestinal tracts of Takifugu pufferfish revealed by full-length 16S amplicon sequencing by Xingkun Jin, Yan Shi, Zhenlong Sun, Yaohui Wang, Zhe Zhao

“…Fish, which are vital for both aquatic ecosystem functionality and global food supply, rely heavily on their gastrointestinal tract (GIT) microbiota for the digestion that underpins their growth and health. …”
Get full text

Differential resting-state functional connectivity patterns in functional movement disorders: Evidence for gait-disorder-specific aberrations by Carl Alexander Gless, Annemarie Reincke, Anne Weissbach, Christina Bolte, Johanna Geritz, Stephan Wolff, Christof Degen-Plöger, Oliver Granert, Christian Erdmann, Svea Seehafer, Philipp J. Koch, Alexander Münchau, Norbert Brüggemann, Kirsten E. Zeuner, Jos S. Becktepe

“…Results: Seed-based functional connectivity analysis revealed decreased connectivity between the left caudate nucleus and the left temporoparietal junction across gait disorder groups compared to both non-gait disorders and healthy controls. …”
Get full text

Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility by Jun Wang, Chen Chen, Jinhui Zhou, Zinan Xu, Lanjing Xu, Xinwei Li, Zhuchun Zhong, Yuebin Lv, Xiaoming Shi

“…We examined the association of combined lifestyle factors and genetic risk with changes in cognitive function and six specific dimensions of cognition among older adults from the Chinese Longitudinal Healthy Longevity Survey (1998–2018, n = 18,811, a subset of 6301 participants with genetic information). …”
Get full text

Dual‐Responsive Multi‐Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury by Guibin Gao, Juanjuan Li, Yanming Ma, Min Xie, Jianxian Luo, Ke Wang, Cheng Peng, Hua Yang, Tianjun Chen, Guowei Zhang, Jiang Ouyang, Hongsheng Lin, Zhisheng Ji

“…ABSTRACT Preserved/rescued mitochondrial functions have a significant effect on maintaining neurogenesis, axonal carriage, and synaptic plasticity following spinal cord injury (SCI). …”
Get full text

Comprehensive analysis of housekeeping genes, tissue-specific genes, and dynamic regulation across developmental stages in pearl millet by Wei Luo, Min Sun, Ailing Zhang, Chuang Lin, Yarong Jin, Xiaoshan Wang, Linkai Huang

“…A detailed understanding of its gene expression patterns across various tissues and developmental stages is essential for enhancing its yield and quality. …”
Get full text

Cross-Correlation of Soil Moisture and Stone Content and Their Spatial Pattern Across the Different Slope Aspects and Soil Depth by Hailu Kendie Addis, Baye Ayalew, Muuz Gebretsadik, Atikilt Abera, Legese Abebaw Getu, Amsalu K. Addis

Get full text

Integrated proteomics and metabolomics network analysis across different delivery modes in human pregnancy: a pilot study by Yun Huang, Yanyan Ni, Yu Meng, Xiaojing Zeng, Xiaoqing He, Lin Zhang, Jun Zhang

“…However, it remains unclear whether protein and metabolite differences across different delivery modes may underlie child development. …”
Get full text

Biomechanical analysis of All-on-4 implant supported framework using different materials across various clinical practice by Xiaoxuan Chen, Zhengyi Xu, Kuo Gai, Xibo Pei, Ruyi Li, Qianbing Wan

Get full text

Proteomic pathways across the ejection fraction spectrum in patients with heart failure and diabetes mellitus: an EXSCEL trial substudy by Anthony E. Peters, Maggie Nguyen, Jennifer B. Green, Ewan R Pearson, John B. Buse, Harald Sourij, Adrian F. Hernandez, Naveed Sattar, Rury R. Holman, Robert J. Mentz, Svati H. Shah

“…Eight principal components analysis (PCA) protein factors differed significantly across the three EF groups, of which 270 individual proteins within those factors were significant. …”
Get full text

Pilot functional magnetic resonance imaging study of clemastine‐aided functional recovery on a mouse model of demyelination by Ander Egimendia, Irati L. de laPisa, Daniel Padro, Lorena Colás, Sandra Plaza‐García, David Otaegui, Pedro Ramos‐Cabrer

“…Its deleterious effects may be reversed by remyelination, a process that restores the integrity of myelin sheaths and, consequently, neuronal function. However, the functional implications of demyelination and remyelination in MS, as well as the potential impact of therapeutic interventions, remain incompletely understood. …”
Get full text

Prefrontal cortex intrinsic functional connectivity and executive function in early childhood and early adulthood using fNIRS by Cassondra M. Eng, Roberto J. Vargas, Howard L. Fung, Selena R. Niemi, Melissa Pocsai, Anna V. Fisher, Erik D. Thiessen

“…However, few studies have explored EF-rsFC associations using functional near-infrared spectroscopy (fNIRS) across age groups. …”
Get full text

Transcriptomic and proteomic signatures of host NK cells delineate distinct immune states across tuberculosis infection statuses by Han Zhang, Liguo Liu, Jie Hu, Xiaolin Wu, Jianhua Zheng, Henan Xin, Jiang Du, Jiarong Yang, Zizheng Lv, Zhuoran Wu, Lei Gao, Rongmei Liu, Haidan Sun, Xiaobing Zhang, Qi Jin

“…IntroductionAlthough natural killer (NK) cells play crucial roles in the immune response to Mycobacterium tuberculosis (M.tb) infection, systematic investigations delineating the immune characteristics of NK cells across the tuberculosis (TB) disease spectrum are scarce.MethodsThis multiomics study employed transcriptomic, proteomic, and RT-qPCR analyses to characterize and validate CD56+ NK cells from 165 participants stratified by TB infection status (active TB (ATB), latent TB infection (LTBI), and healthy control (HC)). …”
Get full text

Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems by Ju Young Lee, Taemin Kim, Shinil Cho, Jiho Shin, Woon-Hong Yeo, Tae Soo Kim, Ki Jun Yu

Get full text

Metabolic, transcriptomic, and proteomic adaptations in pancreatic ductal adenocarcinoma-patient derived xenograft models across serial passages by Pengfei Guo, Haizong Fang, Han Shi, Junrong Zhang, Ge Song, Chongjiu Fan, Xinyu Qiu, Xianchao Lin, Shi Wen, Jianghua Feng, Heguang Huang, Tianhong Teng

“…Transcriptomic and proteomic analyses were performed using RNA-seq and 4D-DIA mass spectrometry, identifying differentially expressed genes (DEGs) and proteins, which were then subjected to enrichment analysis to uncover key biological functions. A gene-protein interaction network was constructed to identify functional modules across passages. …”
Get full text

A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types by Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith

Get full text

Perspectives on electron transfer kinetics across graphene-family nanomaterials and interplay of electronic structure with defects and quantum capacitance by Sanju Gupta, Magdalena Narajczyk, Mirosław Sawczak, Robert Bogdanowicz

“…We examined factors affecting the kinetic rate constant, rationalized through a physical model and parameterized using density functional theory by incorporating defects and dopants. …”
Get full text

Integration of transcriptome and immunophenotyping data highlights differences in the pathogenetic kinetics of B cells across immune-mediated disease by Kazuhiko Yamamoto, Mineto Ota, Keishi Fujio, Yasuo Nagafuchi, Tomohisa Okamura, Saeko Yamada, Hirofumi Shoda, Takahiro Itamiya, Toshihiko Komai, Shinji Izuka, Kosuke Matsuki

Get full text

Nutraceutical Prospects of Pumpkin Seeds: A Study on the Lipid Fraction Composition and Oxidative Stability Across Eleven Varieties by Magdalena Grajzer, Weronika Kozłowska, Iwan Zalewski, Adam Matkowski, Justyna Wiland-Szymańska, Monika Rękoś, Anna Prescha

“…The oxidative stability of nutritive and bioactive lipids is essential for their functionality. This study evaluated the potential of lipid fractions from pumpkin seeds obtained from eleven high-performing cultivars of <i>Cucurbita maxima</i> Duchesne, <i>C. pepo</i> L., and <i>C. moschata</i> Duchesne cultivated in Poland, aiming to evaluate their stability for nutraceutical applications. …”
Get full text

Constructs across a hierarchical, dimensional model of psychopathology show differential associations with social and general cognitive ability. by Scott D Blain, Jerillyn S Kent, Timothy A Allen, Carly A Lasagna, Chloe A Peyromaure de Bord, Aisha L Udochi, Scott R Sponheim, Colin G DeYoung, Ivy F Tso

Get full text

Metaphor as a springboard to scientific communication: a large-scale study of the use of lexical metaphors across disciplines by Zhuolun Li, Yaqian Shi, Lei Lei

“…To be specific, we used a pre-trained large language model to automatically identify and examine the use of lexical metaphors in more than forty-thousand abstracts across five disciplines. The findings showed that lexical metaphors were frequently used across disciplines. …”
Get full text