Environmental settings and families' socioeconomic status influence mobility and the use of mobility devices by children with cerebral palsy Contextos ambientais e nível socioeconô... by Valéria C. R. Cury, Priscilla R. P. Figueiredo, Marisa C. Mancini

“…OBJECTIVES: To describe typical mobility methods used by children with CP at home, school and community and to compare them across family's socioeconomic levels (SES). METHODS: The Functional Mobility Scale was used to assess mobility of 113 children with CP of high and low SES at home, school, and community. …”
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Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques. by Rachele M Bochart, Kathleen Busman-Sahay, Stephen Bondoc, David W Morrow, Alexandra M Ortiz, Christine M Fennessey, Miranda B Fischer, Oriene Shiel, Tonya Swanson, Christine M Shriver-Munsch, Hugh B Crank, Kimberly M Armantrout, Aaron M Barber-Axthelm, Charlotte Langner, Cassandra R Moats, Caralyn S Labriola, Rhonda MacAllister, Michael K Axthelm, Jason M Brenchley, Brandon F Keele, Jacob D Estes, Scott G Hansen, Jeremy V Smedley

“…Treatment combined with expanded practices resulted in successful maintenance of rhesus macaques (RM) free of common EPs, with no evidence of overt microbiota diversity loss or dysbiosis and instead resulted in a more defined luminal microbiota across study subjects. Creation of a GI pathogen free (GPF) status resulted in improved colonic mucosal barrier function (histologically, reduced colonic MPO+, and reduced pan-bacterial 16s rRNA in the MLN), reduced local and systemic innate and adaptive inflammation with reduction of colonic Mx1 and pSTAT1, decreased intermediate (CD14+CD16+) and non-classical monocytes (CD14-CD16+), reduced populations of peripheral dendritic cells, Ki-67+ and CD38+ CD4+ T cells, Ki-67+IgG+, and Ki-67+IgD+ B cells indicating lower levels of background inflammation in the distal descending colon, draining mesenteric lymph nodes, and systemically in peripheral blood, spleen, and axillary lymph nodes. …”
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Interplay of hypoxia, immune dysregulation, and metabolic stress in pathophysiology of type 1 diabetes by Rahul Mittal, Rahul Mittal, Joana R. N. Lemos, Joana R. N. Lemos, Prem Chapagain, Prem Chapagain, Khemraj Hirani, Khemraj Hirani

“…Furthermore, we highlight the potential of therapeutic strategies that target hypoxia and its downstream effects to preserve β-cell function and modulate autoimmunity. Collaborative efforts across disciplines will be crucial to translating these insights into clinical innovations that improve outcomes for individuals with T1D.…”
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Kinesiophobia and its associated factors among patients after transcatheter aortic valve replacement: a cross-sectional study based on latent profile analysis by Zhiyun Shen, Dandan Geng, Chenxu Huang, Daxin Zhou, Xiaohua Xu, Ying Lin, Yuxia Zhang

“…Factors influencing the levels of kinesiophobia across the three latent profiles included education level, aortic stenosis flow type, number of comorbidities, postoperative NYHA cardiac function classification, preoperative physical activity level, social networks, and exercise self-efficacy. …”
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Effect of aerobic exercise combined with meditation on cognitive frailty: study protocol for a parallel group randomised controlled trial by Wenju Wang, Lei Yang, Feng Chen, Weilin Liu, Tao Jiang, Sijia Xia, Jingfang Zhu, Minguang Yang, Qing Xiang

“…The primary outcomes will include the Edmonton Frailty Scale, while secondary outcomes will encompass evaluations of cognitive functions (including global cognitive function, memory, attention, executive function and visuospatial abilities), physical performance (measured by gait speed and lower extremity strength), subjective experiences (such as fatigue, quality of life, mindfulness, mood and sleep quality), as well as structural and functional MRI assessments and serum biomarkers. …”
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Phylogenetic and Structural Insights into Melatonin Receptors in Plants: Case Study in <i>Capsicum chinense</i> Jacq by Adrian Toledo-Castiñeira, Mario E. Valdés-Tresanco, Georgina Estrada-Tapia, Miriam Monforte-González, Manuel Martínez-Estévez, Ileana Echevarría-Machado

“…However, a detailed description of the phylogeny, protein structure, and binding properties of melatonin, which is still lacking, can help determine the signaling and function of this compound. Melatonin receptor homologs (PMTRs) were identified in 90 Viridiplantae sensu lato proteomes using profile Hidden Markov Models (HMM), which yielded 174 receptors across 87 species. …”
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Organisational and social work-environment experiences after care manager implementation: a repeated cross-sectional study in Swedish primary care by Pia Augustsson, Eva-Lisa Petersson, Cecilia Björkelund, Sven Persson Kylén, Carl Wikberg

“…These improvements were consistent across gender, age, PCC size, and geographic location. …”
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Comprehensive transcriptome, miRNA and kinome profiling identifies new treatment options for personalized lung cancer therapy by Shen Zhong, Yvonne Börgeling, Patrick Zardo, Danny Jonigk, Jürgen Borlak

“…Inhibition of kinases which function as master regulators disrupted the signalling networks, and their gene knock‐down studies confirmed inhibition of cell proliferation in a panel of human LC cell lines. …”
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Pericytes as Key Players in Retinal Diseases: A Comprehensive Narrative Review by Fabiana D’Esposito, Francesco Cappellani, Federico Visalli, Matteo Capobianco, Lorenzo Rapisarda, Alessandro Avitabile, Ludovica Cannizzaro, Roberta Malaguarnera, Giuseppe Gagliano, Antonino Maniaci, Mario Lentini, Giuseppe Montalbano, Mohamed Amine Zaouali, Dorra H’mida, Giovanni Giurdanella, Caterina Gagliano

“…Pericytes, specialized mural cells surrounding microvessels, play a crucial role in maintaining vascular homeostasis and function across various organs, including the eye. …”
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Home-Based Inspiratory Muscle Training as Stand-Alone Therapy in COPD: A Randomized Sham-Controlled Trial Assessing Novel and Established Training Methods by Martin Hartman, Filip Dosbaba, Ladislav Batalik, Daniela Vlazna, Marek Plutinsky, Kristian Brat, Roberta Catunda Costa, Artur Solon Lima, Lawrence P. Cahalin, Magno F. Formiga

“…Primary outcomes included inspiratory muscle performance assessed via the Test of Incremental Respiratory Endurance (TIRE), functional exercise capacity, lung function, and other COPD-related measures. …”
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Aging Gut-Brain Interactions: Pro-Inflammatory Gut Bacteria Are Elevated in Fecal Samples from Individuals Living with Alzheimer’s Dementia by Alison I. C. Donaldson, Claire L. Fyfe, Jennifer C. Martin, Ellen E. Smith, Graham W. Horgan, Phyo K. Myint, Alexandra M. Johnstone, Karen P. Scott

“…The altered microbiome included both compositional and functional changes linked to poorer health and gut inflammation.…”
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Time-varying synergy/redundancy dominance in the human cerebral cortex by Maria Pope, Thomas F Varley, Maria Grazia Puxeddu, Joshua Faskowitz, Olaf Sporns

“…Recent work has emphasized the ubiquity of higher-order interactions in brain function. These interactions can be characterized as being either redundancy or synergy-dominated by applying tools from multivariate information theory. …”
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Environmental settings and families' socioeconomic status influence mobility and the use of mobility devices by children with cerebral palsy Contextos ambientais e nível socioeconô... by Valéria C. R. Cury, Priscilla R. P. Figueiredo, Marisa C. Mancini

“…OBJECTIVES: To describe typical mobility methods used by children with CP at home, school and community and to compare them across family's socioeconomic levels (SES). METHODS: The Functional Mobility Scale was used to assess mobility of 113 children with CP of high and low SES at home, school, and community. …”
Get full text

Sternal interferential current stimulation after sternotomy: A randomized, sham-controlled trial on pain and wound healing by Nils Schulz, Gian Vo, Pascal van Wijnen, Tim Wilhelmi, Michael Coch, Uwe Lange, Philipp Klemm

“…Methods: Patients were randomized into an intervention group receiving interferential current stimulation over the sternum (six sessions across 21 days) or a control group receiving sham stimulation. …”
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Assessment of historical and future changes in temperature indices for winegrape suitability in Hungarian wine regions (1971–2100) by László Lakatos, Richárd Nagy

“…Additionally, a temperature impact function was introduced to characterise the suitability of 21 wine grape varieties with values ranging from 0 to 1, based on the average temperature during the growing season. …”
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NeuroScale: evolutional scale-based protein language models enable prediction of neuropeptides by Hongqi Zhang, Shanghua Liu, Wei Su, Xueqin Xie, Junwen Yu, Fuying Dao, Mi Yang, Hao Lyu, Hao Lin

“…Abstract Background Neuropeptides (NPs) are critical signaling molecules involved in various physiological and behavioral processes, including development, metabolism, and memory. They function within both the nervous and endocrine systems and have emerged as promising therapeutic targets for a range of diseases. …”
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Scutellarin prevents obesity-induced renal fibrosis via reduced activation of AP-1 by Haoan Yi, Yibing Jiang, Wei Li, Ling Shen, Wei Zhang, Shude Li, Yushan Xu, Fei Li

“…Renal function was evaluated by analyzing serum uric acid (UA), creatinine (CRE), and blood urea nitrogen (BUN). …”
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Vacuolar sugar transporter OsERD5 increases rice tillering and yield by modulating intracellular hexose homeostasis by Mingjuan Li, Zhen Li, Hongye Li, Qidong Zhu, Dong Liu, Ben Zhang, Youpeng Chen, Junyan Chen, Huimin Zhang, Nader Saad Elsayed, Zhenhua Zhang

“…Here, we identified OsERD5 as an AtERDL6 homologue and explored the function of OsERD5. We found that OsERD5 overexpression significantly enhanced the tiller number and grain yield of rice. …”
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Effect of immunomodulation on cardiac remodelling and outcomes in heart failure: a quantitative synthesis of the literature by Navkaranbir S. Bajaj, Kartik Gupta, Nitin Gharpure, Mike Pate, Lakshay Chopra, Rajat Kalra, Sumanth D. Prabhu

“…Abstract Aims Immunomodulation in heart failure (HF) has been studied in several randomized controlled trials (RCTs) with variable effects on cardiac structure, function, and outcomes. We sought to determine the effect of immunomodulation on left ventricular ejection fraction (LVEF), LV end‐diastolic dimension (LVEDD), and all‐cause mortality in patients with HF with reduced ejection fraction (HFrEF) through meta‐analyses and trial sequential analyses (TSAs) of RCTs. …”
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Effects of almond, dried grape and dried cranberry consumption on endurance exercise performance, recovery and psychomotor speed: protocol of a randomised controlled trial by Jonathan D Buckley, Catherine Yandell, Noah M A d'Unienville, Alison M Hill, Alison M Coates, Maximillian J Nelson

“…The primary outcome is endurance exercise performance (5 min time-trial performance) and secondary outcomes include markers of NO synthesis (plasma and urinary nitrites and nitrates), muscle damage (serum creatine kinase and lactate dehydrogenase), oxidative stress (F2-isoprostanes), endurance exercise function (exercise efficiency, submaximal oxygen consumption and substrate utilisation), markers of internal training load (subjective well-being, rating of perceived exertion, maximal rate of heart rate increase and peak heart rate) and psychomotor speed (choice reaction time).Conclusion This study will evaluate whether consuming AGC improves endurance exercise performance, recovery and psychomotor speed across an endurance training programme, and evaluate the mechanisms responsible for any improvement.Trial registration number ACTRN12618000360213.…”
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