Is a thermal pulsation system (LipiFlow) effective as a standalone treatment for meibomian gland dysfunction and dry eye? A systematic review and meta-analysis by Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan

“…Methods: A comprehensive search was performed across PubMed, MEDLINE, Embase, and Scopus until December 2024. …”
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Phosphoenolpyruvate carboxylase (PEPC) is essential for the glycolytic pathway and parasite proliferation in Babesia gibsoni by Dong-Fang Li, Ling-Na Wang, Yi-Dan Bai, Yu-Xin Yu, Xing Lu, Xing-Ai Guan, Fang-Jie Li, Sen Wang, Lan He, Jun-Long Zhao

“…This study employs reverse genetics to probe the biological role of PEPC in Babesia gibsoni, noting its conservation across similar protozoa, suggesting a pivotal and conserved biological function. …”
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Therapeutic Potential of Melatonin: Multifaceted Applications in Muscle Health, Metabolic Disorders and Cardiovascular Disease by Martyna Dydyk, Jakub Wójcik, Ewa Błaszczak, Piotr Malinowski, Urszula Kopczyńska, Cezary Kopczyński, Kinga Gurdak, Martyna Michalska, Aleksander Małachowski, Aleksandra Zając

“…This review explores melatonin’s therapeutic applications across multiple medical domains, including muscle health, metabolic disorders, chronic pain management, and cardiovascular health. …”
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Macrostructural and microstructural alterations of hippocampal subregions in T2DM: NODDI provides added value to DTI and volumetric analyses by Xuan Huang, Ziyu Diao, Die Shen, Jianyu Li, Jiahe Wang, Kun Wang, Shijun Qiu

“…Neuropsychological and clinical data were further analyzed to explore correlations with cognitive function. Results: Significant microstructural alterations were observed in the hippocampal subregions of T2DM patients, with NODDI detecting abnormalities in approximately 70 % of the subregions, which were characterized by increased neurite density index (NDI), orientation dispersion index (ODI), and free water fraction (FWF) values, thus suggesting increased neurite density, disrupted orientation, and elevated free water content across most hippocampal subfields. …”
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The performance of 76 kHz positional acoustic telemetry is challenged by acoustic conditions in the tailrace of a hydroelectric dam by C. Ryan Hill, Antóin M. O’Sullivan, R. Allen Curry, Tommi Linnansaari, Philip M. Harrison

“…Performance improved marginally for the second array (i.e., 200–500 m downstream), but position efficiency was ultimately low (1%), variable across transmitter locations, and negatively correlated with discharge. …”
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Comparative Analysis of Nature-Inspired Algorithms for Optimal Power Flow Problem: A Focus on Penalty-Vanishing Terms and Algorithm Performance by Gerardo Castanon, Alberto F. Martinez-Herrera, Ana Maria Sarmiento, Alejandro Aragon-Zavala, Fernando Lezama

“…Through numerical evaluations, we assess their performance across diverse objective functions, addressing complexities such as multi-fuel sources, valve point effects, and prohibited zones. …”
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Durable Shoulder Pain Relief and Avoidance of Surgery Up To 5 Years Following 60-Day PNS Treatment by Kevin E. Vorenkamp, Gemayel Lee, Denise D. Lester, Chaitanya Konda, Steven P. Cohen, Nate D. Crosby, Joseph W. Boggs

“…Outcomes were consistent across follow-up durations and shoulder pain etiologies. …”
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Protective Effects of Gardenia Fruit Derived Exosome-like Nanoparticles Towards Rotenone-induced Damage in PC12 Cells by Haobo WANG, Yan WANG, Zhouzhe LAN, Weikang SHEN, Chunlian QIN, Wen CHEN, Lizhou XU

“…This elevation might be related to the promotion of mitochondrial biosynthesis and the improvement of its function by GDENs, thereby contributing to the energy metabolism and function maintenance of cells. …”
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Identification of a rare variant in TNNT3 responsible for familial dilated cardiomyopathy through whole-exome sequencing and in silico analysis by Motahareh Jadidi, Vida Babaali, Kolsoum InanlooRahatloo, Najmeh Salehi, Reza Mollazadeh

“…Given its crucial role in muscle contractile function, rare variants in TNNT3 hold the potential to be a significant contributing factor in the pathogenesis of DCM. …”
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Dataset of shotgun metagenomic evaluation of Sorghum bicolor rhizosphere microbiome in soils preceded by Glycine maxNCBINCBINCBINCBI by Olubukola Oluranti Babalola, Ben Jesuorsemwen Enagbonma

“…Information from the metagenome sequences is accessible under the bioproject numbers PRJNA1166458 (SA1, SA2, and SA3), PRJNA1166463 (SN1, SN2, and SN3), PRJNA1166623 (RA1, RA2, and RA3), PRJNA1166627 (RN1, RN2 and RN3). Actinomycetota and Function unknown dominated the microbiomes across all cropping systems. …”
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Health technology assessment (HTA) of prostatic urethral lift (PUL) for the treatment of benign prostatic hyperplasia (BPH) in the Italian context by Agostino Fortunato, Eugenio Di Brino, Michele Basile, Debora Antonini, Filippo Rumi

“…The Prostatic Urethral Lift (PUL) system (UroLift) offers a minimally invasive alternative, preserving sexual function and ensuring faster recovery. Methods: Using the EUnetHTA Core Model 3.0, UroLift was evaluated across nine domains, combining a systematic review of literature, expert consultation, and real-world evidence. …”
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Role of extracellular vesicle-carried ncRNAs in the interactive ‘dialogue’ within the brain and beyond: emerging theranostic epigenetic modifiers in brain-derived nanoplatforms... by Nima Sanadgol, Pegah Mousavi, Fatemeh Sadri, Clara Voelz, Miriam Scheld, Roghayeh Khalseh, Javad Amini, Elham Karimi, Amid Rahi, Mohammad-Reza Sepand, Cordian Beyer, Markus Kipp

“…Abstract Proper brain function and overall health critically rely on the bidirectional communications among cells in the central nervous system and between the brain and other organs. …”
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Evolutionary Cost Analysis and Computational Intelligence for Energy Efficiency in Internet of Things-Enabled Smart Cities: Multi-Sensor Data Fusion and Resilience to Link and Devi... by Khalid A. Darabkh, Muna Al-Akhras

“…Thorough simulations and comparative analysis reveal the protocol’s superior performance across key performance metrics, namely, network lifespan, energy consumption, throughput, and average delay. …”
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Long‐Ranging Movements of Asiatic Lions: Implications for Conservation and Management in Gujarat, India by Mohan Ram, Aradhana Sahu, Nityanand Srivastava, Rohit Chaudhary, Lahar Jhala, Yashpal Zala

“…Movement metrics, including distance traveled, were analyzed across different habitats during the day and night. …”
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The association between the Kidney Donor Profile Index and one-year outcomes in Brazilian kidney transplant recipients of standard criteria donors by Ana Paula Aquino de Morais, Renato Demarchi Foresto, Maria Amélia Aguiar Hazin, Bianca Cristina Cassão, Helio Tedesco-Silva, José Medina Pestana, Lúcio Requião-Moura

“…The primary outcome was composed of death, graft loss, and 1-yr-graft function <30 mL/min/1.73m2 (eGFR, CKD-EPI). Logistic regression identified variables associated with the primary outcome, while 1-yr eGFR across KDPI strata was compared using the Kruskal-Wallis test, adjusted with the Bonferroni test. …”
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Interpretable longitudinal glaucoma visual field estimation deep learning system from fundus images and clinical narratives by Xiaoling Huang, Xiangyin Kong, Yan Yan, Zhiyuan Gao, Zihan Li, Chun Zhang, Kai Jin, Juan Ye

“…The pointwise mean absolute error across five models ranged from 3.098 to 4.131 dB. …”
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Auditory sensory processing measures using EEG and MEG predict symptom recovery in first-episode psychosis with a single-tone paradigm by F. López-Caballero, B.A. Coffman, M. Curtis, A.L. Sklar, S. Yi, D.F. Salisbury

“…Predicting symptom progression in first-episode psychosis (FEP) is crucial for tailoring treatment and improving outcomes. Temporal lobe function, indicated by neurophysiological biomarkers like N100, predicts symptom progression and correlates with untreated psychosis. …”
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Identification and validation of the nicotine metabolism-related signature of bladder cancer by bioinformatics and machine learning by Yating Zhan, Min Weng, Yangyang Guo, Dingfeng Lv, Feng Zhao, Zejun Yan, Junhui Jiang, Yanyi Xiao, Lili Yao

“…The signature exhibited a reliable and accurate performance in prognostic prediction across TCGA-train, TCGA-test and GSE32894 cohorts. …”
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Estimated Pulse‐Wave Velocity and Magnetic Resonance Imaging Markers of Cerebral Small‐Vessel Disease in the NOMAS by Taylor A. Ariko, Botagoz Aimagambetova, Hannah Gardener, Jose Gutierrez, Mitchell S. V. Elkind, Clinton B. Wright, Weizhao Zhao, Tatjana Rundek

“…The ePWV values were calculated using a nonlinear function of age and mean arterial blood pressure. The association between ePWV and white matter hyperintensity volume was assessed. …”
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Development of a mobile APP to promote physical activity in individuals with knee osteoarthritis: the “Move for Knee”™ study protocol by Sara Liguori, Sara Liguori, Viviana Andreozzi, Antimo Moretti, Roberta Angari, Marco Paoletta, Giovanni Iolascon, Francesca Gimigliano

“…Its features include exercise tracking, real-time monitoring, and communication with healthcare providers through an integrated chat function. A randomized controlled trial (RCT) will evaluate the app's efficacy in improving pain, function, and quality of life among individuals aged 45–70 with KOA. …”
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