CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy by Xinyue Gao, Feichang Liu, Bo Zhang, Tianyi Ren, You Zheng, Zubiao Niu, He Ren, Chenyu Liu, Chengzuo Jiang, Chenxi Wang, Hongyan Huang, Li Ma, Qiang Sun

“…Emerging evidence indicates the oncogenic potential of CDC25 family members across various cancers. However, comprehensive insights into the expression pattern and function of the CDC25 family in diverse cancers remain unexplored. …”
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A novel Parrot Optimizer for robust and scalable PEMFC parameter optimization by Mohammad Aljaidi, Pradeep Jangir, Arpita, Sunilkumar P. Agrawal, Sundaram B. Pandya, Anil Parmar, Gulothungan G., Ali Fayez Alkoradees, Mohammad Khishe, Reena Jangid

“…The results indicate that PO delivers better performance than existing algorithms because it reaches the lowest Sum of Squared Error for stack voltage outputs across every test scenario. I–V and V–P characteristic simulations match experimental results across different temperature and pressure values which proves the theoretical value and practical usage of PO in solving nonlinear optimization problems. …”
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The effects of small geographical resolution and age on the phyllosphere microbial diversity of Castanopsis eyrei in subtropical forest by Lei Xie, XuXu Bao, Shuifei Chen, Hui Ding, Yanming Fang

“…Co-occurrence network analysis showed that C. eyrei saplings supported the most complex network structure, with Recuromyces acting as a key pathogenic fungus, serving as both a module hub and a connector across all age classes. Overall, these findings highlight the ecological importance of habitat in shaping phyllosphere microbial diversity and underscore the interplay between host function and the maintenance of microbial diversity.IMPORTANCEPlant surfaces host diverse microbial communities that significantly impact host health and overall forest productivity. …”
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Association between vascular endothelial growth factor and atrial fibrillation: a systematic review by Nikhil Sharma, Mahalaqua Nazli Khatib, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Muhammed Shabil, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Afukonyo Shidoiku Daniel, Renu Sah

“…The variability observed across studies suggests a need for standardized measurement approaches and further investigation into VEGF subtypes. …”
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Multi‐omics profiling identifies TNFRSF18 as a novel marker of exhausted CD8⁺ T cells and reveals tumour‐immune dynamics in colorectal cancer by Tengfei Jia, Yingxi Guo, Xin meng Cheng, Zeyang Zhou, Xiaojiang Xu, Hebin Liu, Xiaodong Yang

“…Yet, the dynamic evolution of CD8⁺ T cell exhaustion and its impact on clinical prognosis across TNM (tumour‐node‐metastasis) stages in CRC remains incompletely characterized. …”
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Multisensory training based on an APP for enhanced verbal working memory in older adults by Rongjuan Zhu, Xiaoliang Ma, Ziyu Wang, Qi Hui, Xuan Wang, Xuqun You

“…However, no significant transfer effects were observed for the DSF and DSB tasks across the three training groups. The maintenance effect of VA-VWM training persisted for two weeks across tasks involving VA-VWM, V-VWM, and A-VWM. …”
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Complete Chloroplast Genome Sequences of Three <i>Canna</i> Species: Genome Characterization, Comparative Analyses, and Phylogenetic Relationships Within Zingiberales by Linhe Sun, Jixiang Liu, Fangyu Liu, Wei Wang, Yajun Chang, Dongrui Yao

“…Each genome contained 130 genes, including 110 unique genes (78 protein-coding genes, four of unknown function, four rRNAs, and 28 tRNAs), 18 duplicated genes located in the IR regions (six protein-coding genes, two of unknown function, four rRNAs, and eight tRNAs), and two <i>trnM-CAU</i> genes in the LSC region. …”
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Adaptive Compensatory Neurophysiological Biomarkers of Motor Recovery Post-Stroke: Electroencephalography and Transcranial Magnetic Stimulation Insights from the DEFINE Cohort Stud... by Guilherme J. M. Lacerda, Fernanda M. Q. Silva, Kevin Pacheco-Barrios, Linamara Rizzo Battistella, Felipe Fregni

“…Objective: This study aimed to explore longitudinal relationships between neurophysiological biomarkers and upper limb motor function recovery in stroke patients, focusing on electroencephalography (EEG) and transcranial magnetic stimulation (TMS) metrics. …”
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De novo KCNK4 variant caused epilepsy with febrile seizures plus, neurodevelopmental abnormalities, and hypertrichosis by Hong-Jun Yan, Wen-Hui Liu, Min-Xing Xu, Peng-Yu Wang, Yu-Jie Gu, Hua Li, Jing Guo, Sheng Luo

“…The identified variant was absent in normal populations, indicated to alter hydrogen bonds with surrounding residues by various protein modeling, predicted to be damaging for protein function by twenty algorithms, located in residues of high conservation across species, and classified as pathogenic by the ACMG guidelines. …”
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ST-YOLOv8: Small-Target Ship Detection in SAR Images Targeting Specific Marine Environments by Fei Gao, Yang Tian, Yongliang Wu, Yunxia Zhang

“…Additionally, we replace the Complete Intersection over Union (C-IoU) loss function with the Wise Intersection over Union (W-IoU) loss function, which enhances bounding box precision. …”
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Identifying Concepts of Physical Activity Which Are Clinically Meaningful to Patients and Care Providers: A Systematic Review of Qualitative Research by Candice Taguibao, Salma Ajraoui, Jake Centra, Kieran F. Reid, Christina Daskalopoulou, Alberto Conde Freniche, Alan L. Hamilton, Astrid M. H. Horstman, Benjamin X. Collins, Jessilyn Dunn, Elena S. Izmailova

“…This research presents new findings related to PA MAHs across various therapeutic areas, which go beyond walking. …”
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Differences in demographics and clinical outcomes in older, middle-aged, and younger adults with low back pain receiving chiropractic care by L. A. Hansen, J. Hartvigsen, R. K. Jensen

“…The aims of this study were to (i) to explore differences in patient characteristics and symptoms between older, middle-aged and younger patients with LBP seeking chiropractic care, (ii) to investigate whether age was associated with changes in physical function at 2, 13 and 52 weeks follow-up and (iii) to evaluate if other specific demographic variables were associated with changes in physical function over time. …”
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Digital Interventions for Cognitive Dysfunction in Patients With Stroke: Systematic Review and Meta-Analysis by Chen Wang, Min Liu

“… Abstract BackgroundIn recent years, digital technologies have shown possibilities for improving cognitive function after stroke, but their effectiveness and treatment options vary, the optimal treatment remains unclear, and the current evidence is somewhat contradictory. …”
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Biomechanical Analysis of Different Pacifiers and Their Effects on the Upper Jaw and Tongue by Luca Levrini, Luigi Paracchini, Luigia Ricci, Maria Sparaco, Stefano Saran, Giulia Mulè

“…While they provide comfort and aid in soothing, their use can also have significant impacts on the growth and function of the oral cavity. This study aimed to simulate and predict the behavior of six different types of pacifiers and their functional interaction with the tongue and palate, with the goal of understanding their potential effects on orofacial growth and development. …”
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Characterization of visual cognition in pre-manifest, manifest and reduced penetrance Huntington’s disease by Rocio Del Pino, Maria Ángeles Acera, Amaia Ortiz de Echevarrría, Beatriz Tijero, Marta Ruiz-Lopez, Johanne Somme, Javier Ruiz-Martínez, Andrea Gabilondo, Ioana M. Croitoru, Lara Pardina, Naia Ayo-Mentxakatorre, Ane Murueta-Goyena, Iñigo Gabilondo, Rosario Sanchez-Pernaute, Tamara Fernández-Valle, Juan Carlos Gómez Esteban

“…Age, education, CAG repeats, motor status, executive function, and verbal fluency, accounted for up to 72.8% of the variance in general and visual cognitive functions, with motor status having the strongest impact on visual domains in HD carriers. …”
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Conventional and complementary alternative medicine therapies for renal anemia: a literature review by Ching-Ming Lu, Ching-Ming Lu, Yuan-Hsuan Hsu, Yuan-Hsuan Hsu, I-Hsin Lin, Ko-Lin Kuo, Jian-Fu Liao, Hui-Fen Huang, Hui-Fen Huang, Ping-Hsun Lu, Ping-Hsun Lu

“…Inadequate erythropoietin (EPO) production, worsened kidney function, leads to symptoms such as low energy, fatigue, and impaired physical function, significantly affecting patients’ quality of life. …”
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Factors associated with ADL-defined disability-free survival among patients with advanced cancer in a palliative care setting: a retrospective cohort study by Ryo Soeda, Michiyuki Kawakami, Kengo Nagashima, Tsuyoshi Harada, Takuya Yamaguchi, Yu Furukawa, Tetsuya Tsuji

“…FIM™ is a widely used tool for assessing functional independence across multiple domains. DFS was estimated using a competing risk model to account for death as a competing event, and Fine–Gray regression analysis was conducted to identify factors associated with DFS. …”
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Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice by Jason C. Hsu, Panatda Saenkham-Huntsinger, Pinghan Huang, Cassio Pontes Octaviani, Aleksandra K. Drelich, Bi-Hung Peng, Chien-Te K. Tseng, Chien-Te K. Tseng, Chien-Te K. Tseng

“…However, the expression levels of different genes related to neuronal function, including the neurotransmitter dopamine pathway as well as synaptic function, and markers of neuronal damage were altered as compared to mock-infected mice. …”
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Scoping review to identify and map non-pharmacological, non-surgical treatments for dysphagia following moderate-to-severe acquired brain injury by Signe Janum Eskildsen, Daniela Jakobsen, Christian Gunge Riberholt, Ingrid Poulsen, Derek John Curtis

“…Dysphagia rehabilitation is transforming from mainly compensatory strategies to the retraining of swallowing function using principles from neuroscience. However, there are no studies that map interventions available to retrain swallowing function in patients with moderate-to-severe ABI.Objective To systematically map the accessible research literature to answer the research question: Which non-surgical, non-pharmacological interventions are used in the treatment of dysphagia in patients with moderate and severe ABI in the acute and subacute phase?…”
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Prospective, multicenter, uncontrolled study on the effectiveness and safety of a hyaluronic acid water-based vaginal lubricant in alleviating vaginal dryness and dyspareunia by Manuel Sánchez-Prieto, Carmen Pingarrón, Luciana Bergamaschi, Juan Carlos Bermúdez, José Subiris González, Ruth Sánchez Sánchez, Sílvia Poyo Torcal, Matilde Gómez, María Luisa Ruiz Pérez, Marta Castillo Martínez, M. Eugenia Peña Penedo, Rafael Sánchez-Borrego

“…Background Vaginal dryness (VD) represents a significant concern affecting women across diverse life stages, encompassing both pre- and postmenopausal women at any age. …”
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